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Conserved domains on  [gi|507417944|ref|NP_001265252|]
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myelin-associated oligodendrocyte basic protein isoform b [Homo sapiens]

Protein Classification

PHD finger domain-containing protein( domain architecture ID 366290)

PHD (plant homeodomain) finger domain-containing protein

Gene Ontology:  GO:0008270|GO:0005515
PubMed:  16297627|21514168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 1-69 9.90e-14

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member pfam02318:

Pssm-ID: 473978  Cd Length: 118  Bit Score: 64.32  E-value: 9.90e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507417944    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTR 69
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEAR 104
flhF super family cl35529
flagellar biosynthesis protein FlhF;
70-163 1.40e-05

flagellar biosynthesis protein FlhF;


The actual alignment was detected with superfamily member PRK06995:

Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 44.57  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  70 TSRRAKSPQRPKQQPAAPPAVVRAPAKPR--------SPPRSERQPRSPP--RSERQPRSPPRSERQPRSPPRSERQPRP 139
Cdd:PRK06995  52 APPAAAAPAAAQPPPAAAPAAVSRPAAPAaepapwlvEHAKRLTAQREQLvaRAAAPAAPEAQAPAAPAERAAAENAARR 131

                         90       100
                 ....*....|....*....|....
gi 507417944 140 RPEVRPPPAKQRPPQKSKQQPRSS 163
Cdd:PRK06995 132 LARAAAAAPRPRVPADAAAAVADA 155
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-69 9.90e-14

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 64.32  E-value: 9.90e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507417944    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTR 69
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEAR 104
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-69 2.80e-10

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 53.18  E-value: 2.80e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 507417944  24 IHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTR 69
Cdd:cd15753    3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQR 49
flhF PRK06995
flagellar biosynthesis protein FlhF;
70-163 1.40e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 44.57  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  70 TSRRAKSPQRPKQQPAAPPAVVRAPAKPR--------SPPRSERQPRSPP--RSERQPRSPPRSERQPRSPPRSERQPRP 139
Cdd:PRK06995  52 APPAAAAPAAAQPPPAAAPAAVSRPAAPAaepapwlvEHAKRLTAQREQLvaRAAAPAAPEAQAPAAPAERAAAENAARR 131

                         90       100
                 ....*....|....*....|....
gi 507417944 140 RPEVRPPPAKQRPPQKSKQQPRSS 163
Cdd:PRK06995 132 LARAAAAAPRPRVPADAAAAVADA 155
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 53-134 6.04e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 36.41  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   53 YQKKEEDWICCACQKTRTSRRAKSPqrPKQQPAAPPAvvRAPAKPRSPPRSerqPRSPPRSERQPRSPPrSERQPRSPPR 132
Cdd:TIGR00601  62 YKIKEKDFVVVMVSKPKTGTGKVAP--PAATPTSAPT--PTPSPPASPASG---MSAAPASAVEEKSPS-EESATATAPE 133


                  ..
gi 507417944  133 SE 134
Cdd:TIGR00601 134 SP 135
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-69 9.90e-14

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 64.32  E-value: 9.90e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507417944    1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTR 69
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEAR 104
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-69 2.80e-10

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 53.18  E-value: 2.80e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 507417944  24 IHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTR 69
Cdd:cd15753    3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQR 49
flhF PRK06995
flagellar biosynthesis protein FlhF;
70-163 1.40e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 44.57  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  70 TSRRAKSPQRPKQQPAAPPAVVRAPAKPR--------SPPRSERQPRSPP--RSERQPRSPPRSERQPRSPPRSERQPRP 139
Cdd:PRK06995  52 APPAAAAPAAAQPPPAAAPAAVSRPAAPAaepapwlvEHAKRLTAQREQLvaRAAAPAAPEAQAPAAPAERAAAENAARR 131

                         90       100
                 ....*....|....*....|....
gi 507417944 140 RPEVRPPPAKQRPPQKSKQQPRSS 163
Cdd:PRK06995 132 LARAAAAAPRPRVPADAAAAVADA 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
 77-176 2.04e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   77 PQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVRPPPAKQRPPQKS 156
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940

                          90       100
                  ....*....|....*....|
gi 507417944  157 KQQPRSSPLRGPGASRGGSP 176
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVP 2960
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 84-170 2.05e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   84 PAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPrserQPRPRPEVRPPPAKQRPPQKSKQQPRSS 163
Cdd:PRK12270   43 APTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAA----AAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  ....*..
gi 507417944  164 PLRGPGA 170
Cdd:PRK12270  119 PLRGAAA 125
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 71-176 3.28e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 3.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  71 SRRAKSPQRPKQQ-----PAAPPAVVRAPAKPrsPPRSERQPRSPP-RSERQPRSPPRSERQPRSPPRSERQPRPRPEVR 144
Cdd:PRK14951 375 PAEKKTPARPEAAapaaaPVAQAAAAPAPAAA--PAAAASAPAAPPaAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                         90       100       110
                 ....*....|....*....|....*....|..
gi 507417944 145 PPPAKQRPPQKSKQQPRSSPLRGPGASRGGSP 176
Cdd:PRK14951 453 AQAAPETVAIPVRVAPEPAVASAAPAPAAAPA 484
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 66-149 3.78e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  66 QKTRTSRRAKSPQRPKQqpaapPAVVRAPAKPRSP--PRSERQPRSP--PRSERQPRSPPRSERqPRSPPRSERQPRPRP 141
Cdd:PTZ00449 583 KDPKHPKDPEEPKKPKR-----PRSAQRPTRPKSPklPELLDIPKSPkrPESPKSPKRPPPPQR-PSSPERPEGPKIIKS 656


                 ....*...
gi 507417944 142 EVRPPPAK 149
Cdd:PTZ00449 657 PKPPKSPK 664
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
65-168 4.57e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.84  E-value: 4.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  65 CQKTRTSRRAKSPQRPKQ-------QPAA---PPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSE 134
Cdd:PRK14971 360 AQLTQKGDDASGGRGPKQhikpvftQPAAapqPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNP 439

                         90       100       110
                 ....*....|....*....|....*....|....
gi 507417944 135 RQPRPRPEVRPPPAKQRPPQKSKQQPRSSPLRGP 168
Cdd:PRK14971 440 PSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRP 473
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 73-176 1.54e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  73 RAKSPQRPKQQPAAP-PAVVRAPAKPRSPPRSERQPRSPPrsERQPRSPPRSERQPRSPPRSERQPRPRPEVRPPPAKQR 151
Cdd:PRK07764 392 GAPAAAAPSAAAAAPaAAPAPAAAAPAAAAAPAPAAAPQP--APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                         90       100
                 ....*....|....*....|....*
gi 507417944 152 PPQKSKQQPRSSPLRGPGASRGGSP 176
Cdd:PRK07764 470 PAAAPEPTAAPAPAPPAAPAPAAAP 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 72-177 2.02e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   72 RRAKSPQRPKQQPAAPPAV-VRAPAKPRSPPRSERQPRSPPRSERQPrsPPRSERQPRSPPRSERQPRPRPEVRPPPAKQ 150
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPpVRRLARPAVSRSTESFALPPDQPERPP--QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940

                          90       100
                  ....*....|....*....|....*...
gi 507417944  151 RPPQKSKQ-QPRSSPLRGPGASRGGSPV 177
Cdd:PHA03247 2941 PPLAPTTDpAGAGEPSGAVPQPWLGALV 2968
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 72-160 2.08e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  72 RRAKSPQRPKQQpaappavvRAPAKPRSPPRSERqPRSP--PRSERQPRSP--PRSERQPRSPPRSERQPRPRPEVRPPP 147
Cdd:PTZ00449 583 KDPKHPKDPEEP--------KKPKRPRSAQRPTR-PKSPklPELLDIPKSPkrPESPKSPKRPPPPQRPSSPERPEGPKI 653

