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Conserved domains on  [gi|428979907|ref|NP_001258811|]
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leucine-rich repeat-containing protein 73 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 2.98e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.04  E-value: 2.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238  304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 428979907  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238  379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 2.98e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.04  E-value: 2.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238  304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 428979907  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238  379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-132 5.53e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 5.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907  19 AKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTL 98
Cdd:cd00116  163 ANRDLKELNLANN-GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAAL 241

                         90       100       110
                 ....*....|....*....|....*....|....
gi 428979907  99 LDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLA 275
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-131 2.98e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.04  E-value: 2.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDE-AINLICGLlppdGAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:COG5238  304 IGDEgAIALAEGL----QGNKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL 378

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 428979907  81 EVLDLEGTGLTNQSAQTLLDMVENypTALRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238  379 RELNLGKNNIGKQGAEALIDALQT--NRLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-132 5.53e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 5.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907  19 AKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTL 98
Cdd:cd00116  163 ANRDLKELNLANN-GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAAL 241

                         90       100       110
                 ....*....|....*....|....*....|....
gi 428979907  99 LDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLA 275
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-122 1.19e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.42  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDEAINLICGLLPpdgAKSGLKELTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 81
Cdd:COG5238  192 IGDEGIEELAEALT---QNTTVTTLWLKRNP-IGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVE 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 428979907  82 VLDLEGTGLTNQSAQTLLDMVENyPTALRSLVLAENSISPE 122
Cdd:COG5238  268 TLYLSGNQIGAEGAIALAKALQG-NTTLTSLDLSVNRIGDE 307
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 26-131 2.16e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907  26 LTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENY 105
Cdd:COG5238  269 LYLSGNQ-IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN 347

                         90       100
                 ....*....|....*....|....*.
gi 428979907 106 PTaLRSLVLAENSISPELQQQICDLL 131
Cdd:COG5238  348 TT-LHSLDLSDNQIGDEGAIALAKYL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-132 4.81e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 4.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDEAINLICGLLPPdgaKSGLKELTLSAN-PGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAvAVASSRTL 80
Cdd:cd00116   35 LGEEAAKALASALRP---QPSLKELCLSLNeTGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE-SLLRSSSL 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 428979907  81 EVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLS 132
Cdd:cd00116  111 QELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALR 162
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-120 9.17e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 9.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDEAINLICGLLPPdgAKSGLKELTLSANpGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 81
Cdd:cd00116  120 LGDRGLRLLAKGLKD--LPPALEKLVLGRN-RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLE 196

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 428979907  82 VLDLEGTGLTNQSAQTLLDMVENyPTALRSLVLAENSIS 120
Cdd:cd00116  197 VLDLNNNGLTDEGASALAETLAS-LKSLEVLNLGDNNLT 234
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-122 9.75e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 9.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907  23 LKELTLSANPgITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMV 102
Cdd:COG5238  238 LTTLDLSNNQ-IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL 316

                         90       100
                 ....*....|....*....|
gi 428979907 103 ENYPTaLRSLVLAENSISPE 122
Cdd:COG5238  317 QGNKT-LHTLNLAYNGIGAQ 335
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-96 1.44e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   2 LGDEAINLICGLLPpdgAKSGLKELTLSANPgITPKGWSRLAIAVAH-SSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 80
Cdd:cd00116  205 LTDEGASALAETLA---SLKSLEVLNLGDNN-LTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280

                         90
                 ....*....|....*.
gi 428979907  81 EVLDLEGTGLTNQSAQ 96
Cdd:cd00116  281 LELDLRGNKFGEEGAQ 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-125 5.06e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 36.84  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907  21 SGLKELTLSANpGITpkgwsRLAIAVAHSSQVRVLNLDYNPLGDhvagmLAVAVASSRTLEVLDLEGTGLTNQSAQtLLD 100
Cdd:COG4886  159 TNLKSLDLSNN-QLT-----DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPEP-LAN 226

                         90       100
                 ....*....|....*....|....*..
gi 428979907 101 MvenypTALRSLVLAENSIS--PELQQ 125
Cdd:COG4886  227 L-----TNLETLDLSNNQLTdlPELGN 248
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-122 6.81e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428979907   4 DEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQ------VRVLNLDYNPLGDHVAGMLAVAVASS 77
Cdd:COG5238  128 EDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKalqnnsVETVYLGCNQIGDEGIEELAEALTQN 207

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 428979907  78 RTLEVLDLEGTGLTNQSAQTLLDMV-ENypTALRSLVLAENSISPE 122
Cdd:COG5238  208 TTVTTLWLKRNPIGDEGAEILAEALkGN--KSLTTLDLSNNQIGDE 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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