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Conserved domains on  [gi|449083339|ref|NP_001263338|]
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fibronectin isoform c precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.29e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.29e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.64e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.64e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1450-1529 2.27e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1450 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1526
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 449083339  1527 PAS 1529
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
1542-1622 4.84e-18

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 3.74e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 87.75  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----VPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDITANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1374 TVHWVAPRAPITGYIIRHHAehsVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDL 1453
Cdd:COG3401   443 AAASAASNPGVSAAVLADGG---DTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1454 EVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPV 1533
Cdd:COG3401   520 VGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGT 599


                  ....
gi 449083339 1534 SINY 1537
Cdd:COG3401   600 LLVL 603
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.02e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.48e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.48e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449083339   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.75e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.75e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.12e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.42e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1722 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2225-2266 1.49e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.49e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 449083339   2225 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2266
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2180-2224 2.31e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.31e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339   2180 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2224
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.55e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
698-1027 3.83e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 3.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 449083339 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.44e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.44e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1814-1893 8.98e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.31e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.31e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.86e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2268-2307 8.62e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339 2268 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2307
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449083339   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.63e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.63e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 449083339    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.36e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.36e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 449083339   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1712 1.12e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1709 ESQP 1712
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
2094-2149 7.95e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.95e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  2094 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2149
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.78e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.78e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.29e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.29e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.64e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.64e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.84e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.84e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 449083339  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.23e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.23e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 449083339  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.66e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.47  E-value: 1.66e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 449083339   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1450-1529 2.27e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1450 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1526
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 449083339  1527 PAS 1529
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 3.82e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.62  E-value: 3.82e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 449083339   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1542-1622 4.84e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 3.74e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 87.75  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----VPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDITANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1374 TVHWVAPRAPITGYIIRHHAehsVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDL 1453
Cdd:COG3401   443 AAASAASNPGVSAAVLADGG---DTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1454 EVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPV 1533
Cdd:COG3401   520 VGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGT 599


                  ....
gi 449083339 1534 SINY 1537
Cdd:COG3401   600 LLVL 603
fn3 pfam00041
Fibronectin type III domain;
1358-1438 3.81e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.81e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1358 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1434
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1435 ESPP 1438
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.02e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.48e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.48e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449083339   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1903-1983 2.35e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1903 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1980 KSEP 1983
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.74e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 449083339  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.75e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.75e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.12e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.36e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.36e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 449083339    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1722 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2225-2266 1.49e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.49e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 449083339   2225 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2266
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2180-2224 2.31e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.31e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339   2180 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2224
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.55e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 3.83e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 3.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 449083339 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.44e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.44e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1438 5.13e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1358 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1434
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1435 ESPP 1438
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1450-1530 6.61e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 6.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1450 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1526
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 449083339 1527 PASS 1530
Cdd:cd00063    84 PPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1542-1629 7.43e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339 1619 ESQPLVQTAVT 1629
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1814-1893 8.98e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
fn1 pfam00039
Fibronectin type I domain;
561-599 1.18e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
2180-2219 1.72e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.18  E-value: 1.72e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2180 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2219
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.31e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.31e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 3.48e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.48e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1724-1974 9.82e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.50  E-value: 9.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1724 PTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIvsGLMVATKYEVSVYALKDTLTSRPA 1803
Cdd:COG3401   144 GAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--DIEPGTTYYYRVAATDTGGESAPS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1804 QGVITTLENVSP--PRRARVTDATETTITISWRTKTET-ITGFQvdaipangqtpVQRSISPDVR----------SYTIT 1870
Cdd:COG3401   222 NEVSVTTPTTPPsaPTGLTATADTPGSVTLSWDPVTESdATGYR-----------VYRSNSGDGPftkvatvtttSYTDT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1871 GLQPGTDYKIHLYTLNDNARSSP--VIIDASTAI---DAPSNLRFLTTTPNSLLVSWQAPR-ARITGYIIKYEKPGSPPR 1944
Cdd:COG3401   291 GLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTY 370

