|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1855-2181 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site. :
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 459642365 2175 NAGTGKS 2181
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation. :
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 459642365 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT super family |
cl37598 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3097-3441 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component. The actual alignment was detected with superfamily member pfam12777:
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 459642365 3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1721 |
2.04e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region. :
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.91 E-value: 2.04e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 459642365 1714 VRHSITEA 1721
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4219-4514 |
8.11e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain. :
Pssm-ID: 465677 Cd Length: 301 Bit Score: 381.97 E-value: 8.11e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365 4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
1543-4166 |
2.38e-111 |
|
Dynein, heavy chain [Cytoskeleton]; The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 401.29 E-value: 2.38e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245 924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245 992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245 1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245 1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245 1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245 1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245 1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245 1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245 1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245 1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245 1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245 1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245 1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245 1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245 1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245 1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245 2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245 2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245 2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245 2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245 2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245 2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245 2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245 2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245 2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245 2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245 2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245 2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245 2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245 3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1855-2181 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 459642365 2175 NAGTGKS 2181
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 459642365 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3097-3441 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 459642365 3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1721 |
2.04e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.91 E-value: 2.04e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 459642365 1714 VRHSITEA 1721
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4219-4514 |
8.11e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 381.97 E-value: 8.11e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365 4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1543-4166 |
2.38e-111 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 401.29 E-value: 2.38e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245 924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245 992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245 1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245 1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245 1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245 1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245 1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245 1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245 1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245 1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245 1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245 1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245 1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245 1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245 1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245 1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245 2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245 2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245 2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245 2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245 2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245 2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245 2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245 2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245 2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245 2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245 2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245 2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245 2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245 3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3466-3684 |
2.80e-108 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 345.20 E-value: 2.80e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3466 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3544
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3545 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3622
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459642365 3623 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3684
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3312-3407 |
1.49e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3312 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3391
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 459642365 3392 RWGQSIKSFEAQEKTL 3407
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3104-3198 |
7.16e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3104 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3179
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 459642365 3180 LLKAEPALVAATAALNTLN 3198
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1855-2181 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1855 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1934
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1935 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2014
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2015 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2094
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2095 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2174
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 459642365 2175 NAGTGKS 2181
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 459642365 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3097-3441 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3097 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3176
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3177 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3256
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3257 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3337 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3416
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 459642365 3417 FVSYVGPFTRQYRQELVHCKWVPFL 3441
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1721 |
2.04e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.91 E-value: 2.04e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGTVKDMTASLR 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1396 AITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWATMKFS 1474
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1475 YEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVcSE 1554
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1555 DIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSA 1634
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1635 DLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQTMQET 1713
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 459642365 1714 VRHSITEA 1721
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4219-4514 |
8.11e-120 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 381.97 E-value: 8.11e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4219 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4296
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4297 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4376
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4377 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4455
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365 4456 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEKTAKWVLAGVALLL 4514
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1543-4166 |
2.38e-111 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 401.29 E-value: 2.38e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1543 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1622
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1623 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1702
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1703 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1782
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1783 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYLGN 1862
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTI 923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1863 SPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGAWG 1942
Cdd:COG5245 924 PFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG 991
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1943 cFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVAP- 2021
Cdd:COG5245 992 -TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPf 1065
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2022 ------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLMR 2095
Cdd:COG5245 1066 gaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTLDA 1144
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2096 ALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvvGN 2175
Cdd:COG5245 1145 EWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY----------------FR 1190
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2176 AGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE--QA 2246
Cdd:COG5245 1191 VFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdmEA 1239
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2247 NLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY-------- 2318
Cdd:COG5245 1240 RLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrlst 1303
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2319 --VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP--- 2390
Cdd:COG5245 1304 kgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKsie 1381
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2391 --ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLLPw 2464
Cdd:COG5245 1382 laAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNGS- 1456
