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Conserved domains on  [gi|469608414|ref|NP_001264155|]
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leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 534-807 3.64e-172

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15363:

Pssm-ID: 475119  Cd Length: 274  Bit Score: 499.37  E-value: 3.64e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-453 1.19e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  55 LGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 135 QNLRSLQSLRLDANhisyvppSCFSGLHSLRHLWLDDNALTEIPvQAFRSLSALQAMTLALNKIHHIPDyAFGNLSSLVV 214
Cdd:COG4886   93 GDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 215 LHLHNNRIHSLGKKcFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNpiqfvgrsafqhlpelrtltlngasQI 294
Cdd:COG4886  164 LDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-------------------------QL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 295 TEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQL 373
Cdd:COG4886  218 TDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 374 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 453
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 5.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 5.21e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 469608414   33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 534-807 3.64e-172

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 499.37  E-value: 3.64e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-453 1.19e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  55 LGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 135 QNLRSLQSLRLDANhisyvppSCFSGLHSLRHLWLDDNALTEIPvQAFRSLSALQAMTLALNKIHHIPDyAFGNLSSLVV 214
Cdd:COG4886   93 GDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 215 LHLHNNRIHSLGKKcFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNpiqfvgrsafqhlpelrtltlngasQI 294
Cdd:COG4886  164 LDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-------------------------QL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 295 TEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQL 373
Cdd:COG4886  218 TDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 374 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 453
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-360 1.67e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 1.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLRLDANH 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 150 ISYVPPSCFSGLHSLRHLWLDDNALT-EIPVqafrslsalqamtlalnkihhipdyAFGNLSSLVVLHLHNNRIHSLGKK 228
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-------------------------SLGNLKNLQYLFLYQNKLSGPIPP 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 229 CFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELHFYDNpiQFVGR--SAFQHLPELRTLTLNGASQITEFP-DLTGTA 304
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHN 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414 305 NLESLTLTGAQISS-LPQTVCNQlPNLQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHN 360
Cdd:PLN00113 357 NLTVLDLSTNNLTGeIPEGLCSS-GNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDN 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-390 1.09e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 79.83  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 161 LHSLRHLWLDDNALTEIPvqAFRSLSALQAMTLALNKIHHIPDyaFGNLSSLVVLHLHNNRIHSLGKkcFDGLHSLETLD 240
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 241 LNYNNldefptaIRTLSNLkelhfydnpiqfvgrsafQHLPELRTLTLNgaSQitefpdltgtaNLESltltGAQISSLP 320
Cdd:cd21340   75 LGGNR-------ISVVEGL------------------ENLTNLEELHIE--NQ-----------RLPP----GEKLTFDP 112

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469608414 321 QTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIK--VDTFQQLLSLRSLNLAWNKIAIIH 390
Cdd:cd21340  113 RSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
188-246 6.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414  188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 551-796 3.35e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  551 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 629
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  630 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 704
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  705 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 777
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 469608414  778 KFILLVVVPLP---ACLNPLLY 796
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 5.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 5.21e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 469608414   33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 6.01e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 6.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 469608414    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 534-807 3.64e-172

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 499.37  E-value: 3.64e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 534-807 3.23e-155

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 455.85  E-value: 3.23e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15138   81 KVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15138  161 GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISIS 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15138  241 PEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 534-807 9.27e-116

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 354.10  E-value: 9.27e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKySAKFETKAP-FSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLP-- 690
Cdd:cd15362   81 RATGFLSVFASEASILLLTLAAVQCSVSVS-CVRAYGKSPsLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPsp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 691 LPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 770
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 469608414 771 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 534-806 3.34e-85

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 273.66  E-value: 3.34e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15361   81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15361  161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKED 806
Cdd:cd15361  241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 273
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 534-807 3.82e-82

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 266.03  E-value: 3.82e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPI-KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 612
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVpKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 613 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFEtKAPFSSLKVIILLCALLALTMAAVPLLGGSK-------YGAS 685
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINqpgdnrlYGYS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 686 PLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKG-----DLENIWDCSMVKHIALLLFTNCILNCPVAF 760
Cdd:cd14980  160 SICMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSrksarRSSSKRDKRIAIRLALILITDLICWLPYYI 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 469608414 761 LSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd14980  240 VIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 534-807 6.35e-50

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 177.41  E-value: 6.35e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 534 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 613
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 614 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 693
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 694 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLdkGDLENIW---DCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 770
Cdd:cd15136  161 ETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSV--RGSGRAAnsnDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLP 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 469608414 771 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15136  239 LISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 535-807 2.59e-36