                         250       260       270
                  ....*....|....*....|....*....|
gi 449083339 1945 EVVPRPRPGvTEATITGLEPGTEYTIYVIA 1974
Cdd:COG3401   371 TKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
187-226 1.07e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 1.07e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 449083339    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1346 1.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1267 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1345 ES 1346
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.51e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.73  E-value: 3.51e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
726-797 3.69e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.69e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.86e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1903-1981 8.54e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1903 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1980 KS 1981
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2268-2307 8.62e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339 2268 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2307
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 9.55e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.56  E-value: 9.55e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449083339   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.63e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.63e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 449083339    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.78e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.78e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1620 1.79e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.79e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1542 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1616
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 449083339   1617 NGES 1620
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1526 2.95e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.95e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1450 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1525 DS 1526
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.36e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.36e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 449083339   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.12e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339  984 ESNPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2178-2222 6.71e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 6.71e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339 2178 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2222
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2225-2262 6.87e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 6.87e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2225 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2262
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.53e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.11  E-value: 1.53e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2269-2309 2.33e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.33e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339   2269 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2309
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 3.99e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.99e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 449083339   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 5.08e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 5.08e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 7.61e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 7.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 449083339   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1712 1.12e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1709 ESQP 1712
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1722-1809 1.27e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1722 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339 1799 TSRPAQGVITT 1809
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.40e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.40e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1894 1.68e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1814 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 449083339 1890 RSSPV 1894
Cdd:cd00063    82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.07e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.05  E-value: 2.07e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2224-2265 2.84e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.84e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339 2224 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2265
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1632-1712 1.17e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1632 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIREL-FPAPDGEDdTAELQGLRPGSEYTVSVVALHDD 1707
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVPGTTT-SVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 449083339  1708 MESQP 1712
Cdd:pfam00041   80 GEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.78e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 2.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2269-2304 5.38e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2269 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2304
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1722-1793 5.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.43e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339   1722 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1793
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 7.40e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 7.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339    907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339    984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 1.72e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 1.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1888 2.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.40e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1814 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1888
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2094-2149 7.95e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.95e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  2094 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2149
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.21e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.21e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1710 1.43e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.43e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1634 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIRELFPAPDgeDDTAELQGLRPGSEYTVSVVALHDDM 1708
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1709 ES 1710
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.78e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.78e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.57e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.70  E-value: 3.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.26e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 8.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.29e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.29e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.64e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.06  E-value: 1.64e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 449083339    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.84e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.84e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 449083339  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.23e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.23e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 449083339  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.66e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.47  E-value: 1.66e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 449083339   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1450-1529 2.27e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1450 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1526
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 449083339  1527 PAS 1529
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 3.82e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.62  E-value: 3.82e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 449083339   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1542-1622 4.84e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.92  E-value: 4.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1619 ESQP 1622
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1537 3.74e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 87.75  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-----VPAVPPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVrYS 1302
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YR 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1303 PVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY---------EQHESIPLRGRQKTGLDSPTGFDSSDITANSF 1373
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGAT 442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1374 TVHWVAPRAPITGYIIRHHAehsVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDL 1453
Cdd:COG3401   443 AAASAASNPGVSAAVLADGG---DTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1454 EVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPV 1533
Cdd:COG3401   520 VGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGT 599


                  ....
gi 449083339 1534 SINY 1537
Cdd:COG3401   600 LLVL 603
fn3 pfam00041
Fibronectin type III domain;
1358-1438 3.81e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.81e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1358 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1434
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1435 ESPP 1438
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1903-1983 1.02e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1903 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1980 KSEP 1983
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.48e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.48e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 449083339   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1267-1348 1.93e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 1.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1267 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1345 ESIP 1348
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1903-1983 2.35e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1903 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1980 KSEP 1983
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 2.74e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 449083339  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.75e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.75e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.12e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.36e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.36e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 449083339    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1722-1802 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1722 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1799 TSRP 1802
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2225-2266 1.49e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.49e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 449083339   2225 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2266
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2180-2224 2.31e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.31e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339   2180 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2224
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.55e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.55e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 3.83e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 3.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|
gi 449083339 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401   523 APDGTPNVTGASPVTVGAST 542
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.44e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.44e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1166-1667 4.79e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.74  E-value: 4.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1166 VNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVS 1245
Cdd:COG3401    43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1246 VYTVKDDKESAPISDTVVPAVPPPTDLRFTNIGPDTMRVTWAPPpsielTNLLVRYSPVKNEEDVAELSISPSDNAVVLT 1325
Cdd:COG3401   123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGA-----GVVVSPDTSATAAVATTSLTVTSTTLVDGGG 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1326 NLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDITANSFTVHWVAPRAP-ITGYII-RHHAEHS--- 1396
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTESdATGYRVyRSNSGDGpft 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1397 -VGRPRQdrvppsrNSITLTNLNPGTEYVVSIIAVNGR-EESPPLIGQQATVSDI----PRDLEVIASTPTSLLISWEPP 1470
Cdd:COG3401   278 kVATVTT-------TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTppaaPSGLTATAVGSSSITLSWTAS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1471 A-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYKTEIDKPSQMQV 1549
Cdd:COG3401   351 SdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAS 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1550 TDVQDNSISVRWLPSTSPVTGYRVTTTP----------KNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGE 1619
Cdd:COG3401   430 VDAVPLTDVAGATAAASAASNPGVSAAVladggdtgnaVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSV 509

