BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 520975358  88 TSGNRDQVLLAARELRVPEAVELCQSFK 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358 374 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 451
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414

                 ....*...
gi 520975358 452 QMHIKAKH 459
Cdd:COG5189  415 KYHRKHSH 422

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 520975358  88 TSGNRDQVLLAARELRVPEAVELCQSFK 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358    27 DATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGS----VVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAAREL 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkseIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|..
gi 520975358   103 RVPEAVELCQSF 114
Cdd:smart00225  81 QIPGLVELCEEF 92

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358 374 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 451
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414

                 ....*...
gi 520975358 452 QMHIKAKH 459
Cdd:COG5189  415 KYHRKHSH 422

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 520975358  305 YLKVHNRKHTGEKPFECPKCGKCY 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 520975358  88 TSGNRDQVLLAARELRVPEAVELCQSFK 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   7 QHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDG---SGGSVVLPAGF-AEIFGLLLDFFYT 82
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGmseSSKDVVQIHGVePDIFHILLDFIYT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 520975358  83 GHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGS--VVLPAGF--AEIFGLLLDFF 80
Cdd:cd18198    5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDqqNVYEIDFvsPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 520975358  81 YTGHLALTSGNRDQVLLAARELRVPEAVELC 111
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAG--FAEIFGLLLDFFYTGHL 85
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSqvSADGFQKLLEFIYTGNL 80

                         90       100
                 ....*....|....*....|....*..
gi 520975358  86 ALTSGNRDQVLLAARELRVPEAVELCQ 112
Cdd:cd18217   81 NLDSWNVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358  11 RVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGS----------VVLPAGFAEIfgllLDFF 80
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScdqttvthldVVAVQGFSVI----LDFM 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 520975358  81 YTGHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18201   83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNF 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGS---------VVLPAGFAEIfgllLD 78
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSdqatvthldIVTAQGFKAI----ID 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 520975358  79 FFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18230   80 FMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNF 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   7 QHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSV---VLPAGF-AEIFGLLLDFFYT 82
Cdd:cd18332    1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVsvlTLPSGLeARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 520975358  83 GHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFF-----QSLYGDGSGGSVVLPAGFAEIFGLLLDFFYT 82
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFkmllsQNAKETGQPTVATFDVFSPDTFTIILDFVYS 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 520975358  83 GHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18329   84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTF 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLY---GDGSGGSVV-LPAGFAEIFGLLLDFFYTG 83
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFssdSDGESILTVkLDGLDPDAVEVLVNYAYTS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 520975358  84 HLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18306   81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDF 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFF-----QSLYGDGSGGSVVLPAGFAEIFGLLLDFFYT 82
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFrmllsHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 520975358  83 GHLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGS--GGSV-VLPAGFAEIFGLLLDFFYTGH 84
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGevGQSIyMLEGMVAETFGALLEFIYTGC 85

                         90       100
                 ....*....|....*....|....*
gi 520975358  85 LALTSGNRDQVLLAARELRVPEAVE 109
Cdd:cd18212   86 LQVGEKSLEQILATAQFLKVNDLVK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358  12 VLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGF-AEIFGLLLDFFYTGHLALTSG 90
Cdd:cd18290   14 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVqPQSFQQILSFCYTGRLSMNVG 93

                         90       100
                 ....*....|....*....|....*....
gi 520975358  91 NRDQVLLAARELRVPEAVELCQSFKPKTS 119
Cdd:cd18290   94 DQFLLMYTAGFLQIQEIMEKGTEFFLKVS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   7 QHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGD----GSGGSVVLPAGFAEI-FGLLLDFFY 81
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEkgavSSHEAVVDLSGFCKSsFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 520975358  82 TGHLALTSGNRDQVLLAARELRVPEAVELCQS 113
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEICES 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGD---GSGGSVV-LPAGFAEIFGLLLDFFYTG 83
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDytqESKARVIhLPVVSAAGLQRVLDFIYTS 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 520975358  84 HLALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18264   91 WLSLSLDTLEDTLEAASYLQVTEAIGLCSQY 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDG---------SGGSVVLPAgfaeiFGL 75
Cdd:cd18325    3 FPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQldkrdivhlNSDIVTAPA-----FSL 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 520975358  76 LLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQ 112
Cdd:cd18325   78 LLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDG---------SGGSVVLPAgfaeiFGL 75
Cdd:cd18324    3 FPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQldkrdivhlNSDIVTAPA-----FAL 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 520975358  76 LLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQ 112
Cdd:cd18324   78 LLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDG---SGGSVVLPAGfAEIFGL--LLDFFYT 82
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGmreAHQKEVELVG-ASYIGLkaVIDFLYS 86

                         90       100
                 ....*....|....*....|....*....
gi 520975358  83 GHLALTSGNRDQVLLAARELRVPEAVELC 111
Cdd:cd18266   87 SELPLDGGNIDYVLETAHLLQIWKVVDFC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGS--------VVLPAGFAEIfgll 76
Cdd:cd18328    5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADqpyvyeidFVTPEALSAI---- 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 520975358  77 LDFFYTGHLALTSGNRDQVLLAARELRVPEAVELC 111
Cdd:cd18328   81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGS----GGSVVLPAgfaeIFGLLLDFFYTG 83
Cdd:cd18216    3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNlihlDQDMVSPT----VFQQILDFIYTG 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 520975358  84 HLA---LTSGNRDQVLLAARELRVPEAVELCQS 113
Cdd:cd18216   79 KLLdslFEEPNLSEVLAAANYLQLPDLAALCRS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358  16 LNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYG----DGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGN 91
Cdd:cd18237   12 MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTsnmtESKSSEVELKDAEPDIIELLVEFAYTARISVNSNN 91

                         90       100
                 ....*....|....*....|...
gi 520975358  92 RDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18237   92 VQSLLDAANQYQIEPVKKMCVDF 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520975358   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFF-QSLYGDGSGGSVV-LPAGF-AEIFGLLLDFFYTGH 84
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTENDLVVsLPEEVtARGFGPLLQFAYTAK 93

                         90       100       110
                 ....*....|....*....|....*....|
gi 520975358  85 LALTSGNRDQVLLAARELRVPEAVELCQSF 114
Cdd:cd18278   94 LLLSRENIQEVIRCAEFLRMHNLEDSCFRF 123