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 138.50  E-value: 2.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 614
Cdd:cd15964    2 FLRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 615 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 694
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 695 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNL-----DKGDLeniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINL 769
Cdd:cd15964  162 TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVrnpqyKSGDK----DTKIAKRMAVLIFTDFICMAPISFYALSAILNK 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 469608414 770 TFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15964  238 PLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRRDV 275
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 535-807 2.49e-34

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 132.67  E-value: 2.49e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 614
Cdd:cd15360    2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 615 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 694
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 695 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGD-LENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15360  162 SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNfVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLIT 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15360  242 VSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 535-807 1.43e-33

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 130.37  E-value: 1.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 614
Cdd:cd15359    2 FLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 615 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 694
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 695 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENI-WDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 773
Cdd:cd15359  162 TLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLIT 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 469608414 774 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15359  242 VTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-453 1.19e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  55 LGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 135 QNLRSLQSLRLDANhisyvppSCFSGLHSLRHLWLDDNALTEIPvQAFRSLSALQAMTLALNKIHHIPDyAFGNLSSLVV 214
Cdd:COG4886   93 GDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 215 LHLHNNRIHSLGKKcFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNpiqfvgrsafqhlpelrtltlngasQI 294
Cdd:COG4886  164 LDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-------------------------QL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 295 TEFPD-LTGTANLESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQL 373
Cdd:COG4886  218 TDLPEpLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 374 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 453
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 535-805 8.53e-31

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 122.69  E-value: 8.53e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWTIAVLALTCNALVTstVFRSPLYISPI--KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 612
Cdd:cd15137    2 VLRVFIWVVGIIALLGNLFVL--IWRLKYKEENKvhSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 613 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFeTKAPFSSLKVIILLCALLALTMAAVPLLG----GSKYGASPLC 688
Cdd:cd15137   80 CTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSG-RRLGLRRAIIVLACIWLIGLLLAVLPLLPwdyfGNFYGRSGVC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 689 LPLPFGEPSTMG--YMVALIL-LNSLCFLMMTIAYTKLYCNLDK-----GDLENIWDCSMVKHIALLLFTNCILNCPVAF 760
Cdd:cd15137  159 LPLHITDERPAGweYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPIIV 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 469608414 761 LSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 805
Cdd:cd15137  239 IGILALSGVP-IPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-360 1.67e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 1.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLRLDANH 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 150 ISYVPPSCFSGLHSLRHLWLDDNALT-EIPVqafrslsalqamtlalnkihhipdyAFGNLSSLVVLHLHNNRIHSLGKK 228
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-------------------------SLGNLKNLQYLFLYQNKLSGPIPP 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 229 CFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELHFYDNpiQFVGR--SAFQHLPELRTLTLNGASQITEFP-DLTGTA 304
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHN 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414 305 NLESLTLTGAQISS-LPQTVCNQlPNLQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHN 360
Cdd:PLN00113 357 NLTVLDLSTNNLTGeIPEGLCSS-GNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDN 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-401 5.50e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.69  E-value: 5.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  50 VDCSDLGLS-ELPSNLSVFTS---YLDLSMNNISQLLPNPlpSLRFLEELRLAGNALT-YIPK--GAFTglySLKVLMLQ 122
Cdd:PLN00113  98 INLSNNQLSgPIPDDIFTTSSslrYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSgEIPNdiGSFS---SLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 123 NNQLR-HVPTeALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT-EIPVQAFRsLSALQAMTLALNKIH- 199
Cdd:PLN00113 173 GNVLVgKIPN-SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGG-LTSLNHLDLVYNNLTg 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 200 HIPDyAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELHFYDNpiQFVGR--SA 276
Cdd:PLN00113 251 PIPS-SLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSN--NFTGKipVA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 277 FQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISS-LPQTVCN----------------------------- 325
Cdd:PLN00113 328 LTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTGeIPEGLCSsgnlfklilfsnslegeipkslgacrslr 407

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 326 ------------------------------------------QLPNLQVLDLSYN-LLEDLPSFSVCQKLQKIDLRHNEI 362
Cdd:PLN00113 408 rvrlqdnsfsgelpseftklplvyfldisnnnlqgrinsrkwDMPSLQMLSLARNkFFGGLPDSFGSKRLENLDLSRNQF 487

