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Conserved domains on  [gi|407027847|ref|NP_001258369|]
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nuclear encoded mitochondrial protein C21orf2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.39e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                         90
                 ....*....|..
gi 407027847 119 QKLDNQAVTEEE 130
Cdd:cd21340  198 EVLDGKEITDTE 209
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.42e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


:

Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 407027847   19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.39e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                         90
                 ....*....|..
gi 407027847 119 QKLDNQAVTEEE 130
Cdd:cd21340  198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-122 4.21e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                         90       100       110
                 ....*....|....*....|....*....|....
gi 407027847  93 WLAENpccgtsphryRMT----VLRTLPRLQKLD 122
Cdd:COG4886  211 DLSGN----------QLTdlpePLANLTNLETLD 234
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 407027847   19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.50e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.98  E-value: 1.50e-03
                           10
                   ....*....|....*....
gi 407027847   104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.42e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 407027847   19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-104 8.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 8.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 407027847  38 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIpSLAELFYLKGLPRLRVLWLAENPCCGTSP 104
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIP 516
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.39e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                         90
                 ....*....|..
gi 407027847 119 QKLDNQAVTEEE 130
Cdd:cd21340  198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-122 4.21e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                         90       100       110
                 ....*....|....*....|....*....|....
gi 407027847  93 WLAENpccgtsphryRMT----VLRTLPRLQKLD 122
Cdd:COG4886  211 DLSGN----------QLTdlpePLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-98 5.40e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 5.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  15 SELHSVRKLNCWGSRLTDISIC-QEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLW 93
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLD 278


                 ....*
gi 407027847  94 LAENP 98
Cdd:COG4886  279 LSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-77 3.33e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 3.33e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407027847  15 SELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSL 77
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 17-130 1.25e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407027847  17 LHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAelfYLKGLPRLRVLWLAE 96
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGG 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 407027847  97 NpccgtsphryRMTV---LRTLPRLQ--KLDNQAVTEEE 130
Cdd:cd21340   78 N----------RISVvegLENLTNLEelHIENQRLPPGE 106
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 407027847   19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
64-134 3.02e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 3.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 407027847   64 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 134
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 40-80 8.23e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 8.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 407027847   40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRN-RIPSLAEL 80
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.50e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.98  E-value: 1.50e-03
                           10
                   ....*....|....*....
gi 407027847   104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_8 pfam13855
Leucine rich repeat;
40-98 3.69e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 3.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 407027847   40 PSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRIPSL-AELFYlkGLPRLRVLWLAENP 98
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLsPGAFS--GLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.42e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 407027847   19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 62-98 7.66e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 7.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 407027847   62 QRLSELYLRRNRIPSLAELfylKGLPRLRVLWLAENP 98
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL---AKLPNLETLDLSGNN 34
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-104 8.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 8.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 407027847  38 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIpSLAELFYLKGLPRLRVLWLAENPCCGTSP 104
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIP 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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