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Conserved domains on  [gi|525343614|ref|NP_001265722|]
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replication factor C subunit 2 isoform 5 [Homo sapiens]

Protein Classification

replication factor C subunit family protein( domain architecture ID 1001989)

replication factor C subunit family protein such as Saccharomyces cerevisiae replication factor C subunit 4 (RFC4) that is involved in unwinding DNA templates and provide energy for DNA polymerase during DNA replication

Gene Ontology:  GO:0005524|GO:0003677|GO:0006260

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03025 super family cl31966
replication factor C subunit; Provisional
 9-213 2.34e-136

replication factor C subunit; Provisional


The actual alignment was detected with superfamily member PLN03025:

Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 384.85  E-value: 2.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIF 88
Cdd:PLN03025 109 DSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIF 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVC 168
Cdd:PLN03025 189 TADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVV 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 525343614 169 KTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKT 213
Cdd:PLN03025 269 KNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLVR 313
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 9-213 2.34e-136

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 384.85  E-value: 2.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIF 88
Cdd:PLN03025 109 DSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIF 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVC 168
Cdd:PLN03025 189 TADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVV 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 525343614 169 KTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKT 213
Cdd:PLN03025 269 KNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLVR 313
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 123-208 4.22e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 109.10  E-value: 4.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  123 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 201
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343614  202 MAGLLAR 208
Cdd:pfam08542  81 LSALLAA 87
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
9-211 3.63e-25

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 99.66  E-value: 3.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIF 88
Cdd:COG0470  111 DAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFRPPSEEEALAWL----REEGV--DEDALEAILR 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEPHPLlvkEMIQHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvc 168
Cdd:COG0470  185 LAGGDPRAAINLLQALAGRKELL--EDLAALLSRDRAL---ELLDALLKAEALELLDWLLKW---------LLDNLP--- 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 525343614 169 ktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQ 211
Cdd:COG0470  248 --LEYAGEDLARAYEALSEADRRLGRYANDRLLLEALLAKLGR 288
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 58-120 4.97e-22

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 85.27  E-value: 4.97e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343614  58 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 120
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
 
Name Accession Description Interval E-value
PLN03025 PLN03025
replication factor C subunit; Provisional
 9-213 2.34e-136

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 384.85  E-value: 2.34e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIF 88
Cdd:PLN03025 109 DSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIF 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVC 168
Cdd:PLN03025 189 TADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIVRNCLKGKFDDACDGLKQLYDLGYSPTDIITTLFRVV 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 525343614 169 KTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKT 213
Cdd:PLN03025 269 KNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLVR 313
rfc PRK00440
replication factor C small subunit; Reviewed
 9-209 8.00e-70

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 215.89  E-value: 8.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIF 88
Cdd:PRK00440 112 DNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQSRCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYY 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHL-GYSPEDIIGNIFRV 167
Cdd:PRK00440 192 VSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEIREMIELALNGDFTEAREKLRDLMIDyGLSGEDIIKQIHRE 271

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 525343614 168 CKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 209
Cdd:PRK00440 272 VWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLAKL 313
PRK04132 PRK04132
replication factor C small subunit; Provisional
 9-209 1.26e-48

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 170.02  E-value: 1.26e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIF 88
Cdd:PRK04132 640 DALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILY 719

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAH-LWHLGYSPEDIIGNIFRV 167
Cdd:PRK04132 720 IAEGDMRRAINILQAAAALDDKITDENVFLVASRARPEDIREMMLLALKGNFLKAREKLREiLLKQGLSGEDVLVQMHRE 799

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 525343614 168 CKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 209
Cdd:PRK04132 800 VFNLPIDEPKKVELADKIGEYNFRLVEGANEMIQLEALLAQF 841
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 10-209 4.28e-35

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 126.64  E-value: 4.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  10 SMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFT 89
Cdd:PRK12402 136 ALREDAQQALRRIMEQYSRTCRFIIATRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYY 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  90 AQGDMRQALNNLQSTFSGFGFINSENVFKVC-DEPHPLLVKEMIQHCVNANIDEAYKILAHLwhL---GYSPEDIIGNIF 165
Cdd:PRK12402 216 AGGDLRKAILTLQTAALAAGEITMEAAYEALgDVGTDEVIESLLDAAEAGDFTDARKTLDDL--LideGLSGGEVLEELL 293

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 525343614 166 RVCKTFQmAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARL 209
Cdd:PRK12402 294 RVARSRY-RGDNLARLHRLAADADARLTDGANDRIQLEALLAEL 336
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 123-208 4.22e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 109.10  E-value: 4.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  123 PHPLLVKEMIQHCVNANIDEAYKIL-AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQ 201
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVrELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 525343614  202 MAGLLAR 208
Cdd:pfam08542  81 LSALLAA 87
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
9-211 3.63e-25