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 469608414 363 YEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 401
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLV 526
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-312 8.80e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 8.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  47 LLRVDCSDLGLSELPSNLSVFTS--YLDLSMNNISQlLPNPLPSLRFLEELRLAGNALTYIPKgAFTGLYSLKVLMLQNN 124
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNlkELDLSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 125 QLRHVPteALQNLRSLQSLRLDANHISYVPPScfSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIhhipdy 204
Cdd:COG4886  239 QLTDLP--ELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL------ 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 205 afgNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELR 284
Cdd:COG4886  309 ---NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                        250       260
                 ....*....|....*....|....*...
gi 469608414 285 TLTLNGASQITEFPDLTGTANLESLTLT 312
Cdd:COG4886  386 LLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-390 1.09e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 79.83  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 161 LHSLRHLWLDDNALTEIPvqAFRSLSALQAMTLALNKIHHIPDyaFGNLSSLVVLHLHNNRIHSLGKkcFDGLHSLETLD 240
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 241 LNYNNldefptaIRTLSNLkelhfydnpiqfvgrsafQHLPELRTLTLNgaSQitefpdltgtaNLESltltGAQISSLP 320
Cdd:cd21340   75 LGGNR-------ISVVEGL------------------ENLTNLEELHIE--NQ-----------RLPP----GEKLTFDP 112

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469608414 321 QTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIK--VDTFQQLLSLRSLNLAWNKIAIIH 390
Cdd:cd21340  113 RSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 543-800 1.94e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 80.41  E-value: 1.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 543 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTfgsfarhGAWWENGVGCHVIGFLSIF 622
Cdd:cd00637    8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-------GRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 623 ASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY--GASPLCLPLPFGEPSTMG 700
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYdyGGYCCCCLCWPDLTLSKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 701 YMVALILLN-SLCFLMMTIAYTKLYCNL-------------DKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSF-SS 765
Cdd:cd00637  161 YTIFLFVLLfLLPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLlDV 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 469608414 766 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFN 800
Cdd:cd00637  241 FGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 535-807 9.73e-16

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 78.67  E-value: 9.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWTIAVLALTCNALVTS--TVFRSPLYISpiKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 612
Cdd:cd15966    2 ILRVFVWVMAFITCFGNLFVIGmrSFIRAENKTH--AMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 613 CHVIGFLSIFASESSVFLLTLAALERGFSVKYsakfetkaPFSSLK-------VIILLCALLALTMAAVPLLG----GSK 681
Cdd:cd15966   80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVF--------PFSNIRpgkcqtlIILISIWLVGFIIAVIPFWNedffGNY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 682 YGASPLCLPLPFG---EPSTMGYMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENI-------WDCSMVKHIALLLFT 750
Cdd:cd15966  152 YGKNGVCFPLHSDqteKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTevrshihRDVAVANRFFFIVFS 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469608414 751 NCILNCPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 807
Cdd:cd15966  232 DAICWIPIFLLKILSLFQVE-IPGTITSWIVIFILPINSALNPILYTLTTSFFKEKL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-269 5.17e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 5.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  52 CSDLGLSELPsNLSVFTS--YLDLSMNNISQLlPNpLPSLRFLEELRLAGNALTYIPkgAFTGLYSLKVLMLQNNQLRHV 129
Cdd:cd21340    9 LNDKNITKID-NLSLCKNlkVLYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 130 ptEALQNLRSLQSLRLDANHISyvPPSCFSglhslrhlwLDDnalteipvqafRSLSALQAmtlalnkihhipdyafgnl 209
Cdd:cd21340   84 --EGLENLTNLEELHIENQRLP--PGEKLT---------FDP-----------RSLAALSN------------------- 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 469608414 210 sSLVVLHLHNNRIHSLgkKCFDGLHSLETLDLNYNNLDEFP---TAIRTLSNLKELHFYDNPI 269
Cdd:cd21340  121 -SLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
142-375 1.18e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.65  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 142 SLRLDANHISYVPPScfsgLH-SLRHLWLDDNALTEIPvqafRSL-SALQAMTLALNKIHHIPDYAFGNLSSLVVLHlhn 219
Cdd:PRK15370 203 TLILDNNELKSLPEN----LQgNIKTLYANSNQLTSIP----ATLpDTIQEMELSINRITELPERLPSALQSLDLFH--- 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 220 NRIHSLGKKCFDGLhslETLDLNYNNLDEFPTAIRtlSNLKELHFYDNPIQFVGRSAfqhLPELRTLTLnGASQITEFPD 299
Cdd:PRK15370 272 NKISCLPENLPEEL---RYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL---PPGLKTLEA-GENALTSLPA 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 300 LTGTAnLESLTLTGAQISSLPQTVCnqlPNLQVLDLSYNLL-------------------------EDLPSF-SVCQKLQ 353
Cdd:PRK15370 343 SLPPE-LQVLDVSKNQITVLPETLP---PTITTLDVSRNALtnlpenlpaalqimqasrnnlvrlpESLPHFrGEGPQPT 418

                        250       260
                 ....*....|....*....|..
gi 469608414 354 KIDLRHNEIYEIKVDTFQQLLS 375
Cdd:PRK15370 419 RIIVEYNPFSERTIQNMQRLMS 440
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 535-805 1.57e-12

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 69.13  E-value: 1.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 535 LIRIGVWtiAVLALTCNALVTSTVFRSplYISPIKLL----IGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENG 610
Cdd:cd15965    2 VQRVFVW--VVSAVTCFGNIFVICMRP--YIRSENKLhamsIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 611 VGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGG----SKYGASP 686
Cdd:cd15965   78 TQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILI-LIWIIGFIIAFIPLSNKeffrNYYGTNG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 687 LCLPLPFGEPSTMG---YMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENIW-------DCSMVKHIALLLFTNCILN 755
Cdd:cd15965  157 VCFPLHSEQPESTGaqiYSVVIFLgLNLAAFIIIVFSYGSMFYSIHQTAIMATEisnhikkEMTLAKRFFFIVFTDALCW 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 469608414 756 CPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 805
Cdd:cd15965  237 IPIFILKLLSLLQVE-IPGTISSWVVIFILPINSALNPILYTLTTRPFKE 285
LRR_8 pfam13855
Leucine rich repeat;
188-246 6.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414  188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
92-150 7.01e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.01e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414   92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 131-362 7.24e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 67.38  E-value: 7.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 131 TEALQNLRSLQSLRLDAN-----HISYVPPScfsgLH---SLRHLWLDDNALTEIPV------QAFRSLSALQAMTLALN 196
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNtlgeeAAKALASA----LRpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 197 KIHhiPD-----YAFGNLSSLVVLHLHNNRIHSLG-KKCFDGL----HSLETLDLNYNNL-----DEFPTAIRTLSNLKE 261
Cdd:cd00116   92 ALG--PDgcgvlESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLegascEALAKALRANRDLKE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 262 LHFYDNPIQFVG----RSAFQHLPELRTLTLN-------GASQITE-FPDLtgtANLESLTLTGAQISSLP-QTVCNQLP 328
Cdd:cd00116  170 LNLANNGIGDAGiralAEGLKANCNLEVLDLNnngltdeGASALAEtLASL---KSLEVLNLGDNNLTDAGaAALASALL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 469608414 329 N----LQVLDLSYNLLEDLPSFSVCQ------KLQKIDLRHNEI 362
Cdd:cd00116  247 SpnisLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-362 6.98e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 6.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 113 LYSLKVLMLQNNQLRHVptEALQNLRSLQSLRLDANHISYVPPscFSGLHSLRHLWLDDNALTEIPVqafrslsalqamt 192
Cdd:cd21340    1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 193 lalnkihhipdyaFGNLSSLVVLHLHNNRIhslgkKCFDGLHSletldlnynnldefptairtLSNLKELHFyDNpiqfv 272
Cdd:cd21340   64 -------------LENLVNLKKLYLGGNRI-----SVVEGLEN--------------------LTNLEELHI-EN----- 99

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 273 grsafQHLPELRTLTLNGASqitefpdLTGTAN-LESLTLTGAQISSLPQTVCnqLPNLQVLDLSYNLLEDL----PSFS 347
Cdd:cd21340  100 -----QRLPPGEKLTFDPRS-------LAALSNsLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLS 165

                        250
                 ....*....|....*
gi 469608414 348 VCQKLQKIDLRHNEI 362
Cdd:cd21340  166 SWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
115-174 1.02e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
163-222 1.43e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.43e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  163 SLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRI 222
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
138-198 1.40e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469608414  138 RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
210-290 2.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNldefptairtlsnlkelhfydnpIQFVGRSAFQHLPELRTLTLN 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------------------LTTLSPGAFSGLPSLRYLDLS 57


                  .
gi 469608414  290 G 290
Cdd:pfam13855  58 G 58
LRR_8 pfam13855
Leucine rich repeat;
328-386 3.84e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469608414  328 PNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 386
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 51-386 7.41e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.95  E-value: 7.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRlagnALTYIPKG--AFTGLYSLKVL-------ML 121
Cdd:COG5238   99 EVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLI----QVLKDPLGgnAVHLLGLAARLgllaaisMA 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 122 QNNQLRHVPTEALQNLR-SLQSLRLDANHISYVPpscfsglhSLRHLWLDDNALTEipvqafRSLSALQAMtLALNKihh 200
Cdd:COG5238  175 KALQNNSVETVYLGCNQiGDEGIEELAEALTQNT--------TVTTLWLKRNPIGD------EGAEILAEA-LKGNK--- 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 201 ipdyafgnlsSLVVLHLHNNRI-----HSLGKKCFDGlHSLETLDLNYNNLDE-----FPTAIRTLSNLKELHFYDNPIQ 270
Cdd:COG5238  237 ----------SLTTLDLSNNQIgdegvIALAEALKNN-TTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIG 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 271 FVGRSAFQhlpelrtltlngasqitefPDLTGTANLESLTLTGAQIS-----SLPQTVcNQLPNLQVLDLSYNLLEDLPS 345
Cdd:COG5238  306 DEGAIALA-------------------EGLQGNKTLHTLNLAYNGIGaqgaiALAKAL-QENTTLHSLDLSDNQIGDEGA 365

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 469608414 346 FSVCQKLQKIDlrhneiyeikvdtfqqllSLRSLNLAWNKI 386
Cdd:COG5238  366 IALAKYLEGNT------------------TLRELNLGKNNI 388
LRR_8 pfam13855
Leucine rich repeat;
350-430 1.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  350 QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFStlpslikldlssnllssfpitGLHGLTHLKLTGN 429
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS---------------------GLPSLRYLDLSGN 59


                  .
gi 469608414  430 H 430
Cdd:pfam13855  60 R 60
LRR_8 pfam13855
Leucine rich repeat;
305-362 1.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  305 NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEI 362
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-203 2.40e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  57 LSELPSNLSVFTSYLDLSMNNISqLLPNPLP-SLRFLEELRlagNALTYIPKGAFTGLYSLKVlmlQNNQLRHVPTEALQ 135
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKIS-CLPENLPeELRYLSVYD---NSIRTLPAHLPSGITHLNV---QSNSLTALPETLPP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 136 NLR------------------SLQSLRLDANHISYVPPSCFSglhSLRHLWLDDNALTEIPvqafRSL-SALQAMTLALN 196
Cdd:PRK15370 326 GLKtleagenaltslpaslppELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLP----ENLpAALQIMQASRN 398


                 ....*..
gi 469608414 197 KIHHIPD 203
Cdd:PRK15370 399 NLVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-290 2.52e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  52 CSDLGlSELPSNLSvfTSYLDLSMNN------ISQLLPNPLPSLRFLEELRLAGNALTYIPKG---AFTGLYSLKVLMLQ 122
Cdd:cd00116   40 AKALA-SALRPQPS--LKELCLSLNEtgriprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 123 NNQL--RHVPTEAlqnlRSLQSLRldanhisyvppscfsglHSLRHLWLDDNALTEIPVQ----AFRSLSALQAMTLALN 196
Cdd:cd00116  117 NNGLgdRGLRLLA----KGLKDLP-----------------PALEKLVLGRNRLEGASCEalakALRANRDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 197 KIHH--IPDYA--FGNLSSLVVLHLHNNRIHSLGKK----CFDGLHSLETLDLNYNNLDEFPTA------IRTLSNLKEL 262
Cdd:cd00116  176 GIGDagIRALAegLKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAalasalLSPNISLLTL 255

                        250       260       270
                 ....*....|....*....|....*....|..
gi 469608414 263 HFYDNPIQFVG-RSAFQHLPE---LRTLTLNG 290
Cdd:cd00116  256 SLSCNDITDDGaKDLAEVLAEkesLLELDLRG 287
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 542-804 3.34e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 49.74  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 542 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMltgvssavlaGVDAFTF---GSFARHGAWWENGVGCHVIGF 618
Cdd:cd15073    9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDL----------GVSIIGYpfsAASDLHGSWKFGYAGCQWYAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 619 LSIFASESSVFLLTLAALERgFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASP---LC-LPLPFG 694
Cdd:cd15073   79 LNIFFGMASIGLLTVVAVDR-YLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPtgaTCtINWRKN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 695 EPSTMGYMVALILLN-SLCFLMMTIAYTKLYCNLDKGDLENIW-----DCSMVKHIALLLFTnCILNCPVAFLSFSSLIN 768
Cdd:cd15073  158 DSSFVSYTMSVIVVNfIVPLAVMFYCYYNVSRFVKKVLASDCLesvniDWTDQNDVTKMSVI-MIVMFLVAWSPYSIVCL 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 469608414 769 LT-FISPEVIKFILLVVVPLPA----CLNPLLYILFNPHFK 804
Cdd:cd15073  237 WAsFGEPKKIPPWMAIIPPLFAksstFYNPCIYVIANKKFR 277
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 542-805 3.53e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 49.51  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 542 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLtgvsSAVLAGVdaFTFGSFARHgaWWENG-VGCHVIGFLS 620
Cdd:cd14969    9 LIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLL----MSVVGYP--LSFYSNLSG--RWSFGdPGCVIYGFAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 621 IFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGGSKYGASPL---CLP-LPFGEP 696
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIA-FIWLYGLFWALPPLFGWSSYVPEGGgtsCSVdWYSKDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 697 STMGYMVALILlnsLCFLM----MTIAYTKLYC-----------NLDKGDLENIWDCSM--VKHIALLLFTNCILNCPVA 759
Cdd:cd14969  160 NSLSYIVSLFV---FCFFLplaiIIFCYYKIYRtlrkmskraarRKNSAITKRTKKAEKkvAKMVLVMIVAFLIAWTPYA 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 469608414 760 FLSFSSLIN-LTFISPevikfiLLVVVP-----LPACLNPLLYILFNPHFKE 805
Cdd:cd14969  237 VVSLYVSFGgESTIPP------LLATIPalfakSSTIYNPIIYVFMNKQFRR 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-352 4.64e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 4.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  86 LPSLRFLEELRLAGNALTYIP-KGAFTGL---YSLKVLMLQNNQLR------HVPTEALQNLRSLQSLRLDANHISYVPP 155
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEEAaKALASALrpqPSLKELCLSLNETGriprglQSLLQGLTKGCGLQELDLSDNALGPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 156 SCFSGLH---SLRHLWLDDNALTEIPVQ----AFRSLS-ALQAMTLALNKIHHIPDYAFGNL----SSLVVLHLHNNRIH 223
Cdd:cd00116   99 GVLESLLrssSLQELKLNNNGLGDRGLRllakGLKDLPpALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 224 SLG--KKCFDGLHS--LETLDLNYNNLDE-----FPTAIRTLSNLKELHFYDNPIQFVGRSAF-----QHLPELRTLTLN 289
Cdd:cd00116  179 DAGirALAEGLKANcnLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLS 258

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 469608414 290 GASqitefpdltgtanlesLTLTGAQisSLPQtVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 352
Cdd:cd00116  259 CND----------------ITDDGAK--DLAE-VLAEKESLLELDLRGNKFGEEGAQLLAESL 302
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-327 1.29e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  71 LDLSMNNISQ----LLPNPLPSLRFLEELRLAGNALTyiPKGA------FTGLYSLKVLMLQNNQLR----HVPTEALQN 136
Cdd:COG5238  185 VYLGCNQIGDegieELAEALTQNTTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQIGdegvIALAEALKN 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 137 LRSLQSLRLDANHISyvppscfsglhslrhlwlddnalteipVQAFRSLsalqAMTLALNKihhipdyafgNLSSlvvLH 216
Cdd:COG5238  263 NTTVETLYLSGNQIG---------------------------AEGAIAL----AKALQGNT----------TLTS---LD 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 217 LHNNRIHSLGKKCF-DGL---HSLETLDLNYNNLDE-----FPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRT-- 285
Cdd:COG5238  299 LSVNRIGDEGAIALaEGLqgnKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTtl 378

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 469608414 286 LTLN-GASQIT-----EFPDLTGTANLESLTLTGAQISSLPQTVCNQL 327
Cdd:COG5238  379 RELNlGKNNIGkqgaeALIDALQTNRLHTLILDGNLIGAEAQQRLEQL 426
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 551-796 3.35e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  551 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 629
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  630 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 704
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  705 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 777
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 469608414  778 KFILLVVVPLP---ACLNPLLY 796
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 328-360 7.00e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 7.00e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 469608414  328 PNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHN 360
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 139-284 7.03e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.30  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  139 SLQSLRLDaNHISYVPPSCFSGLHSLRHLWLDDNaLTEIPVQAFrSLSALQAMTLAlNKIHHIPDYAFGNLSSLVVLHLH 218
Cdd:pfam13306  12 SLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAF-YNCSLTSITIP-SSLTSIGEYAFSNCSNLKSITLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 469608414  219 NNrIHSLGKKCFdglhsletldlnYNnldefptairtlSNLKELHFYDNpIQFVGRSAFQHLPELR 284
Cdd:pfam13306  88 SN-LTSIGSYAF------------SN------------CSLKSITIPSS-VTTIGSYAFSNCSNLK 127
PLN03150 PLN03150
hypothetical protein; Provisional
 67-178 7.83e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.35  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLD 146
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                         90       100       110
                 ....*....|....*....|....*....|....
gi 469608414 147 ANHISYVPPSCFSG--LHSLRHLWLDDNALTEIP 178
Cdd:PLN03150 499 GNSLSGRVPAALGGrlLHRASFNFTDNAGLCGIP 532
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 540-805 9.00e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 45.25  E-value: 9.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 540 VWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFtfgsfarHGAWWENGVGCHVIGFL 619
Cdd:cd14967    6 LSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL-------LGYWPFGPVLCRFWIAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 620 SIFASESSVFLLTLAALERGFSV----KYSAKFETKapfsSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGE 695
Cdd:cd14967   79 DVLCCTASILNLCAISLDRYLAItrplRYRQLMTKK----RALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 696 PSTmGYMVALILLNSLC-FLMMTIAYTKLYCNLDKgdleniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTF-IS 773
Cdd:cd14967  155 PNK-IYVLVSSVISFFIpLLIMIVLYARIFRVARR-------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDcVP 226

                        250       260       270
                 ....*....|....*....|....*....|..
gi 469608414 774 PEVIKFILLVVVpLPACLNPLLYILFNPHFKE 805
Cdd:cd14967  227 PILYAVFFWLGY-LNSALNPIIYALFNRDFRR 257
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 100-212 1.82e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.15  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  100 NALTYIPKGAFTGLYSLKVLMLQNNqLRHVPTEALQNLrSLQSLRLDANhISYVPPSCFSGLHSLRHLWLDDNaLTEIPV 179
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 469608414  180 QAFRSlSALQAMTLAlNKIHHIPDYAFGNLSSL 212
Cdd:pfam13306  96 YAFSN-CSLKSITIP-SSVTTIGSYAFSNCSNL 126
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 56-246 2.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  56 GLSELPSNLSVftsyLDLSMNNISQL----LPNPLPSLRFLEELRLAGNALTyiPKG------AFTGLYSLKVLMLQNNQ 125
Cdd:cd00116  131 GLKDLPPALEK----LVLGRNRLEGAsceaLAKALRANRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNG 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 126 LRHVPTEALQnlrslqslrldanhisyvppSCFSGLHSLRHLWLDDNALTEIPVQAFrsLSALQAMtlalnkihhipdya 205
Cdd:cd00116  205 LTDEGASALA--------------------ETLASLKSLEVLNLGDNNLTDAGAAAL--ASALLSP-------------- 248

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 469608414 206 fgnLSSLVVLHLHNNRIHSLGKKCF----DGLHSLETLDLNYNNL 246
Cdd:cd00116  249 ---NISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 57-403 2.75e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  57 LSELPSNLSVFTSYLDLSMnnisQLLPNPLPSLRFLEELRLAGNALTYIPKGAftglYSLKVLMLQNNQlRHVPTEALQn 136
Cdd:COG5238   49 LARYLQSRSSITQYLRFEG----QGDPGLNPVALEKAAEAFPTQLLVVDWEGA----EEVSPVALAETA-TAVATPPPD- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 137 lrslqsLRLDANHISYvppscfsGLHSLRHlwlddNALTEIPVQA-FRSLSALQAMTLALNKIHHIPDYAFGnlsslvvl 215
Cdd:COG5238  119 ------LRRIMAKTLE-------DSLILYL-----ALPRRINLIQvLKDPLGGNAVHLLGLAARLGLLAAIS-------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 216 hlhnnrihslgKKCFDGLHSLETLDLNYNNLD-----EFPTAIRTLSNLKELHFYDNPIQFVGRSAF----QHLPELRTL 286
Cdd:COG5238  173 -----------MAKALQNNSVETVYLGCNQIGdegieELAEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 287 TLN-------GASQITEFpdLTGTANLESLTLTGAQIS-----SLPQTVCNQlPNLQVLDLSYNLLED------LPSFSV 348
Cdd:COG5238  242 DLSnnqigdeGVIALAEA--LKNNTTVETLYLSGNQIGaegaiALAKALQGN-TTLTSLDLSVNRIGDegaialAEGLQG 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 469608414 349 CQKLQKIDLRHNEI----YEIKVDTFQQLLSLRSLNLAWNKI----AIIHPNAFSTLPSLIKL 403
Cdd:COG5238  319 NKTLHTLNLAYNGIgaqgAIALAKALQENTTLHSLDLSDNQIgdegAIALAKYLEGNTTLREL 381
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-440 2.87e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 230 FDGLHSLETLDLNYNNLDE-----FPTAIRTLSNLKELHFYDNPIQFVGR------SAFQHLPELRTLTLN----GASQI 294
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSdnalGPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 295 TEFPDLTGTANLESLTLTGAQISSLP-QTVCNQL----PNLQVLDLSYNLLEDLPS------FSVCQKLQKIDLRHNEIY 363
Cdd:cd00116   99 GVLESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLEGASCealakaLRANRDLKELNLANNGIG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 364 EIKVDTFQQLL----SLRSLNLAWNKI----AIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLH-GLthlkLTGNHALQS 434
Cdd:cd00116  179 DAGIRALAEGLkancNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAALAsAL----LSPNISLLT 254


                 ....*.
gi 469608414 435 LISSEN 440
Cdd:cd00116  255 LSLSCN 260
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 234-402 3.49e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.48  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  234 HSLETLDL-NYNNLDEFPTAIRTLSNLKELHFYdNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLtgTANLESLTLT 312
Cdd:PLN03210  778 PSLTRLFLsDIPSLVELPSSIQNLHKLEHLEIE-NCINLETLPTGINLESLESLDLSGCSRLRTFPDI--STNISDLNLS 854

