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Conserved domains on  [gi|525343582|ref|NP_001265720|]
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replication factor C subunit 2 isoform 3 [Homo sapiens]

Protein Classification

replication factor C subunit family protein( domain architecture ID 1001989)

replication factor C subunit family protein such as Saccharomyces cerevisiae replication factor C subunit 4 (RFC4) that is involved in unwinding DNA templates and provide energy for DNA polymerase during DNA replication

Gene Ontology:  GO:0005524|GO:0003677|GO:0006260

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03025 super family cl31966
replication factor C subunit; Provisional
 2-247 1.49e-171

replication factor C subunit; Provisional


The actual alignment was detected with superfamily member PLN03025:

Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 475.37  E-value: 1.49e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PLN03025  68 LELNASDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLL 161
Cdd:PLN03025 148 SRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLH 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 162 VKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLA 241
Cdd:PLN03025 228 VKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLA 307


                 ....*.
gi 525343582 242 RLCQKT 247
Cdd:PLN03025 308 KLCLVR 313
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 2-247 1.49e-171

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 475.37  E-value: 1.49e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PLN03025  68 LELNASDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLL 161
Cdd:PLN03025 148 SRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLH 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 162 VKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLA 241
Cdd:PLN03025 228 VKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLA 307


                 ....*.
gi 525343582 242 RLCQKT 247
Cdd:PLN03025 308 KLCLVR 313
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
1-245 1.13e-37

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 133.56  E-value: 1.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNA---SNDRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKII 77
Cdd:COG0470   69 LLELNPeekSDQIGIDQIR-ELGEFLSLTPLE--GGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  78 EPIQSRCAVLRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEP 157
Cdd:COG0470  146 PTIRSRCQVIRFRPPSEEEALAWL----REEGV--DEDALEAILRLAGGDPRAAINLLQALAGRKELL--EDLAALLSRD 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 158 HPLlvkEMIQHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvcktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMA 237
Cdd:COG0470  218 RAL---ELLDALLKAEALELLDWLLKW---------LLDNLP-----LEYAGEDLARAYEALSEADRRLGRYANDRLLLE 280


                 ....*...
gi 525343582 238 GLLARLCQ 245
Cdd:COG0470  281 ALLAKLGR 288
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 157-242 1.99e-30

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 108.72  E-value: 1.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  157 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 235
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343582  236 MAGLLAR 242
Cdd:pfam08542  81 LSALLAA 87
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 92-154 2.43e-21

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 84.12  E-value: 2.43e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343582  92 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 154
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 2-247 1.49e-171

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 475.37  E-value: 1.49e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PLN03025  68 LELNASDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLL 161
Cdd:PLN03025 148 SRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLH 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 162 VKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLA 241
Cdd:PLN03025 228 VKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLA 307


                 ....*.
gi 525343582 242 RLCQKT 247
Cdd:PLN03025 308 KLCLVR 313
rfc PRK00440
replication factor C small subunit; Reviewed
 1-243 3.85e-93

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 276.75  E-value: 3.85e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFAQQKvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK00440  71 FLELNASDERGIDVIRNKIKEFARTA-PVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPI 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPL 160
Cdd:PRK00440 150 QSRCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 161 LVKEMIQHCVNANIDEAYKILAHLWHL-GYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGL 239
Cdd:PRK00440 230 EIREMIELALNGDFTEAREKLRDLMIDyGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEAL 309


                 ....
gi 525343582 240 LARL 243
Cdd:PRK00440 310 LAKL 313
PRK04132 PRK04132
replication factor C small subunit; Provisional
 2-243 1.55e-63

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 212.39  E-value: 1.55e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNKIKMFAQQKvtlPKG--RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PRK04132 600 LELNASDERGINVIREKVKEFARTK---PIGgaSFKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEP 676

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  80 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHP 159
Cdd:PRK04132 677 IQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAALDDKITDENVFLVASRARP 756