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2465 adkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNYYT 2542
Cdd:COG5245 1457 ---IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCT 1532
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2543 TSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNC 2618
Cdd:COG5245 1533 MTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGI 1612
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2619 QYVACMNP--MVGSFTINPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTMMC 2695
Cdd:COG5245 1613 ILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSSKD 1688
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2696 NFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFEGI 2774
Cdd:COG5245 1689 KT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREM 1767
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2775 D-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISRIL 2844
Cdd:COG5245 1768 IaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRRGL 1832
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2845 RTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLV 2924
Cdd:COG5245 1833 LVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLE 1912
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2925 LINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPAIV 3003
Cdd:COG5245 1913 DFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALK 1992
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3004 NCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPKSF 3074
Cdd:COG5245 1993 NRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKIKF 2072
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3075 LEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREKTI 3154
Cdd:COG5245 2073 IGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSV 2151
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3155 ADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGRVP 3233
Cdd:COG5245 2152 FVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEA 2228
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3234 KDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCD 3312
Cdd:COG5245 2229 KI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEV 2305
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3313 VEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIR 3392
Cdd:COG5245 2306 KIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSE 2385
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3393 WGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDDAT 3464
Cdd:COG5245 2386 WGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DFKE 2460
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3465 IAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVILIE 3541
Cdd:COG5245 2461 EACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKIIG 2532
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3542 NlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAE 3619
Cdd:COG5245 2533 D-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDA 2611
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3620 VVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKIN 3699
Cdd:COG5245 2612 LEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRID 2691
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3700 EARECYRPVAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLFEK 3779
Cdd:COG5245 2692 ALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHE 2760
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3780 DKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkWVE 3859
Cdd:COG5245 2761 DRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-DNR 2827
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3860 SECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSPGV 3937
Cdd:COG5245 2828 THSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKKSL 2888
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3938 DALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRDYR 4017
Cdd:COG5245 2889 ENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVCGK 2951
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4018 VFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGRLR 4096
Cdd:COG5245 2952 VKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASVIS 3025
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 459642365 4097 FGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFMN 4166
Cdd:COG5245 3026 AGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3466-3684 |
2.80e-108 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 345.20 E-value: 2.80e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3466 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3544
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3545 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3622
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 459642365 3623 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3684
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2825-3084 |
1.38e-105 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 339.20 E-value: 1.38e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2825 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 2904
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2905 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 2984
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2985 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 3064
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 459642365 3065 RHNYTTPKSFLEQISLFKNL 3084
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
2474-2649 |
1.00e-89 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 290.45 E-value: 1.00e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2474 DPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLS-EDYIVSRVPFNYYTTSTALQKILE 2552
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2553 KPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGS-F 2631
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 459642365 2632 TINPRLQRHFTVFAFNFP 2649
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
4077-4213 |
6.87e-66 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 220.40 E-value: 6.87e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 4077 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS-KVPWEDLRYLFGEIMYGGHITDDWDRK 4155
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 459642365 4156 LCRVYLEEFMNPSLTEDELMLAPG-FAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNA 4213
Cdd:pfam18198 81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
3924-4045 |
2.91e-49 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 171.86 E-value: 2.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3924 SPATPIFFILSPGVDALKDLEILGKRLGFTidsGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEK 4003
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 459642365 4004 LLERF-SQGSHRDYRVFMSAEsaPTPDehiIPQGLLENSIKIT 4045
Cdd:pfam03028 78 ILEELpEETLHPDFRLWLTSE--PSPK---FPISILQNSIKIT 115
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
2682-2779 |
2.28e-37 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 137.37 E-value: 2.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2682 LIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQR 2761
Cdd:pfam17857 1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
|
90
....*....|....*...
gi 459642365 2762 RMLETAYKYFEGIDSHML 2779
Cdd:pfam17857 81 IQMASLKKFFDDIEDELE 98
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
2349-2466 |
6.81e-30 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 117.00 E-value: 6.81e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2349 LFDKYVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTP-------ENVPSDSPKEVYEVYFVFACIWAFGGTLLQD 2421
Cdd:pfam17852 4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 459642365 2422 QisdyQADFSRWWQKEMKAVKFP--SQGTIFDYYVDHKTKKLLPWAD 2466
Cdd:pfam17852 84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2169-2313 |
5.30e-10 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 60.38 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2169 SVFVVGNAGTGKSKILRTLNRTYVNmkqKPVWNDLNPKAVTTDELFGFIHHATR--EWKDGKIVYSyfiglfssiLREqa 2246
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAALSN---RPVFYVQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRA---------ARE-- 66
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459642365 2247 nlkhdgpKWIVLDGDID---PMWIESLNTVMDDNKVLTLASNERI-ALTPFMRLLFEIHHLR----SATPATVSR 2313
Cdd:pfam07728 67 -------GEIAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVkAAPDGFRLIATMNPLDrglnELSPALRSR 134
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2505-2641 |
3.84e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 49.21 E-value: 3.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 2505 PLMLVGNAGVGKTvFVGDTLASLSEDYIVSRVPFNYYTTSTALQKILEkPLEKKAGHNYGP---GGNKKLIYFIDDMNMP 2581
Cdd:pfam07728 1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 459642365 2582 EVDLYGTVqpHTLI---RQHIDYGHWydrqkVMLKEIHNCQYVACMNP-MVGSFTINPRLQRHF 2641
Cdd:pfam07728 79 NPDVLNSL--LSLLderRLLLPDGGE-----LVKAAPDGFRLIATMNPlDRGLNELSPALRSRF 135
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
1893-2013 |
2.29e-04 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 44.21 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 1893 GPAGTGKTETTKDLGRAL-GMMVYVFNCSEQM---DYKSIGNIYKGL-----------VQTGAWGCFDEFNRISVEVLSV 1957
Cdd:pfam07728 6 GPPGTGKTELAERLAAALsNRPVFYVQLTRDTteeDLFGRRNIDPGGaswvdgplvraAREGEIAVLDEINRANPDVLNS 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 459642365 1958 VavqvkmiHDAIRNRKKRFVFLGEAITLKP-SVGIFITMNPGYAGRTELPENLKALF 2013
Cdd:pfam07728 86 L-------LSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRGLNELSPALRSRF 135
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
3323-3387 |
8.51e-04 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 42.47 E-value: 8.51e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 459642365 3323 ANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELE 3387
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3312-3407 |
1.49e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3312 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3391
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 459642365 3392 RWGQSIKSFEAQEKTL 3407
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
3319-3389 |
2.51e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 2.51e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 459642365 3319 ALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAK 3389
Cdd:COG3883 10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3317-3407 |
2.83e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 43.35 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3317 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3396
Cdd:COG4372 51 REELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130
|
90
....*....|.
gi 459642365 3397 IKSFEAQEKTL 3407
Cdd:COG4372 131 RKQLEAQIAEL 141
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3317-3407 |
5.90e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.58 E-value: 5.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3317 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3396
Cdd:COG4372 79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158
|
90
....*....|.
gi 459642365 3397 IKSFEAQEKTL 3407
Cdd:COG4372 159 LESLQEELAAL 169
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3104-3198 |
7.16e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459642365 3104 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3179
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 459642365 3180 LLKAEPALVAATAALNTLN 3198
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
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