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Conserved domains on  [gi|471270262|ref|NP_001264198|]
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otogelin isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1245-1396 3.06e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


:

Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.06e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1245 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1324
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1325 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1396
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 514-669 5.42e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 5.42e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   514 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 592
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   593 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 669
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 152-302 4.04e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 4.04e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   152 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 228
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262   229 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 302
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 977-1131 1.03e-35

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.45  E-value: 1.03e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    977 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1055
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   1056 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1129
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 471270262   1130 EN 1131
Cdd:smart00216  162 DG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2112-2266 5.70e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 5.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  2112 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2190
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262  2191 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2266
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1166-1240 7.62e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.63  E-value: 7.62e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   1166 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1240
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1476-2041 3.19e-21

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 102.71  E-value: 3.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1476 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1554
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1555 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1634
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1635 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1713
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1714 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1791
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1792 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1865
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1866 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1940
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1941 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 2011
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 471270262 2012 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2041
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2304-2370 7.22e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.68  E-value: 7.22e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 471270262   2304 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2370
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 349-412 1.57e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.57e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262   349 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 412
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2842-2924 9.10e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 9.10e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2842 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2921
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 471270262   2922 CQW 2924
Cdd:smart00041   77 CEP 79
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 713-767 2.25e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.25e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   713 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 767
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 780-844 8.89e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.86  E-value: 8.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262  780 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 844
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 426-474 5.17e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.17e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 471270262   426 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 474
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2373-2434 6.11e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262  2373 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2434
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 2676-2736 2.12e-04

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member smart01002:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.12e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262   2676 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2736
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
476-511 2.18e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 471270262    476 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 511
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 884-946 3.09e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262  884 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 946
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
 
Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1245-1396 3.06e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.06e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1245 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1324
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1325 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1396
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 514-669 5.42e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 5.42e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   514 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 592
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   593 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 669
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 503-668 1.78e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 153.71  E-value: 1.78e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    503 WECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSS-GTFTVTLQNAPCGlnQDGACVQSVSVILHQDprrQ 581
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG--GGATCLKSVKVELNGD---E 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    582 VTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV-FLRVRTNVGV-RVLYDREGlRLYLQVDQRWVEDTVGLCGTFNGNT 659
Cdd:smart00216   76 IELKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGgYLVVITSLGLiQVTFDGLT-LLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*....
gi 471270262    660 QDDFLSPVG 668
Cdd:smart00216  155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 152-302 4.04e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 4.04e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   152 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 228
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262   229 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 302
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 977-1131 1.03e-35

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.45  E-value: 1.03e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    977 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1055
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   1056 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1129
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 471270262   1130 EN 1131
Cdd:smart00216  162 DG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 147-301 1.29e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 131.37  E-value: 1.29e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    147 ERDSICRAWGQHHVETFDGLYYYLSGKGSYTLVgRHEPEGQSFSIQVHNDPqCGSSPyTCSRAVSLFfVGEQEIHLAK-- 224
Cdd:smart00216    7 ECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLA-QDCSSEPTFSVLLKNVP-CGGGA-TCLKSVKVE-LNGDEIELKDdn 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    225 -EVTHGGMRVQLPHVMGSARLQQLA--GYVIVRHQSA-FTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSS 300
Cdd:smart00216   83 gKVTVNGQQVSLPYKTSDGSIQIRSsgGYLVVITSLGlIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162


                    .
gi 471270262    301 G 301
Cdd:smart00216  163 G 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 986-1132 7.40e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 128.64  E-value: 7.40e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   986 CTAYGDRHYRTFDGLPFDFVGACKVHLVK---STSDVSFSVIVENVNCYSSGMiCRKFISINVGNSLIVFDDD-----SG 1057
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKdcsEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGgtvlvNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262  1058 NPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENL 1132
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2112-2266 5.70e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 5.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  2112 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2190
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262  2191 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2266
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1166-1240 7.62e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.63  E-value: 7.62e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   1166 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1240
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2101-2265 1.08e-21

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 1.08e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2101 RCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS----PDEMLTVHVLDCKS--ANLGHLNWPPFCLVMLnmt 2174
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcssePTFSVLLKNVPCGGgaTCLKSVKVELNGDEIE--- 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2175 hlahqvtIDRFNRKVTVDLQPV-WPPVSRYGF-RIEDTGHMYMILTPSDI-QIQWLHSSGLMiVEASKTSKAQGHGLCGI 2251
Cdd:smart00216   78 -------LKDDNGKVTVNGQQVsLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLS-VQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|....
gi 471270262   2252 CDGDAANDLTLKDG 2265
Cdd:smart00216  150 FDGEPEDDFRTPDG 163
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1476-2041 3.19e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 102.71  E-value: 3.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1476 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1554
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1555 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1634
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1635 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1713
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1714 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1791
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1792 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1865
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1866 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1940
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1941 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 2011
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 471270262 2012 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2041
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1497-1960 1.66e-18

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 91.95  E-value: 1.66e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1497 LSQESPRTPTHRPALTPAAPLTTALNPPVTATEepvvspGPTQTTLQQPlELTASQLPAGP-TESPASKGVTASLLA--I 1573
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTK------GTSAAHLNST-EVTAEHTPHGTdLSEPATREGAADGAAsrA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1574 PHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPpaprfplmtKAVTVRGHgslpvrTTPPQPSLTA 1653
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAA---------IAAASAPH------AASPAPRTAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1654 SPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQV-PVSPLATRSLEIV 1732
Cdd:pfam17823  180 SSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVgTVTPAALATLAAA 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1733 LSTEKGEAGHSQpMGSPASPQPHPLPSAPprpaqhTTMATRSPALPpetpaaaslstatdglaatpfmslestrpsqlls 1812
Cdd:pfam17823  260 AGTVASAAGTIN-MGDPHARRLSPAKHMP------SDTMARNPAAP---------------------------------- 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1813 gLPPDTSLPLAKVGTSAPV--ATPGPKASVITTPLQPQATTLPAQTLSPVLPFT------PAAMTQAHPPTHIAPPAAGT 1884
Cdd:pfam17823  299 -MGAQAQGPIIQVSTDQPVhnTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTkaqakePSASPVPVLHTSMIPEVEAT 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1885 APGLLLGATLPTSGV----LPVA------EGTASMVSVVPRKSTTGKVAILSKQVSLPtsmygSAEGgptELTPATSHPL 1954
Cdd:pfam17823  378 SPTTQPSPLLPTQGAagpgILLApeqvatEATAGTASAGPTPRSSGDPKTLAMASCQL-----STQG---QYLVVTTDPL 449


                   ....*.
gi 471270262  1955 TPLVAE 1960
Cdd:pfam17823  450 TPALVD 455
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1173-1239 3.10e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 78.19  E-value: 3.10e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 471270262  1173 CSILL-SEVFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLC 1239
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2304-2370 7.22e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.68  E-value: 7.22e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 471270262   2304 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2370
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 349-412 1.57e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.57e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262   349 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 412
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2842-2924 9.10e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 9.10e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2842 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2921
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 471270262   2922 CQW 2924
Cdd:smart00041   77 CEP 79
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 348-412 5.48e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 66.21  E-value: 5.48e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262    348 EQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 412
Cdd:smart00832    6 SQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTP 72
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 1483-1895 5.15e-11

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 68.03  E-value: 5.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1483 PSQGLpTPSDEEPQLSQESPrtpthrPALTPAAplTTALNPPvtATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP- 1561
Cdd:cd22540     8 PSEYL-QPAASTTQDSQPSP------LALLAAT--CSKIGPP--AVEAAVTPPAPPQPTPRKLVPIKPAPLPLGPGKNSi 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1562 ---ASKGVT----ASLLAIPHTPesSSLPVALQTPTpgMVSGAMETTRVTVI-FAGSPNITVSSRSP------------P 1621
Cdd:cd22540    77 gflSAKGNIiqlqGSQLSSSAPG--GQQVFAIQNPT--MIIKGSQTRSSTNQqYQISPQIQAAGQINnsgqiqiipgtnQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1622 APRFPLMTKAVTVRGHGSLPVRttpPQPSLTASPSSRPVASPGAISRSPtsSGSHKAVLTP-------AVTKVISRTGVP 1694
Cdd:cd22540   153 AIITPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPGNVIKLQ--SGGNVALTLPvnnlvgtQDGATQLQLAAA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1695 QPTQAQSAS-SPSTPLTVAGTAAEQVPVSPLATRSLEIvlstekGEAGHS----QPMGSPASPQPHPLPSAPPRPAQHTt 1769
Cdd:cd22540   228 PSKPSKKIRkKSAQAAQPAVTVAEQVETVLIETTADNI------IQAGNNllivQSPGTGQPAVLQQVQVLQPKQEQQV- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1770 maTRSPALPPETPAAASLstatdGLAATPfmslesTRPSQllsglppdtslplakvGTSAPVATPGPKASVITTPL-QPQ 1848
Cdd:cd22540   301 --VQIPQQALRVVQAASA-----TLPTVP------QKPLQ----------------NIQIQNSEPTPTQVYIKTPSgEVQ 351

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 471270262 1849 ATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLP 1895
Cdd:cd22540   352 TVLLQEAPAATATPSSSTSTVQQQVTANNGTGTSKPNYNVRKERTLP 398
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 713-767 2.25e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.25e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   713 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 767
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 780-844 8.89e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.86  E-value: 8.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262  780 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 844
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 780-844 1.01e-08

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 53.55  E-value: 1.01e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262   780 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 844
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVC---------PEPCVEGCVCPPGFVRNSG-GKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 711-767 1.56e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.88  E-value: 1.56e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 471270262    711 QACSVLTGEM--FAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 767
Cdd:smart00832    6 SQCGILLSPRgpFAACHSVVDPEPFFENCVYDTCACGgdCECLCDALAAYAAACAEAGVCI 66
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1439-2031 4.05e-08

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 58.92  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1439 EGCVPVCPTPQVLDEVTQRCVYLEDCVE---PAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQesprTPTHRP---ALT 1512
Cdd:COG5180    24 PVLSPELWAAANNDAVSQGDRSALASSPtrpYARKIFEPLDIKLALGKPQLPSVAEPEAYLDPA----PPKSSPdtpEEQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1513 PAAPLTTALNPPVTATEEpvvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPG 1592
Cdd:COG5180   100 LGAPAGDLLVLPAAKTPE---LAAGALPAPAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDGDSASTLPP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1593 MVSGAMETTRVtvifagsPNITVSSRSPPAPRFPLMTKAvtvrghgslPVRTTPPQPSLTASPSSRPVASPGAISRSPTS 1672
Cdd:COG5180   177 PAEKLDKVLTE-------PRDALKDSPEKLDRPKVEVKD---------EAQEEPPDLTGGADHPRPEAASSPKVDPPSTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1673 SGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTP---LTVAGTAAEQVPVSPLAtrslEIVLSTEKGEAGHSQPMGSP 1749
Cdd:COG5180   241 EARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEppgLPVLEAGSEPQSDAPEA----ETARPIDVKGVASAPPATRP 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1750 ASPQPHPLPSAPPRPAQhttmATRSPALPPEtpaaaslstatdglAATPfmslESTRPsqllSGLPPdtslplakvGTSA 1829
Cdd:COG5180   317 VRPPGGARDPGTPRPGQ----PTERPAGVPE--------------AASD----AGQPP----SAYPP---------AEEA 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1830 PVATPGPkasvittPLQPQattlPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASM 1909
Cdd:COG5180   362 VPGKPLE-------QGAPR----PGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAG 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1910 VSVVPRKSTTGKVAIlskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEgAQAGTALPVPTsyalsrvsartaPQD 1989
Cdd:COG5180   431 GAGQGPKADFVPGDA-------------ESVSGPAGLADQAGAAASTAMADFV-APVTDATPVDV------------ADV 484

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 471270262 1990 SMLVLLPQLAEAHGTSAG-PHLAAEPVDEATTEPSGRSAPALS 2031
Cdd:COG5180   485 LGVRPDAILGGNVAPASGlDAETRIIEAEGAPATEDFVAAELS 527
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 426-474 5.17e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.17e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 471270262   426 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 474
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2373-2434 6.11e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262  2373 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2434
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2373-2434 6.23e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.69  E-value: 6.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 2373 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2434
Cdd:cd19941     1 CPPNEVYSECGSACPP--TCANPNAPPPCTKQCV---EGCFCPEGYVRNSGGK--CVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 426-474 8.96e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.30  E-value: 8.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 471270262  426 TYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG-CVAPAEC 474
Cdd:cd19941     6 VYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGkCVPPSQC 55
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 2676-2736 2.12e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.12e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262   2676 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2736
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
476-511 2.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 471270262    476 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 511
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1749-1881 3.38e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 45.53  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1749 PASPQPH--PLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVG 1826
Cdd:NF040712  192 FGRPLRPlaTVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 471270262 1827 TSAPVATPGPkASVITTPLQPQATTLPAQTlSPVLPFTPAAMTQAHPPTHIAPPA 1881
Cdd:NF040712  272 EATRDAGEPP-APGAAETPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKP 324
AbfB pfam05270
Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal ...
 1305-1396 9.42e-04

Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.


Pssm-ID: 428401  Cd Length: 137  Bit Score: 41.76  E-value: 9.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1305 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1383
Cdd:pfam05270   47 DSGCVSFESVNFPGSYLrH--YNFRLRLDANDGSALFREDATFCPRAGLGDSGSVSLESYNYPGRYIRHYNYELYIDPNG 124

                           90
                   ....*....|...
gi 471270262  1384 HTEVFRRGTLFRL 1396
Cdd:pfam05270  125 GTASFRADATFVV 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2308-2369 9.49e-04

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 40.06  E-value: 9.49e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262  2308 CLRMVSNRTFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYC 2369
Cdd:pfam08742    2 CGLLSDSGPFAPCHSVVDPEPYFEACVYDMcscgGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 884-946 3.09e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262  884 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 946
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
Pacifastin_I pfam05375
Pacifastin inhibitor (LCMII); Structures of members of this family show that they are ...
 485-511 6.81e-03

Pacifastin inhibitor (LCMII); Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors.