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 160 LLVKEMIQHCVNANIDEAYKILAH-LWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAG 238
Cdd:PRK04132 757 EDIREMMLLALKGNFLKAREKLREiLLKQGLSGEDVLVQMHREVFNLPIDEPKKVELADKIGEYNFRLVEGANEMIQLEA 836


                 ....*
gi 525343582 239 LLARL 243
Cdd:PRK04132 837 LLAQF 841
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 32-243 1.86e-39

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 139.35  E-value: 1.86e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  32 GRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVP 111
Cdd:PRK12402 124 ADYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIATRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 112 YTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC-DEPHPLLVKEMIQHCVNANIDEAYKILAHLwhL--- 187
Cdd:PRK12402 204 YDDDGLELIAYYAGGDLRKAILTLQTAALAAGEITMEAAYEALgDVGTDEVIESLLDAAEAGDFTDARKTLDDL--Lide 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 525343582 188 GYSPEDIIGNIFRVCKTFQmAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 243
Cdd:PRK12402 282 GLSGGEVLEELLRVARSRY-RGDNLARLHRLAADADARLTDGANDRIQLEALLAEL 336
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
1-245 1.13e-37

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 133.56  E-value: 1.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNA---SNDRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKII 77
Cdd:COG0470   69 LLELNPeekSDQIGIDQIR-ELGEFLSLTPLE--GGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  78 EPIQSRCAVLRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEP 157
Cdd:COG0470  146 PTIRSRCQVIRFRPPSEEEALAWL----REEGV--DEDALEAILRLAGGDPRAAINLLQALAGRKELL--EDLAALLSRD 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 158 HPLlvkEMIQHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvcktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMA 237
Cdd:COG0470  218 RAL---ELLDALLKAEALELLDWLLKW---------LLDNLP-----LEYAGEDLARAYEALSEADRRLGRYANDRLLLE 280


                 ....*...
gi 525343582 238 GLLARLCQ 245
Cdd:COG0470  281 ALLAKLGR 288
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 157-242 1.99e-30

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 108.72  E-value: 1.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  157 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 235
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343582  236 MAGLLAR 242
Cdd:pfam08542  81 LSALLAA 87
44 PHA02544
clamp loader, small subunit; Provisional
 1-147 8.53e-27

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 105.46  E-value: 8.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRgIDVVRNKIKMFAQQkVTLpKGRHKIIILDEAD-SMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PHA02544  71 VLFVNGSDCR-IDFVRNRLTRFAST-VSL-TGGGKVIIIDEFDrLGLADAQRHLRSFMEAYSKNCSFIITANNKNGIIEP 147

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525343582  80 IQSRCAVLRYTKLTDA-------QILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQStFSGFGFINS 147
Cdd:PHA02544 148 LRSRCRVIDFGVPTKEeqiemmkQMIVRCKGILEAEGVEVDMKVLAALVKKNFPDFRRTINELQR-YASTGKIDA 221
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 1-190 1.62e-25

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 104.14  E-value: 1.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14953  90 LIEIDAASNRGIDDIRALRDAVSYTPI---KGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINS---ENVFKVCDE 156
Cdd:PRK14953 167 LSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQASEGGMRDAASLLdQASTYGEGKVTIkvvEEFLGIVSQ 246

                        170       180       190
                 ....*....|....*....|....*....|....
gi 525343582 157 PHpllVKEMIQHCVNANIDEAYKILAHLWHLGYS 190
Cdd:PRK14953 247 ES---VRKFLNLLLESDVDEAIKFLRTLEEKGYN 277
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 92-154 2.43e-21

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 84.12  E-value: 2.43e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343582  92 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 154
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
6-195 1.62e-20

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 88.71  E-value: 1.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   6 ASNdRGIDVVRNkikmfAQQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSR 83
Cdd:COG2812   91 ASN-IGVDDIRE-----LIEKVSYApvEGRYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEPQKLLPTILSR 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  84 CAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTfSGFGFINSENvfkvcdephplLVK 163
Cdd:COG2812  165 CQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQA-IAFGLLDRRE-----------LLL 232

                        170       180       190
                 ....*....|....*....|....*....|..
gi 525343582 164 EMIQHCVNANIDEAYKILAHLWHLGYSPEDII 195
Cdd:COG2812  233 DLLEALLAGDVAALLALAEELAKRGRDLKRFL 264
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 2-227 5.08e-18

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 82.51  E-value: 5.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PRK14962  89 IELDAASNRGIDEIR-KIRDAVGYRPME--GKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTII 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQ--STFSGfGFINSENVFK----VCD 155
Cdd:PRK14962 166 SRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEqvWKFSE-GKITLETVHEalglIPI 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 156 EphplLVKEMIQHCVNANIDEAYKILAHLWHLGYSP--------EDIIGNIFRVcKTFQMAEYLK--LEFIKEIGYTHMK 225
Cdd:PRK14962 245 E----VVRDYINAIFNGDVKRVFTVLDDVYYSGKDYevliqqaiEDLVEDLERE-RANDIIQVSRqlLNILREIKFAEEK 319


                 ..
gi 525343582 226 IA 227
Cdd:PRK14962 320 RL 321
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
 3-141 7.91e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 72.98  E-value: 7.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDRGIDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQS 82
Cdd:PRK14970  81 ELDAASNNSVDDIRNLID---QVRIPPQTGKYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILS 157

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582  83 RCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN--NLQSTFSG 141
Cdd:PRK14970 158 RCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSifDRVVTFCG 218
PRK04195 PRK04195
replication factor C large subunit; Provisional
 1-150 2.18e-14

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 71.88  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFAQQKvTLPKGRHKIIILDEADSM---TD-GAQQALRRTMeiysKTTRFALACNASD-- 74
Cdd:PRK04195  67 VIELNASDQRTADVIERVAGEAATSG-SLFGARRKLILLDEVDGIhgnEDrGGARAILELI----KKAKQPIILTANDpy 141

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 525343582  75 -KIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENV 150
Cdd:PRK04195 142 dPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGYGKLTLEDV 218
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 2-131 2.48e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 69.10  E-value: 2.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNkikmfAQQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PRK14963  88 LEIDAASNNSVEDVRD-----LREKVLLAplRGGRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPT 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343582  80 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 131
Cdd:PRK14963 163 ILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEPEALQLVARLADGAMRDA 214
PRK05896 PRK05896
DNA polymerase III subunits gamma and tau; Validated
 1-201 9.11e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235638 [Multi-domain]  Cd Length: 605  Bit Score: 67.56  E-value: 9.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFAQQKVTLPKgrhKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK05896  90 IVELDAASNNGVDEIRNIIDNINYLPTTFKY---KVYIIDEAHMLSTSAWNALLKTLEEPPKHVVFIFATTEFQKIPLTI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQ--STF--SGFGFINSENVFKVCDE 156
Cdd:PRK05896 167 ISRCQRYNFKKLNNSELQELLKSIAKKEKIKIEDNAIDKIADLADGSLRDGLSILDqlSTFknSEIDIEDINKTFGLVDN 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 525343582 157 PHPLLVKEMIQhcvNANIDEAYKILAHLWHLGYSPEDIIGNIFRV 201
Cdd:PRK05896 247 NKKINLIELIQ---KNDIEELRNLINELESKGINFEAFCRDLINL 288
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 1-150 9.48e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 67.43  E-value: 9.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMfAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK08691  90 LLEIDAASNTGIDNIREVLEN-AQYAPTA--GKYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPHKVPVTV 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENV 150
Cdd:PRK08691 167 LSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALSLLdQAIALGSGKVAENDV 237
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 2-202 8.51e-12

