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Conserved domains on  [gi|469608410|ref|NP_001264153|]
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transgelin-2 isoform a [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 39-175 7.18e-99

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 283.31  E-value: 7.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  39 IEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFL 118
Cdd:cd21280    1 IDKQYDADLEQILIQWITAQCGKQVGRPQPGRENFQNWLKDGTVLCHLINSLYPKGQAPVKKIQASTMAFKQMEQISQFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469608410 119 QAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKK 175
Cdd:cd21280   81 QAAERYGINTTDIFQTVDLWEGKNMASVQRTLMNLGGLAVTRDDGLFVGDPNWFPKK 137
Calponin pfam00402
Calponin family repeat;
195-219 1.33e-10

Calponin family repeat;


:

Pssm-ID: 459803  Cd Length: 25  Bit Score: 54.45  E-value: 1.33e-10
                          10        20
                  ....*....|....*....|....*
gi 469608410  195 IGLQMGTNRGASQAGMTGYGMPRQI 219
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25
 
Name Accession Description Interval E-value
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 39-175 7.18e-99

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 283.31  E-value: 7.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  39 IEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFL 118
Cdd:cd21280    1 IDKQYDADLEQILIQWITAQCGKQVGRPQPGRENFQNWLKDGTVLCHLINSLYPKGQAPVKKIQASTMAFKQMEQISQFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469608410 119 QAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKK 175
Cdd:cd21280   81 QAAERYGINTTDIFQTVDLWEGKNMASVQRTLMNLGGLAVTRDDGLFVGDPNWFPKK 137
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 45-154 3.11e-24

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 92.35  E-value: 3.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410   45 ADLEQILIQWITTQCRKDVGRPQpgRENFQNWLKDGTVLCELINALYPEGqapVKKIQASTMAFKQMEQISQFLQAAER- 123
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVR--VTNFTTDLRDGLALCALLNKLAPGL---VDKKKLNKSEFDKLENINLALDVAEKk 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 469608410  124 YGINTTDIfQTVDLWEGKNMaCVQRTLMNLG 154
Cdd:pfam00307  76 LGVPKVLI-EPEDLVEGDNK-SVLTYLASLF 104
SCP1 COG5199
Calponin [Cytoskeleton];
35-209 6.45e-24

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 93.83  E-value: 6.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  35 VQQKIEKQYDADLEQILIQWITTQCRKDVGRPQpgreNFQNWLKDGTVLCELINALYPegqAPVKkIQASTMAFKQMEQI 114
Cdd:COG5199    2 VNTKNRCPGMDKQQKEVTLWIETVLGEKFEPPG----DLLSLLKDGVRLCRILNEASP---LDIK-YKESKMPFVQMENI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410 115 SQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFsgdPNWFPKKSKENPRNFS-DNQLQEGKN 193
Cdd:COG5199   74 SSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKERMFSG---PFLGPHLATKKPRVFSsQEVLDRSKG 150

                        170
                 ....*....|....*.
gi 469608410 194 VIGLQMGTNRGASQAG 209
Cdd:COG5199  151 AIHLQYGYSDLSEQST 166
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 50-153 3.39e-22

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 86.99  E-value: 3.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410    50 ILIQWITTQCRKDvgrPQPGRENFQNWLKDGTVLCELINALYPeGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINtT 129
Cdd:smart00033   2 TLLRWVNSLLAEY---DKPPVTNFSSDLKDGVALCALLNSLSP-GLVDKKKVAASLSRFKKIENINLALSFAEKLGGK-V 76

                           90       100
                   ....*....|....*....|....*
gi 469608410   130 DIFQTVDLWEG-KNMACVQRTLMNL 153
Cdd:smart00033  77 VLFEPEDLVEGpKLILGVIWTLISL 101
Calponin pfam00402
Calponin family repeat;
195-219 1.33e-10

Calponin family repeat;


Pssm-ID: 459803  Cd Length: 25  Bit Score: 54.45  E-value: 1.33e-10
                          10        20
                  ....*....|....*....|....*
gi 469608410  195 IGLQMGTNRGASQAGMTGYGMPRQI 219
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25
 
