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Conserved domains on  [gi|527317371|ref|NP_001268392|]
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structural maintenance of chromosomes protein 1A isoform 2 [Homo sapiens]

Protein Classification

ABC_SMC4_euk domain-containing protein( domain architecture ID 12035156)

ABC_SMC4_euk domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-1188 5.51e-174

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


:

Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 545.34  E-value: 5.51e-174
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTS-NLRVKTLRDLIHgaPVGKPAANRAFVSMVYSEEGA-------EDRTFARVIVGGSSEYKIN 86
Cdd:pfam02463   35 GKSNILDAILFVLGERSAkSLRSERLSDLIH--SKSGAFVNSAEVEITFDNEDHelpidkeEVSIRRRVYRGGDSEYYIN 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    87 NKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR 166
Cdd:pfam02463  113 GKNVTKKEVAELLESQGISPEAYNFLVQGGKIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDL 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   167 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 246
Cdd:pfam02463  193 EELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLK 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   247 ELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQ 326
Cdd:pfam02463  273 ENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKRE 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   327 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 406
Cdd:pfam02463  353 AEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEIL 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   407 EENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 486
Cdd:pfam02463  433 EEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVL 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   487 RLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLREL 566
Cdd:pfam02463  513 LALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   567 KGAKLVIDVIRYEpphikkalqyacgnalvcdnvedarriafgghqrhktvaldgtlfqksgvisggASDLKAKARRWDE 646
Cdd:pfam02463  593 SIAVLEIDPILNL------------------------------------------------------AQLDKATLEADED 618

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   647 KAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRI 726
Cdd:pfam02463  619 DKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQ 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   727 NDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQL 806
Cdd:pfam02463  699 LEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAE 778

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   807 KEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHL 886
Cdd:pfam02463  779 EREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELER 858

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   887 QKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCE 966
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   967 DLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1046
Cdd:pfam02463  939 ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1047 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYK 1126
Cdd:pfam02463 1019 LKEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSGGIEISARPPGKGVKNLDLLSGGEKTLVALALIFAIQKYK 1098

                         1130      1140      1150      1160      1170      1180
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  1127 PAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGVYPEQGDC 1188
Cdd:pfam02463 1099 PAPFYLLDEIDAALDDQNVSRVANLLKELSK-NAQFIVISLREEMLEKADKLVGVTMVENGV 1159
 
Name Accession Description Interval E-value
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-1188 5.51e-174

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 545.34  E-value: 5.51e-174
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTS-NLRVKTLRDLIHgaPVGKPAANRAFVSMVYSEEGA-------EDRTFARVIVGGSSEYKIN 86
Cdd:pfam02463   35 GKSNILDAILFVLGERSAkSLRSERLSDLIH--SKSGAFVNSAEVEITFDNEDHelpidkeEVSIRRRVYRGGDSEYYIN 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    87 NKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR 166
Cdd:pfam02463  113 GKNVTKKEVAELLESQGISPEAYNFLVQGGKIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDL 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   167 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 246
Cdd:pfam02463  193 EELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLK 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   247 ELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQ 326
Cdd:pfam02463  273 ENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKRE 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   327 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 406
Cdd:pfam02463  353 AEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEIL 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   407 EENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 486
Cdd:pfam02463  433 EEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVL 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   487 RLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLREL 566
Cdd:pfam02463  513 LALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   567 KGAKLVIDVIRYEpphikkalqyacgnalvcdnvedarriafgghqrhktvaldgtlfqksgvisggASDLKAKARRWDE 646
Cdd:pfam02463  593 SIAVLEIDPILNL------------------------------------------------------AQLDKATLEADED 618

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   647 KAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRI 726
Cdd:pfam02463  619 DKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQ 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   727 NDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQL 806
Cdd:pfam02463  699 LEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAE 778

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   807 KEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHL 886
Cdd:pfam02463  779 EREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELER 858

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   887 QKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCE 966
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   967 DLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1046
Cdd:pfam02463  939 ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1047 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYK 1126
Cdd:pfam02463 1019 LKEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSGGIEISARPPGKGVKNLDLLSGGEKTLVALALIFAIQKYK 1098

                         1130      1140      1150      1160      1170      1180
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  1127 PAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGVYPEQGDC 1188
Cdd:pfam02463 1099 PAPFYLLDEIDAALDDQNVSRVANLLKELSK-NAQFIVISLREEMLEKADKLVGVTMVENGV 1159
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 15-1181 1.28e-85

