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Conserved domains on  [gi|525343597|ref|NP_001265721|]
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replication factor C subunit 2 isoform 4 [Homo sapiens]

Protein Classification

replication factor C subunit family protein( domain architecture ID 1001989)

replication factor C subunit family protein such as Saccharomyces cerevisiae replication factor C subunit 4 (RFC4) that is involved in unwinding DNA templates and provide energy for DNA polymerase during DNA replication

Gene Ontology:  GO:0005524|GO:0003677|GO:0006260

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03025 super family cl31966
replication factor C subunit; Provisional
 5-245 1.79e-165

replication factor C subunit; Provisional


The actual alignment was detected with superfamily member PLN03025:

Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 459.96  E-value: 1.79e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PLN03025  73 SDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMI 164
Cdd:PLN03025 153 VRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIV 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 165 QHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQK 244
Cdd:PLN03025 233 RNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLV 312


                 .
gi 525343597 245 T 245
Cdd:PLN03025 313 R 313
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 5-245 1.79e-165

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 459.96  E-value: 1.79e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PLN03025  73 SDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMI 164
Cdd:PLN03025 153 VRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIV 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 165 QHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQK 244
Cdd:PLN03025 233 RNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLV 312


                 .
gi 525343597 245 T 245
Cdd:PLN03025 313 R 313
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
5-243 5.41e-37

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 131.64  E-value: 5.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:COG0470   78 SDQIGIDQIR-ELGEFLSLTPLE--GGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQV 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEPHPLlvkEMI 164
Cdd:COG0470  155 IRFRPPSEEEALAWL----REEGV--DEDALEAILRLAGGDPRAAINLLQALAGRKELL--EDLAALLSRDRAL---ELL 223

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525343597 165 QHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvcktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQ 243
Cdd:COG0470  224 DALLKAEALELLDWLLKW---------LLDNLP-----LEYAGEDLARAYEALSEADRRLGRYANDRLLLEALLAKLGR 288
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 155-240 9.70e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 109.49  E-value: 9.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  155 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 233
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343597  234 MAGLLAR 240
Cdd:pfam08542  81 LSALLAA 87
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 90-152 1.36e-21

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 84.89  E-value: 1.36e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343597  90 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 152
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 5-245 1.79e-165

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 459.96  E-value: 1.79e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PLN03025  73 SDDRGIDVVRNKIKMFAQKKVTLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMI 164
Cdd:PLN03025 153 VRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIV 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 165 QHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQK 244
Cdd:PLN03025 233 RNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLV 312


                 .
gi 525343597 245 T 245
Cdd:PLN03025 313 R 313
rfc PRK00440
replication factor C small subunit; Reviewed
 8-241 2.89e-87

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 261.73  E-value: 2.89e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   8 RGIDVVRNKIKMFAQQKvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRY 87
Cdd:PRK00440  80 RGIDVIRNKIKEFARTA-PVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQSRCAVFRF 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  88 TKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHC 167
Cdd:PRK00440 159 SPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEIREMIELA 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525343597 168 VNANIDEAYKILAHLWHL-GYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 241
Cdd:PRK00440 239 LNGDFTEAREKLRDLMIDyGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLAKL 313
PRK04132 PRK04132
replication factor C small subunit; Provisional
 5-241 1.44e-59

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 201.61  E-value: 1.44e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKvtlPKG--RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 82
Cdd:PRK04132 605 SDERGINVIREKVKEFARTK---PIGgaSFKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRC 681

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  83 AVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKE 162
Cdd:PRK04132 682 AIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAALDDKITDENVFLVASRARPEDIRE 761

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 163 MIQHCVNANIDEAYKILAH-LWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 241
Cdd:PRK04132 762 MMLLALKGNFLKAREKLREiLLKQGLSGEDVLVQMHREVFNLPIDEPKKVELADKIGEYNFRLVEGANEMIQLEALLAQF 841
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 30-241 7.84e-40