Name Accession Description Interval E-value
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 39-175 7.18e-99

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 283.31  E-value: 7.18e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  39 IEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFL 118
Cdd:cd21280    1 IDKQYDADLEQILIQWITAQCGKQVGRPQPGRENFQNWLKDGTVLCHLINSLYPKGQAPVKKIQASTMAFKQMEQISQFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469608410 119 QAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKK 175
Cdd:cd21280   81 QAAERYGINTTDIFQTVDLWEGKNMASVQRTLMNLGGLAVTRDDGLFVGDPNWFPKK 137
CH_TAGLN-like cd21209
calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family ...
 44-162 1.50e-82

calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family includes transgelin, transgelin-2 and transgelin-3. Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. It may participate in the development and progression of multiple cancers. Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409058 [Multi-domain]  Cd Length: 119  Bit Score: 241.26  E-value: 1.50e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAER 123
Cdd:cd21209    1 DPELESRLVEWIVAQCGSDVGRPDPGRLGFQKWLKDGTVLCKLINSLYPEGSKPVKKIQSSKMAFKQMEQISQFLKAAED 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 469608410 124 YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDD 162
Cdd:cd21209   81 YGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSLAVTKDD 119
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 44-162 1.68e-68

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 205.58  E-value: 1.68e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAER 123
Cdd:cd21281    1 DPDLESRLVDWIIIQCGGDIERPQPGRQNFQKWLMDGTILCRLINSLYPPGKEPIKKISETKMAFKQMEKISQFLQAAEA 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 469608410 124 YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDD 162
Cdd:cd21281   81 YGVITTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDD 119
CH_TAGLN cd21279
calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa ...
 44-163 1.16e-54

calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. It may also contribute to replicative senescence. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409128 [Multi-domain]  Cd Length: 121  Bit Score: 170.57  E-value: 1.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQAS-TMAFKQMEQISQFLQAAE 122
Cdd:cd21279    1 DEELEERLVEWIVVQCGPDVGRPDRGRLGFQVWLKNGVVLSKLVNSLYPDGSKPVKIPDNPpSMVFKQMEQVAQFLKAAE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 469608410 123 RYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDG 163
Cdd:cd21279   81 DYGVVKTDMFQTVDLYEGKDMAAVQRTLVALGSLAVTKNDG 121
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 43-155 6.12e-36

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 122.42  E-value: 6.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  43 YDADLEQILIQWIttqcRKDVGRPQPGRENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAE 122
Cdd:cd21207    2 RDPALEAEALDWI----EAVTGEKLDDGKDYEDVLKDGVILCKLINILKP---GSVKKINTSKMAFKLMENIENFLTACK 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 469608410 123 RYGINTTDIFQTVDLWEGKNMACVQRTLMNLGG 155
Cdd:cd21207   75 GYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 48-154 1.58e-26

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 98.18  E-value: 1.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  48 EQILIQWITTQCRKdvgRPQPGRENFQNWLKDGTVLCELINALYPEgqAPVKKIQASTMAFKQMEQISQFLQAAERYGIN 127
Cdd:cd00014    1 EEELLKWINEVLGE---ELPVSITDLFESLRDGVLLCKLINKLSPG--SIPKINKKPKSPFKKRENINLFLNACKKLGLP 75

                         90       100
                 ....*....|....*....|....*..
gi 469608410 128 TTDIFQTVDLWEGKNMACVQRTLMNLG 154
Cdd:cd00014   76 ELDLFEPEDLYEKGNLKKVLGTLWALA 102
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 73-154 3.27e-25

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 94.74  E-value: 3.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  73 FQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMN 152
Cdd:cd21210   22 LLDALKDGVVLCKLANRILP---ADIRKYKESKMPFVQMENISAFLNAARKLGVPENDLFQTVDLFERKNPAQVLQCLHA 98


                 ..
gi 469608410 153 LG 154
Cdd:cd21210   99 LS 100
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 45-154 3.11e-24