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 303.14  E-value: 1.28e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTSN-LRVKTLRDLIHGAPVGKPAaNRAFVSMVYSEEGA----EDRTFARVIV---GGSSEYKIN 86
Cdd:TIGR02169   35 GKSNIGDAILFALGLSSSKaMRAERLSDLISNGKNGQSG-NEAYVTVTFKNDDGkfpdELEVVRRLKVtddGKYSYYYLN 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    87 NKVVQLHEYSEELEKLGILIKARNFlVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR 166
Cdd:TIGR02169  114 GQRVRLSEIHDFLAAAGIYPEGYNV-VLQGDVTDFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLI 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   167 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 246
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQ 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   247 ELGKMMR--------EQQQIEKEIKEKDSELNQKRPQyIKAKEntshkiKKLEAAKKSLQNAQKHYKKRKGDMDELEKEm 318
Cdd:TIGR02169  273 LLEELNKkikdlgeeEQLRVKEKIGELEAEIASLERS-IAEKE------RELEDAEERLAKLEAEIDKLLAEIEELERE- 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   319 LSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHR-LKEEASKRAATLAQ---ELEKFNRDQKADQDRLDLEERKKVE 394
Cdd:TIGR02169  345 IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAeTRDELKDYREKLEKlkrEINELKRELDRLQEELQRLSEELAD 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   395 TEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSR 474
Cdd:TIGR02169  425 LNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEE 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   475 QQRKAEIMESIKRLYPGSVYGRLIDLCQpTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYL 554
Cdd:TIGR02169  505 RVRGGRAVEEVLKASIQGVHGTVAQLGS-VGERYATAIEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLNKM 583

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   555 EVKPTDEKLRELKGA-KLVIDVIRYEPpHIKKALQYACGNALVCDNVEDARRIAfgghQRHKTVALDGTLFQKSGVISGG 633
Cdd:TIGR02169  584 RDERRDLSILSEDGViGFAVDLVEFDP-KYEPAFKYVFGDTLVVEDIEAARRLM----GKYRMVTLEGELFEKSGAMTGG 658

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   634 AsdlkaKARRWDEKAVDKLKEKKERLTEELKEqmkAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQtKTRHLALNLQEks 713
Cdd:TIGR02169  659 S-----RAPRGGILFSRSEPAELQRLRERLEG---LKRELSSLQSELRRIENRLDELSQELSDASR-KIGEIEKEIEQ-- 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   714 kLESELANFGPRINDIKRIIQSREREMKDLKEKMnqvedevfeefcreigvrniREFEEEKVKRQNEIAKKRLEFENQKT 793
Cdd:TIGR02169  728 -LEQEEEKLKERLEELEEDLSSLEQEIENVKSEL--------------------KELEARIEELEEDLHKLEEALNDLEA 786

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   794 RLGIQLDFEKNQLKEDQDKVHM-WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQhlakkseVNDKNHEMEEI 872
Cdd:TIGR02169  787 RLSHSRIPEIQAELSKLEEEVSrIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQ-------IKSIEKEIENL 859

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   873 RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKlplskgtmddisQEEGSSQGEDSvsgSQRISSiya 952
Cdd:TIGR02169  860 NGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERK------------IEELEAQIEKK---RKRLSE--- 921

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   953 REALIEIDYGDLCEDLKDAQAEEEIKQE---MNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKR 1029
Cdd:TIGR02169  922 LKAKLEALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEE 1001

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1030 AKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSrNSSAQAFLgpENPEEPYLDGINYNCVAPGKRFRPMDNLSGG 1109
Cdd:TIGR02169 1002 RKAILERIEEYEKKKREVFMEAFEAINENFNEIFAELS-GGTGELIL--ENPDDPFAGGLELSAKPKGKPVQRLEAMSGG 1078

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  1110 EKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGV 1181
Cdd:TIGR02169 1079 EKSLTALSFIFAIQRYKPSPFYAFDEVDMFLDGVNVERVAKLIREKAG-EAQFIVVSLRSPMIEYADRAIGV 1149
ABC_SMC1_euk cd03275
ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of ...
 1095-1198 5.46e-66

ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213242 [Multi-domain]  Cd Length: 247  Bit Score: 223.22  E-value: 5.46e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1095 APGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTK 1174
Cdd:cd03275   145 PPGKRFRDMDNLSGGEKTMAALALLFAIHSYQPAPFFVLDEVDAALDNTNVGKVASYIREQAGPNFQFIVISLKEEFFSK 224

                          90       100
                  ....*....|....*....|....
gi 527317371 1175 AESLIGVYPEQgDCVISKVLTFDL 1198
Cdd:cd03275   225 ADALVGVYRDQ-ECNSSKVLTLDL 247
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 15-749 7.12e-49

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 189.38  E-value: 7.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLGE-KTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYS-EEGAEDRTFARVIV------GGSSEYKIN 86
Cdd:COG1196    36 GKSNIVDAIRWVLGEqSAKSLRGGKMEDVIFAGSSSRKPLGRAEVSLTFDnSDGTLPIDYDEVTItrrlyrSGESEYYIN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   87 NKVVQLHEYSEELEKLGIliKARNF-LVFQGAVESIAMKNPKERTALFEE---ISRsgelaqeYDKRKKEmvkAE---ED 159
Cdd:COG1196   116 GKPCRLKDIQDLFLDTGL--GPESYsIIGQGMIDRIIEAKPEERRAIIEEaagISK-------YKERKEE---AErklEA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  160 TQFNYHRKKNIAAE----RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD 235
Cdd:COG1196   184 TEENLERLEDILGElerqLEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  236 KVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELE 315
Cdd:COG1196   264 ELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELE 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  316 KEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERkkvet 395
Cdd:COG1196   344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER----- 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  396 eakikqKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 475
Cdd:COG1196   419 ------LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  476 QRKAEIMESIKRLYPGSVY-----------GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGE 544
Cdd:COG1196   493 LLLLLEAEADYEGFLEGVKaalllaglrglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAG 572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  545 PETFLPLDYLEVKPTDEKLRE----LKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALD 620
Cdd:COG1196   573 RATFLPLDKIRARAALAAALArgaiGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE 652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  621 GTLFQKSGVISGGASDLKAKARRwdeKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 700
Cdd:COG1196   653 GEGGSAGGSLTGGSRRELLAALL---EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQ 729

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*....
gi 527317371  701 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQ 749
Cdd:COG1196   730 LEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
SMC_hinge smart00968
SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC ...
 491-606 3.98e-32

SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction.


Pssm-ID: 214944 [Multi-domain]  Cd Length: 120  Bit Score: 121.57  E-value: 3.98e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    491 GSVYGRLIDLCQPtQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVK-PTDEKLRELK-- 567
Cdd:smart00968    1 PGVLGRVADLISV-DPKYETALEAALGGRLQAVVVDTEETAKKAIEFLKKNRLGRATFLPLDKIKPRsPAGSKLREALlp 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 527317371    568 ---GAKLVIDVIRYePPHIKKALQYACGNALVCDNVEDARRI 606
Cdd:smart00968   80 epgFVGPAIDLVEY-DPELRPALEYLLGNTLVVDDLETARRL 120
PTZ00121 PTZ00121
MAEBL; Provisional
 134-487 2.06e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 69.01  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQ-EYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVE 212
Cdd:PTZ00121 1339 EEAKKAAEAAKaEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  213 IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE---------NT 283
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEakkkaeeakKK 1498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  284 SHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKR 363
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNM 1578

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  364 AATLAQELEKFNRDQKADQDRLDLEERK------KVETEAKIK-QKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 436
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKmkaeeaKKAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEE 1658

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 527317371  437 LTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKR 487
Cdd:PTZ00121 1659 NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKK 1709
 
Name Accession Description Interval E-value
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-1188 5.51e-174

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 545.34  E-value: 5.51e-174
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTS-NLRVKTLRDLIHgaPVGKPAANRAFVSMVYSEEGA-------EDRTFARVIVGGSSEYKIN 86
Cdd:pfam02463   35 GKSNILDAILFVLGERSAkSLRSERLSDLIH--SKSGAFVNSAEVEITFDNEDHelpidkeEVSIRRRVYRGGDSEYYIN 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    87 NKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR 166
Cdd:pfam02463  113 GKNVTKKEVAELLESQGISPEAYNFLVQGGKIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDL 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   167 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 246
Cdd:pfam02463  193 EELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLK 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   247 ELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQ 326
Cdd:pfam02463  273 ENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKRE 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   327 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 406
Cdd:pfam02463  353 AEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEIL 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   407 EENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 486
Cdd:pfam02463  433 EEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVL 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   487 RLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLREL 566
Cdd:pfam02463  513 LALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   567 KGAKLVIDVIRYEpphikkalqyacgnalvcdnvedarriafgghqrhktvaldgtlfqksgvisggASDLKAKARRWDE 646
Cdd:pfam02463  593 SIAVLEIDPILNL------------------------------------------------------AQLDKATLEADED 618

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   647 KAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRI 726
Cdd:pfam02463  619 DKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQ 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   727 NDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQL 806
Cdd:pfam02463  699 LEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAE 778

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   807 KEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHL 886
Cdd:pfam02463  779 EREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELER 858

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   887 QKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCE 966
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   967 DLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1046
Cdd:pfam02463  939 ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1047 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYK 1126
Cdd:pfam02463 1019 LKEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSGGIEISARPPGKGVKNLDLLSGGEKTLVALALIFAIQKYK 1098

                         1130      1140      1150      1160      1170      1180
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  1127 PAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGVYPEQGDC 1188
Cdd:pfam02463 1099 PAPFYLLDEIDAALDDQNVSRVANLLKELSK-NAQFIVISLREEMLEKADKLVGVTMVENGV 1159
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 15-1181 1.28e-85

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 303.14  E-value: 1.28e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTSN-LRVKTLRDLIHGAPVGKPAaNRAFVSMVYSEEGA----EDRTFARVIV---GGSSEYKIN 86
Cdd:TIGR02169   35 GKSNIGDAILFALGLSSSKaMRAERLSDLISNGKNGQSG-NEAYVTVTFKNDDGkfpdELEVVRRLKVtddGKYSYYYLN 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    87 NKVVQLHEYSEELEKLGILIKARNFlVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR 166
Cdd:TIGR02169  114 GQRVRLSEIHDFLAAAGIYPEGYNV-VLQGDVTDFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLI 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   167 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 246
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQ 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   247 ELGKMMR--------EQQQIEKEIKEKDSELNQKRPQyIKAKEntshkiKKLEAAKKSLQNAQKHYKKRKGDMDELEKEm 318
Cdd:TIGR02169  273 LLEELNKkikdlgeeEQLRVKEKIGELEAEIASLERS-IAEKE------RELEDAEERLAKLEAEIDKLLAEIEELERE- 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   319 LSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHR-LKEEASKRAATLAQ---ELEKFNRDQKADQDRLDLEERKKVE 394
Cdd:TIGR02169  345 IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAeTRDELKDYREKLEKlkrEINELKRELDRLQEELQRLSEELAD 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   395 TEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSR 474
Cdd:TIGR02169  425 LNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEE 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   475 QQRKAEIMESIKRLYPGSVYGRLIDLCQpTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYL 554
Cdd:TIGR02169  505 RVRGGRAVEEVLKASIQGVHGTVAQLGS-VGERYATAIEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLNKM 583

