NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|508083041|ref|NP_001265231|]
View 

diablo IAP-binding mitochondrial protein isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Smac_DIABLO super family cl09466
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 6-142 3.05e-69

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


The actual alignment was detected with superfamily member pfam09057:

Pssm-ID: 462664  Cd Length: 231  Bit Score: 208.16  E-value: 3.05e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083041    6 YFQAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASIT 85
Cdd:pfam09057  86 YTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVT 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508083041   86 ARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT---------QEEGEERAESEQEAYLRED 142
Cdd:pfam09057 166 ARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQergesasepQGVELSEEEDIPEAYLRED 231
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 6-142 3.05e-69

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 208.16  E-value: 3.05e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083041    6 YFQAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASIT 85
Cdd:pfam09057  86 YTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVT 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508083041   86 ARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT---------QEEGEERAESEQEAYLRED 142
Cdd:pfam09057 166 ARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQergesasepQGVELSEEEDIPEAYLRED 231
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 6-142 3.05e-69

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 208.16  E-value: 3.05e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083041    6 YFQAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASIT 85
Cdd:pfam09057  86 YTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVT 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508083041   86 ARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT---------QEEGEERAESEQEAYLRED 142
Cdd:pfam09057 166 ARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQergesasepQGVELSEEEDIPEAYLRED 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH