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Conserved domains on  [gi|507417942|ref|NP_001265251|]
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myelin-associated oligodendrocyte basic protein isoform a [Homo sapiens]

Protein Classification

PHD finger domain-containing protein( domain architecture ID 366290)

PHD (plant homeodomain) finger domain-containing protein

Gene Ontology:  GO:0008270|GO:0005515
PubMed:  16297627|21514168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 1-68 7.85e-13

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member pfam02318:

Pssm-ID: 473978  Cd Length: 118  Bit Score: 62.39  E-value: 7.85e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507417942    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 84-200 3.60e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   84 PPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRP 163
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 507417942  164 RPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-68 7.85e-13

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 62.39  E-value: 7.85e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507417942    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-68 1.43e-09

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 52.02  E-value: 1.43e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 507417942  24 IHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:cd15753    3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQ 48
PHA03247 PHA03247
large tegument protein UL36; Provisional
 84-200 3.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   84 PPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRP 163
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 507417942  164 RPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-68 7.85e-13

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 62.39  E-value: 7.85e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507417942    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-68 1.43e-09

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 52.02  E-value: 1.43e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 507417942  24 IHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:cd15753    3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQ 48
PHA03247 PHA03247
large tegument protein UL36; Provisional
 84-200 3.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   84 PPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRP 163
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 507417942  164 RPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 86-200 7.94e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.86  E-value: 7.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  86 PASFGPLRTSRRAKSPQRPKQQ-----PAAPPAVVRAPAKPrsPPRSERQPRSPP-RSERQPRSPPRSERQPRSPPRSER 159
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAapaaaPVAQAAAAPAPAAA--PAAAASAPAAPPaAAPPAPVAAPAAAAPAAAPAAAPA 443

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 507417942 160 QPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PRK14951 444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPA 484
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 76-192 1.54e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  76 SSRGEPWLPPPASFGPLRTSRRAKSPQRPKQQPAAPPAVV-RAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSP 154
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPApAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 507417942 155 PRSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGP 192
Cdd:PRK07764 743 PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 81-192 1.92e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   81 PWLPPPASFGPLRTSRRAKSPQRP-----KQQPAAPP--AVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSER---- 149
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPavtsrARRPDAPPqsARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSpaan 2636

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 507417942  150 QPRSPPRSERQPRPRPEVRPPPAKQRPPQKSKQQPR----SSPLRGP 192
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRaaqaSSPPQRP 2683
flhF PRK06995
flagellar biosynthesis protein FlhF;
94-187 2.43e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 44.19  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  94 TSRRAKSPQRPKQQPAAPPAVVRAPAKPR--------SPPRSERQPRSPP--RSERQPRSPPRSERQPRSPPRSERQPRP 163
Cdd:PRK06995  52 APPAAAAPAAAQPPPAAAPAAVSRPAAPAaepapwlvEHAKRLTAQREQLvaRAAAPAAPEAQAPAAPAERAAAENAARR 131

                         90       100
                 ....*....|....*....|....
gi 507417942 164 RPEVRPPPAKQRPPQKSKQQPRSS 187
Cdd:PRK06995 132 LARAAAAAPRPRVPADAAAAVADA 155
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 108-194 3.10e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  108 PAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPrserQPRPRPEVRPPPAKQRPPQKSKQQPRSS 187
Cdd:PRK12270   43 APTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAA----AAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  ....*..
gi 507417942  188 PLRGPGA 194
Cdd:PRK12270  119 PLRGAAA 125
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 96-173 1.09e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  96 RRAKSPQRPKQqPAAP--PAVVRAPAKPRSP--PRSERQPRSP--PRSERQPRSPPRSERqPRSPPRSERQPRPRPEVRP 169
Cdd:PTZ00449 583 KDPKHPKDPEE-PKKPkrPRSAQRPTRPKSPklPELLDIPKSPkrPESPKSPKRPPPPQR-PSSPERPEGPKIIKSPKPP 660


                 ....
gi 507417942 170 PPAK 173
Cdd:PTZ00449 661 KSPK 664
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
84-200 1.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  84 PPPASFGPLRTSRRAKSPQR----PKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQP-RSPPRSERQPRSPPRSE 158
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAaaapAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAaRQASARGPGGAPAPAPA 453

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 507417942 159 RQPRPRPEVRPPPAKQRPP--QKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PRK12323 454 PAAAPAAAARPAAAGPRPVaaAAAAAPARAAPAAAPAPADDDPP 497
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 83-200 2.42e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  83 LPPPASFGPLRTSRRAKSPQRPKQQPAAP-PAVVRAPAKPRSPPRSERQPRSPPrsERQPRSPPRSERQPRSPPRSERQP 161
Cdd:PRK07764 378 LERLERRLGVAGGAGAPAAAAPSAAAAAPaAAPAPAAAAPAAAAAPAPAAAPQP--APAPAPAPAPPSPAGNAPAGGAPS 455