Pssm-ID: 253170  Cd Length: 40  Bit Score: 36.60  E-value: 6.81e-03
                           10        20
                   ....*....|....*....|....*...
gi 471270262   485 PGSVVKEDCNTCTCT-SGKWECSTAVCP 511
Cdd:pfam05375    4 PGSTFKDDCNTCTCTaNGIAACTLKGCP 31
 
Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1245-1396 3.06e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.06e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1245 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1324
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1325 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1396
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
beta-trefoil_ABD_OTOG-like cd23398
Arabinose-binding domain (ABD), beta-trefoil fold, found in the otogelin (OTOG) family; The ...
 1250-1396 1.84e-51

Arabinose-binding domain (ABD), beta-trefoil fold, found in the otogelin (OTOG) family; The OTOG family includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in the OTOG or OTOGL gene may cause hearing loss. Members of this family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467808  Cd Length: 143  Bit Score: 178.67  E-value: 1.84e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1250 LGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVaPADIVSFLLTAALYKAKAhdpDVVSLEAADRPNFFLHVTANGSL 1329
Cdd:cd23398     1 LGEGPYKLSSYNYPGYLLGANDDSGVVSLIPTENS-PSGGVSFMVTPGLNGDKA---NLVSFESAERPNYFLCVQANGTL 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262 1330 ELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1396
Cdd:cd23398    77 KLVKWENSALFRNAASFFLRQGTWIPGYVAFESTSKPGYFIRHSNSSLKLQKYDHTEEFRRSSSFKL 143
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 514-669 5.42e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 5.42e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   514 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 592
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   593 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 669
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 503-668 1.78e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 153.71  E-value: 1.78e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    503 WECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSS-GTFTVTLQNAPCGlnQDGACVQSVSVILHQDprrQ 581
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG--GGATCLKSVKVELNGD---E 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    582 VTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV-FLRVRTNVGV-RVLYDREGlRLYLQVDQRWVEDTVGLCGTFNGNT 659
Cdd:smart00216   76 IELKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGgYLVVITSLGLiQVTFDGLT-LLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*....
gi 471270262    660 QDDFLSPVG 668
Cdd:smart00216  155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 152-302 4.04e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 4.04e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   152 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 228
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262   229 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 302
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 977-1131 1.03e-35

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.45  E-value: 1.03e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    977 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1055
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   1056 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1129
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 471270262   1130 EN 1131
Cdd:smart00216  162 DG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 147-301 1.29e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 131.37  E-value: 1.29e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    147 ERDSICRAWGQHHVETFDGLYYYLSGKGSYTLVgRHEPEGQSFSIQVHNDPqCGSSPyTCSRAVSLFfVGEQEIHLAK-- 224
Cdd:smart00216    7 ECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLA-QDCSSEPTFSVLLKNVP-CGGGA-TCLKSVKVE-LNGDEIELKDdn 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262    225 -EVTHGGMRVQLPHVMGSARLQQLA--GYVIVRHQSA-FTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSS 300
Cdd:smart00216   83 gKVTVNGQQVSLPYKTSDGSIQIRSsgGYLVVITSLGlIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162


                    .
gi 471270262    301 G 301
Cdd:smart00216  163 G 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 986-1132 7.40e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 128.64  E-value: 7.40e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   986 CTAYGDRHYRTFDGLPFDFVGACKVHLVK---STSDVSFSVIVENVNCYSSGMiCRKFISINVGNSLIVFDDD-----SG 1057
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKdcsEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGgtvlvNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262  1058 NPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENL 1132
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
beta-trefoil_ABD_OTOGL cd23401
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin-like protein (OTOGL) and ...
 1245-1394 3.91e-26

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin-like protein (OTOGL) and similar proteins; OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in the OTOGL gene may cause hearing loss. OTOGL contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467811  Cd Length: 154  Bit Score: 106.87  E-value: 3.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1245 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1324
Cdd:cd23401     1 YYNQGLGEGPYTLSSYGQSDCVLGANLTSGEVFPLPKISAQGSTFFHFMITPGLFKDKASSLPVVSLESAERPNYFLCVH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1325 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLF 1394
Cdd:cd23401    81 DNRTLRLEQWQPSSEFRRRATFFHHQGLWIPGYSSFELHSKKGFFITLTHSGAKASKYDDSEEFKTSSSF 150
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2112-2266 5.70e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 5.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  2112 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2190
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262  2191 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2266
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1166-1240 7.62e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.63  E-value: 7.62e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   1166 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1240
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2101-2265 1.08e-21

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 1.08e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2101 RCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS----PDEMLTVHVLDCKS--ANLGHLNWPPFCLVMLnmt 2174
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcssePTFSVLLKNVPCGGgaTCLKSVKVELNGDEIE--- 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2175 hlahqvtIDRFNRKVTVDLQPV-WPPVSRYGF-RIEDTGHMYMILTPSDI-QIQWLHSSGLMiVEASKTSKAQGHGLCGI 2251
Cdd:smart00216   78 -------LKDDNGKVTVNGQQVsLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLS-VQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|....
gi 471270262   2252 CDGDAANDLTLKDG 2265
Cdd:smart00216  150 FDGEPEDDFRTPDG 163
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1476-2041 3.19e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 102.71  E-value: 3.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1476 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1554
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1555 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1634
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1635 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1713
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1714 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1791
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1792 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1865
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1866 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1940
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1941 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 2011
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 471270262 2012 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2041
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1467-1955 4.50e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 102.32  E-value: 4.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1467 PAVWVPTEALGNETLPPSQGLPTPSdeEPQLsqespRTPTHRPALTPAAplttalNPPVTATEEPVVSPGPTQTTLQQPl 1546
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPS--EPAV-----TSRARRPDAPPQS------ARPRAPVDDRGDPRGPAPPSPLPP- 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1547 eltASQLPAGPTESPASKgvtASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVifAGSPNITVSSRSPPAPRFP 1626
Cdd:PHA03247 2620 ---DTHAPDPPPPSPSPA---ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGR--AAQASSPPQRPRRRAARPT 2691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1627 LMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTgVPQPTQAQSASSPS 1706
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPA 2770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1707 TPLTVAGTAAEQVPVSPLATRSleivlstekgEAGHSQPmgSPASPQPHPLPSAPPRPAQhTTMATRSPALPPETPAAAS 1786
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLS----------ESRESLP--SPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPT 2837

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1787 LSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPlakvgtSAPVATPGPKASVITTP-LQPQATTLPAQTLSPVLPFTP 1865
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPA------AKPAAPARPPVRRLARPaVSRSTESFALPPDQPERPPQP 2911

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1866 AAMTQAHPPTHIAPPAAGT----APGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTsmygsaeg 1941
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQppppPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-------- 2983

                         490
                  ....*....|....*
gi 471270262 1942 gPTELTPATS-HPLT 1955
Cdd:PHA03247 2984 -PSREAPASStPPLT 2997
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1497-1960 1.66e-18

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 91.95  E-value: 1.66e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1497 LSQESPRTPTHRPALTPAAPLTTALNPPVTATEepvvspGPTQTTLQQPlELTASQLPAGP-TESPASKGVTASLLA--I 1573
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTK------GTSAAHLNST-EVTAEHTPHGTdLSEPATREGAADGAAsrA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1574 PHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPpaprfplmtKAVTVRGHgslpvrTTPPQPSLTA 1653
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAA---------IAAASAPH------AASPAPRTAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1654 SPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQV-PVSPLATRSLEIV 1732
Cdd:pfam17823  180 SSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVgTVTPAALATLAAA 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1733 LSTEKGEAGHSQpMGSPASPQPHPLPSAPprpaqhTTMATRSPALPpetpaaaslstatdglaatpfmslestrpsqlls 1812
Cdd:pfam17823  260 AGTVASAAGTIN-MGDPHARRLSPAKHMP------SDTMARNPAAP---------------------------------- 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1813 gLPPDTSLPLAKVGTSAPV--ATPGPKASVITTPLQPQATTLPAQTLSPVLPFT------PAAMTQAHPPTHIAPPAAGT 1884
Cdd:pfam17823  299 -MGAQAQGPIIQVSTDQPVhnTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTkaqakePSASPVPVLHTSMIPEVEAT 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1885 APGLLLGATLPTSGV----LPVA------EGTASMVSVVPRKSTTGKVAILSKQVSLPtsmygSAEGgptELTPATSHPL 1954
Cdd:pfam17823  378 SPTTQPSPLLPTQGAagpgILLApeqvatEATAGTASAGPTPRSSGDPKTLAMASCQL-----STQG---QYLVVTTDPL 449


                   ....*.
gi 471270262  1955 TPLVAE 1960
Cdd:pfam17823  450 TPALVD 455
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1173-1239 3.10e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 78.19  E-value: 3.10e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 471270262  1173 CSILL-SEVFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLC 1239
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1519-1975 5.72e-16

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 84.97  E-value: 5.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1519 TALNPpVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHT-PESSSLPVAlqTPTP-GMVSG 1596
Cdd:pfam05109  408 TATNA-TTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTgPTVSTADVT--SPTPaGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1597 AMETTRvtvifagSPNITVSSRSPPAPRFPLMTKAVTV---RGHGSLPVRTTPP----QPSLTASPSSRPVASPGAISRS 1669
Cdd:pfam05109  485 ASPVTP-------SPSPRDNGTESKAPDMTSPTSAVTTptpNATSPTPAVTTPTpnatSPTLGKTSPTSAVTTPTPNATS 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1670 PTSsgshkAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSplatrsleivlstekgeaghSQPMGSP 1749
Cdd:pfam05109  558 PTP-----AVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTT--------------------NHTLGGT 612

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1750 ASPqphPLPSAPPRPA-------QH--TTMATRSPALPPETPAAA-SLSTATDGLAATPFMSLESTRPSQLLSGLPPdTS 1819
Cdd:pfam05109  613 SST---PVVTSPPKNAtsavttgQHniTSSSTSSMSLRPSSISETlSPSTSDNSTSHMPLLTSAHPTGGENITQVTP-AS 688

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1820 LPLAKVGTSAPVATPGpKASVITTPLQPQATTLPAQTlspvlpftpaAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGV 1899
Cdd:pfam05109  689 TSTHHVSTSSPAPRPG-TTSQASGPGNSSTSTKPGEV----------NVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1900 LPVAEGTasmvsvvprKSTTGKVAILSKQvslPTSMYGSAEGGP-------TELTPATSHPLTP--LVAEPEGAQAGTAL 1970
Cdd:pfam05109  758 ANSTTGG---------KHTTGHGARTSTE---PTTDYGGDSTTPrtrynatTYLPPSTSSKLRPrwTFTSPPVTTAQATV 825


                   ....*
gi 471270262  1971 PVPTS 1975
Cdd:pfam05109  826 PVPPT 830
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2304-2370 7.22e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.68  E-value: 7.22e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 471270262   2304 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2370
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 349-412 1.57e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.57e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262   349 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 412
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1481-1852 2.34e-15

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 83.04  E-value: 2.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1481 LPPSQGLPT----PSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAG 1556
Cdd:pfam05109  448 LPSSTHVPTnltaPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAV 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1557 PTESPASKGVT------ASLLAIPhTPESSSLPVALQTPTPGMVSGAM-ETTRVTVIFAGSPNITVSSRSPPAPRfpLMT 1629
Cdd:pfam05109  528 TTPTPNATSPTlgktspTSAVTTP-TPNATSPTPAVTTPTPNATIPTLgKTSPTSAVTTPTPNATSPTVGETSPQ--ANT 604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1630 KAVTVRGHGSLPVRTTPP----------QPSLTASPSSRPVASPGAISR--SPTSSG---SHKAVLTPAvtkviSRTGVP 1694
Cdd:pfam05109  605 TNHTLGGTSSTPVVTSPPknatsavttgQHNITSSSTSSMSLRPSSISEtlSPSTSDnstSHMPLLTSA-----HPTGGE 679

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1695 QPTQAQSAS------SPSTPLTVAGTAAEQVPVSPLATrsleivlSTEKGEAGHSQpmGSPasPQPHPLPSAPprpaqht 1768
Cdd:pfam05109  680 NITQVTPAStsthhvSTSSPAPRPGTTSQASGPGNSST-------STKPGEVNVTK--GTP--PKNATSPQAP------- 741

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1769 tmATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG--------------LPPDTSLPLAK--VGTSAPVA 1832
Cdd:pfam05109  742 --SGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGdsttprtrynattyLPPSTSSKLRPrwTFTSPPVT 819

                          410       420
                   ....*....|....*....|.
gi 471270262  1833 TpgPKASVITTPL-QPQATTL 1852
Cdd:pfam05109  820 T--AQATVPVPPTsQPRFSNL 838
PHA03378 PHA03378
EBNA-3B; Provisional
 1493-1974 1.65e-14

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 80.11  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1493 EEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPG-PTQTTLQQPLelTASQLPAGPTESPASKGVTA--S 1569
Cdd:PHA03378  427 EEEHRKKKAARTEQPRATPHSQAPTVVLHRPPTQPLEGPTGPLSvQAPLEPWQPL--PHPQVTPVILHQPPAQGVQAhgS 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1570 LLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNItvsSRSPPAPRFPLMTKAVTVRGHGSLPVR--TTPP 1647
Cdd:PHA03378  505 MLDLLEKDDEDMEQRVMATLLPPSPPQPRAGRRAPCVYTEDLDI---ESDEPASTEPVHDQLLPAPGLGPLQIQplTSPT 581

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1648 QPSL-TASPS----SRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSAS-------SPSTPLTVAGTA 1715
Cdd:PHA03378  582 TSQLaSSAPSyaqtPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITfnvlvfpTPHQPPQVEITP 661

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1716 AE-------QVPVSPLATRSLEIVLSteKGEAGHSQPmgSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLS 1788
Cdd:PHA03378  662 YKptwtqigHIPYQPSPTGANTMLPI--QWAPGTMQP--PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPP 737

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1789 TATDGLAATPFMSLESTRPSQLLSG-LPPDTSLPLAKVGTSAPVATPGPKASVITTPL-QPQATTLPAqtlsPVLPFTPA 1866
Cdd:PHA03378  738 AAAPGRARPPAAAPGRARPPAAAPGrARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTpQPPPQAGPT----SMQLMPRA 813

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1867 AMTQAHPPTHIAP----------------PAAGTAPGLLLGATLPTSGVL------PVAEGTASMVSVVPRKSTTGKVAI 1924
Cdd:PHA03378  814 APGQQGPTKQILRqlltggvkrgrpslkkPAALERQAAAGPTPSPGSGTSdkivqaPVFYPPVLQPIQVMRQLGSVRAAA 893

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 471270262 1925 LSKQVSLPTSMYGSAEGG----PTELTPaTSHPLTPLVAEPEGAQAGtALPVPT 1974
Cdd:PHA03378  894 ASTVTQAPTEYTGERRGVgpmhPTDIPP-SKRAKTDAYVESQPPHGG-QSHSFS 945
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1471-1847 1.77e-14

