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Conserved domains on  [gi|499137509|ref|NP_001265114|]
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probable E3 ubiquitin-protein ligase HERC4 isoform c [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 709-977 2.44e-108

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 339.54  E-value: 2.44e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 709 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFS-- 785
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNps 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 786 -----------------------DKITV---------------------------------------------------- 790
Cdd:cd00078   81 sfadedhlklfrflgrllgkalyEGRLLdlpfsrafykkllgkplsledleeldpelykslkelldndgdeddleltfti 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 791 ---ENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 867
Cdd:cd00078  161 eldSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 868 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSH 945
Cdd:cd00078  241 DIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTAH 320

                        330       340       350
                 ....*....|....*....|....*....|..
gi 499137509 946 TCFNLLDLPKYTEKETLRSKLIQAIDHNEGFS 977
Cdd:cd00078  321 TCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 3.49e-85

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 277.63  E-value: 3.49e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184   21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184   97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 160 CWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184  172 CWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTEIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184  249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                        330
                 ....*....|....*....
gi 499137509 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184  324 GDNAYGQLGDGTTTDRSTP 342
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 709-977 2.44e-108

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 339.54  E-value: 2.44e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 709 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFS-- 785
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNps 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 786 -----------------------DKITV---------------------------------------------------- 790
Cdd:cd00078   81 sfadedhlklfrflgrllgkalyEGRLLdlpfsrafykkllgkplsledleeldpelykslkelldndgdeddleltfti 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 791 ---ENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 867
Cdd:cd00078  161 eldSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 868 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSH 945
Cdd:cd00078  241 DIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTAH 320

                        330       340       350
                 ....*....|....*....|....*....|..
gi 499137509 946 TCFNLLDLPKYTEKETLRSKLIQAIDHNEGFS 977
Cdd:cd00078  321 TCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 3.49e-85

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 277.63  E-value: 3.49e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184   21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184   97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 160 CWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184  172 CWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTEIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184  249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                        330
                 ....*....|....*....
gi 499137509 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184  324 GDNAYGQLGDGTTTDRSTP 342
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 735-976 4.59e-84

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 274.11  E-value: 4.59e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   735 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSD---------------------------- 786
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPrsgfaneehlsyfrfigrvlgkalydnr 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   787 -----------------KIT------------------------------------VENFGATEVKELVLNGADTAVNKQ 813
Cdd:smart00119  84 lldlffarpfykkllgkPVTlhdlesldpelykslkwlllnndtseeldltfsivlTSEFGQVKVVELKPGGSNIPVTEE 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   814 NRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKI 893
Cdd:smart00119 164 NKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTIKW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   894 FWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAID 971
Cdd:smart00119 244 FWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLLAIN 323


                   ....*
gi 499137509   972 HNEGF 976
Cdd:smart00119 324 EGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 789-979 1.01e-74

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 247.91  E-value: 1.01e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  789 TVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 868
Cdd:pfam00632 112 TIPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALSLFTPEELELLICGSPE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  869 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-KLVIQSTGG-GEEYLPVSHT 946
Cdd:pfam00632 192 IDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHT 271

                         170       180       190
                  ....*....|....*....|....*....|...
gi 499137509  947 CFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 979
Cdd:pfam00632 272 CFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
660-979 4.88e-66

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 238.90  E-value: 4.88e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 660 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 731
Cdd:COG5021  458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 732 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMF-----------------------RYYE----------- 777
Cdd:COG5021  538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFeyitedlytlpinplssinpehlSYFKflgrvigkaiy 617

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 778 DSR----------------------------------LIW----------FSDKITVEN--FGATEVKELVLNGADTAVN 811
Cdd:COG5021  618 DSRildvqfskafykkllgkpvslvdlesldpelyrsLVWllnndidetiLDLTFTVEDdsFGESRTVELIPNGRNISVT 697

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 812 KQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEHPT 890
Cdd:COG5021  698 NENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPI 776

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 891 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLR 963
Cdd:COG5021  777 IVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLR 856

                        410
                 ....*....|....*.
gi 499137509 964 SKLIQAIDHNEGFSLI 979
Cdd:COG5021  857 SKLLTAINEGAGFGLL 872
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.22e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 72.55  E-value: 5.22e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499137509  208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 709-977 2.44e-108

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 339.54  E-value: 2.44e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 709 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFS-- 785
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNps 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 786 -----------------------DKITV---------------------------------------------------- 790
Cdd:cd00078   81 sfadedhlklfrflgrllgkalyEGRLLdlpfsrafykkllgkplsledleeldpelykslkelldndgdeddleltfti 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 791 ---ENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 867
Cdd:cd00078  161 eldSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 868 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSH 945
Cdd:cd00078  241 DIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPTAH 320