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 140.51  E-value: 7.84e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  30 GRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVP 109
Cdd:PRK12402 124 ADYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIATRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 110 YTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC-DEPHPLLVKEMIQHCVNANIDEAYKILAHLwhL--- 185
Cdd:PRK12402 204 YDDDGLELIAYYAGGDLRKAILTLQTAALAAGEITMEAAYEALgDVGTDEVIESLLDAAEAGDFTDARKTLDDL--Lide 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 525343597 186 GYSPEDIIGNIFRVCKTFQmAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 241
Cdd:PRK12402 282 GLSGGEVLEELLRVARSRY-RGDNLARLHRLAADADARLTDGANDRIQLEALLAEL 336
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
5-243 5.41e-37

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 131.64  E-value: 5.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:COG0470   78 SDQIGIDQIR-ELGEFLSLTPLE--GGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQV 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEPHPLlvkEMI 164
Cdd:COG0470  155 IRFRPPSEEEALAWL----REEGV--DEDALEAILRLAGGDPRAAINLLQALAGRKELL--EDLAALLSRDRAL---ELL 223

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525343597 165 QHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvcktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQ 243
Cdd:COG0470  224 DALLKAEALELLDWLLKW---------LLDNLP-----LEYAGEDLARAYEALSEADRRLGRYANDRLLLEALLAKLGR 288
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 155-240 9.70e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 109.49  E-value: 9.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  155 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 233
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343597  234 MAGLLAR 240
Cdd:pfam08542  81 LSALLAA 87
44 PHA02544
clamp loader, small subunit; Provisional
 9-145 2.65e-25

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 101.22  E-value: 2.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   9 GIDVVRNKIKMFAQQkVTLpKGRHKIIILDEAD-SMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRY 87
Cdd:PHA02544  80 RIDFVRNRLTRFAST-VSL-TGGGKVIIIDEFDrLGLADAQRHLRSFMEAYSKNCSFIITANNKNGIIEPLRSRCRVIDF 157

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525343597  88 TKLTDA-------QILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQStFSGFGFINS 145
Cdd:PHA02544 158 GVPTKEeqiemmkQMIVRCKGILEAEGVEVDMKVLAALVKKNFPDFRRTINELQR-YASTGKIDA 221
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 5-188 2.99e-23

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 97.59  E-value: 2.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14953  96 ASNRGIDDIRALRDAVSYTPI---KGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSRCQR 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINS---ENVFKVCDEPHpllV 160
Cdd:PRK14953 173 FIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQASEGGMRDAASLLdQASTYGEGKVTIkvvEEFLGIVSQES---V 249

                        170       180
                 ....*....|....*....|....*...
gi 525343597 161 KEMIQHCVNANIDEAYKILAHLWHLGYS 188
Cdd:PRK14953 250 RKFLNLLLESDVDEAIKFLRTLEEKGYN 277
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 90-152 1.36e-21

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 84.89  E-value: 1.36e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343597  90 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 152
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
3-193 5.57e-20

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 87.17  E-value: 5.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   3 PTSSLRGIDVVRNkikmfAQQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQS 80
Cdd:COG2812   89 AEASNIGVDDIRE-----LIEKVSYApvEGRYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEPQKLLPTILS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  81 RCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTfSGFGFINSENvfkvcdephplLV 160
Cdd:COG2812  164 RCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQA-IAFGLLDRRE-----------LL 231

                        170       180       190
                 ....*....|....*....|....*....|...
gi 525343597 161 KEMIQHCVNANIDEAYKILAHLWHLGYSPEDII 193
Cdd:COG2812  232 LDLLEALLAGDVAALLALAEELAKRGRDLKRFL 264
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 5-225 6.38e-16

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 76.34  E-value: 6.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRnKIKMFAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14962  94 ASNRGIDEIR-KIRDAVGYRPME--GKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQ--STFSGfGFINSENVFK----VCDEphpl 158
Cdd:PRK14962 171 IEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEqvWKFSE-GKITLETVHEalglIPIE---- 245