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  313 GAQISSLPQTVcNQLPNLQVLDLSYnlledlpsfsvCQKLQKIDLRHNEIYEIKVDTFQQLLSLR--SLNLAWNKIAIIH 390
Cdd:PLN03210  855 RTGIEEVPWWI-EKFSNLSFLDMNG-----------CNNLQRVSLNISKLKHLETVDFSDCGALTeaSWNGSPSEVAMAT 922

                         170
                  ....*....|..
gi 469608414  391 PNAFSTLPSLIK 402
Cdd:PLN03210  923 DNIHSKLPSTVC 934
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 5.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 5.21e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 469608414   33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
70-126 5.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 469608414   70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 211-261 5.97e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 5.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 469608414  211 SLVVLHLHNNRIHSLGKkcFDGLHSLETLDLNYNNLdefptaIRTLSNLKE 261
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK------ITDLSDLAN 44
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 6.01e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 6.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 469608414    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 191-444 1.98e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.17  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  191 MTLALNKIH--HIPDYAFGNLSSLVVLHLHNNRIHSLGK------KCFDGL-HSLETLDLNYNNLDEFPTAIRTlSNLKE 261
Cdd:PLN03210  537 ITLDIDEIDelHIHENAFKGMRNLLFLKFYTKKWDQKKEvrwhlpEGFDYLpPKLRLLRWDKYPLRCMPSNFRP-ENLVK 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  262 LHFYDNPIQFVGrSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTG-AQISSLPQTVCNqLPNLQVLDLSYNL- 339
Cdd:PLN03210  616 LQMQGSKLEKLW-DGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQY-LNKLEDLDMSRCEn 693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  340 LEDLPS-----------FSVCQKLQKI-DLRHN----EIYEIKVDTFQQLLSLRSLNL----------AWNKIAIIHPNA 393
Cdd:PLN03210  694 LEILPTginlkslyrlnLSGCSRLKSFpDISTNiswlDLDETAIEEFPSNLRLENLDElilcemksekLWERVQPLTPLM 773

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469608414  394 -----------FSTLPSLIKLDLSsnllssfpITGLHGLTHLKLTGNHALQSLISSENFPEL 444
Cdd:PLN03210  774 tmlspsltrlfLSDIPSLVELPSS--------IQNLHKLEHLEIENCINLETLPTGINLESL 827
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 543-807 2.20e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.11  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 543 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFgsfarhgAWWENGVGCHVIGFLSIF 622
Cdd:cd15074   10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAH-------RWLFGDIGCVFYGFCGFL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 623 ASESSVFLLTLAALER---GFSVKYSAKFETKAPFSSLKVIillcALLALTMAAVPLLGGSKYGasplclPLPFG----- 694
Cdd:cd15074   83 FGCCSINTLTAISIYRylkICHPPYGPKLSRRHVCIVIVAI----WLYALFWAVAPLVGWGSYG------PEPFGtscsi 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 695 -------EPSTMGYMVALILlnsLCFLM----MTIAYTKLYCNLDKGDLENIWDCSMVKHIALL---LFTNCILNC---- 756
Cdd:cd15074  153 dwtgasaSVGGMSYIISIFI---FCYLLpvliIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIerkVTKVAVLICagfl 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 469608414 757 ----PVAFLSFSSlinlTFISPEVIKFILLVVVPLPA---CL-NPLLYILFNPHFKEDL 807
Cdd:cd15074  230 iawtPYAVVSMWS----AFGSPDSVPILASILPALFAkssCMyNPIIYLLFSSKFRQDL 284
LRR_8 pfam13855
Leucine rich repeat;
257-340 3.53e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414  257 SNLKELHFYDNPIQFVGRSAFQHLPelrtltlngasqitefpdltgtaNLESLTLTGAQISSLPQTVCNQLPNLQVLDLS 336
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 469608414  337 YNLL 340
Cdd:pfam13855  58 GNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 185-268 3.64e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469608414 185 LSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIH-----SLGKkcfdgLHSLETLDLNYNNLD-EFPTAI--RTL 256
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgsipeSLGQ-----LTSLRILNLNGNSLSgRVPAALggRLL 515

                         90
                 ....*....|..
gi 469608414 257 SNLKeLHFYDNP 268
Cdd:PLN03150 516 HRAS-FNFTDNA 526
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 258-300 8.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 8.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 469608414  258 NLKELHFYDNPIQFVgrSAFQHLPELRTLTLNGASQITEFPDL 300
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKITDLSDL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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