                         90
                 ....*....|...
gi 507417944 148 AKQRPPQKSKQQP 160
Cdd:PTZ00449 654 IKSPKPPKSPKPP 666
dnaA PRK14086
chromosomal replication initiator protein DnaA;
74-179 3.22e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.58  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  74 AKSPQRPKQQPAAP-------PAVVRAPAKPRSP--PRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVR 144
Cdd:PRK14086 134 PRQDQLPTARPAYPayqqrpePGAWPRAADDYGWqqQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDH 213

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507417944 145 PPPAKQRPPQKSKQQPRSSPLRGPGASRGGSPVKA 179
Cdd:PRK14086 214 PRPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPER 248
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 77-168 4.66e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  77 PQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVRPPPAKQRPPQKS 156
Cdd:PRK07764 689 APAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAA 768

                         90
                 ....*....|..
gi 507417944 157 KQQPRSSPLRGP 168
Cdd:PRK07764 769 APAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 66-168 5.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   66 QKTRTSRRAKSPQRP-----KQQPAAPP--AVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSER----QPRSPPRSE 134
Cdd:PHA03247 2566 RSVPPPRPAPRPSEPavtsrARRPDAPPqsARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSpaanEPDPHPPPT 2645

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 507417944  135 RQPRPRPEVRPPPAKQRPPQKSKQQPR----SSPLRGP 168
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRaaqaSSPPQRP 2683
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 74-131 9.31e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 9.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 507417944  74 AKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSErqPRSPPRSERQPRSPP 131
Cdd:PRK14950 375 APSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPR--PVAPPVPHTPESAPK 430
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 70-176 3.42e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 37.19  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  70 TSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRS---PPRSERQPRSPPRSERQPRSPPRSERQPRPRPEVRPP 146
Cdd:PRK12678  56 KEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAeaaAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGE 135

                         90       100       110
                 ....*....|....*....|....*....|
gi 507417944 147 PAKQRPPQKSKQQPRSSPLRGPGASRGGSP 176
Cdd:PRK12678 136 AARRGAARKAGEGGEQPATEARADAAERTE 165
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 66-163 4.94e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 36.99  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   66 QKTRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPprseRQPRSPprSERQPRPRPEVRP 145
Cdd:PRK10263  753 QQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP----QQPVAP--QPQYQQPQQPVAP 826

                          90
                  ....*....|....*...
gi 507417944  146 PPAKQRPPQKSKQQPRSS 163
Cdd:PRK10263  827 QPQYQQPQQPVAPQPQDT 844
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 73-168 5.90e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 36.89  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  73 RAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQP-RSPPRSERQPRPRPEVRPPPAKQR 151
Cdd:PRK07764 416 APAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPaAAPEPTAAPAPAPPAAPAPAAAPA 495

                         90
                 ....*....|....*..
gi 507417944 152 PPQKSKQQPRSSPLRGP 168
Cdd:PRK07764 496 APAAPAAPAGADDAATL 512
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 74-131 6.02e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 36.43  E-value: 6.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 507417944  74 AKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERqprspPRSERQPRSPP 131
Cdd:PRK01297  19 PAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDK-----PRRERKPKPAS 71
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 53-134 6.04e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 36.41  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944   53 YQKKEEDWICCACQKTRTSRRAKSPqrPKQQPAAPPAvvRAPAKPRSPPRSerqPRSPPRSERQPRSPPrSERQPRSPPR 132
Cdd:TIGR00601  62 YKIKEKDFVVVMVSKPKTGTGKVAP--PAATPTSAPT--PTPSPPASPASG---MSAAPASAVEEKSPS-EESATATAPE 133