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 525343597 159 LVKEMIQHCVNANIDEAYKILAHLWHLGYSP--------EDIIGNIFRVcKTFQMAEYLK--LEFIKEIGYTHMKIA 225
Cdd:PRK14962 246 VVRDYINAIFNGDVKRVFTVLDDVYYSGKDYevliqqaiEDLVEDLERE-RANDIIQVSRqlLNILREIKFAEEKRL 321
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
 5-139 7.56e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 67.21  E-value: 7.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14970  85 ASNNSVDDIRNLID---QVRIPPQTGKYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILSRCQI 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN--NLQSTFSG 139
Cdd:PRK14970 162 FDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSifDRVVTFCG 218
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 22-129 1.59e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 63.71  E-value: 1.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  22 QQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRL 99
Cdd:PRK14963 105 REKVLLAplRGGRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPTILSRTQHFRFRRLTEEEIAGKL 184

                         90       100       110
                 ....*....|....*....|....*....|
gi 525343597 100 MNVIEKERVPYTDDGLEAIIFTAQGDMRQA 129
Cdd:PRK14963 185 RRLLEAEGREAEPEALQLVARLADGAMRDA 214
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 31-200 2.61e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 62.88  E-value: 2.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  31 RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPY 110
Cdd:PRK14964 116 KFKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKFILATTEVKKIPVTIISRCQRFDLQKIPTDKLVEHLVDIAKKENIEH 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 111 TDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKV--CDEPHPLLvkEMIQHCVNANIDEAYKILAHLWHLgY 187
Cdd:PRK14964 196 DEESLKLIAENSSGSMRNALFLLeQAAIYSNNKISEKSVRDLlgCVDKHILE--DLVEAILLGDAQSALNVFRELCNT-S 272

                        170
                 ....*....|....*..
gi 525343597 188 SP----EDIIGNIFRVC 200
Cdd:PRK14964 273 NPviilEGMLQIIYEIC 289
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 29-183 8.67e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 61.64  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14957 117 QGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHLKHISQADIKDQLKIILAKENI 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQALNNLQSTFS-------------GFGFINSENVFKVCD---EPHPLLVKEMIQH--CVNA 170
Cdd:PRK14957 197 NSDEQSLEYIAYHAKGSLRDALSLLDQAISfcggelkqaqikqMLGIIDSEEVYSIINaiiDNDPKAILPAIKNlaLTES 276

                        170
                 ....*....|...
gi 525343597 171 NIDEAYKILAHLW 183
Cdd:PRK14957 277 SADAVLDRIAEIW 289
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 29-229 4.98e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 58.67  E-value: 4.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14961 117 KSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESI 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQALNNLQSTFS-GFGFINSENVFK---VCDEPHPLLVKEMIqhcVNANIDEAYKILAHLWH 184
Cdd:PRK14961 197 DTDEYALKLIAYHAHGSMRDALNLLEHAINlGKGNINIKNVTDmlgLLNEKQSFLLTDAL---LKKDSKKTMLLLNKISS 273

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 525343597 185 LGYSPEDIIGNIFRVCKTFQMAEYLKL----EFIKEIGYTHMKIAEGVN 229
Cdd:PRK14961 274 IGIEWENILIEMLRFLHHISMSQSFPKiwntIFIKNYKNQIQKIAQNNK 322
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 5-148 5.22e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 59.34  E-value: 5.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMfAQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK08691  96 ASNTGIDNIREVLEN-AQYAPTA--GKYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPHKVPVTVLSRCLQ 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENV 148
Cdd:PRK08691 173 FVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALSLLdQAIALGSGKVAENDV 237
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 27-133 5.22e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 58.98  E-value: 5.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  27 LP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEK 105
Cdd:PRK14965 114 LPsRSRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFRRIPLQKIVDRLRYIADQ 193

                         90       100
                 ....*....|....*....|....*...
gi 525343597 106 ERVPYTDDGLEAIIFTAQGDMRQALNNL 133
Cdd:PRK14965 194 EGISISDAALALVARKGDGSMRDSLSTL 221
PRK08451 PRK08451
DNA polymerase III subunits gamma and tau; Validated
 6-216 5.61e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236267 [Multi-domain]  Cd Length: 535  Bit Score: 58.89  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   6 SLRGIDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVL 85
Cdd:PRK08451  95 SNRGIDDIRELIE---QTKYKPSMARFKIFIIDEVHMLTKEAFNALLKTLEEPPSYVKFILATTDPLKLPATILSRTQHF 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  86 RYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKVCDEPHPLLVKEMI 164
Cdd:PRK08451 172 RFKQIPQNSIISHLKTILEKEGVSYEPEALEILARSGNGSLRDTLTLLdQAIIYCKNAITESKVADMLGLLDPSKLEDFF 251