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 79.23  E-value: 1.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1471 VPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPthrpalTPAAPLTTALNPPVTATEEPVVSpgpTQTTLQQPLELTA 1550
Cdd:pfam17823  114 ALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAA------ACRANASAAPRAAIAAASAPHAA---SPAPRTAASSTTA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1551 SQLPAGPTESPASKGVTASLLAIPHTPESSSlPVALQTPTPGMVSGAMETTRVTvifAGSPNITVSSRSpPAPRFPLMTK 1630
Cdd:pfam17823  185 ASSTTAASSAPTTAASSAPATLTPARGISTA-ATATGHPAAGTALAAVGNSSPA---AGTVTAAVGTVT-PAALATLAAA 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1631 AVTV-----RGHGSLPVRTTP-PQPSLTASPSSR-PVASPGAISRSPTSSGShkaVLTPavtkVISRTGVPQPTQAQSAS 1703
Cdd:pfam17823  260 AGTVasaagTINMGDPHARRLsPAKHMPSDTMARnPAAPMGAQAQGPIIQVS---TDQP----VHNTAGEPTPSPSNTTL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1704 SPSTPLTVAGTaaeqvpvsplatrSLEIVLSTEkgeaghSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPA 1783
Cdd:pfam17823  333 EPNTPKSVAST-------------NLAVVTTTK------AQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAA 393

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262  1784 AASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLplakvgTSAPVATPGPKASVITTPLQP 1847
Cdd:pfam17823  394 GPGILLAPEQVATEATAGTASAGPTPRSSGDPKTLAM------ASCQLSTQGQYLVVTTDPLTP 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1479-1880 2.14e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.37  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1479 ETLPPSQGLPTPSDEEPQLSQESPRTPTHRPAlTPAAPLTTALNPPVTATEEPVVSPGPTQTtlqqplelTASQLPAGP- 1557
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPGGPARPARPPTTAGPPAP--------APPAAPAAGp 2779

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1558 ---TESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPnitVSSRSPPAPRFPLMTKAVTV 1634
Cdd:PHA03247 2780 prrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP---TAPPPPPGPPPPSLPLGGSV 2856

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1635 RGHGSL----PVRTTPPQPSLTASPSSRPVASPgAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPtQAQSASSPSTPLT 1710
Cdd:PHA03247 2857 APGGDVrrrpPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQP-QPPPPPQPQPPPP 2934

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1711 VAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPmGSPASPQPHPLPSAPPRPAqhttmatrsPALPPETPAAASLSTA 1790
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP-GRVAVPRFRVPQPAPSREA---------PASSTPPLTGHSLSRV 3004

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1791 TDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKvGTSAPVATPGPKASVITTPLQPQATTLPAQtlsPVLPFTPAAMTQ 1870
Cdd:PHA03247 3005 SSWASSLALHEETDPPPVSLKQTLWPPDDTEDSD-ADSLFDSDSERSDLEALDPLPPEPHDPFAH---EPDPATPEAGAR 3080

                         410
                  ....*....|
gi 471270262 1871 AHPPTHIAPP 1880
Cdd:PHA03247 3081 ESPSSQFGPP 3090
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1478-1881 2.52e-14

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 79.81  E-value: 2.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1478 NETLPPSqgLPTPSDEEPQL--SQESPRTPTHRPALTPAAPLTTALNPPVTA-TEEPVVSPGPTQTTLQQPLELTASQLP 1554
Cdd:pfam03154  141 NRSTSPS--IPSPQDNESDSdsSAQQQILQTQPPVLQAQSGAASPPSPPPPGtTQAATAGPTPSAPSVPPQGSPATSQPP 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1555 AGPtESPAskgvtASLLAIPHTPesSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRF-----PLMT 1629
Cdd:pfam03154  219 NQT-QSTA-----APHTLIQQTP--TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtgpSHMQ 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1630 KAVTVRGHGSLPVRT---TPPQPSLTAS-PSSRPVASPGAISRSPTSSGSHKAVLTPAV-----TKVISRTGVPQPTQAQ 1700
Cdd:pfam03154  291 HPVPPQPFPLTPQSSqsqVPPGPSPAAPgQSQQRIHTPPSQSQLQSQQPPREQPLPPAPlsmphIKPPPTTPIPQLPNPQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1701 SASSPStplTVAGTAAEQVPVS---PLATRSLEiVLSTEKGEAGHSQPMgsPASPQPHPLPSAPPRPAqhttMATRSPAL 1777
Cdd:pfam03154  371 SHKHPP---HLSGPSPFQMNSNlppPPALKPLS-SLSTHHPPSAHPPPL--QLMPQSQQLPPPPAQPP----VLTQSQSL 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1778 PPETPAAASLSTATDGLAATPF--MSLESTRPSQLLSGLPPDTSLPLAKVG----TSAPVATPGPKASVITTPLQP---- 1847
Cdd:pfam03154  441 PPPAASHPPTSGLHQVPSQSPFpqHPFVPGGPPPITPPSGPPTSTSSAMPGiqppSSASVSSSGPVPAAVSCPLPPvqik 520

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 471270262  1848 -QATTLPAQTLSPvlpfTPAAMTQAHPPTHIAPPA 1881
Cdd:pfam03154  521 eEALDEAEEPESP----PPPPRSPSPEPTVVNTPS 551
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2842-2924 9.10e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 9.10e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262   2842 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2921
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 471270262   2922 CQW 2924
Cdd:smart00041   77 CEP 79
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 348-412 5.48e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 66.21  E-value: 5.48e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262    348 EQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 412
Cdd:smart00832    6 SQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTP 72
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1450-1836 1.82e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 73.67  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1450 VLDEVTQRCVYLEDCVEPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATE 1529
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1530 -----EPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVT 1604
Cdd:PHA03307  134 lsemlRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1605 VIFAGSPnitvSSRSPPAPRFPLMTKAVTV-----RGHGSLPVRTTP-PQPSLTASPSSRPVASPGAISRSPTSSGShka 1678
Cdd:PHA03307  214 SASASSP----APAPGRSAADDAGASSSDSsssesSGCGWGPENECPlPRPAPITLPTRIWEASGWNGPSSRPGPAS--- 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1679 vltpavtkviSRTGVPQPTQAQSASSPSTPLTVAGTAA--EQVPVSPLATRSleivlSTEKGEAGHSQPMGSPASPQPHP 1756
Cdd:PHA03307  287 ----------SSSSPRERSPSPSPSSPGSGPAPSSPRAssSSSSSRESSSSS-----TSSSSESSRGAAVSPGPSPSRSP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1757 LPSAPPRPAQHTTMATRSPALPPETPAAASLSTAT--DGLAATPFMSLESTRPSQLLSGLPPdtSLPLAKVGTSAPVATP 1834
Cdd:PHA03307  352 SPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTrrRARAAVAGRARRRDATGRFPAGRPR--PSPLDAGAASGAFYAR 429


                  ..
gi 471270262 1835 GP 1836
Cdd:PHA03307  430 YP 431
beta-trefoil_ABD_ABFB-like cd23265
Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family ...
 1250-1390 3.76e-12

Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family includes alpha-L-arabinofuranosidase B (ABF B)-like proteins and otogelin-like proteins. Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. Hungateiclostridium thermocellum anti-sigma-I factor RsgI5 shows high sequence similarity with ABF B. It negatively regulates SigI5 activity through direct interaction. The OTOG subfamily includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in OTOG or OTOGL genes may cause hearing loss. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467807  Cd Length: 135  Bit Score: 66.15  E-value: 3.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1250 LGKGPYQLSSLAAGGALVGmkaVGDDIVLVRTEDVAPADIVSFLLTAALYkakahDPDVVSLEAADRPNFFLHVtANGSL 1329
Cdd:cd23265     1 DGGTPVRLRSASDPGYYIR---HDGGSGSVTSDDDDSAEDAFFRVVPGLA-----GEGTVSFESVDKPGYYLRH-RGGEL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 471270262 1330 ELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRlYEHTEVFRR 1390
Cdd:cd23265    72 RLEKNDGSAAFREDATFRPRPGLADPGGVSFESVNYPGYYLRHRNNRLVLG-KVDSTAFKE 131
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1622-2029 7.93e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 71.17  E-value: 7.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1622 APRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAvtkvisrtgvPQPTQAQS 1701
Cdd:PRK07764  375 LARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPA----------PAPAPPSP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1702 ASSPSTPLTVAGTAAEQVPVSPlatrsleivlsTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTtmATRSPALPPET 1781
Cdd:PRK07764  445 AGNAPAGGAPSPPPAAAPSAQP-----------APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAP--AAPAGADDAAT 511

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1782 P------------------AAASLSTAT----DG----LA-ATPFM--SLESTRPSQLLSGLppdtslpLAKV--GTSAP 1830
Cdd:PRK07764  512 LrerwpeilaavpkrsrktWAILLPEATvlgvRGdtlvLGfSTGGLarRFASPGNAEVLVTA-------LAEElgGDWQV 584

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1831 VATPGPKASvittPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMV 1910
Cdd:PRK07764  585 EAVVGPAPG----AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVP 660

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1911 SVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPQds 1990
Cdd:PRK07764  661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDP-- 738

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 471270262 1991 mlVLLPQLAEAHGTSAGPH--LAAEPVDEATTEPSGRSAPA 2029
Cdd:PRK07764  739 --VPLPPEPDDPPDPAGAPaqPPPPPAPAPAAAPAAAPPPS 777
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 1483-1895 5.15e-11

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 68.03  E-value: 5.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1483 PSQGLpTPSDEEPQLSQESPrtpthrPALTPAAplTTALNPPvtATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP- 1561
Cdd:cd22540     8 PSEYL-QPAASTTQDSQPSP------LALLAAT--CSKIGPP--AVEAAVTPPAPPQPTPRKLVPIKPAPLPLGPGKNSi 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1562 ---ASKGVT----ASLLAIPHTPesSSLPVALQTPTpgMVSGAMETTRVTVI-FAGSPNITVSSRSP------------P 1621
Cdd:cd22540    77 gflSAKGNIiqlqGSQLSSSAPG--GQQVFAIQNPT--MIIKGSQTRSSTNQqYQISPQIQAAGQINnsgqiqiipgtnQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1622 APRFPLMTKAVTVRGHGSLPVRttpPQPSLTASPSSRPVASPGAISRSPtsSGSHKAVLTP-------AVTKVISRTGVP 1694
Cdd:cd22540   153 AIITPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPGNVIKLQ--SGGNVALTLPvnnlvgtQDGATQLQLAAA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1695 QPTQAQSAS-SPSTPLTVAGTAAEQVPVSPLATRSLEIvlstekGEAGHS----QPMGSPASPQPHPLPSAPPRPAQHTt 1769
Cdd:cd22540   228 PSKPSKKIRkKSAQAAQPAVTVAEQVETVLIETTADNI------IQAGNNllivQSPGTGQPAVLQQVQVLQPKQEQQV- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1770 maTRSPALPPETPAAASLstatdGLAATPfmslesTRPSQllsglppdtslplakvGTSAPVATPGPKASVITTPL-QPQ 1848
Cdd:cd22540   301 --VQIPQQALRVVQAASA-----TLPTVP------QKPLQ----------------NIQIQNSEPTPTQVYIKTPSgEVQ 351

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 471270262 1849 ATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLP 1895
Cdd:cd22540   352 TVLLQEAPAATATPSSSTSTVQQQVTANNGTGTSKPNYNVRKERTLP 398
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 713-767 2.25e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.25e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 471270262   713 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 767
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1471-1901 3.46e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 3.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1471 VPTEALGNETLPPSQGLPTPSDE-EPQLSQESPRTPTHRPALTPAAPL----TTALNPPVTATEEPVVSPG----PTQTT 1541
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGtEAPANESRSTPTWSLSTLAPASPAregsPTPPGPSSPDPPPPTPPPAspppSPAPD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1542 LQQPLELTASQLPAGPTESPAskgvtasllaiphtPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPP 1621
Cdd:PHA03307  134 LSEMLRPVGSPGPPPAASPPA--------------AGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1622 APRFPlmtkavtvrghgslpvrTTPPQPSLTASPSSRPVASPG---AISRSPTSSGSHKAVLTPAVTKVISRTGVPQPtq 1698
Cdd:PHA03307  200 AAASP-----------------RPPRRSSPISASASSPAPAPGrsaADDAGASSSDSSSSESSGCGWGPENECPLPRP-- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1699 aqsasSPSTPLTVAGTAAEQVPVSPLatrsleivlstekgeAGHSQPMGSPASPQPHPLPSAP---PRPAQHTTMATRSP 1775
Cdd:PHA03307  261 -----APITLPTRIWEASGWNGPSSR---------------PGPASSSSSPRERSPSPSPSSPgsgPAPSSPRASSSSSS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1776 ALPPETPAAASLSTATDGLAATPfmSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQ 1855
Cdd:PHA03307  321 SRESSSSSTSSSSESSRGAAVSP--GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRA 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 471270262 1856 TLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLL---GATLPTSGVLP 1901
Cdd:PHA03307  399 RRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLtpsGEPWPGSPPPP 447
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1615-1880 6.09e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 65.26  E-value: 6.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1615 VSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAV--TKVISRTG 1692
Cdd:PRK07003  375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADgdAPVPAKAN 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1693 VPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivlsTEKGEAGHSQPMGSPASPQPHPlPSAPPRPAQHTTMAT 1772
Cdd:PRK07003  455 ARASADSRCDERDAQPPADSGSASAPASDAPPDAAF------EPAPRAAAPSAATPAAVPDARA-PAAASREDAPAAAAP 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1773 RSPALPPETPAAASLSTATDGLAA------TPFMSLESTRpsqllSGLPPDTSLPLAKVGTSAPVATPGPKASViTTPLQ 1846
Cdd:PRK07003  528 PAPEARPPTPAAAAPAARAGGAAAaldvlrNAGMRVSSDR-----GARAAAAAKPAAAPAAAPKPAAPRVAVQV-PTPRA 601

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 471270262 1847 PQATtlPAQTLSPVLPFTPAAMT-QAHPPTHIAPP 1880
Cdd:PRK07003  602 RAAT--GDAPPNGAARAEQAAESrGAPPPWEDIPP 634
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1692-2056 1.89e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.80  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1692 GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLA-TRSLEIVLSTEKGEaghsqpmgspasPQPhPLPSAPPRPAQHTTM 1770
Cdd:PHA03247 2502 GPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTwIRGLEELASDDAGD------------PPP-PLPPAAPPAAPDRSV 2568

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1771 ATRSPALPPETPAAASlstatdglaatpfmslESTRPsqllsGLPPDTSLPLAKVGTSAPVATPGPKASV--ITTPLQPQ 1848
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTS----------------RARRP-----DAPPQSARPRAPVDDRGDPRGPAPPSPLppDTHAPDPP 2627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1849 ATTLPAQTLSPVLPFTPAAMTQAHP-----PTHIAPPAAGTAPGLLLGATLPTSG----VLPVAEGTASMVSVVPRKSTT 1919
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPrddpaPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGSLTSLADPPPPPPT 2707

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1920 GKVAILSKQVSLPTSMYGSAEGGPTELTPATshPLTPLVAEPEGAQAGTAlPVPTSYALSRVSARTAPQDSMLVLLPQLA 1999
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262 2000 EAHGTSAGPHLAAEPvdeATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIA 2056
Cdd:PHA03247 2785 RPAVASLSESRESLP---SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1482-1849 2.92e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 63.08  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1482 PPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP 1561
Cdd:PRK07764  431 PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAA 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1562 ASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGametTRVTVIFagspnitvsSRSPPAPRF------PLMTKAVTVR 1635
Cdd:PRK07764  511 TLRERWPEILAAVPKRSRKTWAILLPEATVLGVRG----DTLVLGF---------STGGLARRFaspgnaEVLVTALAEE 577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1636 GHGSLpvrttppQPSLTASPSsrPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTA 1715
Cdd:PRK07764  578 LGGDW-------QVEAVVGPA--PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVA 648

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1716 AEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQP--HPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDG 1793
Cdd:PRK07764  649 APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPaaPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGA 728

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262 1794 LAATPFMSLESTRPSQ-LLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQA 1849
Cdd:PRK07764  729 SAPSPAADDPVPLPPEpDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1472-1809 5.01e-09

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 62.40  E-value: 5.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1472 PTEALGNETLPPSQ-GLPTPSDEEPQLSQESPRTPTHRpaltpaaplttalNPPVTATEEPVVSPGPTQTtlQQPLEL-T 1549
Cdd:PTZ00449  510 PPEGPEASGLPPKApGDKEGEEGEHEDSKESDEPKEGG-------------KPGETKEGEVGKKPGPAKE--HKPSKIpT 574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1550 ASQLPAGPTESPASKGvtasllaiPHTPESSSLPVALQTPTpgmvsgamettrvtvifagspnitvSSRSPPAPRFPLMT 1629
Cdd:PTZ00449  575 LSKKPEFPKDPKHPKD--------PEEPKKPKRPRSAQRPT-------------------------RPKSPKLPELLDIP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1630 KAVTVRGHGSLPVRttPPQPSLTASPsSRPvASPGAIsRSPTSSGSHKAVLTPAVTKVI-------------SRTGVPQP 1696
Cdd:PTZ00449  622 KSPKRPESPKSPKR--PPPPQRPSSP-ERP-EGPKII-KSPKPPKSPKPPFDPKFKEKFyddyldaaakskeTKTTVVLD 696

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1697 TQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivlstekgEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMAtrspa 1776
Cdd:PTZ00449  697 ESFESILKETLPETPGTPFTTPRPLPPKLPRD----------EEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFH----- 761

                         330       340       350
                  ....*....|....*....|....*....|...
gi 471270262 1777 lppETPAAASLSTATDGLAATPFMSLESTRPSQ 1809
Cdd:PTZ00449  762 ---ETPADTPLPDILAEEFKEEDIHAETGEPDE 791
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 780-844 8.89e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.86  E-value: 8.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262  780 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 844
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 780-844 1.01e-08

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 53.55  E-value: 1.01e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262   780 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 844
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVC---------PEPCVEGCVCPPGFVRNSG-GKCVPPSDC 55
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1633-2012 1.04e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 61.32  E-value: 1.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1633 TVRGHGSLPV-----RTTPPQPSLTASPSSRPVASPGAISRSP--TSSGSHKAVLTPAVTKVIsRTGVPQP--------- 1696
Cdd:pfam03154    7 TRRSRGSMSTlrsgrKKQTASPDGRASPTNEDLRSSGRNSPSAasTSSNDSKAESMKKSSKKI-KEEAPSPlksakrqre 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1697 ----------------TQAQSASSPSTPLTVAGTAAEqvpvsplaTRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSA 1760
Cdd:pfam03154   86 kgasdteeperatakkSKTQEISRPNSPSEGEGESSD--------GRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1761 PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVatpgpkasv 1840
Cdd:pfam03154  158 SDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPH--------- 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1841 itTPLQPQATTLPAQTLSPVLPFTPaaMTQAHPPTHIAPPAagTAPGLLLGATLPtsGVLPVAEGTASMVSVVPRKSTTG 1920
Cdd:pfam03154  229 --TLIQQTPTLHPQRLPSPHPPLQP--MTQPPPPSQVSPQP--LPQPSLHGQMPP--MPHSLQTGPSHMQHPVPPQPFPL 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1921 KVAILSKQVSLPTSMYGSAEGGPTELTPATShpltplvAEPEGAQAGTALPVPTSyALSRVSARTAPQDSmlvlLPQLAE 2000
Cdd:pfam03154  301 TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQ-------SQLQSQQPPREQPLPPA-PLSMPHIKPPPTTP----IPQLPN 368

                          410
                   ....*....|..
gi 471270262  2001 AHGTSAGPHLAA 2012
Cdd:pfam03154  369 PQSHKHPPHLSG 380
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1466-1925 1.46e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 60.63  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1466 EPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEE--PVVSPGPTQTtlq 1543
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAeaPPAAPAPPAT--- 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1544 qpleltasqlpAGPTESPASKGVTA-SLLAIPHTPESSSLPVALQTPTpgmvsgamettrvtvifAGSPNITVSSRSPPA 1622
Cdd:PRK07003  436 -----------ADRGDDAADGDAPVpAKANARASADSRCDERDAQPPA-----------------DSGSASAPASDAPPD 487

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1623 PRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTssgshkavltpavtkvisrtgvpqPTQAQSA 1702
Cdd:PRK07003  488 AAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT------------------------PAAAAPA 543

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1703 SSpstpltvAGTAAEQVPVsplaTRSLEIVLSTEKGEAGHSQPmgSPASPQPHPLPSAPPRpaqhttmatrsPALPPETP 1782
Cdd:PRK07003  544 AR-------AGGAAAALDV----LRNAGMRVSSDRGARAAAAA--KPAAAPAAAPKPAAPR-----------VAVQVPTP 599

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1783 -AAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK---VGTS----APVATPGPKaSVITTPLQPQATTLPA 1854
Cdd:PRK07003  600 rARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSAdegFGGPddgfVPVFDSGPD-DVRVAPKPADAPAPPV 678

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1855 QT--LSPVLPFTPAAMTQAHPPthiappaagtapgllLGATLPTSGV---------LPVAEGTASMVSV-VPRKSTTGKV 1922
Cdd:PRK07003  679 DTrpLPPAIPLDAIGFDGEWPA---------------LAARLPLKGVayqlafnseLTAADGGTLKLAVpVPQYADAAQV 743


                  ...
gi 471270262 1923 AIL 1925
Cdd:PRK07003  744 AKL 746
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 711-767 1.56e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.88  E-value: 1.56e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 471270262    711 QACSVLTGEM--FAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 767
Cdd:smart00832    6 SQCGILLSPRgpFAACHSVVDPEPFFENCVYDTCACGgdCECLCDALAAYAAACAEAGVCI 66
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1643-1933 2.09e-08

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 60.48  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1643 RTTPPQ-----PSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQA-QSASSPSTPLTVAGTAA 1716
Cdd:PRK10263  298 RATQPEydeydPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAwQPVPGPQTGEPVIAPAP 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1717 EQVPVSPlatrsleivlSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQ--------HTTMATRSPALPPETPAAASLS 1788
Cdd:PRK10263  378 EGYPQQS----------QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQqpyyapapEQPAQQPYYAPAPEQPVAGNAW 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1789 TATDglAATPFMSLESTRPSQ-LLSGLPPDTSLPLAKVGTSAPVATPGPKASViTTPLQP-------------------- 1847
Cdd:PRK10263  448 QAEE--QQSTFAPQSTYQTEQtYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEE-TKPARPplyyfeeveekrarereqla 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1848 ---QATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGlLLGATLPTSGVLPVAEGTASMVS-VVPR---KSTTG 1920
Cdd:PRK10263  525 awyQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASG-VKKATLATGAAATVAAPVFSLANsGGPRpqvKEGIG 603

                         330
                  ....*....|...
gi 471270262 1921 KVAILSKQVSLPT 1933
Cdd:PRK10263  604 PQLPRPKRIRVPT 616
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1439-2031 4.05e-08

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 58.92  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1439 EGCVPVCPTPQVLDEVTQRCVYLEDCVE---PAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQesprTPTHRP---ALT 1512
Cdd:COG5180    24 PVLSPELWAAANNDAVSQGDRSALASSPtrpYARKIFEPLDIKLALGKPQLPSVAEPEAYLDPA----PPKSSPdtpEEQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1513 PAAPLTTALNPPVTATEEpvvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPG 1592
Cdd:COG5180   100 LGAPAGDLLVLPAAKTPE---LAAGALPAPAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDGDSASTLPP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1593 MVSGAMETTRVtvifagsPNITVSSRSPPAPRFPLMTKAvtvrghgslPVRTTPPQPSLTASPSSRPVASPGAISRSPTS 1672
Cdd:COG5180   177 PAEKLDKVLTE-------PRDALKDSPEKLDRPKVEVKD---------EAQEEPPDLTGGADHPRPEAASSPKVDPPSTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1673 SGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTP---LTVAGTAAEQVPVSPLAtrslEIVLSTEKGEAGHSQPMGSP 1749
Cdd:COG5180   241 EARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEppgLPVLEAGSEPQSDAPEA----ETARPIDVKGVASAPPATRP 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1750 ASPQPHPLPSAPPRPAQhttmATRSPALPPEtpaaaslstatdglAATPfmslESTRPsqllSGLPPdtslplakvGTSA 1829
Cdd:COG5180   317 VRPPGGARDPGTPRPGQ----PTERPAGVPE--------------AASD----AGQPP----SAYPP---------AEEA 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1830 PVATPGPkasvittPLQPQattlPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASM 1909
Cdd:COG5180   362 VPGKPLE-------QGAPR----PGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAG 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1910 VSVVPRKSTTGKVAIlskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEgAQAGTALPVPTsyalsrvsartaPQD 1989
Cdd:COG5180   431 GAGQGPKADFVPGDA-------------ESVSGPAGLADQAGAAASTAMADFV-APVTDATPVDV------------ADV 484

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 471270262 1990 SMLVLLPQLAEAHGTSAG-PHLAAEPVDEATTEPSGRSAPALS 2031
Cdd:COG5180   485 LGVRPDAILGGNVAPASGlDAETRIIEAEGAPATEDFVAAELS 527
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1748-2054 5.03e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 5.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1748 SPASPQPHPLPSAPPRPAQHTtmatrspalPPETPAAASLSTATDGLAATPFM--------SLESTRPSQLLSGLPPDts 1819
Cdd:PHA03247 2490 FAAGAAPDPGGGGPPDPDAPP---------APSRLAPAILPDEPVGEPVHPRMltwirgleELASDDAGDPPPPLPPA-- 2558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1820 LPLAKVGTSAPVATPGPKasvittPLQPQATT------LPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAgTAPGLLLGAT 1893
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPR------PSEPAVTSrarrpdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT-HAPDPPPPSP 2631

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1894 LPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV---SLPTSMYGSAEGGPTELTPATSHPLT--------PLVAEPE 1962
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRArrlGRAAQASSPPQRPRRRAARPTVGSLTsladppppPPTPEPA 2711

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1963 GAQAGTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEAHG---------TSAGPHLAAEPVDEATTEPSGRSAPALSIV 2033
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgparparppTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791

                         330       340
                  ....*....|....*....|.
gi 471270262 2034 EGLAEALATTTEANTSTTCVP 2054
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVL 2812
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1641-1879 5.87e-08

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 58.40  E-value: 5.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1641 PVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVisrtgvPQPTQAQSASSPSTPLTVAGTAAEQVP 1720
Cdd:PLN03209  341 PVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSPI------PTPPSSSPASSKSVDAVAKPAEPDVVP 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1721 VSPLATRSLEIVLSTEkgEAGHSQPMgSPAS------PQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDgl 1794
Cdd:PLN03209  415 SPGSASNVPEVEPAQV--EAKKTRPL-SPYAryedlkPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAP-- 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1795 aATPFMSLEStrPSQLLSGLPPDTS-LPLAKVGTSAPVATPGP----KASVITTPLQPQATTLPAQtlSPVLPFTpaAMT 1869
Cdd:PLN03209  490 -PPANMRPLS--PYAVYDDLKPPTSpSPAAPVGKVAPSSTNEVvkvgNSAPPTALADEQHHAQPKP--RPLSPYT--MYE 562

                         250
                  ....*....|
gi 471270262 1870 QAHPPTHIAP 1879
Cdd:PLN03209  563 DLKPPTSPTP 572
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1726-1988 6.26e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.71  E-value: 6.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1726 TRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLEST 1805
Cdd:PRK07003  349 TMTLLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1806 RPSQLLSG----LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPA------AMTQAHPPT 1875
Cdd:PRK07003  429 APAPPATAdrgdDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPApraaapSAATPAAVP 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1876 HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASmvsvvPRKSTTGKVAILSkqVSLPTSMYGSAEGGptELTPATSHPLT 1955
Cdd:PRK07003  509 DARAPAAASREDAPAAAAPPAPEARPPTPAAAA-----PAARAGGAAAALD--VLRNAGMRVSSDRG--ARAAAAAKPAA 579

                         250       260       270
                  ....*....|....*....|....*....|...
gi 471270262 1956 PLVAEPEGAQAGTALPVPTSYALSRVSARTAPQ 1988
Cdd:PRK07003  580 APAAAPKPAAPRVAVQVPTPRARAATGDAPPNG 612
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1702-2030 1.62e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 56.89  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1702 ASSPSTPLTVA-GTAAEQVPVSPLAT----RSLEIVLSTEKGEAGHSQPMGSPASPQphplpSAPPRPAQHTTMATRS-- 1774
Cdd:pfam17823   63 ATAAPAPVTLTkGTSAAHLNSTEVTAehtpHGTDLSEPATREGAADGAASRALAAAA-----SSSPSSAAQSLPAAIAal 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1775 PALPPETPAAASLSTATDGLAATPFMSLESTRpsqllsglppdtslplakVGTSAPVATPGPKASVITTPLQPQATTLPA 1854
Cdd:pfam17823  138 PSEAFSAPRAAACRANASAAPRAAIAAASAPH------------------AASPAPRTAASSTTAASSTTAASSAPTTAA 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1855 QTlspvlpfTPAAMTQAHP----PTHIAPPAAGTAPGlLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAilSKQVS 1930
Cdd:pfam17823  200 SS-------APATLTPARGistaATATGHPAAGTALA-AVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVA--SAAGT 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1931 LPTSMYGSAEGGPTELTPATSHPLTPlvAEPEGAQA-GTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEAHGTSAGPH 2009
Cdd:pfam17823  270 INMGDPHARRLSPAKHMPSDTMARNP--AAPMGAQAqGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAV 347