                  ..
gi 507417944  133 SE 134
Cdd:TIGR00601 134 SP 135
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 68-164 6.30e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 36.59  E-value: 6.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  68 TRTSRRAKSPQRPKQQPAAPPAVVRAPAKPRSP---PRSERQPRSP--PRSERQPRSpPRSERQPRSPPRSERQPRPRPE 142
Cdd:PTZ00449 537 SKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPskiPTLSKKPEFPkdPKHPKDPEE-PKKPKRPRSAQRPTRPKSPKLP 615

                         90       100
                 ....*....|....*....|..
gi 507417944 143 VRPPPAKQRPPQKSKQQPRSSP 164
Cdd:PTZ00449 616 ELLDIPKSPKRPESPKSPKRPP 637
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 72-131 6.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 36.64  E-value: 6.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  72 RRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQPRSPP 131
Cdd:PRK14965 372 DRLEALERGAPAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPARPAAARPAPAPAPPAAA 431
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 67-176 7.03e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 36.59  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  67 KTRTSRRAKSPQRPKQ-QPAAPPAVVRAPAKPRSPprseRQPRSP--PRSERQPRSPPRSERqPRSP--PRSERQPRPRP 141
Cdd:PTZ00449 551 ETKEGEVGKKPGPAKEhKPSKIPTLSKKPEFPKDP----KHPKDPeePKKPKRPRSAQRPTR-PKSPklPELLDIPKSPK 625

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507417944 142 EVRPPPAKQRPPqkSKQQPrSSPLRGPGASRGGSP 176
Cdd:PTZ00449 626 RPESPKSPKRPP--PPQRP-SSPERPEGPKIIKSP 657
FYVE_SlaC2-a cd15752
FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins; ...
 24-73 8.40e-03

FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins; SlaC2-a, also termed melanophilin, or exophilin-3, is a GTP-bound form of Rab27A-, myosin Va-, and actin-binding protein present on melanosomes. It is involved in the control of transferring of melanosomes from microtubules to actin filaments. It also functions as a melanocyte type myosin Va (McM5) binding partner and directly activates the actin-activated ATPase activity of McM5 through forming a tripartite protein complex with Rab27A and an actin-based motor myosin Va. SlaC2-a belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-a are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-a has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277291  Cd Length: 76  Bit Score: 34.00  E-value: 8.40e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 507417944  24 IHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKKEEDWICCACQKTRTSRR 73
Cdd:cd15752    4 ARCLQPFQFLlNSGRQCLDCGLRTCKSCSRYHPEEQGWVCDPCHLARVVKI 54
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 71-181 9.02e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 36.12  E-value: 9.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  71 SRRAKSPQRPKQQPAAPPAVVRAPAKPRSPPRSERQPRSPPRSERQPRSPPRSERQ-PRSPPRSERQPRPRPEVRPPPAK 149
Cdd:PRK07764 399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPsPPPAAAPSAQPAPAPAAAPEPTA 478

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507417944 150 QRPPQKSKQQPRSSPLR---GPGASRGGSPVKASR 181
Cdd:PRK07764 479 APAPAPPAAPAPAAAPAapaAPAAPAGADDAATLR 513
flhF PRK06995
flagellar biosynthesis protein FlhF;
67-159 9.06e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 36.10  E-value: 9.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507417944  67 KTRTSRRAKSPQ---------RPKQQPAAP-PAVV---RAPAKPRSPP--RSERQPRSPPRSERQPRSPPRSERQPRSPP 131
Cdd:PRK06995  54 PAAAAPAAAQPPpaaapaavsRPAAPAAEPaPWLVehaKRLTAQREQLvaRAAAPAAPEAQAPAAPAERAAAENAARRLA 133

                         90       100
                 ....*....|....*....|....*...
gi 507417944 132 RSERQPRPRPEVRPPPAKQRPPQKSKQQ 159
Cdd:PRK06995 134 RAAAAAPRPRVPADAAAAVADAVKARIE 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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