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 449083339 1620 S-QPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS 1667
Cdd:COG3401   510 SvIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1438 5.13e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1358 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1434
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1435 ESPP 1438
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1450-1530 6.61e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 6.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1450 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1526
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 449083339 1527 PASS 1530
Cdd:cd00063    84 PPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1542-1629 7.43e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1542 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1618
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339 1619 ESQPLVQTAVT 1629
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1814-1893 8.98e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1814 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 449083339  1890 RSSP 1893
Cdd:pfam00041   81 EGPP 84
fn1 pfam00039
Fibronectin type I domain;
561-599 1.18e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
2180-2219 1.72e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.18  E-value: 1.72e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2180 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2219
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.31e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.31e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 3.48e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.48e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1724-1974 9.82e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.50  E-value: 9.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1724 PTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIvsGLMVATKYEVSVYALKDTLTSRPA 1803
Cdd:COG3401   144 GAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--DIEPGTTYYYRVAATDTGGESAPS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1804 QGVITTLENVSP--PRRARVTDATETTITISWRTKTET-ITGFQvdaipangqtpVQRSISPDVR----------SYTIT 1870
Cdd:COG3401   222 NEVSVTTPTTPPsaPTGLTATADTPGSVTLSWDPVTESdATGYR-----------VYRSNSGDGPftkvatvtttSYTDT 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1871 GLQPGTDYKIHLYTLNDNARSSP--VIIDASTAI---DAPSNLRFLTTTPNSLLVSWQAPR-ARITGYIIKYEKPGSPPR 1944
Cdd:COG3401   291 GLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTY 370