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   555 EVKPTDEKLRELKGA-KLVIDVIRYEPpHIKKALQYACGNALVCDNVEDARRIAfgghQRHKTVALDGTLFQKSGVISGG 633
Cdd:TIGR02169  584 RDERRDLSILSEDGViGFAVDLVEFDP-KYEPAFKYVFGDTLVVEDIEAARRLM----GKYRMVTLEGELFEKSGAMTGG 658

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   634 AsdlkaKARRWDEKAVDKLKEKKERLTEELKEqmkAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQtKTRHLALNLQEks 713
Cdd:TIGR02169  659 S-----RAPRGGILFSRSEPAELQRLRERLEG---LKRELSSLQSELRRIENRLDELSQELSDASR-KIGEIEKEIEQ-- 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   714 kLESELANFGPRINDIKRIIQSREREMKDLKEKMnqvedevfeefcreigvrniREFEEEKVKRQNEIAKKRLEFENQKT 793
Cdd:TIGR02169  728 -LEQEEEKLKERLEELEEDLSSLEQEIENVKSEL--------------------KELEARIEELEEDLHKLEEALNDLEA 786

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   794 RLGIQLDFEKNQLKEDQDKVHM-WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQhlakkseVNDKNHEMEEI 872
Cdd:TIGR02169  787 RLSHSRIPEIQAELSKLEEEVSrIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQ-------IKSIEKEIENL 859

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   873 RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKlplskgtmddisQEEGSSQGEDSvsgSQRISSiya 952
Cdd:TIGR02169  860 NGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERK------------IEELEAQIEKK---RKRLSE--- 921

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   953 REALIEIDYGDLCEDLKDAQAEEEIKQE---MNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKR 1029
Cdd:TIGR02169  922 LKAKLEALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEE 1001

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1030 AKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSrNSSAQAFLgpENPEEPYLDGINYNCVAPGKRFRPMDNLSGG 1109
Cdd:TIGR02169 1002 RKAILERIEEYEKKKREVFMEAFEAINENFNEIFAELS-GGTGELIL--ENPDDPFAGGLELSAKPKGKPVQRLEAMSGG 1078

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  1110 EKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGV 1181
Cdd:TIGR02169 1079 EKSLTALSFIFAIQRYKPSPFYAFDEVDMFLDGVNVERVAKLIREKAG-EAQFIVVSLRSPMIEYADRAIGV 1149
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 15-1198 3.42e-82

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 293.50  E-value: 3.42e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGE-KTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEgaeDRTFA-----------RVIVGGSSE 82
Cdd:TIGR02168   35 GKSNIVDAIRWVLGEqSAKALRGGKMEDVIFNGSETRKPLSLAEVELVFDNS---DGLLPgadyseisitrRLYRDGESE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    83 YKINNKVVQLHEYSEELekLGILIKARNF-LVFQGAVESIAMKNPKERTALFEE---ISRsgelaqeYDKRKKEMVKAEE 158
Cdd:TIGR02168  112 YFINGQPCRLKDIQDLF--LDTGLGKRSYsIIEQGKISEIIEAKPEERRAIFEEaagISK-------YKERRKETERKLE 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   159 DTQFNYHRKKNIAAERKEA----KQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRM 234
Cdd:TIGR02168  183 RTRENLDRLEDILNELERQlkslERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAEL 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   235 DKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL 314
Cdd:TIGR02168  263 QELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   315 EKEMLSVEKarqefeermeeesqsqgrDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVE 394
Cdd:TIGR02168  343 EEKLEELKE------------------ELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIER 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   395 TEAKIKQKLREIEENQKRIEKLEEYITTSK-----QSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDR 469
Cdd:TIGR02168  405 LEARLERLEDRRERLQQEIEELLKKLEEAElkelqAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   470 QES--------SRQQRKAEIMESIK-----RLYPGSVYGRLIDLCQpTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQ 536
Cdd:TIGR02168  485 AQLqarldsleRLQENLEGFSEGVKallknQSGLSGILGVLSELIS-VDEGYEAAIEAALGGRLQAVVVENLNAAKKAIA 563

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   537 YIKEQRGEPETFLPLDYLE----VKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQ 612
Cdd:TIGR02168  564 FLKQNELGRVTFLPLDSIKgteiQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRP 643

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   613 RHKTVALDGTLFQKSGVISGGASDLKAK--ARRwdeKAVDKLKEKKERLTEELKE-QMKAKRKEAELRQVQSQAHGLQMR 689
Cdd:TIGR02168  644 GYRIVTLDGDLVRPGGVITGGSAKTNSSilERR---REIEELEEKIEELEEKIAElEKALAELRKELEELEEELEQLRKE 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   690 LKYSQsdleqtktrhlalnlQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFcreigvRNIRE 769
Cdd:TIGR02168  721 LEELS---------------RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE------EELAE 779