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 525343597 165 QHCVN---ANIDEAYKILAhlwhlGYSPEDIIGnifrvcktfQMAEYLKLEFIKE 216
Cdd:PRK08451 252 QAILNqdkEKLFELLKELE-----DYEAEMVLD---------EMMLFLKEKFLSK 292
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
 10-130 5.69e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 58.51  E-value: 5.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  10 IDVVRNKIKMFAQqkvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTK 89
Cdd:PRK09112 123 VDEIRRVGHFLSQ---TSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLKP 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 525343597  90 LTDAQILTRLMNVIEKerVPYTDDGLEAIIFTAQGDMRQAL 130
Cdd:PRK09112 200 LDDDELKKALSHLGSS--QGSDGEITEALLQRSKGSVRKAL 238
PRK04195 PRK04195
replication factor C large subunit; Provisional
 8-148 6.36e-10

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 58.78  E-value: 6.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   8 RGIDVVRNKIKMFAQQKvTLPKGRHKIIILDEADSM---TD-GAQQALRRTMeiysKTTRFALACNASD---KIIEPIQS 80
Cdd:PRK04195  76 RTADVIERVAGEAATSG-SLFGARRKLILLDEVDGIhgnEDrGGARAILELI----KKAKQPIILTANDpydPSLRELRN 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525343597  81 RCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENV 148
Cdd:PRK04195 151 ACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGYGKLTLEDV 218
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 30-148 1.00e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 58.22  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  30 GRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVP 109
Cdd:PRK14969 118 GRFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQMPPPLIVSHLQHILEQENIP 197

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 525343597 110 YTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENV 148
Cdd:PRK14969 198 FDATALQLLARAAAGSMRDALSLLdQAIAYGGGTVNESEV 237
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 5-133 5.44e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 56.23  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14959  96 ASNRGIDDAKRLKEAIGYAPM---EGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFPVTIVSRCQH 172

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 133
Cdd:PRK14959 173 FTFTRLSEAGLEAHLTKVLGREGVDYDPAAVRLIARRAAGSVRDSMSLL 221
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 18-133 6.35e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 55.48  E-value: 6.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  18 KMFAQQKVTLPKGRHKIIILDEADSMTDGAQQAL-----RRTMEIYSKTTRfalacNASDKIIEPIQSRCAVLRYTKLTD 92
Cdd:PRK13342  79 EVIEEARQRRSAGRRTILFIDEIHRFNKAQQDALlphveDGTITLIGATTE-----NPSFEVNPALLSRAQVFELKPLSE 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 525343597  93 A---QILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 133
Cdd:PRK13342 154 EdieQLLKRALEDKERGLVELDDEALDALARLANGDARRALNLL 197
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
 29-165 6.66e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 55.89  E-value: 6.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14958 117 KGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHHKLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENV 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKVCDEPHPLLVKEMIQ 165
Cdd:PRK14958 197 EFENAALDLLARAANGSVRDALSLLdQSIAYGNGKVLIADVKTMLGTIEPLLLFDILE 254
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 31-141 6.97e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 55.59  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  31 RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPY 110
Cdd:PRK14950 120 RYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEVHKVPATILSRCQRFDFHRHSVADMAAHLRKIAAAEGINL 199

                         90       100       110
                 ....*....|....*....|....*....|.
gi 525343597 111 TDDGLEAIIFTAQGDMRQALNNLQSTFSGFG 141
Cdd:PRK14950 200 EPGALEAIARAATGSMRDAENLLQQLATTYG 230
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 5-129 9.00e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 55.16  E-value: 9.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVR--NKIKMFaqqkvTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 82
Cdd:PRK06305  98 ASHRGIEDIRqiNETVLF-----TPSKSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIHKIPGTILSRC 172

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 525343597  83 AVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 129
Cdd:PRK06305 173 QKMHLKRIPEETIIDKLALIAKQEGIETSREALLPIARAAQGSLRDA 219
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 29-129 1.69e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 54.56  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14954 125 KGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIASRCQRFNFKRIPLDEIQSQLQMICRAEGI 204

                         90       100
                 ....*....|....*....|.
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQA 129
Cdd:PRK14954 205 QIDADALQLIARKAQGSMRDA 225
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
10-139 1.96e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 54.40  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  10 IDVVRNKIKmfaQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTK 89
Cdd:PRK14971 103 VDDIRNLIE---QVRIPPQIGKYKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHKILPTILSRCQIFDFNR 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 525343597  90 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN--NLQSTFSG 139
Cdd:PRK14971 180 IQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSifDQVVSFTG 231
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
 29-196 4.24e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 53.32  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK06645 126 QGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISRCQRYDLRRLSFEEIFKLLEYITKQENL 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQA---LNNLQSTFSGFGFINSENVF-KVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWH 184
Cdd:PRK06645 206 KTDIEALRIIAYKSEGSARDAvsiLDQAASMSAKSDNIISPQVInQMLGLVDSSVIIEFVEYIIHRETEKAINLINKLYG 285

                        170
                 ....*....|..
gi 525343597 185 LGYSPEDIIGNI 196
Cdd:PRK06645 286 SSVNLEIFIESV 297
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
 5-131 7.31e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 52.64  E-value: 7.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDVVRnkiKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14956  98 ASNRGIENIR---ELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETILSRCQD 174

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525343597  85 LRYTKLTdaqiLTRLMNVIEK----ERVPYTDDGLEAIIFTAQGDMRQALN 131
Cdd:PRK14956 175 FIFKKVP----LSVLQDYSEKlckiENVQYDQEGLFWIAKKGDGSVRDMLS 221
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 4-82 1.57e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.45  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   4 TSSLRGIDVVRNKIKMFA--QQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTT------RFALACNASD--K 73
Cdd:cd00009   55 ASDLLEGLVVAELFGHFLvrLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNDLRidrenvRVIGATNRPLlgD 134


                 ....*....
gi 525343597  74 IIEPIQSRC 82
Cdd:cd00009  135 LDRALYDRL 143
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
5-130 2.10e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 51.42  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDvvrnKIKMFAQQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCA 83
Cdd:PRK12323 101 ASNRGVD----EMAQLLDKAVYAPtAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCL 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 525343597  84 VLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 130
Cdd:PRK12323 177 QFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAAQGSMRDAL 223
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
 29-129 2.46e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 51.05  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14955 125 KGRYRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIASRCQRFNFKRIPLEEIQQQLQGICEAEGI 204

                         90       100
                 ....*....|....*....|.
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQA 129
Cdd:PRK14955 205 SVDADALQLIGRKAQGSMRDA 225
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
29-148 4.86e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 50.43  E-value: 4.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14960 116 QGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQI 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQALN-NLQSTFSGFGFINSENV 148
Cdd:PRK14960 196 AADQDAIWQIAESAQGSLRDALSlTDQAIAYGQGAVHHQDV 236
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
5-130 5.85e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 5.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   5 SSLRGIDvvrnkiKMFA--QQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSR 81
Cdd:PRK07003  96 ASNRGVD------EMAAllERAVYAPvDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSR 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 525343597  82 CAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 130
Cdd:PRK07003 170 CLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDAL 218
PRK06871 PRK06871
DNA polymerase III subunit delta'; Validated
 9-84 6.57e-07

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180738 [Multi-domain]  Cd Length: 325  Bit Score: 49.35  E-value: 6.57e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525343597   9 GIDVVRN---KIKMFAQQkvtlpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK06871  88 GVDQVREineKVSQHAQQ------GGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRCQT 160
HLD_clamp cd18133
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ...
 93-135 1.13e-06

helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.