                          330       340
                   ....*....|....*....|.
gi 471270262  2010 LAAEPVDeaTTEPSGRSAPAL 2030
Cdd:pfam17823  348 VTTTKAQ--AKEPSASPVPVL 366
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1487-1887 3.26e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 56.15  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1487 LPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGV 1566
Cdd:PRK07764  364 LPSASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPS 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1567 TASllaiphTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPlmtkAVTVRGHGSLPVRTTP 1646
Cdd:PRK07764  444 PAG------NAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAP----AAPAAPAGADDAATLR 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1647 PQ-PSLTASPSSRPVASPGAISRSPTSSGSHKAVLTpavtkvisrTGVPQPTQAQSASSPSTPLTVAGTAAEQV------ 1719
Cdd:PRK07764  514 ERwPEILAAVPKRSRKTWAILLPEATVLGVRGDTLV---------LGFSTGGLARRFASPGNAEVLVTALAEELggdwqv 584

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1720 -------PVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATD 1792
Cdd:PRK07764  585 eavvgpaPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1793 GLAATPfmsLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAH 1872
Cdd:PRK07764  665 GGDGWP---AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         410
                  ....*....|....*
gi 471270262 1873 PPTHIAPPAAGTAPG 1887
Cdd:PRK07764  742 PPEPDDPPDPAGAPA 756
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
1490-1912 3.51e-07

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 55.85  E-value: 3.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1490 PSDEEPQL------SQESPR--TPTHRPALT-PAAPLTTALNP---PVTATEE-------PVVSPGPTQTTLQQPL---- 1546
Cdd:pfam03546   49 PSGKTPQVraasapAKESPRkgAPPVPPGKTgPAAAQAQAGKPeedSESSSEEsdsdgetPAAATLTTSPAQVKPLgkns 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1547 ----ELTASQLPAGPTESPASKGVTASLLAIPHTP------ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVS 1616
Cdd:pfam03546  129 qvrpASTVGKGPSGKGANPAPPGKAGSAAPLVQVGkkeedsESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGA 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1617 SRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPV-ASPGAISRSPTSSGSHKAVLTPAVTKVIS-RTGVP 1694
Cdd:pfam03546  209 APAPPQKAGPVATQVKAERSKEDSESSEESSDSEEEAPAAATPAqAKPALKTPQTKASPRKGTPITPTSAKVPPvRVGTP 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1695 QPTQAQSASSPstpltvagtAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPrpaqhtTMATRS 1774
Cdd:pfam03546  289 APWKAGTVTSP---------ACASSPAVARGAQRPEEDSSSSEESESEEETAPAAAVGQAKSVGKGLQ------GKAASA 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1775 PALPPETPAAASLSTATDGLAATPF--MSLESTRPSQLLSGlppdtslplakvgTSAPVATPGPKASVITTPlQPQATTL 1852
Cdd:pfam03546  354 PTKGPSGQGTAPVPPGKTGPAVAQVkaEAQEDSESSEEESD-------------SEEAAATPAQVKASGKTP-QAKANPA 419

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 471270262  1853 PAQT-LSPVLPFTPAAMTQAHPPTHIAPPAAGTAPglllGATLPTSGVLpvAEGTASMVSV 1912
Cdd:pfam03546  420 PTKAsSAKGAASAPGKVVAAAAQAKQGSPAKVKPP----ARTPQNSAIS--VRGQASVPAV 474
PHA03378 PHA03378
EBNA-3B; Provisional
 1458-1841 4.54e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 55.84  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1458 CVYLEDCV----EPAVWVPT--EALGNETLPPSQGLPTPSDEEPQLSQESPR-----TPTHRPALTPAAPLTTALNPPVT 1526
Cdd:PHA03378  540 CVYTEDLDiesdEPASTEPVhdQLLPAPGLGPLQIQPLTSPTTSQLASSAPSyaqtpWPVPHPSQTPEPPTTQSHIPETS 619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1527 A---------------------TEEPVVSPGPTQT--TLQQPLELTASQLPAGPTEsPASKGVTASLLaIPHTPESSSLP 1583
Cdd:PHA03378  620 AprqwpmplrpipmrplrmqpiTFNVLVFPTPHQPpqVEITPYKPTWTQIGHIPYQ-PSPTGANTMLP-IQWAPGTMQPP 697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1584 VALQTPT--PGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMtkavtvRGHGSLPVRTTPPQPSLTASPSsrPVA 1661
Cdd:PHA03378  698 PRAPTPMrpPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRA------RPPAAAPGRARPPAAAPGRARP--PAA 769

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1662 SPGAISRSPTSSGSHKAVLTPavtkvisrTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVL-----STE 1736
Cdd:PHA03378  770 APGAPTPQPPPQAPPAPQQRP--------RGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVkrgrpSLK 841

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1737 KGEAGHSQpmgSPASPQPHPLPSAPPRPAQHTTMAtrSPALPP-ETPAAASLSTATdGLAATPFMSLESTRPSQLLSGLP 1815
Cdd:PHA03378  842 KPAALERQ---AAAGPTPSPGSGTSDKIVQAPVFY--PPVLQPiQVMRQLGSVRAA-AASTVTQAPTEYTGERRGVGPMH 915

                         410       420       430
                  ....*....|....*....|....*....|..
gi 471270262 1816 PDTSLPLAKVGTSA------PVATPGPKASVI 1841
Cdd:PHA03378  916 PTDIPPSKRAKTDAyvesqpPHGGQSHSFSVI 947
beta-trefoil_ABD_ABFB cd23399
Arabinose-binding domain (ABD), beta-trefoil fold, found in alpha-L-arabinofuranosidase B (ABF ...
 1305-1394 4.73e-07

Arabinose-binding domain (ABD), beta-trefoil fold, found in alpha-L-arabinofuranosidase B (ABF B) and similar proteins; Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. The family also includes Hungateiclostridium thermocellum anti-sigma-I factor RsgI5. It negatively regulates SigI5 activity through direct interaction. Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI5 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI5. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467809  Cd Length: 138  Bit Score: 51.44  E-value: 4.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1305 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1383
Cdd:cd23399    50 DSGCVSFESVNYPGYYLrH--YNFRLRLDKNDGSALFKEDATFCPRPGLADGGGVSFRSYNYPGRYIRHRNFELWLDPND 127

                          90
                  ....*....|.
gi 471270262 1384 HTEVFRRGTLF 1394
Cdd:cd23399   128 GTALFRQDATF 138
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1467-1821 6.56e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.31  E-value: 6.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1467 PAVWVPTEALGNETL---PPSQGL--PTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTT 1541
Cdd:pfam05109  525 PAVTTPTPNATSPTLgktSPTSAVttPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANT 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1542 LQQPLELTASQlpagPTESPASKGVTASLLAIPHTPESSSlpVALQTPTPGMVSGAMettrvtvifagSPNITVSSRSpp 1621
Cdd:pfam05109  605 TNHTLGGTSST----PVVTSPPKNATSAVTTGQHNITSSS--TSSMSLRPSSISETL-----------SPSTSDNSTS-- 665

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1622 apRFPLMTKAVTVRGHGSLPVrtTPPQPSLTASPSSRPVASPGAISRSpTSSGSHKAVLTPAvtkvisRTGVPQPTQAQS 1701
Cdd:pfam05109  666 --HMPLLTSAHPTGGENITQV--TPASTSTHHVSTSSPAPRPGTTSQA-SGPGNSSTSTKPG------EVNVTKGTPPKN 734

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1702 ASSPSTPltvagtaAEQVPVSPLATRSLEIVLSTEKGEagHSQPMGSPASPQPhplpsAPPRPAQHTTMATRSPALPPET 1781
Cdd:pfam05109  735 ATSPQAP-------SGQKTAVPTVTSTGGKANSTTGGK--HTTGHGARTSTEP-----TTDYGGDSTTPRTRYNATTYLP 800

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 471270262  1782 PAAASLSTATDGLAATPFMSLESTRPsqllsgLPPdTSLP 1821
Cdd:pfam05109  801 PSTSSKLRPRWTFTSPPVTTAQATVP------VPP-TSQP 833
PHA03379 PHA03379
EBNA-3A; Provisional
 1483-1887 7.14e-07

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 55.06  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1483 PSQGLPTPSDE--EPQLSQESPRTPTHRPALTPAAPlTTALNPPVTATEEPVVSPGPTQTTLQQPLELTA--SQLPaGPT 1558
Cdd:PHA03379  411 PTYGTPRPPVEkpRPEVPQSLETATSHGSAQVPEPP-PVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEpgDQLP-GVV 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1559 ESPASKGVTASLLAIPHTP--ESSSLPVALQTPTPGMvsgameTTRVTVIFAGSPNITVSSRSPPAPRFPLMTKavtvrg 1636
Cdd:PHA03379  489 QDGRPACAPVPAPAGPIVRpwEASLSQVPGVAFAPVM------PQPMPVEPVPVPTVALERPVCPAPPLIAMQG------ 556

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1637 hgslpvrttPPQPSLTASPSSRPVASPGAisrsptssgshkavltpavtkvisrtgvPQPTQaqsassPSTPLTVAGTAA 1716
Cdd:PHA03379  557 ---------PGETSGIVRVRERWRPAPWT----------------------------PNPPR------SPSQMSVRDRLA 593

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1717 EQVPVSPLATRSLEiVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAA 1796
Cdd:PHA03379  594 RLRAEAQPYQASVE-VQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPL 672

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1797 TPFMSLESTRPSqllsgLPPDT--------SLPLAKvGTSAPVATPGPKAsviTTPLQPQATTLPAQTLSPV-------- 1860
Cdd:PHA03379  673 APLRASMGPVPP-----VPATQpqyfdiplTEPINQ-GASAAHFLPQQPM---EGPLVPERWMFQGATLSQSvrpgvaqs 743

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 471270262 1861 ----LPFT-------PAAMTQAHPPT-----------HIAPPAAGTAPG 1887
Cdd:PHA03379  744 qyfdLPLTqpinhgaPAAHFLHQPPMegpwvpeqwmfQGAPPSQGTDVV 792
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1692-1898 7.31e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 54.88  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1692 GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivLSTEKGEAGHSQPMG-SPASPQPHPLPSAPPRPAQHTTM 1770
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPA----AAPAAAAAARAVAAApARRSPAPEALAAARQASARGPGG 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1771 ATRSPALPPETPA------AASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLP--LAKVGTSAPVATPGPKASVIT 1842
Cdd:PRK12323  447 APAPAPAPAAAPAaaarpaAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpeFASPAPAQPDAAPAGWVAESI 526

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 471270262 1843 TPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAP-PAAGTAPGLL---------LGATLPTSG 1898
Cdd:PRK12323  527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPrPPRASASGLPdmfdgdwpaLAARLPVRG 592
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1654-1888 8.38e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.08  E-value: 8.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1654 SPSSRPVASPGA-----ISRSPTSSGSHKAVLTPAVTKVISRTGVPQ-PTQAQSASSPSTPLTVAGTAAeqvPVSPLATR 1727
Cdd:PTZ00449  540 SDEPKEGGKPGEtkegeVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKhPKDPEEPKKPKRPRSAQRPTR---PKSPKLPE 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1728 SLEIVLSTEKGEAGHSqpmgsPASPQPHPLPSAPPRPAQHTTMATRSPALPPETP----------------AAASLSTAT 1791
Cdd:PTZ00449  617 LLDIPKSPKRPESPKS-----PKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPfdpkfkekfyddyldaAAKSKETKT 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1792 DGLAATPFMS-LESTRPSQllSGLPPDTSLPLAKV---GTSAPVATPGPKASVITTPLQ---------------PQATTL 1852
Cdd:PTZ00449  692 TVVLDESFESiLKETLPET--PGTPFTTPRPLPPKlprDEEFPFEPIGDPDAEQPDDIEfftppeeertffhetPADTPL 769

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 471270262 1853 P-------------AQTLSPvlpftPAAMTQAHPPTHIAPPAAGTAPGL 1888
Cdd:PTZ00449  770 PdilaeefkeedihAETGEP-----DEAMKRPDSPSEHEDKPPGDHPSL 813
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1580-1778 1.62e-06

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 53.84  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1580 SSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASpssrp 1659
Cdd:PRK12727   60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVRAAS----- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1660 VASPGAISRSPTSSGSHKAVLTPAVTKV--------ISRTGVPQPTQAQSASSPSTPlTVAGTAAEQVPVSPLATRSLEI 1731
Cdd:PRK12727  135 IPSPAAQALAHAAAVRTAPRQEHALSAVpeqlfadfLTTAPVPRAPVQAPVVAAPAP-VPAIAAALAAHAAYAQDDDEQL 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 471270262 1732 VlstekgEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP 1778
Cdd:PRK12727  214 D------DDGFDLDDALPQILPPAALPPIVVAPAAPAALAAVAAAAP 254
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1482-1765 1.81e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 1.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1482 PPSQGLPTPSD--EEPQLSQESPRTPTHRPALTPAAPLTTALNPP-----------VTATEEPVVSPGPTQTTLQQPLEL 1548
Cdd:PHA03307  123 PASPPPSPAPDlsEMLRPVGSPGPPPAASPPAAGASPAAVASDAAssrqaalplssPEETARAPSSPPAEPPPSTPPAAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1549 TASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRV---------TVIFAGSPNI------ 1613
Cdd:PHA03307  203 SPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLprpapitlpTRIWEASGWNgpssrp 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1614 -TVSSRSPPAPRFPlmtkaVTVRGHGSLPVRTTPP---------QPSLTASPSSRPVASPGAISRSPTSSGSH------K 1677
Cdd:PHA03307  283 gPASSSSSPRERSP-----SPSPSSPGSGPAPSSPrasssssssRESSSSSTSSSSESSRGAAVSPGPSPSRSpspsrpP 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1678 AVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVP--VSPLATRSLEIVLSTEKGEAGHSQPM-GSPASPQP 1754
Cdd:PHA03307  358 PPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRrdATGRFPAGRPRPSPLDAGAASGAFYArYPLLTPSG 437

                         330
                  ....*....|.
gi 471270262 1755 HPLPSAPPRPA 1765
Cdd:PHA03307  438 EPWPGSPPPPP 448
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1765-2023 1.94e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1765 AQHTTMATRSPALPPETPAAASLSTATDglAATpfmsLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTP 1844
Cdd:pfam17823   50 ADNKSSEQ*NFCAATAAPAPVTLTKGTS--AAH----LNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSP 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1845 LQPQATTLPAQTLSPVLPFT--------------PAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMV 1910
Cdd:pfam17823  124 SSAAQSLPAAIAALPSEAFSapraaacranasaaPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAP 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1911 S-VVP-RKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPA--TSHPLT-PLVAEPEGAQAGTALPVPTSYALSRV--SA 1983
Cdd:pfam17823  204 AtLTPaRGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAvgTVTPAAlATLAAAAGTVASAAGTINMGDPHARRlsPA 283