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 92.35  E-value: 3.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410   45 ADLEQILIQWITTQCRKDVGRPQpgRENFQNWLKDGTVLCELINALYPEGqapVKKIQASTMAFKQMEQISQFLQAAER- 123
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVR--VTNFTTDLRDGLALCALLNKLAPGL---VDKKKLNKSEFDKLENINLALDVAEKk 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 469608410  124 YGINTTDIfQTVDLWEGKNMaCVQRTLMNLG 154
Cdd:pfam00307  76 LGVPKVLI-EPEDLVEGDNK-SVLTYLASLF 104
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 44-157 5.43e-24

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 91.60  E-value: 5.43e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGrpqpgrENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAER 123
Cdd:cd21211    1 DHQKEAELRTWIEGVTGLSIG------PNFQKGLKDGIILCELINKLQP---GSVKKINESMQNWHQLENIGNFIKAIVS 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 469608410 124 YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLA 157
Cdd:cd21211   72 YGMKPHDIFEANDLFENGNMTQVQVTLLALAGKA 105
SCP1 COG5199
Calponin [Cytoskeleton];
35-209 6.45e-24

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 93.83  E-value: 6.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  35 VQQKIEKQYDADLEQILIQWITTQCRKDVGRPQpgreNFQNWLKDGTVLCELINALYPegqAPVKkIQASTMAFKQMEQI 114
Cdd:COG5199    2 VNTKNRCPGMDKQQKEVTLWIETVLGEKFEPPG----DLLSLLKDGVRLCRILNEASP---LDIK-YKESKMPFVQMENI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410 115 SQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFsgdPNWFPKKSKENPRNFS-DNQLQEGKN 193
Cdd:COG5199   74 SSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKERMFSG---PFLGPHLATKKPRVFSsQEVLDRSKG 150

                        170
                 ....*....|....*.
gi 469608410 194 VIGLQMGTNRGASQAG 209
Cdd:COG5199  151 AIHLQYGYSDLSEQST 166
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 42-157 1.86e-23

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 90.35  E-value: 1.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  42 QYDADLEQILIQWITTQCRKDVGrpqpgrENFQNWLKDGTVLCELINALYPEGqapVKKIQASTMAFKQMEQISQFLQAA 121
Cdd:cd21284    1 KYDPQKEEELRNWIEEVTGMSIG------ENFQKGLKDGVILCELINKLQPGS---IRKINESKLNWHQLENIGNFIKAI 71

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 469608410 122 ERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLA 157
Cdd:cd21284   72 QAYGMKPHDIFEANDLFENGNMTQVQTTLLALAGLA 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 50-153 3.39e-22

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 86.99  E-value: 3.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410    50 ILIQWITTQCRKDvgrPQPGRENFQNWLKDGTVLCELINALYPeGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINtT 129
Cdd:smart00033   2 TLLRWVNSLLAEY---DKPPVTNFSSDLKDGVALCALLNSLSP-GLVDKKKVAASLSRFKKIENINLALSFAEKLGGK-V 76

                           90       100
                   ....*....|....*....|....*
gi 469608410   130 DIFQTVDLWEG-KNMACVQRTLMNL 153
Cdd:smart00033  77 VLFEPEDLVEGpKLILGVIWTLISL 101
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 44-157 6.01e-22

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 86.47  E-value: 6.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGrpqpgrENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAER 123
Cdd:cd21282    1 DPQTEEELRVWIEGVTGRRIG------DNFMDGLKDGVILCELINKLQP---GSVRKINESTQNWHKLENIGNFIKAIMH 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 469608410 124 YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLA 157
Cdd:cd21282   72 YGVKPHDIFEANDLFENTNHTQVQSTLIALASMA 105
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 44-157 3.03e-21

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 84.60  E-value: 3.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  44 DADLEQILIQWITTQCRKDVGrpqpgrENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAER 123
Cdd:cd21283    1 DPQKEAELRTWIEGLTGRSIG------PDFQKGLKDGVILCELMNKLQP---GSVPKINRSMQNWHQLENLSNFIKAMVS 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 469608410 124 YGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLA 157
Cdd:cd21283   72 YGMKPVDLFEANDLFESGNMTQVQVSLLALAGMA 105
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 53-143 1.21e-13

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 64.94  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  53 QWIT--TQCRKdvgrpqPGRENFQNWLKDGTVLCELINALYPEGqAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTD 130
Cdd:cd21206   15 QWIEacLNEEL------PPTTEFEEELRNGVVLAKLANKFAPKL-VPLKKIYDVGLQFRHTDNINHFLRALKKIGLPKIF 87

                         90
                 ....*....|...
gi 469608410 131 IFQTVDLWEGKNM 143
Cdd:cd21206   88 HFETTDLYEKKNI 100
Calponin pfam00402
Calponin family repeat;
195-219 1.33e-10

Calponin family repeat;


Pssm-ID: 459803  Cd Length: 25  Bit Score: 54.45  E-value: 1.33e-10
                          10        20
                  ....*....|....*....|....*
gi 469608410  195 IGLQMGTNRGASQAGMTGYGMPRQI 219
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 77-150 4.80e-10

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 55.34  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  77 LKDGTVLCELINALYPeGQAPVKKIQASTmafkQMEQ------ISQFLQAA-ERYGINTTDIFQTVDLWEGKNMACVQRT 149
Cdd:cd21201   36 LRDGVLLCQLLNRLSP-GSVDDREINLRP----QMSQflclknIRTFLQACrTVFGLRSADLFEPEDLYDVTNFGKVIRT 110


                 .
gi 469608410 150 L 150
Cdd:cd21201  111 L 111
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 71-137 1.42e-09

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 53.88  E-value: 1.42e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 469608410  71 ENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDL 137
Cdd:cd21208   20 DDFRESLEDGILLCELINAIKP---GSIKKINRLPTPIAGLDNLNLFLKACEDLGLKDSQLFDPTDL 83
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 51-160 7.99e-08

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 49.57  E-value: 7.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  51 LIQWITTQCRKDVGRpqpgrENFQNWLKDGTVLCELINAL-----------YPEGQAPVKKIQ----ASTMAFKQMEQIS 115
Cdd:cd21204   11 LAEWLNDLLGDDLTP-----DNFLDELRNGVVLCQLAQKIqeaaekareagKKNGPPPSYKLKcnenAKPGSFFARDNVA 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 469608410 116 QFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVAR 160
Cdd:cd21204   86 NFLRWCRKLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARY 130
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 63-137 2.41e-07

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 47.79  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  63 VGRPQPGRENFQNWLKDGTVLCELINALYPE-----GQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTtdiFQTVDL 137
Cdd:cd21203   16 LVLPDPSEEEFRLCLRDGVVLCKLLNKLQPGavpkvVESPDDPDGAAGSAFQYFENVRNFLVAIEEMGLPT---FEASDL 92
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 77-153 8.35e-07

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 46.37  E-value: 8.35e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 469608410  77 LKDGTVLCELINALYPegqAPVKKI-QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNL 153
Cdd:cd21202   34 LKNGVVLCRLVNRLKP---GTVEKIyDEPTTEEECLYNFESFLKACQELGILAEEIFDPNDLYSGGNFQKVLSTLERL 108
CH_LIMCH1 cd21278
calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; ...
 69-149 1.46e-05

calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; LIM and calponin homology domains-containing protein 1 (LIMCH1) acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. LIMCH1 contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409127 [Multi-domain]  Cd Length: 118  Bit Score: 42.93  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  69 GRENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQR 148
Cdd:cd21278   18 GDKDFRSGLENGILLCELLNAIKP---GLVKKINRLPTPIAGLDNITLFLRGCKELGLKESQLFDPGDLQDTSNRVTIKS 94


                 .
gi 469608410 149 T 149
Cdd:cd21278   95 S 95
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 61-148 1.84e-05

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 42.52  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  61 KDVGRPQPGRENFQNWLKDGTVLCELINALYPegqAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEG 140
Cdd:cd21277   10 EAVTGKNFGNKDFRSALENGVLLCDLINKIKP---GIIKKINRLSTPIAGLDNINVFLKACEKLGLKEAQLFHPGDLQDL 86


