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Conserved domains on  [gi|487439205|ref|NP_001264920|]
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thyrotropin subunit beta isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 7-81 6.61e-29

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00068:

Pssm-ID: 473907  Cd Length: 107  Bit Score: 99.67  E-value: 6.61e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487439205     7 FPQDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCT 81
Cdd:smart00068  35 YTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 7-81 6.61e-29

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 99.67  E-value: 6.61e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487439205     7 FPQDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCT 81
Cdd:smart00068  35 YTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 13-80 1.21e-25

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 91.31  E-value: 1.21e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487439205   13 GKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYC 80
Cdd:pfam00007  38 PVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGNCPTDNSDCTRLSLQPDSC 105
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 10-73 3.42e-25

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 90.03  E-value: 3.42e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487439205 10 DINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHE 73
Cdd:cd00069  34 DPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALSCRCGLCNTDTTDCTRL 96
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 7-81 6.61e-29

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 99.67  E-value: 6.61e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487439205     7 FPQDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCT 81
Cdd:smart00068  35 YTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 13-80 1.21e-25

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 91.31  E-value: 1.21e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487439205   13 GKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYC 80
Cdd:pfam00007  38 PVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGNCPTDNSDCTRLSLQPDSC 105
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 10-73 3.42e-25

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 90.03  E-value: 3.42e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487439205 10 DINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHE 73
Cdd:cd00069  34 DPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALSCRCGLCNTDTTDCTRL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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