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Conserved domains on  [gi|442629536|ref|NP_001261280|]
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uncharacterized protein Dmel_CG13921, isoform E [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD20 super family cl04401
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 54-220 2.35e-05

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


The actual alignment was detected with superfamily member pfam04103:

Pssm-ID: 461174  Cd Length: 155  Bit Score: 45.33  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536   54 LICGGFSCLLGVLFLGV-YFLLHSYTitvgnfetvpTFVPATLLILTGicIMSLARRRNRYSYLIKLSGACGLVSALTCA 132
Cdd:pfam04103   7 ILLGLLSIVLGFILYSVsSSLLASGY----------PFWGGIIFIISG--VLGIAAEKRSTKLLVLLSLLLNLLSLFTAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  133 LVTVtTTVLHMSRLQALRECeyaqktrtCTCYSDLIESQVDRVDKGVRLVFDSLSDCGVVHGSLYSCLRAIFGLSVAGVL 212
Cdd:pfam04103  75 AGII-LLSLSLALLTSAHEC--------CMSESDLTPSTSTCSCKSSSEDPECRAYCSSLRGLFTGILSMLLILTVLELL 145


                  ....*...
gi 442629536  213 IAVFSCML 220
Cdd:pfam04103 146 VSLLSAIL 153
MISS super family cl25801
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 311-422 8.63e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


The actual alignment was detected with superfamily member pfam15822:

Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 38.81  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  311 PPGNFYSPNPGGDDPVGTCRSGERAGGagrsssgWSWPRMPWQRTTPDAGRRFRQAAASPDSQYGFSSSTA-VQGDGNQM 389
Cdd:pfam15822  85 PPSGPSCPPPGGPYPAPTVPGPGPIGP-------YPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPwAPGMGGQY 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 442629536  390 L---IEEPVVAAYSGMPPPNA-----------LPYGVWGPPPPYSDP 422
Cdd:pfam15822 158 PapnMPYPSPGPYPAVPPPQSpgaappvpwgtVPPGPWGPPAPYPDP 204
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 54-220 2.35e-05

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 45.33  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536   54 LICGGFSCLLGVLFLGV-YFLLHSYTitvgnfetvpTFVPATLLILTGicIMSLARRRNRYSYLIKLSGACGLVSALTCA 132
Cdd:pfam04103   7 ILLGLLSIVLGFILYSVsSSLLASGY----------PFWGGIIFIISG--VLGIAAEKRSTKLLVLLSLLLNLLSLFTAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  133 LVTVtTTVLHMSRLQALRECeyaqktrtCTCYSDLIESQVDRVDKGVRLVFDSLSDCGVVHGSLYSCLRAIFGLSVAGVL 212
Cdd:pfam04103  75 AGII-LLSLSLALLTSAHEC--------CMSESDLTPSTSTCSCKSSSEDPECRAYCSSLRGLFTGILSMLLILTVLELL 145


                  ....*...
gi 442629536  213 IAVFSCML 220
Cdd:pfam04103 146 VSLLSAIL 153
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 311-422 8.63e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 38.81  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  311 PPGNFYSPNPGGDDPVGTCRSGERAGGagrsssgWSWPRMPWQRTTPDAGRRFRQAAASPDSQYGFSSSTA-VQGDGNQM 389
Cdd:pfam15822  85 PPSGPSCPPPGGPYPAPTVPGPGPIGP-------YPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPwAPGMGGQY 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 442629536  390 L---IEEPVVAAYSGMPPPNA-----------LPYGVWGPPPPYSDP 422
Cdd:pfam15822 158 PapnMPYPSPGPYPAVPPPQSpgaappvpwgtVPPGPWGPPAPYPDP 204
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 54-220 2.35e-05

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 45.33  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536   54 LICGGFSCLLGVLFLGV-YFLLHSYTitvgnfetvpTFVPATLLILTGicIMSLARRRNRYSYLIKLSGACGLVSALTCA 132
Cdd:pfam04103   7 ILLGLLSIVLGFILYSVsSSLLASGY----------PFWGGIIFIISG--VLGIAAEKRSTKLLVLLSLLLNLLSLFTAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  133 LVTVtTTVLHMSRLQALRECeyaqktrtCTCYSDLIESQVDRVDKGVRLVFDSLSDCGVVHGSLYSCLRAIFGLSVAGVL 212
Cdd:pfam04103  75 AGII-LLSLSLALLTSAHEC--------CMSESDLTPSTSTCSCKSSSEDPECRAYCSSLRGLFTGILSMLLILTVLELL 145


                  ....*...
gi 442629536  213 IAVFSCML 220
Cdd:pfam04103 146 VSLLSAIL 153
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 311-422 8.63e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 38.81  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629536  311 PPGNFYSPNPGGDDPVGTCRSGERAGGagrsssgWSWPRMPWQRTTPDAGRRFRQAAASPDSQYGFSSSTA-VQGDGNQM 389
Cdd:pfam15822  85 PPSGPSCPPPGGPYPAPTVPGPGPIGP-------YPTPNMPFPELPRPYGAPTDPAAAAPSGPWGSMSSGPwAPGMGGQY 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 442629536  390 L---IEEPVVAAYSGMPPPNA-----------LPYGVWGPPPPYSDP 422
Cdd:pfam15822 158 PapnMPYPSPGPYPAVPPPQSpgaappvpwgtVPPGPWGPPAPYPDP 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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