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507417942 162 RPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PRK07764 456 PPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
98-192 2.68e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  98 AKSPQRPKQ-------QPAA---PPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRPRPEV 167
Cdd:PRK14971 369 ASGGRGPKQhikpvftQPAAapqPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVR 448

                         90       100
                 ....*....|....*....|....*
gi 507417942 168 RPPPAKQRPPQKSKQQPRSSPLRGP 192
Cdd:PRK14971 449 PAQFKEEKKIPVSKVSSLGPSTLRP 473
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 90-184 3.00e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  90 GPLRTSRRAKSPQRPKQqPAAP--PAVVRAPAKPRSP--PRSERQPRSP-----PRSERQPRSP--PRSERQPRSPPRSE 158
Cdd:PTZ00449 562 GPAKEHKPSKIPTLSKK-PEFPkdPKHPKDPEEPKKPkrPRSAQRPTRPkspklPELLDIPKSPkrPESPKSPKRPPPPQ 640

                         90       100
                 ....*....|....*....|....*.
gi 507417942 159 RQPRPRPEVRPPPAKQRPPQKSKQQP 184
Cdd:PTZ00449 641 RPSSPERPEGPKIIKSPKPPKSPKPP 666
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 84-155 3.48e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 3.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507417942  84 PPPASFGPlrtSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSErqPRSPPRSERQPRSPP 155
Cdd:PRK14950 364 PAPQPAKP---TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPR--PVAPPVPHTPESAPK 430
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
84-203 6.73e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  84 PPPASFGPLRTSRRAKSPqRPKQQPAAPPAVVRAPAKPRSPPRSErQPRSPPRSERQP----RSPPRSERQPRSPPRSER 159
Cdd:PRK07003 425 APPAAPAPPATADRGDDA-ADGDAPVPAKANARASADSRCDERDA-QPPADSGSASAPasdaPPDAAFEPAPRAAAPSAA 502

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 507417942 160 QPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSPVKA 203
Cdd:PRK07003 503 TPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARA 546
PHA03247 PHA03247
large tegument protein UL36; Provisional
 68-199 1.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   68 TSSCQRRLSSRGEPWLPPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRspPRS 147
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA--GAG 2953

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 507417942  148 ERQPRSP-PRSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGS 199
Cdd:PHA03247 2954 EPSGAVPqPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PHA03247 PHA03247
large tegument protein UL36; Provisional
 80-201 1.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   80 EPWLPPPASFGPLRTSRRAKSPQRPKQQPAAPPAV-VRAPAKPRSPPRSERQPRSPPRSER--QPRSPPRSERQPRSPPR 156
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPpVRRLARPAVSRSTESFALPPDQPERppQPQAPPPPQPQPQPPPP 2926

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 507417942  157 SERQPRPRPEVRPPPAkqrPPQKSKQQPRSSPLRGPGASRGGSPV 201
Cdd:PHA03247 2927 PQPQPPPPPPPRPQPP---LAPTTDPAGAGEPSGAVPQPWLGALV 2968
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 90-188 1.62e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  90 GPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSP---PRSERQPRSP--PRSERQPRSpPRSERQPRSPPRSERQPRPR 164
Cdd:PTZ00449 535 EDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPskiPTLSKKPEFPkdPKHPKDPEE-PKKPKRPRSAQRPTRPKSPK 613

                         90       100
                 ....*....|....*....|....
gi 507417942 165 PEVRPPPAKQRPPQKSKQQPRSSP 188
Cdd:PTZ00449 614 LPELLDIPKSPKRPESPKSPKRPP 637
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 85-201 2.03e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  85 PPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPA-KPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRP 163
Cdd:PRK07764 660 PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAgAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 507417942 164 RPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSPV 201
Cdd:PRK07764 740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPS 777
PHA03378 PHA03378
EBNA-3B; Provisional
 83-204 2.47e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.51  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  83 LPPPASFGPLRTSRRAKSPQRPkqqPAAPPAVVRAPA-------KPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPP 155
Cdd:PHA03378 685 LPIQWAPGTMQPPPRAPTPMRP---PAAPPGRAQRPAaatgrarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP 761