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 64.42  E-value: 8.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDvvrnKIKMFAQQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14964  88 IEIDAASNTSVD----DIKVILENSCYLPiSSKFKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKFILATTEVKKIPVTI 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKV--CDEP 157
Cdd:PRK14964 164 ISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLeQAAIYSNNKISEKSVRDLlgCVDK 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 525343582 158 HPLLvkEMIQHCVNANIDEAYKILAHLWHLgYSP----EDIIGNIFRVC 202
Cdd:PRK14964 244 HILE--DLVEAILLGDAQSALNVFRELCNT-SNPviilEGMLQIIYEIC 289
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 1-150 1.36e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 64.00  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMfAQQKVTlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14969  90 LIEVDAASNTQVDAMRELLDN-AQYAPT--RGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTV 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENV 150
Cdd:PRK14969 167 LSRCLQFNLKQMPPPLIVSHLQHILEQENIPFDATALQLLARAAAGSMRDALSLLdQAIAYGGGTVNESEV 237
PRK08451 PRK08451
DNA polymerase III subunits gamma and tau; Validated
 2-218 6.26e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236267 [Multi-domain]  Cd Length: 535  Bit Score: 61.97  E-value: 6.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PRK08451  89 IEMDAASNRGIDDIRELIE---QTKYKPSMARFKIFIIDEVHMLTKEAFNALLKTLEEPPSYVKFILATTDPLKLPATIL 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKVCDEPHPL 160
Cdd:PRK08451 166 SRTQHFRFKQIPQNSIISHLKTILEKEGVSYEPEALEILARSGNGSLRDTLTLLdQAIIYCKNAITESKVADMLGLLDPS 245

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582 161 LVKEMIQHCVN---ANIDEAYKILAhlwhlGYSPEDIIGnifrvcktfQMAEYLKLEFIKE 218
Cdd:PRK08451 246 KLEDFFQAILNqdkEKLFELLKELE-----DYEAEMVLD---------EMMLFLKEKFLSK 292
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 1-185 7.50e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 61.64  E-value: 7.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRnkiKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14957  90 LIEIDAASRTGVEETK---EILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFS-------------GFGFINS 147
Cdd:PRK14957 167 LSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISfcggelkqaqikqMLGIIDS 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 525343582 148 ENVFKVCD---EPHPLLVKEMIQH--CVNANIDEAYKILAHLW 185
Cdd:PRK14957 247 EEVYSIINaiiDNDPKAILPAIKNlaLTESSADAVLDRIAEIW 289
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 2-135 7.70e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 61.68  E-value: 7.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVR---NKIKMfaqqkvtLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKII 77
Cdd:PRK14965  91 FEIDGASNTGVDDIRelrENVKY-------LPsRSRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVP 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 525343582  78 EPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 135
Cdd:PRK14965 164 ITILSRCQRFDFRRIPLQKIVDRLRYIADQEGISISDAALALVARKGDGSMRDSLSTL 221
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
3-141 2.11e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 60.17  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDRGIDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQS 82
Cdd:PRK14971  94 ELDAASNNSVDDIRNLIE---QVRIPPQIGKYKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHKILPTILS 170

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582  83 RCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN--NLQSTFSG 141
Cdd:PRK14971 171 RCQIFDFNRIQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSifDQVVSFTG 231
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1-135 2.34e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 60.08  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14959  90 VVEIDGASNRGIDDAKRLKEAIGYAPM---EGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFPVTI 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 135
Cdd:PRK14959 167 VSRCQHFTFTRLSEAGLEAHLTKVLGREGVDYDPAAVRLIARRAAGSVRDSMSLL 221
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
 1-133 4.59e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 59.19  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRnkiKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK14956  92 VLEIDAASNRGIENIR---ELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETI 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 525343582  81 QSRCAVLRYTKLTdaqiLTRLMNVIEK----ERVPYTDDGLEAIIFTAQGDMRQALN 133
Cdd:PRK14956 169 LSRCQDFIFKKVP----LSVLQDYSEKlckiENVQYDQEGLFWIAKKGDGSVRDMLS 221
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 31-231 6.83e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 58.28  E-value: 6.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  31 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 110
Cdd:PRK14961 117 KSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESI 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582 111 PYTDDGLEAIIFTAQGDMRQALNNLQSTFS-GFGFINSENVFK---VCDEPHPLLVKEMIqhcVNANIDEAYKILAHLWH 186
Cdd:PRK14961 197 DTDEYALKLIAYHAHGSMRDALNLLEHAINlGKGNINIKNVTDmlgLLNEKQSFLLTDAL---LKKDSKKTMLLLNKISS 273