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 99.66  E-value: 3.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLmnviEKERVpyTDDGLEAIIF 88
Cdd:COG0470  111 DAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFRPPSEEEALAWL----REEGV--DEDALEAILR 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  89 TAQGDMRQALNNLQSTFSGFGFInsENVFKVCDEPHPLlvkEMIQHCVNANIDEAYKILAHLwhlgyspedIIGNIFrvc 168
Cdd:COG0470  185 LAGGDPRAAINLLQALAGRKELL--EDLAALLSRDRAL---ELLDALLKAEALELLDWLLKW---------LLDNLP--- 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 525343614 169 ktFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQ 211
Cdd:COG0470  248 --LEYAGEDLARAYEALSEADRRLGRYANDRLLLEALLAKLGR 288
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 58-120 4.97e-22

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 85.27  E-value: 4.97e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525343614  58 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVC 120
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 11-156 5.90e-16

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 75.63  E-value: 5.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14953 131 LTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQAS 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  91 QGDMRQALNNL-QSTFSGFGFINS---ENVFKVCDEPHpllVKEMIQHCVNANIDEAYKILAHLWHLGYS 156
Cdd:PRK14953 211 EGGMRDAASLLdQASTYGEGKVTIkvvEEFLGIVSQES---VRKFLNLLLESDVDEAIKFLRTLEEKGYN 277
44 PHA02544
clamp loader, small subunit; Provisional
 6-113 1.36e-14

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 71.17  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   6 ASNDSMTDgAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDA-------QILTRLMNVIEKERVPY 78
Cdd:PHA02544 109 FDRLGLAD-AQRHLRSFMEAYSKNCSFIITANNKNGIIEPLRSRCRVIDFGVPTKEeqiemmkQMIVRCKGILEAEGVEV 187

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 525343614  79 TDDGLEAIIFTAQGDMRQALNNLQStFSGFGFINS 113
Cdd:PHA02544 188 DMKVLAALVKKNFPDFRRTINELQR-YASTGKIDA 221
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
11-161 4.89e-12

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 64.06  E-value: 4.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:COG2812  126 LTTEAFNALLKTLEEPPPHVVFILATTEPQKLLPTILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAA 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525343614  91 QGDMRQALNNLQSTfSGFGFINSENvfkvcdephplLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDII 161
Cdd:COG2812  206 DGSMRDALSLLDQA-IAFGLLDRRE-----------LLLDLLEALLAGDVAALLALAEELAKRGRDLKRFL 264
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 11-193 2.84e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 59.01  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14962 129 LTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRA 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  91 QGDMRQALNNLQ--STFSGfGFINSENVFK----VCDEphplLVKEMIQHCVNANIDEAYKILAHLWHLGYSP------- 157
Cdd:PRK14962 209 SGGLRDALTMLEqvWKFSE-GKITLETVHEalglIPIE----VVRDYINAIFNGDVKRVFTVLDDVYYSGKDYevliqqa 283

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 525343614 158 -EDIIGNIFRVcKTFQMAEYLK--LEFIKEIGYTHMKIA 193
Cdd:PRK14962 284 iEDLVEDLERE-RANDIIQVSRqlLNILREIKFAEEKRL 321
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 37-101 9.54e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 54.32  E-value: 9.54e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525343614  37 NASDKIIEPIQSRCAVLRYTKLTDA---QILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 101
Cdd:PRK13342 130 NPSFEVNPALLSRAQVFELKPLSEEdieQLLKRALEDKERGLVELDDEALDALARLANGDARRALNLL 197
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 1-168 9.99e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 54.41  E-value: 9.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   1 MLELNASNdsmtdgaqqALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTD 80
Cdd:PRK14964 127 MLSNSAFN---------ALLKTLEEPAPHVKFILATTEVKKIPVTIISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDE 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  81 DGLEAIIFTAQGDMRQALNNL-QSTFSGFGFINSENVFKV--CDEPHPLLvkEMIQHCVNANIDEAYKILAHLWHLgYSP 157
Cdd:PRK14964 198 ESLKLIAENSSGSMRNALFLLeQAAIYSNNKISEKSVRDLlgCVDKHILE--DLVEAILLGDAQSALNVFRELCNT-SNP 274

                        170
                 ....*....|....*
gi 525343614 158 ----EDIIGNIFRVC 168
Cdd:PRK14964 275 viilEGMLQIIYEIC 289
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
 11-107 6.34e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 52.18  E-value: 6.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14970 120 LSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKA 199