                         250       260       270
                  ....*....|....*....|....*....|
gi 449083339 1945 EVVPRPRPGvTEATITGLEPGTEYTIYVIA 1974
Cdd:COG3401   371 TKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
187-226 1.07e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 1.07e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 449083339    885 NQES 888
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
1174-1257 1.67e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1174 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQGTsLEEVVHADQSSCTFENLNPGLEYNVSVYTVK 1250
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGEPW-NEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 449083339  1251 DDKESAP 1257
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1346 1.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1267 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1345 ES 1346
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
997-1075 2.47e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   997 DAPTNLQFVNETDRTVLVTWTPPRAR---IAGYRLTAGLTRGGQPKQ-YNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 449083339  1073 QSP 1075
Cdd:pfam00041   81 EGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
807-1291 2.97e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.96  E-value: 2.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  807 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQ 886
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  887 ESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGqrlpvnrntfaeitGL 966
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  967 SPGVTYLFKVFAVHQGRESNP----LTAQQTTKLDAPTNLQFVNETDRTVLVTWTP-PRARIAGYRLTAGLTRGGQPKQY 1041
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKV 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1042 NVGPLASkYPLRNLQPGSEYTVTLVAVKGN-QQSPKATGVFTTLQPLRSIPPYN---TEVTETTIVITWTPAP---RIGF 1114
Cdd:COG3401   280 ATVTTTS-YTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTPPAAPSGltaTAVGSSSITLSWTASSdadVTGY 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1115 KLGVRPSQGGEAPREVTSDSG-SIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA-------NPD 1186
Cdd:COG3401   359 NVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAsvdavplTDV 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1187 TGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAP 1257
Cdd:COG3401   439 AGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510
                  ....*....|....*....|....*....|....
gi 449083339 1258 ISDTVVPAVPPPTDLRFTNIGPDTMRVTWAPPPS 1291
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVS 552
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.51e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.73  E-value: 3.51e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
726-797 3.69e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.69e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.86e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
907-987 7.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.20  E-value: 7.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   907 PPPTDLQFVELTDVKVTIMWTPP---DSVVSGYRVEVLPVSLpGEHGQRLPVNRNTF-AEITGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 449083339   983 RESNP 987
Cdd:pfam00041   80 GEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1903-1981 8.54e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1903 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1980 KS 1981
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2268-2307 8.62e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339 2268 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2307
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 9.55e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.56  E-value: 9.55e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1267-1348 9.98e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 9.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1267 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1344
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1345 ESIP 1348
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
619-688 1.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.10e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449083339   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.63e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.63e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 449083339    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.78e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.78e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1620 1.79e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.79e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1542 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1616
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 449083339   1617 NGES 1620
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 997-1083 2.89e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 2.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  997 DAPTNLQFVNETDRTVLVTWTPPR---ARIAGYRLTAGLTRGGQPKQYNVGPL-ASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 449083339 1073 QSPKATGV-FTT 1083
Cdd:cd00063    82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1526 2.95e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.95e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1450 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1524
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1525 DS 1526
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1436 3.45e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.45e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1358 DSPTGFDSSDITANSFTVHWVAPRAP-ITGYIIRHHAEHSVGRPRQDRV--PPSRNSITLTNLNPGTEYVVSIIAVNGRE 1434
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1435 ES 1436
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.36e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.36e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 449083339   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.12e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339  984 ESNPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2178-2222 6.71e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 6.71e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339 2178 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2222
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2225-2262 6.87e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 6.87e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2225 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2262
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.53e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.11  E-value: 1.53e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2269-2309 2.33e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.33e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339   2269 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2309
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1174-1263 2.75e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1174 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGTSLEeVVHADQSSCTFENLNPGLEYNVSVYTVKD 1251
Cdd:cd00063     2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|..
gi 449083339 1252 DKESAPISDTVV 1263
Cdd:cd00063    80 GGESPPSESVTV 91
fn1 pfam00039
Fibronectin type I domain;
524-555 3.99e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.99e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 449083339   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 5.08e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 5.08e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 7.61e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 7.61e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 449083339   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1632-1712 1.12e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1632 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDM 1708
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 449083339 1709 ESQP 1712
Cdd:cd00063    82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1722-1809 1.27e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1722 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1798
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 449083339 1799 TSRPAQGVITT 1809
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.40e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.40e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1894 1.68e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1814 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 449083339 1890 RSSPV 1894
Cdd:cd00063    82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.07e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.05  E-value: 2.07e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
704-898 2.19e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 63.04  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  704 PVTSNTVTGETAPYSPVVATSESVTEITassfvVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPG 782
Cdd:COG4733   528 PPQWPPVNVTTSESLSVVAQGTAVTTLT-----VSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAG 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  783 RkYIVNVYQISEEGKQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELN 856
Cdd:COG4733   598 D-YEVRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVA 676

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 449083339  857 LPE-TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 898
Cdd:COG4733   677 QALyPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2224-2265 2.84e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.84e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339 2224 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2265
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 997-1074 3.89e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 3.89e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339    997 DAPTNLQFVNETDRTVLVTWTPP-----RARIAGYRLTaGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGN 1071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVE-YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 449083339   1072 QQS 1074
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-940 5.89e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.17  E-value: 5.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  563 DSETRTFYQIGDSWEKFVHGVRYQCY--CYGRGIGEWHCQPLQTYPGTTGPVQVI-ITETPSQPNSHPIQWNAPEPSHIT 639
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRvaATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  640 KYILrWRPKTSTGRWKE-ATIPGhlNSYTIKGLTPGVIYEgqlisiqqYGhreVTRFDFTTSASTPvtSNTVTGETAPYS 718
Cdd:COG3401   263 GYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTYY--------YR---VTAVDAAGNESAP--SNVVSVTTDLTP 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  719 PVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:COG3401   327 PAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGN 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  798 QSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYR--IVYSPSVEGSSTELNLPETANSVTLSDLQPGVQY 875
Cdd:COG3401   406 ESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASnpGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTT 485