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 471270262  1984 RTAPQDSMLV--LLPQLAEAHGTSAGPHLaAEPVDEATTEPS 2023
Cdd:pfam17823  284 KHMPSDTMARnpAAPMGAQAQGPIIQVST-DQPVHNTAGEPT 324
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1748-2001 2.48e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1748 SPASPQPHPLPSAPPrPAQHTTMATRSPALPPETPAAASLSTAtdglAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGT 1827
Cdd:PRK12323  373 GPATAAAAPVAQPAP-AAAAPAAAAPAPAAPPAAPAAAPAAAA----AARAVAAAPARRSPAPEALAAARQASARGPGGA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1828 SAPV----ATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPA--------AGTAPGLLLGATLP 1895
Cdd:PRK12323  448 PAPApapaAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEfaspapaqPDAAPAGWVAESIP 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1896 TSGVLPvAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTP-----ATSHPLTPLVAEpegaqagtal 1970
Cdd:PRK12323  528 DPATAD-PDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGdwpalAARLPVRGLAQQ---------- 596

                         250       260       270
                  ....*....|....*....|....*....|....
gi 471270262 1971 pvptsyaLSRVSARTAPQDSMLVL---LPQLAEA 2001
Cdd:PRK12323  597 -------LARQSELAGVEGDTVRLrvpVPALAEA 623
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 1481-1841 2.85e-06

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 52.48  E-value: 2.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1481 LPPSQGLPTPSDEEPQLSQESPRTPTHRPA-----LTPAAPLTTAlNPPVTATEEPVvspgptqttlqqpleltasqLPA 1555
Cdd:pfam13254   49 VAGPSGSLSPGLSPTKLSREGSPESTSRPSsshseATIVRHSKDD-ERPSTPDEGFV--------------------KPA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1556 GPTESPASKGVTASllaiPHTPESSSLPValqtpTPGMVSGAMETTRvtvifaGSPniTVSS---------RSPPAPRFP 1626
Cdd:pfam13254  108 LPRHSRSSSALSNT----GSEEDSPSLPT-----SPPSPSKTMDPKR------WSP--TKSSwlesalnrpESPKPKAQP 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1627 lmtkavtvrghgslpvrTTPPQPSLTASpssrpvaspgaISRSPTSSGSHKavLT-PAVTKVISRTGVPQPTQAQSASSP 1705
Cdd:pfam13254  171 -----------------SQPAQPAWMKE-----------LNKIRQSRASVD--LGrPNSFKEVTPVGLMRSPAPGGHSKS 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1706 StplTVAGTAAEQVPVSPlatrsleivlstekGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAA 1785
Cdd:pfam13254  221 P---SVSGISADSSPTKE--------------EPSEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEA 283

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 471270262  1786 SLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVI 1841
Cdd:pfam13254  284 STEKKEPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKPKPQSPPK 339
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1631-2039 4.02e-06

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 52.49  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1631 AVTVRGHGSLPVRTTppqpsltaspSSRPVASP------------GAISRSPTssgshkAVLTPAVTKVISRTgvPQPTQ 1698
Cdd:COG3170    59 AVERRADGRPVLRVT----------SSRPVNEPfldflvevnwpsGRLVREYT------LLLDPPAYAAAAAA--PAAAP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1699 AQSASSPSTPltvagTAAEQVPVSPLATRSLEIVLSTEKGEAghsqpMGSPASpqphplpsAPPRPAQHTTMATRSPALP 1778
Cdd:COG3170   121 APAPAAPAAA-----AAAADQPAAEAAPAASGEYYPVRPGDT-----LWSIAA--------RPVRPSSGVSLDQMMVALY 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1779 PETPAA------------ASLST-ATDGLAATPfmSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASvittPL 1845
Cdd:COG3170   183 RANPDAfidgninrlkagAVLRVpAAEEVAALS--PAEARQEVQAQSADWAAYRARLAAAVEPAPAAAAPAAPP----AA 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1846 QPQATTLPAQTLSPVlpfTPAAMTQAHPPTHIAPPAAGTapglllgatlptsgvlPVAEGTASMVSvvprksttgKVAIL 1925
Cdd:COG3170   257 AAAAGPVPAAAEDTL---SPEVTAAAAAEEADALPEAAA----------------ELAERLAALEA---------QLAEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1926 SKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQA----GTALPVPTSYALSRVSARTAPQDSMlvllpQLAEA 2001
Cdd:COG3170   309 QRLLALKNPAPAAAVSAPAAAAAAATVEAAAPAAAAQPAAAapapALDNPLLLAGLLRRRKAEADEVDPV-----AEADV 383

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 471270262 2002 HGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLAEA 2039
Cdd:COG3170   384 YLAYGRDDQAEEILKEALASEPERLDLRLKLLEIYAAR 421
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1425-1682 1.11e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 51.08  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1425 RDPRAASCRDVPRV-EGCVPVCPTPQVLDEV-TQRcvyledcVEPAVwvPTEALGNETLPPSQGLP----TPSDEEP-QL 1497
Cdd:PLN03209  293 KNRRLSYCKVVEVIaETTAPLTPMEELLAKIpSQR-------VPPKE--SDAADGPKPVPTKPVTPeapsPPIEEEPpQP 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1498 SQESPRtpthrpaltpaaPLTtalnpPVTATEE--PVVSPGPTQTT--LQQPLELTASQLPAGPTESPASKGVTASLLAI 1573
Cdd:PLN03209  364 KAVVPR------------PLS-----PYTAYEDlkPPTSPIPTPPSssPASSKSVDAVAKPAEPDVVPSPGSASNVPEVE 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1574 PHTPESSSL-------------PVALQTPTP--GMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHG 1638
Cdd:PLN03209  427 PAQVEAKKTrplspyaryedlkPPTSPSPTAptGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDL 506

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 471270262 1639 SLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTP 1682
Cdd:PLN03209  507 KPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQP 550
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1647-1765 1.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1647 PQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVIsrtgVPQPTQAQSASSPSTPlTVAGTAAEQVPVSPLAT 1726
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAP----AAPPAAAPPAPVAAPA-AAAPAAAPAAAPAAVAL 447

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 471270262 1727 RSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPA 1765
Cdd:PRK14951  448 APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
PRK11901 PRK11901
hypothetical protein; Reviewed
 1585-1798 1.84e-05

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 49.68  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1585 ALQTPTPGMVSGAMETTrvtvifAGSPNITVSSRSPpaprfplMTKavtvrGHGSLPVRTTPPQPSLTASPSSrPVASPG 1664
Cdd:PRK11901   57 ALKSPTEHESQQSSNNA------GAEKNIDLSGSSS-------LSS-----GNQSSPSAANNTSDGHDASGVK-NTAPPQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1665 AISRSPTSSGSHKA--VLTPA----------VTKVISRT-----GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPlatr 1727
Cdd:PRK11901  118 DISAPPISPTPTQAapPQTPNgqqrielpgnISDALSQQqgqvnAASQNAQGNTSTLPTAPATVAPSKGAKVPATA---- 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 471270262 1728 sleivlstekgeaghsqpmgsPASPQPHPLPSAPPRPAQHTTMATRSPAlPPETPAAASLSTATDGLAATP 1798
Cdd:PRK11901  194 ---------------------ETHPTPPQKPATKKPAVNHHKTATVAVP-PATSGKPKSGAASARALSSAP 242
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
1750-1951 1.89e-05

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 49.93  E-value: 1.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1750 ASPQPHPLPSAP------PRPAQHTTMAtrspalPPETPAAASLStatdglaatpfmsleSTRPSQLLSGLPPDTSLPLA 1823
Cdd:pfam16014    4 SSPRPSILRKKPategakPKPDIHVAVA------PPVTVAVEALP---------------GQNSEQQTASASPPSQHPAQ 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1824 KVGTSAPVATPgpkasvittPLQPQATTLPAQTLSPVLPFTPAAMTQ-AHPPTHiapPAAGTAPGLLLGATLPTSGVLPV 1902
Cdd:pfam16014   63 AIPTILAPAAP---------PSQPSVVLSTLPAAMAVTPPIPASMANvVAPPTQ---PAASSTAACAVSSVLPEIKIKQE 130

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 471270262  1903 AEGTASMVSVVPRKSTTGKVAILSKQVSLPTSmygsaeggPTELTPATS 1951
Cdd:pfam16014  131 AEPMDTSQSVPPLTPTSISPALTSLANNLSVP--------AGDLLPGAS 171
PHA03379 PHA03379
EBNA-3A; Provisional
 1465-1883 2.08e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 50.44  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1465 VEPaVWVPTEALGNETLP-PSQGLPTPSDEEPQLSQESPRtptHRPAltPAAPlttalNPPVTATEEPV---VSPG-PTQ 1539
Cdd:PHA03379  531 VEP-VPVPTVALERPVCPaPPLIAMQGPGETSGIVRVRER---WRPA--PWTP-----NPPRSPSQMSVrdrLARLrAEA 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1540 TTLQQPLELTASQLPAGPTESPASKgvtasllaiPHTPESSSLPVALQTptpgMVSGAMETTRVTVIfagspnitvssrS 1619
Cdd:PHA03379  600 QPYQASVEVQPPQLTQVSPQQPMEY---------PLEPEQQMFPGSPFS----QVADVMRAGGVPAM------------Q 654

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1620 PPAPRFPLmTKAVTVRG------HGSLPVrttPPQPSLTASPSSRPVASPGAISrsptSSGSHKAVLTPAvtkvisrTGV 1693
Cdd:PHA03379  655 PQYFDLPL-QQPISQGAplaplrASMGPV---PPVPATQPQYFDIPLTEPINQG----ASAAHFLPQQPM-------EGP 719

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1694 PQPTQAQSASSPSTPLTVAGTAAEQVPVSPLaTRSleIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRP----AQHTT 1769
Cdd:PHA03379  720 LVPERWMFQGATLSQSVRPGVAQSQYFDLPL-TQP--INHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQgtdvVQHQL 796

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1770 MATRSPAL---PPETPAAAS-----LSTATDGLAATPFMSLESTRPSQllsglpPDTSLPLAKVGTSAPVAtpgPKASVI 1841
Cdd:PHA03379  797 DALGYVLHvlnHPGVPVSPAvnqyhVSQAAFGLPIDEDESGEGSDTSE------PCEALDLSIHGRPCPQA---PEWPVQ 867

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 471270262 1842 TTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAG 1883
Cdd:PHA03379  868 GEGGQDATEVLDLSIHGRPRPRTPEWPVQGEDGQNVTGAESR 909
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1658-1793 3.47e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 49.33  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1658 RPVASPGAISRSPTSSGSHKAVLTPAVTKVISRT--GVPQPTQAQSASSPSTPLTVAGTAAEQVP--VSPLATRsleivl 1733
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAaaPAPAAAPAAAASAPAAPPAAAPPAPVAAPaaAAPAAAP------ 438

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1734 stEKGEAghSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDG 1793
Cdd:PRK14951  439 --AAAPA--AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1511-1785 4.15e-05

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 49.02  E-value: 4.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1511 LTPAAPLTTALNPPVTATEEPVvSPGPTQTTLQQPLelTASQLPAGPTESPASKGVTASLLA-IPHTPESS-SLP---VA 1585
Cdd:COG3170   104 LDPPAYAAAAAAPAAAPAPAPA-APAAAAAAADQPA--AEAAPAASGEYYPVRPGDTLWSIAaRPVRPSSGvSLDqmmVA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1586 LQTPTPGMVSG----AMETTRVTVIFAGSpniTVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVA 1661
Cdd:COG3170   181 LYRANPDAFIDgninRLKAGAVLRVPAAE---EVAALSPAEARQEVQAQSADWAAYRARLAAAVEPAPAAAAPAAPPAAA 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1662 SPGAisrsptssgshkavltpavtkvisrtgvPQPTQAQSASSPSTPltvAGTAAEQVPVSPLATRSLEIVLSTEKGEAG 1741
Cdd:COG3170   258 AAAG----------------------------PVPAAAEDTLSPEVT---AAAAAEEADALPEAAAELAERLAALEAQLA 306

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 471270262 1742 HSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAA 1785
Cdd:COG3170   307 ELQRLLALKNPAPAAAVSAPAAAAAAATVEAAAPAAAAQPAAAA 350
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1698-1886 4.32e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 49.22  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1698 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASP--------QPHPLPSAPPRPAQHTT 1769
Cdd:PRK12727   53 RALETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDmiaamalrQPVSVPRQAPAAAPVRA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1770 MATRSPALPPETPAAAslstatdGLAATPFMSLESTRPSQLLSGLP-----PDTSLPLAKVGTSAPVAT-PGPKASVITT 1843
Cdd:PRK12727  133 ASIPSPAAQALAHAAA-------VRTAPRQEHALSAVPEQLFADFLttapvPRAPVQAPVVAAPAPVPAiAAALAAHAAY 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1844 ------PLQPQATTL---PAQTLSPVlPFTPAAMTQAHPPTHIAPPAAGTAP 1886
Cdd:PRK12727  206 aqdddeQLDDDGFDLddaLPQILPPA-ALPPIVVAPAAPAALAAVAAAAPAP 256
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 1539-1817 4.84e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 48.69  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1539 QTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPesssLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSR 1618
Cdd:COG3266   112 AAALLLLKLLLLLLTLLLLVLLLLLALLLALLLDLPLLT----LLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1619 SPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLtpavtkvISRTGVPQPTQ 1698
Cdd:COG3266   188 KAEEALALRAGSAAADALALLLLLLASALGEAVAAAAELAALALLAAGAAEVLTARLVLLLL-------IIGSALKAPSQ 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1699 AQSASSPSTPLTVAGTAAEQVPVSPLATrsleiVLSTEKGEAGHSQPMgSPASPQPHPLPSAPPRPAQHTTMATRSPALP 1778
Cdd:COG3266   261 ASSASAPATTSLGEQQEVSLPPAVAAQP-----AAAAAAQPSAVALPA-APAAAAAAAAPAEAAAPQPTAAKPVVTETAA 334

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 471270262 1779 PETPAAASLSTATdgLAATPFMSLESTRPSQLLSGLPPD 1817
Cdd:COG3266   335 PAAPAPEAAAAAA--APAAPAVAKKLAADEQWLASQPAS 371
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 426-474 5.17e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.17e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 471270262   426 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 474
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
PHA03379 PHA03379
EBNA-3A; Provisional
 1724-1996 5.17e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.90  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1724 LATRSLEIVLSTEKGEAGHSQPM-GSPASPQPHPLPSAPPRPAQHTTMAT-RSPALPPETPAAASLSTATDGLAATPFMS 1801
Cdd:PHA03379  390 LLMRAGKLTERAREALEKASEPTyGTPRPPVEKPRPEVPQSLETATSHGSaQVPEPPPVHDLEPGPLHDQHSMAPCPVAQ 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1802 LEST-----RPSQLLSGLPPDtslplakvGTSAPVATPGPkASVITTPLQPQATTLPAQTLSPVLP------FTPAAMTQ 1870
Cdd:PHA03379  470 LPPGplqdlEPGDQLPGVVQD--------GRPACAPVPAP-AGPIVRPWEASLSQVPGVAFAPVMPqpmpvePVPVPTVA 540