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   770 FEEEKVKRQNEIAKKRLEFENQKTRLGIQldfeKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQ 849
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDEL----RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIE 855

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   850 DLKnqhlakkSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS 929
Cdd:TIGR02168  856 SLA-------AEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   930 QEEGSSQgedsvsgsQRISSIyaREALIEiDYGDLCEDLkdAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKL 1009
Cdd:TIGR02168  929 LRLEGLE--------VRIDNL--QERLSE-EYSLTLEEA--EALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEY 995

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1010 ESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQ-AFLGPENPEEPyldG 1088
Cdd:TIGR02168  996 EELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTFDQVNENFQRVFPKLFGGGEAElRLTDPEDLLEA---G 1072

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  1089 INYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLK 1168
Cdd:TIGR02168 1073 IEIFAQPPGKKNQNLSLLSGGEKALTALALLFAIFKVKPAPFCILDEVDAPLDDANVERFANLLKEFSK-NTQFIVITHN 1151

                         1210      1220      1230
                   ....*....|....*....|....*....|.
gi 527317371  1169 EEFYTKAESLIGV-YPEQGdcvISKVLTFDL 1198
Cdd:TIGR02168 1152 KGTMEVADQLYGVtMQEKG---VSKIVSVDL 1179
ABC_SMC1_euk cd03275
ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of ...
 1095-1198 5.46e-66

ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213242 [Multi-domain]  Cd Length: 247  Bit Score: 223.22  E-value: 5.46e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1095 APGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTK 1174
Cdd:cd03275   145 PPGKRFRDMDNLSGGEKTMAALALLFAIHSYQPAPFFVLDEVDAALDNTNVGKVASYIREQAGPNFQFIVISLKEEFFSK 224

                          90       100
                  ....*....|....*....|....
gi 527317371 1175 AESLIGVYPEQgDCVISKVLTFDL 1198
Cdd:cd03275   225 ADALVGVYRDQ-ECNSSKVLTLDL 247
ABC_SMC1_euk cd03275
ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of ...
 14-126 5.92e-59

ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213242 [Multi-domain]  Cd Length: 247  Bit Score: 203.19  E-value: 5.92e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   14 RGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLH 93
Cdd:cd03275    33 SGKSNLMDAISFVLGEKSSHLRSKNLKDLIYRARVGKPDSNSAYVTAVYEDDDGEEKTFRRIITGGSSSYRINGKVVSLK 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 527317371   94 EYSEELEKLGILIKARNFLVFQGAVESIAMKNP 126
Cdd:cd03275   113 EYNEELEKINILVKARNFLVFQGDVESIASKNP 145
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 15-749 7.12e-49

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 189.38  E-value: 7.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLGE-KTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYS-EEGAEDRTFARVIV------GGSSEYKIN 86
Cdd:COG1196    36 GKSNIVDAIRWVLGEqSAKSLRGGKMEDVIFAGSSSRKPLGRAEVSLTFDnSDGTLPIDYDEVTItrrlyrSGESEYYIN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   87 NKVVQLHEYSEELEKLGIliKARNF-LVFQGAVESIAMKNPKERTALFEE---ISRsgelaqeYDKRKKEmvkAE---ED 159
Cdd:COG1196   116 GKPCRLKDIQDLFLDTGL--GPESYsIIGQGMIDRIIEAKPEERRAIIEEaagISK-------YKERKEE---AErklEA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  160 TQFNYHRKKNIAAE----RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD 235
Cdd:COG1196   184 TEENLERLEDILGElerqLEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  236 KVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELE 315
Cdd:COG1196   264 ELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELE 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  316 KEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERkkvet 395
Cdd:COG1196   344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER----- 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  396 eakikqKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 475
Cdd:COG1196   419 ------LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  476 QRKAEIMESIKRLYPGSVY-----------GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGE 544
Cdd:COG1196   493 LLLLLEAEADYEGFLEGVKaalllaglrglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAG 572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  545 PETFLPLDYLEVKPTDEKLRE----LKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALD 620
Cdd:COG1196   573 RATFLPLDKIRARAALAAALArgaiGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE 652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  621 GTLFQKSGVISGGASDLKAKARRwdeKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 700
Cdd:COG1196   653 GEGGSAGGSLTGGSRRELLAALL---EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQ 729

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*....
gi 527317371  701 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQ 749
Cdd:COG1196   730 LEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
SMC_hinge smart00968
SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC ...
 491-606 3.98e-32

SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction.