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 525343582 187 LGYSPEDIIGNIFRVCKTFQMAEYLKL----EFIKEIGYTHMKIAEGVN 231
Cdd:PRK14961 274 IGIEWENILIEMLRFLHHISMSQSFPKiwntIFIKNYKNQIQKIAQNNK 322
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
 12-132 7.05e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 58.51  E-value: 7.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  12 IDVVRNKIKMFAQqkvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTK 91
Cdd:PRK09112 123 VDEIRRVGHFLSQ---TSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLKP 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 525343582  92 LTDAQILTRLMNVIEKerVPYTDDGLEAIIFTAQGDMRQAL 132
Cdd:PRK09112 200 LDDDELKKALSHLGSS--QGSDGEITEALLQRSKGSVRKAL 238
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 3-135 8.75e-10

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 58.17  E-value: 8.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDrGIDVVRnkiKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQAL-----RRTMEIYSKTTRfalacNASDKII 77
Cdd:PRK13342  66 ALSAVTS-GVKDLR---EVIEEARQRRSAGRRTILFIDEIHRFNKAQQDALlphveDGTITLIGATTE-----NPSFEVN 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343582  78 EPIQSRCAVLRYTKLTDA---QILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 135
Cdd:PRK13342 137 PALLSRAQVFELKPLSEEdieQLLKRALEDKERGLVELDDEALDALARLANGDARRALNLL 197
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 2-131 1.08e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 58.25  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVR--NKIKMFaqqkvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PRK06305  93 LEIDGASHRGIEDIRqiNETVLF-----TPSKSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIHKIPGT 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343582  80 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 131
Cdd:PRK06305 168 ILSRCQKMHLKRIPEETIIDKLALIAKQEGIETSREALLPIARAAQGSLRDA 219
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2-132 1.12e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 58.35  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDvvrnKIKMFAQQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK12323  96 IEMDAASNRGVD----EMAQLLDKAVYAPtAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTV 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 132
Cdd:PRK12323 172 LSRCLQFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAAQGSMRDAL 223
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 2-143 2.85e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 57.13  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PRK14950  92 IEMDAASHTSVDDAR-EIIERVQFRPAL--ARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEVHKVPATIL 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFG 143
Cdd:PRK14950 169 SRCQRFDFHRHSVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAENLLQQLATTYG 230
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1-84 3.90e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.07  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMFA--QQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTT------RFALACNA 72
Cdd:cd00009   50 FLYLNASDLLEGLVVAELFGHFLvrLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNDLRidrenvRVIGATNR 129

                         90
                 ....*....|....
gi 525343582  73 SD--KIIEPIQSRC 84
Cdd:cd00009  130 PLlgDLDRALYDRL 143
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
 1-198 4.66e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 56.41  E-value: 4.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   1 MLELNASNDRGIDVVRNKIKMfAQQKVTlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPI 80
Cdd:PRK06645  99 IIEIDAASKTSVDDIRRIIES-AEYKPL--QGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATI 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  81 QSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFS----GFGFINSENVFKVCDE 156
Cdd:PRK06645 176 ISRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKSEGSARDAVSILDQAASmsakSDNIISPQVINQMLGL 255