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1871 AHPPTHIAPP-AAGTAPGlllgatlPTSGVLPVAEG------TASMVSVVPRKSTTGKVAILSKQVSLPTSmygSAEGGP 1943
Cdd:PHA03379  541 LERPVCPAPPlIAMQGPG-------ETSGIVRVRERwrpapwTPNPPRSPSQMSVRDRLARLRAEAQPYQA---SVEVQP 610

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 471270262 1944 TELTPA-TSHPLT-PLVAEPEGAQAGTALPVPTSYALSRVSARTAPQDSMLVLLP 1996
Cdd:PHA03379  611 PQLTQVsPQQPMEyPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQP 665
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2373-2434 6.11e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262  2373 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2434
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2373-2434 6.23e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.69  E-value: 6.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 2373 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2434
Cdd:cd19941     1 CPPNEVYSECGSACPP--TCANPNAPPPCTKQCV---EGCFCPEGYVRNSGGK--CVPPSQC 55
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1614-1816 7.91e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1614 TVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAvltPAVTKVisrtGV 1693
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA---PAPAPA----AA 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1694 PQPTQAQSASSPSTPltvagtAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPmGSPASPQPHPLPSAPPRPAQHTTM--A 1771
Cdd:PRK12323  458 PAAAARPAAAGPRPV------AAAAAAAPARAAPAAAPAPADDDPPPWEELP-PEFASPAPAQPDAAPAGWVAESIPdpA 530

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 471270262 1772 TRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPP 1816
Cdd:PRK12323  531 TADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1633-1848 8.40e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 48.06  E-value: 8.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1633 TVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRT-------GVPQPTQAQSASSP 1705
Cdd:PRK12727   57 TARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRqpvsvprQAPAAAPVRAASIP 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1706 StPLTVAGTAAEQVPVSPLATRSLeivlsTEKGEAGHSQPMGSPASPqphplpsAPPRPAQHTTMATRSPALPPETPAAA 1785
Cdd:PRK12727  137 S-PAAQALAHAAAVRTAPRQEHAL-----SAVPEQLFADFLTTAPVP-------RAPVQAPVVAAPAPVPAIAAALAAHA 203

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 471270262 1786 SLSTATDGLAATPFMSLESTRPSQLlsglpPDTSLPLAKVgtsAPVATPGPKASVITTPlQPQ 1848
Cdd:PRK12727  204 AYAQDDDEQLDDDGFDLDDALPQIL-----PPAALPPIVV---APAAPAALAAVAAAAP-APQ 257
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 426-474 8.96e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.30  E-value: 8.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 471270262  426 TYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG-CVAPAEC 474
Cdd:cd19941     6 VYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGkCVPPSQC 55
PHA03369 PHA03369
capsid maturational protease; Provisional
 1646-1971 1.31e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 47.69  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1646 PPQPSLTASPSSRPVASPGAISRSPTSSGShkaVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGtaaeqVPVSPLA 1725
Cdd:PHA03369  371 APQTHTGPADRQRPQRPDGIPYSVPARSPM---TAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGP-----VPPQPTN 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1726 TRSLEIVLSTekgeaghsqpMGSPASPQPHPLPSAPPRP----AQHTTMATRSPALPPETPAAASLSTAtdglaatpfMS 1801
Cdd:PHA03369  443 PYVMPISMAN----------MVYPGHPQEHGHERKRKRGgelkEELIETLKLVKKLKEEQESLAKELEA---------TA 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1802 LESTRPSQLLSGLPPdtslplAKVGTSAPVATPGPKASViTTPLQPQATTLPAQTLSPVLPFtPAAMTQAHPPTHIAPPA 1881
Cdd:PHA03369  504 HKSEIKKIAESEFKN------AGAKTAAANIEPNCSADA-AAPATKRARPETKTELEAVVRF-PYQIRNMESPAFVHSFT 575

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1882 AGTAPGLllgatlpTSGVLPVAEGTASMVSVVPRKSTtgkvailskqvSLPTSMYGSAEGGPteLTPATSHPLTPLVAEP 1961
Cdd:PHA03369  576 STTLAAA-------AGQGSDTAEALAGAIETLLTQAS-----------AQPAGLSLPAPAVP--VNASTPASTPPPLAPQ 635

                         330
                  ....*....|
gi 471270262 1962 EGAQAGTALP 1971
Cdd:PHA03369  636 EPPQPGTSAP 645
PRK10905 PRK10905
cell division protein DamX; Validated
 1488-1674 1.35e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.85  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1488 PTPSDEEPQLSQE-----SPRTPTHRPALTPAAPLTTALNPPVTATEE---PVVSPGPTQ------TTLQQPLE------ 1547
Cdd:PRK10905   23 PSTSSSDQTASGEksidlAGNATDQANGVQPAPGTTSAEQTAGNTQQDvslPPISSTPTQgqtpvaTDGQQRVEvqgdln 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1548 --LTASQLPAG----------PTEsPASKGVTASLLAIPHTPESSSLPVAlQTPTPgmvsgameTTRVTVIFAGSPNITV 1615
Cdd:PRK10905  103 naLTQPQNQQQlnnvavnstlPTE-PATVAPVRNGNASRQTAKTQTAERP-ATTRP--------ARKQAVIEPKKPQATA 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 471270262 1616 SSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSG 1674
Cdd:PRK10905  173 KTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGG 231
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1724-1912 1.68e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 47.29  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1724 LATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQH----------------TTMATRSPA-LPPETPAAAS 1786
Cdd:PRK12727   50 LVQRALETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANAnmsqrqrvasaaedmiAAMALRQPVsVPRQAPAAAP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1787 LSTATDGLAATPFMSLEST-----RPSQLLSGLPPDTslpLAKVGTSAPVATPG--PKASVITTPLQPQATTLPAqtlsp 1859
Cdd:PRK12727  130 VRAASIPSPAAQALAHAAAvrtapRQEHALSAVPEQL---FADFLTTAPVPRAPvqAPVVAAPAPVPAIAAALAA----- 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262 1860 vlPFTPA--AMTQAHPP--THIAPPAAGTAPglllgATLPTSGVLPVAEGTASMVSV 1912
Cdd:PRK12727  202 --HAAYAqdDDEQLDDDgfDLDDALPQILPP-----AALPPIVVAPAAPAALAAVAA 251
PRK10905 PRK10905
cell division protein DamX; Validated
 1630-1808 2.00e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.47  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1630 KAVTVRGHGSLPVRTTPPQPSLT-----ASPSSRPVASPgAISRSPTSSGShkavltPAVTKVISRTGVP---------- 1694
Cdd:PRK10905   36 KSIDLAGNATDQANGVQPAPGTTsaeqtAGNTQQDVSLP-PISSTPTQGQT------PVATDGQQRVEVQgdlnnaltqp 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1695 -QPTQAQSASSPST----PLTVA----GTAAEQVPVSPLATRSL-------EIVLSTEKGEAGHSQPMGSPASPQPHPLP 1758
Cdd:PRK10905  109 qNQQQLNNVAVNSTlptePATVApvrnGNASRQTAKTQTAERPAttrparkQAVIEPKKPQATAKTEPKPVAQTPKRTEP 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1759 SAPPRPAqhTTMATRSPALPPET----------PAAASLSTATDGLAATPFMSLESTrPS 1808
Cdd:PRK10905  189 AAPVAST--KAPAATSTPAPKETattapvqtasPAQTTATPAAGGKTAGNVGSLKSA-PS 245
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 2676-2736 2.12e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.12e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262   2676 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2736
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
476-511 2.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 471270262    476 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 511
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1471-1651 2.73e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.49  E-value: 2.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1471 VPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTA 1550
Cdd:pfam17823  263 VASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVAS 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1551 SQLPAGPTESPASKGVTASLLAIPHT---PE---------SSSLPVALQTPTPGMVSGAMET-TRVTvifAGSPNITVSS 1617
Cdd:pfam17823  343 TNLAVVTTTKAQAKEPSASPVPVLHTsmiPEveatspttqPSPLLPTQGAAGPGILLAPEQVaTEAT---AGTASAGPTP 419

                          170       180       190
                   ....*....|....*....|....*....|....
gi 471270262  1618 RSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSL 1651
Cdd:pfam17823  420 RSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPAL 453
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1612-2028 2.84e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1612 NITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGshkavlTPAVTKVISRT 1691
Cdd:PHA03307   24 PPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRS------TPTWSLSTLAP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1692 GVPQPTQAQSASSPSTPltvAGTAAEQVPVSPLAT----RSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQH 1767
Cdd:PHA03307   98 ASPAREGSPTPPGPSSP---DPPPPTPPPASPPPSpapdLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1768 TTMATRSPALPPETPaAASLSTATDGLAATPFMSLEStRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQP 1847
Cdd:PHA03307  175 PLSSPEETARAPSSP-PAEPPPSTPPAAASPRPPRRS-SPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1848 QATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSk 1927
Cdd:PHA03307  253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS- 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1928 qvSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSrvSARTAPQDSMLVLLPQLAEAHGTSAG 2007
Cdd:PHA03307  332 --SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS--AGRPTRRRARAAVAGRARRRDATGRF 407

                         410       420
                  ....*....|....*....|.
gi 471270262 2008 PHLAAEPVDEATTEPSGRSAP 2028
Cdd:PHA03307  408 PAGRPRPSPLDAGAASGAFYA 428
PRK10905 PRK10905
cell division protein DamX; Validated
 1761-1867 2.86e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 45.70  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1761 PPRPAqhTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV 1840
Cdd:PRK10905  124 PTEPA--TVAPVRNGNASRQTAKTQTAERPATTRPARKQAVIEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPAAT 201

                          90       100
                  ....*....|....*....|....*..
gi 471270262 1841 ITTPLQPQATTLPAQTLSPVLPFTPAA 1867
Cdd:PRK10905  202 STPAPKETATTAPVQTASPAQTTATPA 228
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1749-1881 3.38e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 45.53  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1749 PASPQPH--PLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVG 1826
Cdd:NF040712  192 FGRPLRPlaTVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 471270262 1827 TSAPVATPGPkASVITTPLQPQATTLPAQTlSPVLPFTPAAMTQAHPPTHIAPPA 1881
Cdd:NF040712  272 EATRDAGEPP-APGAAETPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKP 324
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1744-1886 3.76e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 46.01  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1744 QPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPfmSLESTRPSQ-------LLSGLPP 1816
Cdd:PRK07994  373 QSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQ--QLQRAQGATkakksepAAASRAR 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1817 DTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLpfTPAAMTQA--HPPThiAPPAAGTAP 1886
Cdd:PRK07994  451 PVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVA--TPKALKKAleHEKT--PELAAKLAA 518
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1630-1950 5.76e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 45.30  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1630 KAVTVRGHGSLPVrtTPPQPSLTASPSSRPvaspgaisrSPTSSGSHKAVlTPAVTKVisrtGVPQPTQAQSASSPSTPL 1709
Cdd:PLN03209  301 KVVEVIAETTAPL--TPMEELLAKIPSQRV---------PPKESDAADGP-KPVPTKP----VTPEAPSPPIEEEPPQPK 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1710 TVAgtaaeQVPVSPLATrsleivlstekgeaghSQPMGSPASPQPHPLPSAPPRPAQhtTMATRSPALPPETPAAASLSt 1789
Cdd:PLN03209  365 AVV-----PRPLSPYTA----------------YEDLKPPTSPIPTPPSSSPASSKS--VDAVAKPAEPDVVPSPGSAS- 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1790 atdGLAATPFMSLES--TRPsqlLSGL-------PPDTSLPLAKVGTSAPVATPgpkASVITTPLQPqattlpaqtlspv 1860
Cdd:PLN03209  421 ---NVPEVEPAQVEAkkTRP---LSPYaryedlkPPTSPSPTAPTGVSPSVSST---SSVPAVPDTA------------- 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1861 lPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSL--------P 1932
Cdd:PLN03209  479 -PATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAqpkprplsP 557

                         330
                  ....*....|....*...
gi 471270262 1933 TSMYGSAEgGPTELTPAT 1950
Cdd:PLN03209  558 YTMYEDLK-PPTSPTPSP 574
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1644-1769 6.15e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1644 TTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAvtkvisrtgVPQPTQAQSASSPSTPLTVAGTAAEQVPVSP 1723
Cdd:PRK14951  382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA---------PPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 471270262 1724 L--ATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTT 1769
Cdd:PRK14951  453 AqaAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHAT 500
PHA01929 PHA01929
putative scaffolding protein
 1694-1798 7.01e-04

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 44.66  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1694 PQPTQAQSASSPSTPLTVAGTAAEQVPvsplatrsleivlsTEKGEAGHSQPMGSPASPQ--PHPLPSAPPRPAQHTTMA 1771
Cdd:PHA01929   27 PQPNPVIQPQAPVQPGQPGAPQQLAIP--------------TQQPQPVPTSAMTPHVVQQapAQPAPAAPPAAGAALPEA 92

                          90       100
                  ....*....|....*....|....*..
gi 471270262 1772 TRSPALPPETPAAASLSTATDGLAATP 1798
Cdd:PHA01929   93 LEVPPPPAFTPNGEIVGTLAGNLEGDP 119
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 1608-1791 7.65e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 44.06  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1608 AGSPNITVSSRSPPAP--RFPlmtkavtvrghgslpvrTTPPQPSLTASPSSRPVASPGAISRSPTS--SGSHKAVLTPA 1683
Cdd:PLN02983   18 VGSRLSRSSFRLQPKPniSFP-----------------SKGPNPKRSAVPKVKAQLNEVAVDGSSNSakSDDPKSEVAPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1684 VTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVP---VSPLATRSLEIVLSTEKGEAGHSQPMGSPA----SPQPHP 1756
Cdd:PLN02983   81 EPKDEPPSNSSSKPNLPDEESISEFMTQVSSLVKLVDsrdIVELQLKQLDCELVIRKKEALPQPPPPAPVvmmqPPPPHA 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 471270262 1757 LPSAPPRPAQhtTMATRSPALPPETPAAASLSTAT 1791
Cdd:PLN02983  161 MPPASPPAAQ--PAPSAPASSPPPTPASPPPAKAP 193
AbfB pfam05270
Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal ...
 1305-1396 9.42e-04

Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.


Pssm-ID: 428401  Cd Length: 137  Bit Score: 41.76  E-value: 9.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1305 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1383
Cdd:pfam05270   47 DSGCVSFESVNFPGSYLrH--YNFRLRLDANDGSALFREDATFCPRAGLGDSGSVSLESYNYPGRYIRHYNYELYIDPNG 124

                           90
                   ....*....|...
gi 471270262  1384 HTEVFRRGTLFRL 1396
Cdd:pfam05270  125 GTASFRADATFVV 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2308-2369 9.49e-04

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 40.06  E-value: 9.49e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 471270262  2308 CLRMVSNRTFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYC 2369
Cdd:pfam08742    2 CGLLSDSGPFAPCHSVVDPEPYFEACVYDMcscgGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1496-1728 9.98e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 9.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1496 QLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPH 1575
Cdd:PRK12323  364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPA-APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1576 TPESSSLPVALQTPTPGmvsgamettrvtvifAGSPNITVSSRSPPAPRFPLMTKAVtvrghgslPVRTTPPQPSLTASP 1655
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPA---------------AAARPAAAGPRPVAAAAAAAPARAA--------PAAAPAPADDDPPPW 499

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 471270262 1656 SSRPVASPgAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRS 1728
Cdd:PRK12323  500 EELPPEFA-SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
Tymo_45kd_70kd pfam03251
Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a ...
 1487-1778 1.23e-03

Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.