                         90
                 ....*....|....*....
gi 525343614  91 QGDMRQALN--NLQSTFSG 107
Cdd:PRK14970 200 DGALRDALSifDRVVTFCG 218
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 18-197 3.98e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 49.42  E-value: 3.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  18 ALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 97
Cdd:PRK14961 138 ALLKTLEEPPQHIKFILATTDVEKIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESIDTDEYALKLIAYHAHGSMRDA 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  98 LNNLQSTFS-GFGFINSENVFK---VCDEPHPLLVKEMIqhcVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQM 173
Cdd:PRK14961 218 LNLLEHAINlGKGNINIKNVTDmlgLLNEKQSFLLTDAL---LKKDSKKTMLLLNKISSIGIEWENILIEMLRFLHHISM 294

                        170       180
                 ....*....|....*....|....*...
gi 525343614 174 AEYLKL----EFIKEIGYTHMKIAEGVN 197
Cdd:PRK14961 295 SQSFPKiwntIFIKNYKNQIQKIAQNNK 322
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 18-151 8.49e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 48.92  E-value: 8.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  18 ALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 97
Cdd:PRK14957 138 ALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDA 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525343614  98 LNNLQSTFS-------------GFGFINSENVFKVCD---EPHPLLVKEMIQH--CVNANIDEAYKILAHLW 151
Cdd:PRK14957 218 LSLLDQAISfcggelkqaqikqMLGIIDSEEVYSIINaiiDNDPKAILPAIKNlaLTESSADAVLDRIAEIW 289
HLD_clamp cd18133
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ...
 61-103 1.22e-06

helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.


Pssm-ID: 350838 [Multi-domain]  Cd Length: 65  Bit Score: 44.38  E-value: 1.22e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 525343614  61 AQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQS 103
Cdd:cd18133    4 EQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQR 46
PRK04195 PRK04195
replication factor C large subunit; Provisional
 45-116 3.93e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.84  E-value: 3.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525343614  45 PIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENV 116
Cdd:PRK04195 147 ELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGYGKLTLEDV 218
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 11-97 6.10e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 46.37  E-value: 6.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14963 128 MSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPTILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEPEALQLVARLA 207


                 ....*..
gi 525343614  91 QGDMRQA 97
Cdd:PRK14963 208 DGAMRDA 214
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 1-109 6.69e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 46.34  E-value: 6.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   1 MLELNASNdsmtdgaqqALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTD 80
Cdd:PRK14950 131 MLSTAAFN---------ALLKTLEEPPPHAIFILATTEVHKVPATILSRCQRFDFHRHSVADMAAHLRKIAAAEGINLEP 201

                         90       100
                 ....*....|....*....|....*....
gi 525343614  81 DGLEAIIFTAQGDMRQALNNLQSTFSGFG 109
Cdd:PRK14950 202 GALEAIARAATGSMRDAENLLQQLATTYG 230
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 1-101 8.63e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 45.89  E-value: 8.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   1 MLELNASNdsmtdgaqqALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTD 80
Cdd:PRK14965 130 MLSTNAFN---------ALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFRRIPLQKIVDRLRYIADQEGISISD 200

                         90       100
                 ....*....|....*....|.
gi 525343614  81 DGLEAIIFTAQGDMRQALNNL 101
Cdd:PRK14965 201 AALALVARKGDGSMRDSLSTL 221
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 11-116 1.51e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 45.12  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14969 131 LSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQMPPPLIVSHLQHILEQENIPFDATALQLLARAA 210

                         90       100
                 ....*....|....*....|....*..
gi 525343614  91 QGDMRQALNNL-QSTFSGFGFINSENV 116
Cdd:PRK14969 211 AGSMRDALSLLdQAIAYGGGTVNESEV 237
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
 18-133 4.73e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 43.57  E-value: 4.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  18 ALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 97
Cdd:PRK14958 138 ALLKTLEEPPSHVKFILATTDHHKLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENVEFENAALDLLARAANGSVRDA 217

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 525343614  98 LNNL-QSTFSGFGFINSENVFKVCDEPHPLLVKEMIQ 133
Cdd:PRK14958 218 LSLLdQSIAYGNGKVLIADVKTMLGTIEPLLLFDILE 254
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 11-116 1.04e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.77  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK08691 131 LSKSAFNAMLKTLEEPPEHVKFILATTDPHKVPVTVLSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAA 210

