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Conserved domains on  [gi|472339085|ref|NP_001264261|]
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keratin-associated protein 9-7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-140 3.43e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085    4 CCSPCCQPTCCRTTCWKPTtvttCSSTPCCQPSCCVSSCCQPCCHPtCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQP 83
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPS----CCQTSCCQPTTFQSSCCRPTCQP-CCQTSCCQPTCCQT----SSCQTGCGGIGYGQE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 472339085   84 ICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPT-----SVYLPGCLNQSCGSSCCQPCC 140
Cdd:pfam01500  91 GSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTccqlhHAQASCCRPSYCGQSCCRPAC 152
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-140 3.43e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085    4 CCSPCCQPTCCRTTCWKPTtvttCSSTPCCQPSCCVSSCCQPCCHPtCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQP 83
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPS----CCQTSCCQPTTFQSSCCRPTCQP-CCQTSCCQPTCCQT----SSCQTGCGGIGYGQE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 472339085   84 ICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPT-----SVYLPGCLNQSCGSSCCQPCC 140
Cdd:pfam01500  91 GSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTccqlhHAQASCCRPSYCGQSCCRPAC 152
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 1.44e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 38.38  E-value: 1.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 472339085  32 CCQPSCCvsSCCQPCCHPTCCQ--NTCCRTTCCQPTCvtsCCQPSCCSTPCCQPICC 86
Cdd:COG3901  631 RRECCCG--CCCCCCKCCCIVIiiDGIIIINECCCCC---CLCCRRCQDDPLCPPRI 682
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-140 3.43e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085    4 CCSPCCQPTCCRTTCWKPTtvttCSSTPCCQPSCCVSSCCQPCCHPtCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQP 83
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPS----CCQTSCCQPTTFQSSCCRPTCQP-CCQTSCCQPTCCQT----SSCQTGCGGIGYGQE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 472339085   84 ICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPT-----SVYLPGCLNQSCGSSCCQPCC 140
Cdd:pfam01500  91 GSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTccqlhHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 12-168 5.23e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.28  E-value: 5.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   12 TCCRTTCWKPTTVTTCSS--TPCCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCCQPICCGS 88
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTcgSGCCQPCCCQSSCCRPsCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   89 SCCGQTSCGSSCCQPSSCAPIYCRRTCYHPTSVYLPGCLNQSCGSSCCQ------PCCRPACCETTCCrttcfQPTCVTS 162
Cdd:pfam01500  81 GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCC-----RPACCCQ 155


                  ....*.
gi 472339085  163 CCQPAC 168
Cdd:pfam01500 156 CSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
75-119 2.71e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.46  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 472339085   75 CCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPT 119
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
66-109 9.09e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 9.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 472339085   66 CVTSCCQPSCCSTPCCQPICCGSSCCGQTSCGSSCCQPSSCAPI 109
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-84 1.02e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 1.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 472339085   32 CCQPSCCVSSCCQPcchpTCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPI 84
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQP----SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
46-91 1.33e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 472339085   46 CCHPTCCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPICCGSSCC 91
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQP----SCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
27-70 1.78e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 1.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 472339085   27 CSSTPCCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPTCVTSC 70
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPsCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
51-104 4.53e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 4.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 472339085   51 CCQNTCCRTTCCQPtcvtSCCQPSCCSTPCCQPICCGSSCcgqtsCGSSCCQPS 104
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCCRPSC-----CRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
8-65 7.48e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 7.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 472339085    8 CCQPTCCRTTCwkpttvttcsstpcCQPSCCVSSCCQP-CCHPTCCQNTCCRTTCCQPT 65
Cdd:pfam13885   1 CCQPSCCQPSC--------------CQPSCCQPSCCQPsCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 41-169 1.06e-07

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 49.02  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   41 SCCQP--CCHPTCCQNTCCRTTCCQPTCV-TSCCQPSCCSTPCCQPICCGSSCC---GQTSCGSSCCQPSSCAPIYCRRT 114
Cdd:pfam01500   2 ACCGTsfCGFPTCSTGGTCGSGCCQPCCCqSSCCRPSCCQTSCCQPTTFQSSCCrptCQPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 472339085  115 CYHPTSVYLPGCLNQSCGSSCCQPCCrpaccettccrttcfqptCVTSCCQPACC 169
Cdd:pfam01500  82 CGGIGYGQEGSSGAVSSRTRWCRPDC------------------RVEGTCLPPCC 118
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 4-161 1.56e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 43.27  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085    4 CCSPCCQPTCCRTTCWKP--------TTVTTCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQP-TCVTSCCQPS 74
Cdd:pfam05287   5 CCSGNFSSRSLRNHLHYPvsscgsscPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPcTSSTSYCVPS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   75 CCSTPC-----------CQPICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCYHPTSVYLPGCLNQSCGSSCCQPCCrpa 143
Cdd:pfam05287  85 PCQRSCysprtscvcspCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSY--- 161

                         170
                  ....*....|....*...
gi 472339085  144 cCETTCCRTTCFQPTCVT 161
Cdd:pfam05287 162 -VSSRSYQPSCFRPSCGS 178
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-140 2.26e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 42.50  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085    1 MTHCCSPCCQPTCCRTTCwkptTVTTCSSTPCCQPSCCVSSCCQPccHPTCCQNTCCRTTCCQPTCVTSCCQPSCCSTPC 80
Cdd:pfam05287  53 RDNCQETCGEPTSCQTSS----CEPCTSSTSYCVPSPCQRSCYSP--RTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNS 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   81 CQPICCGSSCCGQTSCGSSCCQPSSCAPIYCRRTCyhptsvylpgCLNQSCGSSCCQPCC 140
Cdd:pfam05287 127 CQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSY----------VSSRSYQPSCFRPSC 176
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
32-86 1.44e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 38.38  E-value: 1.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 472339085  32 CCQPSCCvsSCCQPCCHPTCCQ--NTCCRTTCCQPTCvtsCCQPSCCSTPCCQPICC 86
Cdd:COG3901  631 RRECCCG--CCCCCCKCCCIVIiiDGIIIINECCCCC---CLCCRRCQDDPLCPPRI 682
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
4-46 1.73e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 1.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 472339085    4 CCSPCCQPTCCRTTCWKPTtvttcsstpCCQPSCCVSSCCQPC 46
Cdd:pfam13885  12 CQPSCCQPSCCQPSCCQPS---------CCRPSCCRSSCCQPT 45
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
1-91 2.00e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 37.70  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339085   1 MTHCCSPCCQPTCCRTTC---WKPTTVTTCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPTCVTSCCQPSCCS 77
Cdd:COG4624    6 RACCCCCIEEGDELLLLEeaeRVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPS 85

                         90
                 ....*....|....
gi 472339085  78 TPCCQPICCGSSCC 91
Cdd:COG4624   86 IIRDKEKCKNCYPC 99
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
4-64 5.61e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 36.45  E-value: 5.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 472339085   4 CCSPCCQPTCCRTTCWKPTTVTTCsstpCCqpsccvssCCQPCCHPTCCQNTCCRTTCCQP 64
Cdd:COG3901  636 CGCCCCCCKCCCIVIIIDGIIIIN----EC--------CCCCCLCCRRCQDDPLCPPRIKK 684
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
27-84 9.91e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 35.68  E-value: 9.91e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 472339085  27 CSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQptcvtsCCQPSCCSTPCCQPI 84
Cdd:COG3901  634 CCCGCCCCCCKCCCIVIIIDGIIIINECCCCCCLCCR------RCQDDPLCPPRIKKK 685
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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