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 525343582 157 PHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNI 198
Cdd:PRK06645 256 VDSSVIIEFVEYIIHRETEKAINLINKLYGSSVNLEIFIESV 297
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
 31-167 7.79e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 55.51  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  31 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 110
Cdd:PRK14958 117 KGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHHKLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENV 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 525343582 111 PYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKVCDEPHPLLVKEMIQ 167
Cdd:PRK14958 197 EFENAALDLLARAANGSVRDALSLLdQSIAYGNGKVLIADVKTMLGTIEPLLLFDILE 254
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
2-132 1.12e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 55.24  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDvvrnkiKMFA--QQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIE 78
Cdd:PRK07003  91 VEMDAASNRGVD------EMAAllERAVYAPvDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPV 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 525343582  79 PIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 132
Cdd:PRK07003 165 TVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDAL 218
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 3-131 1.20e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 54.95  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDRGID---VVRNKIKMFAQqkvtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PRK14954 100 EFDAASNNSVDdirQLRENVRYGPQ------KGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIFIFATTELHKIPAT 173

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343582  80 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 131
Cdd:PRK14954 174 IASRCQRFNFKRIPLDEIQSQLQMICRAEGIQIDADALQLIARKAQGSMRDA 225
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 3-132 5.78e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 53.18  E-value: 5.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDRGIDvvrnKIKMFAQQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ 81
Cdd:PRK14951  97 ELDAASNRGVD----EVQQLLEQAVYKPvQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVL 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525343582  82 SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 132
Cdd:PRK14951 173 SRCLQFNLRPMAPETVLEHLTQVLAAENVPAEPQALRLLARAARGSMRDAL 223
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
 3-131 1.67e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 51.43  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   3 ELNASNDRGID---VVRNKIKMFAQqkvtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 79
Cdd:PRK14955 100 EFDAASNNSVDdirLLRENVRYGPQ------KGRYRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIFIFATTELHKIPAT 173

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343582  80 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 131
Cdd:PRK14955 174 IASRCQRFNFKRIPLEEIQQQLQGICEAEGISVDADALQLIGRKAQGSMRDA 225
PRK06871 PRK06871
DNA polymerase III subunit delta'; Validated
 9-86 2.96e-07

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180738 [Multi-domain]  Cd Length: 325  Bit Score: 50.50  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   9 DRGIDVVRN---KIKMFAQQkvtlpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCA 85
Cdd:PRK06871  86 DIGVDQVREineKVSQHAQQ------GGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRCQ 159


                 .
gi 525343582  86 V 86
Cdd:PRK06871 160 T 160
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 6-204 3.10e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 50.64  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   6 ASNdRGIDVVRNKIkmfaqQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTME------IyskttrFALACNASDKII 77
Cdd:PRK05563  96 ASN-NGVDEIRDIR-----DKVKYApsEAKYKVYIIDEVHMLSTGAFNALLKTLEeppahvI------FILATTEPHKIP 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  78 EPIQSRCAvlRY--TKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL-----------------NNLQST 138
Cdd:PRK05563 164 ATILSRCQ--RFdfKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALsildqaisfgdgkvtyeDALEVT 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343582 139 fsgfGFINSENVFKvcdephpllvkeMIQHCVNANIDEAYKILAHLWHLGYSP----EDIIGnIFR---VCKT 204
Cdd:PRK05563 242 ----GSVSQEALDD------------LVDAIVEGDVAKALKILEELLDEGKDPnrfiEDLIY-YLRdllLVKT 297
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
31-150 4.98e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 50.43  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  31 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 110
Cdd:PRK14960 116 QGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQI 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 525343582 111 PYTDDGLEAIIFTAQGDMRQALN-NLQSTFSGFGFINSENV 150
Cdd:PRK14960 196 AADQDAIWQIAESAQGSLRDALSlTDQAIAYGQGAVHHQDV 236
HLD_clamp cd18133
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ...
 95-137 1.74e-06

helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.