                         90       100
                 ....*....|....*....|....*..
gi 525343614  91 QGDMRQALNNL-QSTFSGFGFINSENV 116
Cdd:PRK08691 211 AGSMRDALSLLdQAIALGSGKVAENDV 237
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
11-98 2.89e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK07003 131 LTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAA 210


                 ....*...
gi 525343614  91 QGDMRQAL 98
Cdd:PRK07003 211 QGSMRDAL 218
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
 9-98 3.21e-04

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 40.79  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   9 DSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKerVPYTDDGLEAIIF 88
Cdd:PRK09112 151 DDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLKPLDDDELKKALSHLGSS--QGSDGEITEALLQ 228

                         90
                 ....*....|
gi 525343614  89 TAQGDMRQAL 98
Cdd:PRK09112 229 RSKGSVRKAL 238
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 58-102 4.53e-04

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 37.61  E-value: 4.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525343614  58 LTDAQILTRLMNVIEKER------VPYTDDGLEAIIFTAQGDMRQALNNLQ 102
Cdd:cd18139    1 LSEEDLEKLLKRALEDKErggdrkVTIDDEALELLAEAADGDARSALNLLE 51
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1-107 8.21e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.76  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614   1 MLELNASNdsmtdgaqqALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTD 80
Cdd:PRK14971 132 MLSQAAFN---------AFLKTLEEPPSYAIFILATTEKHKILPTILSRCQIFDFNRIQVADIVNHLQYVASKEGITAEP 202

                         90       100
                 ....*....|....*....|....*....
gi 525343614  81 DGLEAIIFTAQGDMRQALN--NLQSTFSG 107
Cdd:PRK14971 203 EALNVIAQKADGGMRDALSifDQVVSFTG 231
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
18-116 9.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 39.65  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  18 ALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA 97
Cdd:PRK14960 137 ALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQIAADQDAIWQIAESAQGSLRDA 216

                         90       100
                 ....*....|....*....|
gi 525343614  98 LN-NLQSTFSGFGFINSENV 116
Cdd:PRK14960 217 LSlTDQAIAYGQGAVHHQDV 236
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 11-97 9.62e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.54  E-value: 9.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK14954 139 LSTAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIASRCQRFNFKRIPLDEIQSQLQMICRAEGIQIDADALQLIARKA 218


                 ....*..
gi 525343614  91 QGDMRQA 97
Cdd:PRK14954 219 QGSMRDA 225
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
11-98 1.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK12323 136 LTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAA 215


                 ....*...
gi 525343614  91 QGDMRQAL 98
Cdd:PRK12323 216 QGSMRDAL 223
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
 11-99 2.76e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 38.39  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTdaqiLTRLMNVIEK----ERVPYTDDGLEAI 86
Cdd:PRK14956 133 LTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETILSRCQDFIFKKVP----LSVLQDYSEKlckiENVQYDQEGLFWI 208

                         90
                 ....*....|...
gi 525343614  87 IFTAQGDMRQALN 99
Cdd:PRK14956 209 AKKGDGSVRDMLS 221
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
 11-164 3.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 37.92  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  11 MTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTA 90
Cdd:PRK06645 140 LSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKS 219

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525343614  91 QGDMRQA---LNNLQSTFSGFGFINSENVF-KVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNI 164
Cdd:PRK06645 220 EGSARDAvsiLDQAASMSAKSDNIISPQVInQMLGLVDSSVIIEFVEYIIHRETEKAINLINKLYGSSVNLEIFIESV 297
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 46-170 4.86e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 37.54  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  46 IQSRCAvlRY--TKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL-QS-TFSGfGFINSENVFK--- 118
Cdd:PRK05563 166 ILSRCQ--RFdfKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALSILdQAiSFGD-GKVTYEDALEvtg 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614 119 -VCDEphplLVKEMIQHCVNANIDEAYKILAHLWHLGYSP----EDIIGnIFR---VCKT 170
Cdd:PRK05563 243 sVSQE----ALDDLVDAIVEGDVAKALKILEELLDEGKDPnrfiEDLIY-YLRdllLVKT 297
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
 58-99 5.62e-03

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 34.40  E-value: 5.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 525343614  58 LTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALN 99
Cdd:cd18137    1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALS 42
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
 15-97 7.12e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 36.79  E-value: 7.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525343614  15 AQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDM 94
Cdd:PRK14955 143 AFNAFLKTLEEPPPHAIFIFATTELHKIPATIASRCQRFNFKRIPLEEIQQQLQGICEAEGISVDADALQLIGRKAQGSM 222


                 ...
gi 525343614  95 RQA 97
Cdd:PRK14955 223 RDA 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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