Pssm-ID: 214944 [Multi-domain]  Cd Length: 120  Bit Score: 121.57  E-value: 3.98e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    491 GSVYGRLIDLCQPtQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVK-PTDEKLRELK-- 567
Cdd:smart00968    1 PGVLGRVADLISV-DPKYETALEAALGGRLQAVVVDTEETAKKAIEFLKKNRLGRATFLPLDKIKPRsPAGSKLREALlp 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 527317371    568 ---GAKLVIDVIRYePPHIKKALQYACGNALVCDNVEDARRI 606
Cdd:smart00968   80 epgFVGPAIDLVEY-DPELRPALEYLLGNTLVVDDLETARRL 120
ABC_SMC_barmotin cd03278
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ...
 1095-1181 1.19e-29

ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213245 [Multi-domain]  Cd Length: 197  Bit Score: 117.18  E-value: 1.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1095 APGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTK 1174
Cdd:cd03278   103 APGKKVQRLSLLSGGEKALTALALLFAIFRVRPSPFCVLDEVDAALDDANVERFARLLKEFSK-ETQFIVITHRKGTMEA 181


                  ....*..
gi 527317371 1175 AESLIGV 1181
Cdd:cd03278   182 ADRLYGV 188
ABC_SMC4_euk cd03274
ATP-binding cassette domain of eukaryotic SMC4 proteins; The structural maintenance of ...
 1096-1182 4.33e-29

ATP-binding cassette domain of eukaryotic SMC4 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213241 [Multi-domain]  Cd Length: 212  Bit Score: 115.86  E-value: 4.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1096 PGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQsTCNFQAIVISLKEEFYTKA 1175
Cdd:cd03274   118 PKKSWKNISNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVANYIKER-TKNAQFIVISLRNNMFELA 196


                  ....*..
gi 527317371 1176 ESLIGVY 1182
Cdd:cd03274   197 DRLVGIY 203
SMC_hinge pfam06470
SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC ...
 493-607 1.08e-27

SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction.


Pssm-ID: 461926 [Multi-domain]  Cd Length: 116  Bit Score: 108.50  E-value: 1.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   493 VYGRLIDLCQPtQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLV 572
Cdd:pfam06470    4 VLGRLADLIEV-DEGYEKAVEAALGGRLQAVVVDDEDDAKRAIEFLKKNKLGRATFLPLDRLKPRPRRPGADLKGGAGPL 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 527317371   573 IDVIRYEPPhIKKALQYACGNALVCDNVEDARRIA 607
Cdd:pfam06470   83 LDLVEYDDE-YRKALRYLLGNTLVVDDLDEALELA 116
ABC_SMC_head cd03239
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural ...
 1106-1186 1.19e-25

The SMC head domain belongs to the ATP-binding cassette superfamily; The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.


Pssm-ID: 213206 [Multi-domain]  Cd Length: 178  Bit Score: 105.08  E-value: 1.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1106 LSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQ 1185
Cdd:cd03239    95 LSGGEKSLSALALIFALQEIKPSPFYVLDEIDAALDPTNRRRVSDMIKEMAKHTSQFIVITLKKEMFENADKLIGVLFVH 174


                  .
gi 527317371 1186 G 1186
Cdd:cd03239   175 G 175
ABC_Class2 cd03227
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ...
 1106-1186 1.04e-19

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.


Pssm-ID: 213194 [Multi-domain]  Cd Length: 162  Bit Score: 87.42  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1106 LSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQ 1185
Cdd:cd03227    78 LSGGEKELSALALILALASLKPRPLYILDEIDRGLDPRDGQALAEAILEHLVKGAQVIVITHLPELAELADKLIHIKKVI 157


                  .
gi 527317371 1186 G 1186
Cdd:cd03227   158 T 158
ABC_SMC2_euk cd03273
ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of ...
 1106-1191 5.61e-16

ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213240 [Multi-domain]  Cd Length: 251  Bit Score: 78.88  E-value: 5.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1106 LSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALD--NT-NIGKVanyIKEQSTcNFQAIVISLKEEFYTKAESLIGVY 1182
Cdd:cd03273   167 LSGGQRSLVALSLILALLLFKPAPMYILDEVDAALDlsHTqNIGRM---IKTHFK-GSQFIVVSLKEGMFNNANVLFRTR 242


                  ....*....
gi 527317371 1183 PEQGDCVIS 1191
Cdd:cd03273   243 FVDGTSTVT 251
ABC_SMC3_euk cd03272
ATP-binding cassette domain of eukaryotic SMC3 proteins; The structural maintenance of ...
 1103-1181 2.21e-15

ATP-binding cassette domain of eukaryotic SMC3 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213239 [Multi-domain]  Cd Length: 243  Bit Score: 77.30  E-value: 2.21e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 527317371 1103 MDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTcNFQAIVISLKEEFYTKAESLIGV 1181
Cdd:cd03272   156 MQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDAALDAQYRTAVANMIKELSD-GAQFITTTFRPELLEVADKFYGV 233
PTZ00121 PTZ00121
MAEBL; Provisional
 134-487 2.06e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 69.01  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQ-EYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVE 212
Cdd:PTZ00121 1339 EEAKKAAEAAKaEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  213 IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE---------NT 283
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEakkkaeeakKK 1498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  284 SHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKR 363
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNM 1578

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  364 AATLAQELEKFNRDQKADQDRLDLEERK------KVETEAKIK-QKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 436
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKmkaeeaKKAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEE 1658

