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Conserved domains on  [gi|526253088|ref|NP_001268227|]
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endothelial differentiation-related factor 1 isoform 4 [Homo sapiens]

Protein Classification

EDF1/MBF1 family transcription factor( domain architecture ID 12094462)

EDF1/MBF1 family transcription factor such as vertebrate endothelial differentiation-related factor (EDF1) and multiprotein bridging factor 1 (MBF1), which function as transcriptional coactivators

Gene Ontology:  GO:0003677
PubMed:  2644244|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-71 1.22e-26

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


:

Pssm-ID: 462508  Cd Length: 68  Bit Score: 94.23  E-value: 1.22e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 526253088    5 DWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQ-HSITKNTAKLDRETEELHHD 71
Cdd:pfam08523   1 DWDSVTVIGKKAPRATVARSESALNAARRSGAVVETEKKFYAGTNKAhHGEGQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 76-111 1.57e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.61  E-value: 1.57e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 526253088  76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKL 111
Cdd:COG1813   33 EKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
 
Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-71 1.22e-26

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


Pssm-ID: 462508  Cd Length: 68  Bit Score: 94.23  E-value: 1.22e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 526253088    5 DWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQ-HSITKNTAKLDRETEELHHD 71
Cdd:pfam08523   1 DWDSVTVIGKKAPRATVARSESALNAARRSGAVVETEKKFYAGTNKAhHGEGQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 76-111 1.57e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.61  E-value: 1.57e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 526253088  76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKL 111
Cdd:COG1813   33 EKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
76-112 1.12e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.80  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 526253088    76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLR 112
Cdd:smart00530  18 EKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 76-112 4.15e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 33.28  E-value: 4.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 526253088   76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLR 112
Cdd:pfam01381  17 EKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLD 53
 
Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-71 1.22e-26

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


Pssm-ID: 462508  Cd Length: 68  Bit Score: 94.23  E-value: 1.22e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 526253088    5 DWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQ-HSITKNTAKLDRETEELHHD 71
Cdd:pfam08523   1 DWDSVTVIGKKAPRATVARSESALNAARRSGAVVETEKKFYAGTNKAhHGEGQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 76-111 1.57e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.61  E-value: 1.57e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 526253088  76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKL 111
Cdd:COG1813   33 EKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
76-112 1.12e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.80  E-value: 1.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 526253088    76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLR 112
Cdd:smart00530  18 EKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 76-112 4.15e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 33.28  E-value: 4.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 526253088   76 EKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLR 112
Cdd:pfam01381  17 EKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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