Pssm-ID: 350838 [Multi-domain]  Cd Length: 65  Bit Score: 44.38  E-value: 1.74e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 525343582  95 AQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQS 137
Cdd:cd18133    4 EQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQR 46
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 11-99 2.80e-06

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 47.33  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  11 GIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYT 90
Cdd:PRK05564  74 GVDDIRNIIEEVNKKPY---EGDKKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQIYKLN 150


                 ....*....
gi 525343582  91 KLTDAQILT 99
Cdd:PRK05564 151 RLSKEEIEK 159
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
 2-195 1.70e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 45.53  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   2 LELNASNDRGIDVVRnKIK---MFAQQKvtlpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIE 78
Cdd:PRK06647  91 IEIDGASNTSVQDVR-QIKeeiMFPPAS-----SRYRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHKLPA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  79 PIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA---------LNNLQSTF----SGFGFI 145
Cdd:PRK06647 165 TIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIKYEDEALKWIAYKSTGSVRDAytlfdqvvsFSDSDITLeqirSKMGLT 244

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 525343582 146 NSENVFKVcdephpllvkemIQHCVNANIDEAYKILAHLWHLGYSPEDII 195
Cdd:PRK06647 245 GDEFLEKL------------ASSILNEDAKELLCVLDSVFLSGVSVEQFL 282
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
 11-93 3.35e-05

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 42.97  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582   11 GIDVVRnKIKMFAQQKVTlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYT 90
Cdd:pfam13177  82 KIDQIR-ELQKEFSKSPY--EGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFK 158


                  ...
gi 525343582   91 KLT 93
Cdd:pfam13177 159 PLS 161
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 92-136 6.67e-04

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 37.23  E-value: 6.67e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525343582  92 LTDAQILTRLMNVIEKER------VPYTDDGLEAIIFTAQGDMRQALNNLQ 136
Cdd:cd18139    1 LSEEDLEKLLKRALEDKErggdrkVTIDDEALELLAEAADGDARSALNLLE 51
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
 23-84 8.27e-04

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 40.17  E-value: 8.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525343582  23 AQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 84
Cdd:PRK06090 100 AQESSQL--NGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRC 159
PRK07940 PRK07940
DNA polymerase III subunit delta'; Validated
 11-84 1.58e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236134 [Multi-domain]  Cd Length: 394  Bit Score: 39.12  E-value: 1.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525343582  11 GIDVVRNKIKMFAQQKVTlpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 84
Cdd:PRK07940  98 GVDEVRELVTIAARRPST---GRWRIVVIEDADRLTERAANALLKAVEEPPPRTVWLLCAPSPEDVLPTIRSRC 168
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 31-132 1.92e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 39.32  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582  31 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 110
Cdd:PRK14949 117 RGRFKVYLIDEVHMLSRSSFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKSLTQDEIGTQLNHILTQEQL 196

                         90       100
                 ....*....|....*....|..
gi 525343582 111 PYTDDGLEAIIFTAQGDMRQAL 132
Cdd:PRK14949 197 PFEAEALTLLAKAANGSMRDAL 218
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
 92-133 7.87e-03

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 34.02  E-value: 7.87e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 525343582  92 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN 133
Cdd:cd18137    1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALS 42
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 1-89 8.31e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 35.65  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343582    1 MLELNASN--DRGIDVVRNKI-KMFAQQKVTLPKgrhkIIILDEADSM-----------TDGAQQALRRTMEIYSKTTR- 65
Cdd:pfam00004  26 FIEISGSElvSKYVGESEKRLrELFEAAKKLAPC----VIFIDEIDALagsrgsggdseSRRVVNQLLTELDGFTSSNSk 101

                          90       100
                  ....*....|....*....|....*.
gi 525343582   66 --FALACNASDKIIEPIQSRCAVLRY 89
Cdd:pfam00004 102 viVIAATNRPDKLDPALLGRFDRIIE 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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