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 527317371  437 LTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKR 487
Cdd:PTZ00121 1659 NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKK 1709
PTZ00121 PTZ00121
MAEBL; Provisional
 134-487 2.54e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 68.63  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRK-KEMVKAEEDTQFNYHRKKniAAERKEAKQEKEEADRYQRLKDEVVR-AQVQLQLFKLYHNEV 211
Cdd:PTZ00121 1275 EEARKADELKKAEEKKKaDEAKKAEEKKKADEAKKK--AEEAKKADEAKKKAEEAKKKADAAKKkAEEAKKAAEAAKAEA 1352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  212 EIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE--NTSHKIKK 289
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEakKKAEEKKK 1432

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  290 LEAAKKSLQNAQK--HYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYH---RLKEEASKRA 364
Cdd:PTZ00121 1433 ADEAKKKAEEAKKadEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAdeaKKAAEAKKKA 1512

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  365 ATL--------AQELEKFNRDQKADQDR-----------LDLEERKKVETEAKIKQKLREIEENQKRIEKLEEY------ 419
Cdd:PTZ00121 1513 DEAkkaeeakkADEAKKAEEAKKADEAKkaeekkkadelKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAkkaeea 1592

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527317371  420 -ITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINK--ELNQVMEQLGDARIDRQESSRQQRKAEIMESIKR 487
Cdd:PTZ00121 1593 rIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKaeEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663
ABC_SMC2_euk cd03273
ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of ...
 15-118 2.74e-11

ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213240 [Multi-domain]  Cd Length: 251  Bit Score: 65.01  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLG-EKTSNLRVKTLRDLIHGApvGKPAANRAFVSMVY-------SEEGAEDR---TFAR-VIVGGSSE 82
Cdd:cd03273    37 GKSNILDAICFVLGiTNLSTVRASNLQDLIYKR--GQAGITKASVTIVFdnsdksqSPIGFENYpeiTVTRqIVLGGTNK 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 527317371   83 YKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAV 118
Cdd:cd03273   115 YLINGHRAQQQRVQDLFQSVQLNVNNPHFLIMQGRI 150
PTZ00121 PTZ00121
MAEBL; Provisional
 122-486 6.06e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.47  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  122 AMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNiAAERKEAKQEKEEADRYQRLKDEVVRAQvql 201
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKK-ADELKKAAAAKKKADEAKKKAEEKKKAD--- 1434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  202 QLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE 281
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE 1514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  282 -------NTSHKIKKLEAAKKSlQNAQKHYKKRKGD----MDELEK--EMLSVEKARQEFEERMEEESQSQGRDlTLEEN 348
Cdd:PTZ00121 1515 akkaeeaKKADEAKKAEEAKKA-DEAKKAEEKKKADelkkAEELKKaeEKKKAEEAKKAEEDKNMALRKAEEAK-KAEEA 1592

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  349 QVKKYHRLKEEASKRAATLAQELEKfnRDQKADQDRLDLEERKKVE----TEAKIKQKLREI----EENQKRIEKLEEYI 420
Cdd:PTZ00121 1593 RIEEVMKLYEEEKKMKAEEAKKAEE--AKIKAEELKKAEEEKKKVEqlkkKEAEEKKKAEELkkaeEENKIKAAEEAKKA 1670

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527317371  421 TTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKelnqvMEQLGDARIDRQESSRQQRKAEIMESIK 486
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKK-----AEELKKKEAEEKKKAEELKKAEEENKIK 1731
PTZ00121 PTZ00121
MAEBL; Provisional
 122-483 6.99e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 6.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  122 AMKNPKERTALFEEISRSGELAQEYDKRKKemvKAEEDTQFNYHRKKNIAAER-KEAKQEKEEADRYQRLKDEVVRAQVQ 200
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKK---KAEEKKKADEAKKKAEEAKKaDEAKKKAEEAKKAEEAKKKAEEAKKA 1472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  201 LQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKE---KDSELNQKRPQYI 277
Cdd:PTZ00121 1473 DEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAdeaKKAEEKKKADELK 1552

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  278 KAKE-NTSHKIKKLEAAKKSLQNAQKHYKK----RKGDMDELEKEM--LSVEKARQEFEERMEEESQSQGRDLTLEENQV 350
Cdd:PTZ00121 1553 KAEElKKAEEKKKAEEAKKAEEDKNMALRKaeeaKKAEEARIEEVMklYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK 1632

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  351 KKYHRLK--EEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE 428
Cdd:PTZ00121 1633 KKVEQLKkkEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  429 EQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIME 483
Cdd:PTZ00121 1713 EEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEE 1767
PTZ00121 PTZ00121
MAEBL; Provisional
 134-753 2.91e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRKKEMV-------KAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEvvRAQVQLQLFKL 206
Cdd:PTZ00121 1185 EEVRKAEELRKAEDARKAEAArkaeeerKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNN--EEIRKFEEARM 1262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  207 YHNEVEIEKLNKELASKNKEIEK--DKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQyikAKENTS 284
Cdd:PTZ00121 1263 AHFARRQAAIKAEEARKADELKKaeEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA---AKKKAE 1339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  285 HKIKKLEAAKKSLQNAQKHYK--KRKGDMDELEKEmlsvekarqefeermeeESQSQGRDLTLEENQVKKYHRLKEEASK 362
Cdd:PTZ00121 1340 EAKKAAEAAKAEAEAAADEAEaaEEKAEAAEKKKE-----------------EAKKKADAAKKKAEEKKKADEAKKKAEE 1402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  363 RAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE-----------EQK 431
Cdd:PTZ00121 1403 DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEakkadeakkkaEEA 1482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  432 KLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIA 511
Cdd:PTZ00121 1483 KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE 1562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  512 VTKVLGKNMDAiiVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYAC 591
Cdd:PTZ00121 1563 KKKAEEAKKAE--EDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  592 GNALVCDNVEDARRIAFGGHQRHKTVAldgtlfQKSGVISGGASDLKaKARRWDEKAVDKLKEKKE--RLTEELKEQMKA 669
Cdd:PTZ00121 1641 KEAEEKKKAEELKKAEEENKIKAAEEA------KKAEEDKKKAEEAK-KAEEDEKKAAEALKKEAEeaKKAEELKKKEAE 1713