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 507417942 156 RSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSPVKAS 204
Cdd:PHA03378 762 GRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLM 810
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 79-190 2.48e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.16  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  79 GEPWLPPPASFGPLRTSRRAKSPQRPKQQP------AAPPAVVRAPAKP---RSPPRSERQPRSPPRSERQPRSPPRSER 149
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAaapapaAAPAAAASAPAAPpaaAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 507417942 150 QPRSPPRSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLR 190
Cdd:PRK14951 449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLT 489
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 84-192 2.72e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.04  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  84 PPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSErqprp 163
Cdd:PRK07764 411 APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPP----- 485

                         90       100
                 ....*....|....*....|....*....
gi 507417942 164 rpEVRPPPAKQRPPQKSKQQPRSSPLRGP 192
Cdd:PRK07764 486 --AAPAPAAAPAAPAAPAAPAGADDAATL 512
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 89-155 3.27e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 37.58  E-value: 3.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507417942  89 FGPLRTSRRAKSPQ-RPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERqprspPRSERQPRSPP 155
Cdd:PRK01297   9 FGKGEAEQPAPAPPsPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDK-----PRRERKPKPAS 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 72-155 3.65e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   72 QRRLSSRGEPWLPPPASFGPLRTSRRAKSPQRPKQQPAAPPAvvraPAKPRSPPrSERQPRSPPRSERQPRSPPRSERQP 151
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ----PERPPQPQ-APPPPQPQPQPPPPPQPQPPPPPPP 2937


                  ....
gi 507417942  152 RSPP 155
Cdd:PHA03247 2938 RPQP 2941
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-192 4.93e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   76 SSRGEPWLPPPASFGPLRTSRRAKSPQR--PKQQPAAPPAVVRAPAKPRSPPRSERQPRSPP-RSERQPRSPPRSERQPR 152
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPslPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvRRLARPAVSRSTESFAL 2900

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 507417942  153 SPPRSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGP 192
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 94-200 4.95e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 37.19  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  94 TSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRS---PPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVRPP 170
Cdd:PRK12678  56 KEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAeaaAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGE 135

                         90       100       110
                 ....*....|....*....|....*....|
gi 507417942 171 PAKQRPPQKSKQQPRSSPLRGPGASRGGSP 200
Cdd:PRK12678 136 AARRGAARKAGEGGEQPATEARADAAERTE 165
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
64-205 5.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.16  E-value: 5.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  64 ACQKTSSCQRRLSSRGEPWLPPPAsfgPLRTSRRAKSPQRPKQQPAAP------PAVVRAPAKPRSPPRSERQPRSPPRS 137
Cdd:PRK12323 434 AAARQASARGPGGAPAPAPAPAAA---PAAAARPAAAGPRPVAAAAAAaparaaPAAAPAPADDDPPPWEELPPEFASPA 510

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507417942 138 ERQP---------RSPPRSERQPRSPPRSERQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGPGASRGGSPVKASR 205
Cdd:PRK12323 511 PAQPdaapagwvaESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAAR 587
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 73-200 7.60e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 36.69  E-value: 7.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942   73 RRLSSRGEPWLPPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKpRSPPRSERQPRSPPRSERQPRSPPRSERQPR 152
Cdd:PHA03307  794 AAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGA-AARPPPARSSESSKSKPAAAGGRARGKNGRR 872

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 507417942  153 SPPRSERQPRPRPEVRPPPAKQRPPQKS-KQQPRSSPLRGPGASRGGSP 200
Cdd:PHA03307  873 RPRPPEPRARPGAAAPPKAAAAAPPAGApAPRPRPAPRVKLGPMPPGGP 921
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
84-204 7.78e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 36.78  E-value: 7.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  84 PPPASFGPLRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRseRQPRSPPRSERQPRP 163
Cdd:PRK12323 428 PAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPA--PADDDPPPWEELPPE 505

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 507417942 164 RPEVRPPPAKQRPPQ---KSKQQPRSSPLRGPGASRGGSPVKAS 204
Cdd:PRK12323 506 FASPAPAQPDAAPAGwvaESIPDPATADPDDAFETLAPAPAAAP 549
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 78-157 8.54e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 36.64  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  78 RGEPWLPPPASfgplrtsrrakSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPrSERQPRSPPRSERQPRSPPRS 157
Cdd:PRK14965 379 RGAPAPPSAAW-----------GAPTPAAPAAPPPAAAPPVPPAAPARPAAARPAPAP-APPAAAAPPARSADPAAAASA 446
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 96-155 9.79e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 36.26  E-value: 9.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417942  96 RRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPP 155
Cdd:PRK14965 372 DRLEALERGAPAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPARPAAARPAPAPAPPAAA 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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