                 ....*...
gi 469608410 141 KNMACVQR 148
Cdd:cd21277   87 STRVTVKQ 94
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 77-159 3.96e-05

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 41.85  E-value: 3.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  77 LKDGTVLCELINALYPEGqAPVKKI--QASTMAFKQMEQISQFLQA-AERYGINTTDIFQTVDLWEGKNMACVQRTLMNL 153
Cdd:cd21262   36 LRDGVLLCQLLNNLLPHA-VNLREInlRPQMSQFLCLKNIRTFLSTcCEKFGLRKSELFEAFDLFDVRDFGKVIDTLSIL 114


                 ....*.
gi 469608410 154 GGLAVA 159
Cdd:cd21262  115 SWTPIA 120
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 77-153 7.52e-05

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 41.10  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  77 LKDGTVLCELINALYPEgQAPVKKI--QASTMAFKQMEQISQFLQA-AERYGINTTDIFQTVDLWEGKNMACVQRTLMNL 153
Cdd:cd21264   36 LRDGVLLCQLLNNLRPH-SINLKEInlRPQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDLFDVRDFGKVIETLSKL 114
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 77-153 8.28e-05

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 40.36  E-value: 8.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  77 LKDGTVLCELINALYP-------EGQAPVKKIqasTMAfKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRT 149
Cdd:cd21205   26 LMDGVVLCHLANHVRPrsvpsihVPSPAVPKL---SMA-KCRRNVENFLEACRKLGVPEERLCSPGDILEEKGLVRVAVT 101


                 ....
gi 469608410 150 LMNL 153
Cdd:cd21205  102 VQAL 105
CH_alphaPIX cd21265
calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak ...
 77-150 2.54e-04

calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor; Alpha-Pak Interactive eXchange factor (alpha-PIX), also called PAK-interacting exchange factor alpha, Rho guanine nucleotide exchange factor 6 (ARHGEF6), Rac/Cdc42 guanine nucleotide exchange factor 6, or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Alpha-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409114  Cd Length: 117  Bit Score: 39.42  E-value: 2.54e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 469608410  77 LKDGTVLCELINALYPEGQAPV---KKIQASTmafkqMEQISQFLQAAERYGInttDIFQTVDLWEGKNMACVQRTL 150
Cdd:cd21265   35 LKDGVVLCKLIERLLPGSVEKYclePKTEADC-----IGNIKEFLKGCAALKV---ETFEPDDLYTGENFSKVLSTL 103
IQG1 COG5261
Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and ...
 69-153 3.88e-04

Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms];


Pssm-ID: 227586 [Multi-domain]  Cd Length: 1054  Bit Score: 41.02  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410   69 GRENFQNWLKDGTVLCELINALYPEgqaPVKKI-QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQ 147
Cdd:COG5261    62 PELCFEDSLRNGVFLAKLTQRFNPD---LTTVIfPADKLQFRHTDNINAFLDLIEHVGLPESFHFELQDLYEKKNIPKVI 138


                  ....*.
gi 469608410  148 RTLMNL 153
Cdd:COG5261   139 YCIHAL 144
CH_IQGAP3 cd21276
calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP3; IQ motif ...
 39-143 6.73e-04

calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP3; IQ motif containing GTPase activating protein 3 (IQGAP3) associates with Ras GTP-binding proteins. It regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton. It belongs to the IQGAP family, which consists of multi-domain proteins having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP3 contains a single copy of the CH domain at the N-terminus.


Pssm-ID: 409125 [Multi-domain]  Cd Length: 152  Bit Score: 38.81  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  39 IEKQYDADLEQILiQWITTQCRKDVGRPQPGRENfqnwLKDGTVLCELINALYPEgQAPVKKI--------QASTMAFKQ 110
Cdd:cd21276    2 VAYQYLCRLEEAK-RWMEACLKEELPPPTELEES----LRNGVYLAKLGHCFAPR-VVPLKKIydleqmryQATGLHFRH 75

                         90       100       110
                 ....*....|....*....|....*....|...
gi 469608410 111 MEQISQFLQAAERYGINTTDIFQTVDLWEGKNM 143
Cdd:cd21276   76 TDNINHWRNAMMHIGLPSIFHPETTDIYDKKNM 108
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 61-141 7.31e-04

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066 [Multi-domain]  Cd Length: 114  Bit Score: 37.94  E-value: 7.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  61 KDVGRPQPGRENFQNWLKDGTVLCELINALYPeGQAPVKKI--QASTMAFKQMEQISQFLQAAERYGINTTDIfQTVDLW 138
Cdd:cd21217   21 KHLLPIDPDGDDLFEALRDGVLLCKLINKIVP-GTIDERKLnkKKPKNIFEATENLNLALNAAKKIGCKVVNI-GPQDIL 98


                 ...
gi 469608410 139 EGK 141
Cdd:cd21217   99 DGN 101
CH_PLS_FIM_rpt2 cd21218
second calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
 48-128 7.40e-04

second calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409067  Cd Length: 114  Bit Score: 38.05  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  48 EQILIQWITTQCRKdVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMA--FKQMEQIsqfLQAAERYG 125
Cdd:cd21218   12 EEILLRWVNYHLKK-AGPTKKRVTNFSSDLKDGEVYALLLHSLAPELCDKELVLEVLSEEdlEKRAEKV---LQAAEKLG 87


                 ...
gi 469608410 126 INT 128
Cdd:cd21218   88 CKY 90
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 55-153 8.70e-04

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 37.57  E-value: 8.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  55 ITTQCRKDV----GRPQPgrENFQNWLKDGTVLCELINALYPEG----QAPVKKIqASTMAFKQMEQISQFLQAAERYGI 126
Cdd:cd21273    5 LRAQLRKTLesrlKVTLP--EDLAEALSNGAVLCQLANQLRPRSvsiiHVPSPAV-PKLSKAKCRKNVENFIEACRKMGV 81

                         90       100
                 ....*....|....*....|....*..
gi 469608410 127 NTTDIFQTVDLWEgKNMACVQRTLMNL 153
Cdd:cd21273   82 PEVDLCSPSDVLL-QGPAAVLRTVLAL 107
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 77-157 1.00e-03

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 37.66  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  77 LKDGTVLCELINALYPEG----QAPVKKIQASTMAfKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMN 152
Cdd:cd21272   26 LTDGVVLCHLANHVRPRSvpsiHVPSPAVPKLTMA-KCRRNVENFLEACRRIGVPQEQLCLPLHILEEKGLSQVAVTVQA 104


                 ....*
gi 469608410 153 LGGLA 157
Cdd:cd21272  105 LLELA 109
CH_betaPIX cd21266
calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak ...
 71-153 1.49e-03

calponin homology (CH) domain found in beta-Pak Interactive eXchange factor; Beta-Pak Interactive eXchange factor (beta-PIX), also called PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor 7 (ARHGEF7), p85, or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1, and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Beta-PIX contains a single copy of the CH domain at its N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409115  Cd Length: 112  Bit Score: 37.21  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608410  71 ENF-QNWLKDGTVLCELINALYPegqAPVKKI-QASTMAFKQMEQISQFLQAAERYGINTtdiFQTVDLWEGKNMACVQR 148
Cdd:cd21266   26 EGFlQASLKDGVVLCRLLERLLP---GSIDKVyPEPRTESECLSNIREFLRGCGALRLET---FDANDLYQGQNFNKVLS 99


                 ....*
gi 469608410 149 TLMNL 153
Cdd:cd21266  100 SLVAL 104
CH_SMTNL2 cd21261
calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 ...
 47-115 3.29e-03

calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 (SMTNL2) is highly expressed in skeletal muscle and could be associated with differentiating myocytes. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409110  Cd Length: 107  Bit Score: 36.10  E-value: 3.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 469608410  47 LEQILIQWittqCR-KDVGRPQPGRENFQNWLKDGTVLCELINALYPE-----GQAPVKKIQASTMAFKQMEQIS 115
Cdd:cd21261    2 IKQILLEW----CRsKTIGYKNIDLQNFSSSWSDGMAFCALVHSFFPEafdydSLSPSNRKHNFELAFSMAEKLA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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