Pssm-ID: 350838 [Multi-domain]  Cd Length: 65  Bit Score: 44.77  E-value: 1.13e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 525343597  93 AQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQS 135
Cdd:cd18133    4 EQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQR 46
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 9-97 1.79e-06

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 48.10  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   9 GIDVVRNKIKMFAQQKVtlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYT 88
Cdd:PRK05564  74 GVDDIRNIIEEVNKKPY---EGDKKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQIYKLN 150


                 ....*....
gi 525343597  89 KLTDAQILT 97
Cdd:PRK05564 151 RLSKEEIEK 159
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 6-202 3.76e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 47.56  E-value: 3.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   6 SLRGIDVVRNKIkmfaqQKVTLP--KGRHKIIILDEADSMTDGAQQALRRTME------IyskttrFALACNASDKIIEP 77
Cdd:PRK05563  97 SNNGVDEIRDIR-----DKVKYApsEAKYKVYIIDEVHMLSTGAFNALLKTLEeppahvI------FILATTEPHKIPAT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  78 IQSRCAvlRY--TKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QS-TFSGfGFINSENVFK--- 150
Cdd:PRK05563 166 ILSRCQ--RFdfKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALSILdQAiSFGD-GKVTYEDALEvtg 242

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 151 -VCDEphplLVKEMIQHCVNANIDEAYKILAHLWHLGYSP----EDIIGnIFR---VCKT 202
Cdd:PRK05563 243 sVSQE----ALDDLVDAIVEGDVAKALKILEELLDEGKDPnrfiEDLIY-YLRdllLVKT 297
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 6-130 7.43e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.63  E-value: 7.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597   6 SLRGIDvvrnKIKMFAQQKVTLP-KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV 84
Cdd:PRK14951 102 SNRGVD----EVQQLLEQAVYKPvQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQ 177

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 525343597  85 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQAL 130
Cdd:PRK14951 178 FNLRPMAPETVLEHLTQVLAAENVPAEPQALRLLARAARGSMRDAL 223
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
 30-193 1.63e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 45.53  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  30 GRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVP 109
Cdd:PRK06647 118 SRYRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHKLPATIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIK 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597 110 YTDDGLEAIIFTAQGDMRQA---------LNNLQSTF----SGFGFINSENVFKVcdephpllvkemIQHCVNANIDEAY 176
Cdd:PRK06647 198 YEDEALKWIAYKSTGSVRDAytlfdqvvsFSDSDITLeqirSKMGLTGDEFLEKL------------ASSILNEDAKELL 265

                        170
                 ....*....|....*..
gi 525343597 177 KILAHLWHLGYSPEDII 193
Cdd:PRK06647 266 CVLDSVFLSGVSVEQFL 282
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
 9-91 2.97e-05

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 42.97  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597    9 GIDVVRnKIKMFAQQKVTlpKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYT 88
Cdd:pfam13177  82 KIDQIR-ELQKEFSKSPY--EGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFK 158


                  ...
gi 525343597   89 KLT 91
Cdd:pfam13177 159 PLS 161
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 90-134 3.66e-04

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 38.00  E-value: 3.66e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525343597  90 LTDAQILTRLMNVIEKER------VPYTDDGLEAIIFTAQGDMRQALNNLQ 134
Cdd:cd18139    1 LSEEDLEKLLKRALEDKErggdrkVTIDDEALELLAEAADGDARSALNLLE 51
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
 21-82 8.59e-04

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 39.79  E-value: 8.59e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525343597  21 AQQKVTLpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 82
Cdd:PRK06090 100 AQESSQL--NGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRC 159
PRK07940 PRK07940
DNA polymerase III subunit delta'; Validated
 9-82 1.56e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236134 [Multi-domain]  Cd Length: 394  Bit Score: 39.12  E-value: 1.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525343597   9 GIDVVRNKIKMFAQQKVTlpkGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRC 82
Cdd:PRK07940  98 GVDEVRELVTIAARRPST---GRWRIVVIEDADRLTERAANALLKAVEEPPPRTVWLLCAPSPEDVLPTIRSRC 168
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 29-130 1.89e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 39.32  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343597  29 KGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERV 108
Cdd:PRK14949 117 RGRFKVYLIDEVHMLSRSSFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKSLTQDEIGTQLNHILTQEQL 196

                         90       100
                 ....*....|....*....|..
gi 525343597 109 PYTDDGLEAIIFTAQGDMRQAL 130
Cdd:PRK14949 197 PFEAEALTLLAKAANGSMRDAL 218
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
 90-131 5.86e-03

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 34.40  E-value: 5.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 525343597  90 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN 131
Cdd:cd18137    1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALS 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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