Pssm-ID: 281269 [Multi-domain]  Cd Length: 468  Bit Score: 44.40  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1487 LPTPSDEEPQLSQESPRT-----------PTHRPALTPAApLTTALNPPVTATEEPVVSPGPTQTTLQQPLeLTASQLPA 1555
Cdd:pfam03251  150 LPSVPDHGPVLTETKPRTsvrqprsatrgPSFRPILLPKV-VHVHDDPPHSSLRPRGSRSRQLQPTVRRPL-LAPNQFHS 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1556 gPTESPASKGVTASLLAIPHTPESSslpvalQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRfplmtKAVTVR 1635
Cdd:pfam03251  228 -PRQPPPLSDDPGILGPRPLAPHST------RDPPPRPITPGPSNTHDLRPLSVLPRTSPRRGLLPNPR-----RHRTST 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1636 GHgsLPvRTTPPQPSLTASPSSRPV----ASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPST---- 1707
Cdd:pfam03251  296 GH--IP-PTTTSRPTGPPSRLQRPVhlyqSSPHTPNFRPSSIRKDALLQTGPRLGHLERLGQPANLRTSERSPPTKrrlp 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262  1708 ----------PLTVAGTAAEQ--------VPVSPLATRSleIVLSTEKGEAGHSQPMGS----PASPQPHPLPSAPPRPA 1765
Cdd:pfam03251  373 rssepnrlpkPLPEATLAPSYrhrrpyplLPNPPAALPS--IAYTSSRGKIHHSLPKGAlpkeGAPPPPRRLPSPAPRPQ 450

                          330
                   ....*....|...
gi 471270262  1766 QHTTMATRSPALP 1778
Cdd:pfam03251  451 LPLRDLGRTPGFP 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1634-1899 1.90e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1634 VRGHGSLPvrttPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKV--ISRTGVPQPTQAQSASSPSTPLTV 1711
Cdd:PHA03247  248 LRGDIAAP----APPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVwgAALAGAPLALPAPPDPPPPAPAGD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1712 AGTAAEQVpvsplatRSLEIVLSTEKGEAGHsqPMGSPASPQPHPLP-------SAPPRPAQHTTMATRSPALPPE--TP 1782
Cdd:PHA03247  324 AEEEDDED-------GAMEVVSPLPRPRQHY--PLGFPKRRRPTWTPpssledlSAGRHHPKRASLPTRKRRSARHaaTP 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1783 AAASLSTATDGLAATPF-MSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVL 1861
Cdd:PHA03247  395 FARGPGGDDQTRPAAPVpASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKAL 474

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 471270262 1862 PftpaAMTQAHPPthiAPPAAGTAPglLLGATLPTSGV 1899
Cdd:PHA03247  475 D----ALRERRPP---EPPGADLAE--LLGRHPDTAGT 503
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1806-2041 2.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1806 RPSQLLSGLPPDTSlplakvgTSAPVATPGPKASVittplqPQATTLPAQTLSPVLPFTPAAMTQAHPPTHiAPPAAGTA 1885
Cdd:PRK12323  364 RPGQSGGGAGPATA-------AAAPVAQPAPAAAA------PAAAAPAPAAPPAAPAAAPAAAAAARAVAA-APARRSPA 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1886 PGLLLGATLPTSGVLPVAEGTASMVSVVP----RKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEP 1961
Cdd:PRK12323  430 PEALAAARQASARGPGGAPAPAPAPAAAPaaaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1962 EGAQAGTALPVPTSYALSRVSARTAPQDSmlvllPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSI--------- 2032
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPDPATADPDDAF-----ETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDmfdgdwpal 584

                         250
                  ....*....|....
gi 471270262 2033 -----VEGLAEALA 2041
Cdd:PRK12323  585 aarlpVRGLAQQLA 598
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1737-1910 2.54e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1737 KGEAGHSQPMGSPASPqphPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPfmslestrpsqllsgLPP 1816
Cdd:PRK14951  365 KPAAAAEAAAPAEKKT---PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPP---------------APV 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1817 DTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPthiAPPAAGTAPGLLLGATLPT 1896
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPA---AARLTPTEEGDVWHATVQQ 503

                         170
                  ....*....|....
gi 471270262 1897 sgvLPVAEGTASMV 1910
Cdd:PRK14951  504 ---LAAAEAITALA 514
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 1680-2029 2.85e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 42.91  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1680 LTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASpqpHPLPS 1759
Cdd:COG3266     5 ETLSTLALALLLLSLSLVLGDLGLLLLLLLRALLSALELLLATGLRLLLLAGLLLLLIRLLSEAVDLGALAS---AALLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1760 APPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKAS 1839
Cdd:COG3266    82 ALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLLALLLDLPLLTLLIVLPLLEEQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1840 VITTPLQPQATTLPAQTLSPVLPFTPAAMTQ-AHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKST 1918
Cdd:COG3266   162 LLLLALQDIQGTLQALGAVAALLGLRKAEEAlALRAGSAAADALALLLLLLASALGEAVAAAAELAALALLAAGAAEVLT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1919 TGKVAILSkqvslptsMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPqdsmlvllpql 1998
Cdd:COG3266   242 ARLVLLLL--------IIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALP----------- 302

                         330       340       350
                  ....*....|....*....|....*....|.
gi 471270262 1999 aeahgtsagphlAAEPVDEATTEPSGRSAPA 2029
Cdd:COG3266   303 ------------AAPAAAAAAAAPAEAAAPQ 321
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1477-1725 2.98e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1477 GNETLPPSQGLPTPSDEEPQLSQESPRTPT-HRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTtlqqPLELTASQLPA 1555
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPApAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL----AAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1556 GPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETtrvtvifAGSPNITvssrsPPAPRFPlmtKAVTVR 1635
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAP-------APADDDP-----PPWEELP---PEFASP 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1636 GhgslPVRTTPPQPSLTASPSSRPVASPGAISRsPTSSGSHKAVLTPAVTKVISRTGVPQPTqaqSASSPSTPLTVAG-- 1713
Cdd:PRK12323  510 A----PAQPDAAPAGWVAESIPDPATADPDDAF-ETLAPAPAAAPAPRAAAATEPVVAPRPP---RASASGLPDMFDGdw 581

                         250
                  ....*....|...
gi 471270262 1714 -TAAEQVPVSPLA 1725
Cdd:PRK12323  582 pALAARLPVRGLA 594
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1553-1835 3.02e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1553 LPAGPtESPASKGVTASLLAIPHTPES-------------SSLP----VALQTPTPGMVSGAMETTRVTVIFAGSPNITV 1615
Cdd:PHA03247  205 VPSGP-GPAAPADLTAAALHLYGASETylqdepfverrvvISHPlrgdIAAPAPPPVVGEGADRAPETARGATGPPPPPE 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1616 SSRSPPAPRFPLMTKAVTVRGhgslpvrtTPPqpSLTASPSSRPVASPGAISRSPTSSGSHKaVLTPavtkvisrtgVPQ 1695
Cdd:PHA03247  284 AAAPNGAAAPPDGVWGAALAG--------APL--ALPAPPDPPPPAPAGDAEEEDDEDGAME-VVSP----------LPR 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1696 PTQAQSASSP-------STPLTVAG-TAAEQVPVS-PLATRSLEIVLSTE----KGEAGHSQPMGSPASPQPHPLPSAPP 1762
Cdd:PHA03247  343 PRQHYPLGFPkrrrptwTPPSSLEDlSAGRHHPKRaSLPTRKRRSARHAAtpfaRGPGGDDQTRPAAPVPASVPTPAPTP 422

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 471270262 1763 RPAqhttmatrSPALPPETPAAASLSTATDGLAATPfmSLESTRPSQLLSGLPPDTSLP--LAKVGTSAPVATPG 1835
Cdd:PHA03247  423 VPA--------SAPPPPATPLPSAEPGSDDGPAPPP--ERQPPAPATEPAPDDPDDATRkaLDALRERRPPEPPG 487
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1819-2040 3.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1819 SLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAhPPTHIAPPAAGTAPglllgatlPTSG 1898
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAA-AATRAEAPPAAPAP--------PATA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1899 vlpvAEGTASMVSVVPRKSTtgkvailskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEGAQAGTAlPVPTSYAL 1978
Cdd:PRK07003  437 ----DRGDDAADGDAPVPAK-------------------ANARASADSRCDERDAQPPADSGSASAPASDA-PPDAAFEP 492

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1979 SRVSARTAPQDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSiVEGLAEAL 2040
Cdd:PRK07003  493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAAR-AGGAAAAL 553
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 884-946 3.09e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 471270262  884 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 946
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1619-1863 4.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1619 SPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTkviSRTGVPQPTQ 1698
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQ---ASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1699 AQSASSPSTPLTVAGTAAEQVPVSPLAtrsleivlstekgeAGHSQPMGSPAsPQPHPLPSA-PPRPAQHTTMATRSPAL 1777
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVAAA--------------AAAAPARAAPA-AAPAPADDDpPPWEELPPEFASPAPAQ 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1778 PPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTL 1857
Cdd:PRK12323  514 PDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPVRGL 593


                  ....*.
gi 471270262 1858 SPVLPF 1863
Cdd:PRK12323  594 AQQLAR 599
PPE COG5651
PPE-repeat protein [Function unknown];
1768-1987 5.17e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 42.19  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1768 TTMATRSPalPPETPA------AASLSTATDGLAATP----FMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPK 1837
Cdd:COG5651   158 SAAAVALT--PFTQPPptitnpGGLLGAQNAGSGNTSsnpgFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTG 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1838 ASViTTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKS 1917
Cdd:COG5651   236 AAA-GAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGG 314

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1918 TTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAP 1987
Cdd:COG5651   315 AAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
beta-trefoil_ABD_ABFB-like cd23265
Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family ...
 1308-1395 5.60e-03

Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family includes alpha-L-arabinofuranosidase B (ABF B)-like proteins and otogelin-like proteins. Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. Hungateiclostridium thermocellum anti-sigma-I factor RsgI5 shows high sequence similarity with ABF B. It negatively regulates SigI5 activity through direct interaction. The OTOG subfamily includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in OTOG or OTOGL genes may cause hearing loss. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467807  Cd Length: 135  Bit Score: 39.57  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1308 VVSLEAADRPNFFL-HVTANGSLELAKwqgrDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTE 1386
Cdd:cd23265     5 PVRLRSASDPGYYIrHDGGSGSVTSDD----DDSAEDAFFRVVPGLAGEGTVSFESVDKPGYYLRHRGGELRLEKNDGSA 80


                  ....*....
gi 471270262 1387 VFRRGTLFR 1395
Cdd:cd23265    81 AFREDATFR 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1747-1914 6.26e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1747 GSPASPQPHP--LPSAPPRPAQHTTMATRSPALP----PETPAAASLSTATDGLAATPFMSLESTRPSQLLS-GLP---- 1815
Cdd:PHA03247  277 GPPPPPEAAApnGAAAPPDGVWGAALAGAPLALPappdPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQHYPlGFPkrrr 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1816 ----PDTSLPLAKVGTSAPVATPGPKASVITTPlqpQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPglllg 1891
Cdd:PHA03247  357 ptwtPPSSLEDLSAGRHHPKRASLPTRKRRSAR---HAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAP----- 428

                         170       180
                  ....*....|....*....|...
gi 471270262 1892 atLPTSGVLPVAEGTASMVSVVP 1914
Cdd:PHA03247  429 --PPPATPLPSAEPGSDDGPAPP 449
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1738-2032 6.51e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1738 GEAGHSQPMGSPA--SPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLP 1815
Cdd:PHA03307   29 GDAADDLLSGSQGqlVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1816 PDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPthiappaagTAPGLLLGATLP 1895
Cdd:PHA03307  109 PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA---------SSRQAALPLSSP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1896 TSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTP---ATSHPLTPLVAEPEGAQAGTALPV 1972
Cdd:PHA03307  180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAgasSSDSSSSESSGCGWGPENECPLPR 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1973 PTSYALSRVSARTAPQDSMLVlLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSI 2032
Cdd:PHA03307  260 PAPITLPTRIWEASGWNGPSS-RPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSS 318
Pacifastin_I pfam05375
Pacifastin inhibitor (LCMII); Structures of members of this family show that they are ...
 485-511 6.81e-03

Pacifastin inhibitor (LCMII); Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors.


Pssm-ID: 253170  Cd Length: 40  Bit Score: 36.60  E-value: 6.81e-03
                           10        20
                   ....*....|....*....|....*...
gi 471270262   485 PGSVVKEDCNTCTCT-SGKWECSTAVCP 511
Cdd:pfam05375    4 PGSTFKDDCNTCTCTaNGIAACTLKGCP 31
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1854-2041 6.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1854 AQTLSPVLPFTPAAMT-QAHPPTHIAPPAAGTAPGLLL-GATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSL 1931
Cdd:PRK12323  354 TMTLLRMLAFRPGQSGgGAGPATAAAAPVAQPAPAAAApAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1932 PTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVS--ARTAPQDSMlvlLPQLAEAHGTSAGPH 2009
Cdd:PRK12323  434 AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAApaAAPAPADDD---PPPWEELPPEFASPA 510

                         170       180       190
                  ....*....|....*....|....*....|..
gi 471270262 2010 LAAEPVDEATTEPSGRSAPALSIVEGLAEALA 2041
Cdd:PRK12323  511 PAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1472-1679 9.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 9.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1472 PTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAP-----LTTALNPPVTATEEPVVSPGPTQTTLQQPL 1546
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaeasaAPAPGVAAPEHHPKHVAVPDASDGGDGWPA 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471270262 1547 ELTASQlPAGPTESPASKGVTASllaiphTPESSSLPVALQTPTP---GMVSGAMETTRVTVifAGSPNITVSSRSPPAP 1623
Cdd:PRK07764  672 KAGGAA-PAAPPPAPAPAAPAAP------AGAAPAQPAPAPAATPpagQADDPAAQPPQAAQ--GASAPSPAADDPVPLP 742

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 471270262 1624 RFPLMTKAV-----TVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAI-SRSPTSSGSHKAV 1679
Cdd:PRK07764  743 PEPDDPPDPagapaQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDApSMDDEDRRDAEEV 804
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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