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339  876 NITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEV 940
Cdd:COG3401   486 TANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDL 550
fn3 pfam00041
Fibronectin type III domain;
1632-1712 1.17e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  1632 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIREL-FPAPDGEDdTAELQGLRPGSEYTVSVVALHDD 1707
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVPGTTT-SVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 449083339  1708 MESQP 1712
Cdd:pfam00041   80 GEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1174-1255 2.17e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 2.17e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1174 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEV-VHADQSSCTFENLNPGLEYNVSVYTVKDD 1252
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 449083339   1253 KES 1255
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.78e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 2.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 449083339  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2269-2304 5.38e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339  2269 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2304
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1722-1793 5.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.43e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339   1722 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1793
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 7.40e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 7.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 449083339  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339    907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339    984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 1.72e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 1.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 449083339    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1888 2.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.40e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1814 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1888
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 726-808 5.92e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 5.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  726 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLIL 802
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 449083339  803 STSQTT 808
Cdd:cd00063    88 SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1091-1158 7.07e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449083339  1091 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYTYTIQVLRDG 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2094-2149 7.95e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.95e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  2094 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2149
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1784-1972 5.43e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 51.87  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1784 ATKYEVSVYALKDT--LTSRPAQGVITTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQ-TPVQRSI 1860
Cdd:COG4733   508 AVQHAPEKYAAIDAgaFDDVPPQWPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTS 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1861 SPdvrSYTITGLQPGtDYKIHLYTLNDNARSSPVIIDASTAI----DAPSNLRFLTTTPNSLLV--SW-QAPRARITGYI 1933
Cdd:COG4733   586 GT---SFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTE 661

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 449083339 1934 IKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYV 1972
Cdd:COG4733   662 IRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRA 700
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 726-790 7.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.50e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 449083339    726 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 790
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.21e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.21e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 449083339    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-1224 1.14e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 51.10  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  723 TSESVTEITASSFVVSWVSASDTVSGFRVEyelSEEGDE----PQYLDLPSTATSVNI-PDLLPGRKYIV--------NV 789
Cdd:COG4733   427 TLDRPVTMEAGDRYLRVRLPDGTSVARTVQ---SVAGRTltvsTAYSETPEAGAVWAFgPDELETQLFRVvsieenedGT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  790 YQIS----EEGKQSLILSTSQTTAPDAPPDPTV----------DQVDDTSIVVRWSRPQAPITgYRIVYSPsveGSSTEL 855
Cdd:COG4733   504 YTITavqhAPEKYAAIDAGAFDDVPPQWPPVNVttseslsvvaQGTAVTTLTVSWDAPAGAVA-YEVEWRR---DDGNWV 579

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  856 NLPET-ANSVTLSDLQPGvQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDvKVTIMWT-PPDSVV 933
Cdd:COG4733   580 SVPRTsGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLG-GITLSWSfPVDADT 657

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  934 SGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAV-HQGRESnPLTAQQTTKLDAPTNLQFVN----ET 1008
Cdd:COG4733   658 LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGILDAITgqilET 736

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1009 DRTVLVTWTPPRARIAGYRLTAGLTRGGQpkqynVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQPLR 1088
Cdd:COG4733   737 ELGQELDAIIQNATVAEVVAATVTDVTAQ-----IDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDA 811

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339 1089 SIppYNTEVTETTIVITWTPAPRIgfklgvrpsqggeapREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNR 1168
Cdd:COG4733   812 SG--GVTAGTSGTTGAGDTAASTT---------------RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAV 874

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 449083339 1169 VVTplspPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVV 1224
Cdd:COG4733   875 ATT----VSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTREPAGDIGAS 926
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1710 1.43e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.43e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339   1634 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIRELFPAPDgeDDTAELQGLRPGSEYTVSVVALHDDM 1708
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 449083339   1709 ES 1710
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1095-1160 2.45e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.45e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449083339   1095 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.78e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.78e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 449083339    308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.57e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.70  E-value: 3.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 449083339  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.26e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 8.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449083339  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1095-1160 2.54e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 2.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 449083339 1095 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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