                        330       340       350
                 ....*....|....*....|....*....|..
gi 499137509 946 TCFNLLDLPKYTEKETLRSKLIQAIDHNEGFS 977
Cdd:cd00078  321 TCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 3.49e-85

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 277.63  E-value: 3.49e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184   21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184   97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 160 CWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184  172 CWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTEIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184  249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                        330
                 ....*....|....*....
gi 499137509 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184  324 GDNAYGQLGDGTTTDRSTP 342
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 735-976 4.59e-84

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 274.11  E-value: 4.59e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   735 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSD---------------------------- 786
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPrsgfaneehlsyfrfigrvlgkalydnr 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   787 -----------------KIT------------------------------------VENFGATEVKELVLNGADTAVNKQ 813
Cdd:smart00119  84 lldlffarpfykkllgkPVTlhdlesldpelykslkwlllnndtseeldltfsivlTSEFGQVKVVELKPGGSNIPVTEE 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   814 NRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKI 893
Cdd:smart00119 164 NKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTIKW 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   894 FWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAID 971
Cdd:smart00119 244 FWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLLAIN 323


                   ....*
gi 499137509   972 HNEGF 976
Cdd:smart00119 324 EGKGF 328
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-343 5.62e-81

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 266.46  E-value: 5.62e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  37 RDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGdgTTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 115 QLGLvGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGiPFMQ 194
Cdd:COG5184   79 QLGD-GTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT-TNRLTPVQVDAGLS-GVVA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Cdd:COG5184  154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQL 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499137509 275 GHNSTSHEINPRKVFELMGsiVTEIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Cdd:COG5184  232 GDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 789-979 1.01e-74

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 247.91  E-value: 1.01e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  789 TVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 868
Cdd:pfam00632 112 TIPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALSLFTPEELELLICGSPE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  869 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-KLVIQSTGG-GEEYLPVSHT 946
Cdd:pfam00632 192 IDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHT 271

                         170       180       190
                  ....*....|....*....|....*....|...
gi 499137509  947 CFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 979
Cdd:pfam00632 272 CFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
660-979 4.88e-66

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 238.90  E-value: 4.88e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 660 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 731
Cdd:COG5021  458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 732 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMF-----------------------RYYE----------- 777
Cdd:COG5021  538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFeyitedlytlpinplssinpehlSYFKflgrvigkaiy 617

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 778 DSR----------------------------------LIW----------FSDKITVEN--FGATEVKELVLNGADTAVN 811
Cdd:COG5021  618 DSRildvqfskafykkllgkpvslvdlesldpelyrsLVWllnndidetiLDLTFTVEDdsFGESRTVELIPNGRNISVT 697

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 812 KQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEHPT 890
Cdd:COG5021  698 NENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPI 776

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509 891 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLR 963
Cdd:COG5021  777 IVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLR 856

                        410
                 ....*....|....*.
gi 499137509 964 SKLIQAIDHNEGFSLI 979
Cdd:COG5021  857 SKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-182 3.80e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 157.83  E-value: 3.80e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509   1 MLCWGNASFGQLGLGGIDEEIVlePRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQV 78
Cdd:COG5184  170 VWCWGANSYGQLGDGTTTDRPT--PVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGttTDRATPVQV 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499137509  79 VALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLvGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKASEV 158
Cdd:COG5184  246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTV 320

                        170       180
                 ....*....|....*....|....
gi 499137509 159 FCWGQNKYGQLGLGTDcKKQTSPQ 182
Cdd:COG5184  321 WCWGDNAYGQLGDGTT-TDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.22e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 72.55  E-value: 5.22e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499137509  208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
102-152 2.85e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 2.85e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 499137509  102 KGQVYAWGLDSDGQLGLvGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGL-GTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 2.97e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.85  E-value: 2.97e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499137509   52 DGTVYTCGCNDLGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLAL 99
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLgtTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
157-205 4.70e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 4.70e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 499137509  157 EVFCWGQNKYGQLGLGTDcKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
260-308 2.31e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.15  E-value: 2.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 499137509  260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSA 308
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
139-168 1.54e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 1.54e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137509  139 IVQVACGYYHSLALSKASEVFCWGQNKYGQ 168
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 3.61e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 49.73  E-value: 3.61e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137509   86 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQ 115
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 1.23e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137509   36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
3-49 1.63e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.67  E-value: 1.63e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 499137509    3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFV 49
Cdd:pfam00415   6 TWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
194-221 1.85e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.11  E-value: 1.85e-06
                          10        20
                  ....*....|....*....|....*...
gi 499137509  194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-343 1.50e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 42.89  E-value: 1.50e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 499137509  313 SGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG 31
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-273 1.57e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137509  244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-326 3.61e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 35.86  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 499137509  296 VTEIACGRQHTsAFVPSSGRIYSFGLGGNGQ 326
Cdd:pfam13540   1 VVSVAAGDNHT-LALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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