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  670 KRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQ 749
Cdd:PTZ00121 1714 EKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793


                  ....
gi 527317371  750 VEDE 753
Cdd:PTZ00121 1794 MEVD 1797
ABC_SMC_barmotin cd03278
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ...
 15-78 9.98e-10

ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213245 [Multi-domain]  Cd Length: 197  Bit Score: 59.40  E-value: 9.98e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371   15 GKSNLMDAISFVLGEKTS-NLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEegaEDRTFArvIVG 78
Cdd:cd03278    34 GKSNIIDAIRWVLGEQSAkSLRGEKMSDVIFAGSETRKPANFAEVTLTFDN---SDGRYS--IIS 93
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
214-832 1.52e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  214 EKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELnqkrPQYIKAKENTSHKIKKLEAA 293
Cdd:PRK03918  161 ENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSEL----PELREELEKLEKEVKELEEL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  294 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKaRQEFEERMEEESQSQGRDLTLEENQVKKYHRLKE---EASKRAATLAQE 370
Cdd:PRK03918  237 KEEIEELEKELESLEGSKRKLEEKIRELEE-RIEELKKEIEELEEKVKELKELKEKAEEYIKLSEfyeEYLDELREIEKR 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  371 LEKFNRDQKADQDRLDLEERKKVETEaKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELT-EEVEMAKRRID 449
Cdd:PRK03918  316 LSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTgLTPEKLEKELE 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  450 EINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIdlcqptqkkyqiavtkvlgknmdaiivDS 527
Cdd:PRK03918  395 ELEKAKEEIEEEISKitARIGELKKEIKELKKAIEELKKAKGKCPVCGREL---------------------------TE 447

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  528 EKTGRDCIQYIKEQRGEPEtflpldylEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYA-----CGNALVCDNVED 602
Cdd:PRK03918  448 EHRKELLEEYTAELKRIEK--------ELKEIEEKERKLRKELRELEKVLKKESELIKLKELAeqlkeLEEKLKKYNLEE 519

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  603 ARRIAfgghqrHKTVALDGTLFQKSGVISGGASDLKA-----KARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELR 677
Cdd:PRK03918  520 LEKKA------EEYEKLKEKLIKLKGEIKSLKKELEKleelkKKLAELEKKLDELEEELAELLKELEELGFESVEELEER 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  678 -QVQSQAHGLQMRLKYSQSDLEQTktrhlalnLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQvedevfE 756
Cdd:PRK03918  594 lKELEPFYNEYLELKDAEKELERE--------EKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE------E 659

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527317371  757 EFcreigvrniREFEEEKVKRQNEIAKKRLEFEnqktrlgiQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKK 832
Cdd:PRK03918  660 EY---------EELREEYLELSRELAGLRAELE--------ELEKRREEIKKTLEKLKEELEEREKAKKELEKLEK 718
PTZ00121 PTZ00121
MAEBL; Provisional
 123-487 1.03e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  123 MKNPKERTALFEEISRSGELAQEYD--KRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQrlKDEVVRAQVQ 200
Cdd:PTZ00121 1449 AKKKAEEAKKAEEAKKKAEEAKKADeaKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK--KAEEAKKADE 1526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  201 LQLFKLYHNEVEIEKLN-KELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKrpQYIKA 279
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEeKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMK--LYEEE 1604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  280 KENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERmeeesqsqgrdltlEENQVKKYH-RLKE 358
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE--------------EENKIKAAEeAKKA 1670

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  359 EASKRAATLAQELEKFNRdQKADQDRLDLEERKKVEteakikQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELT 438
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEK-KAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK 1743

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 527317371  439 EEVEMAKRRIDEINKelnqvMEQLGDARIDRQESSRQQRKAEIMESIKR 487
Cdd:PTZ00121 1744 KKAEEAKKDEEEKKK-----IAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
287-847 2.29e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 2.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  287 IKKLEAAKKSLQNAQKHYKKRKGDMDELE-----KEMLSVEKARQEFeermeeesQSQGRDLTLEENQVKKYHRLKEEAS 361
Cdd:COG4913   244 LEDAREQIELLEPIRELAERYAAARERLAeleylRAALRLWFAQRRL--------ELLEAELEELRAELARLEAELERLE 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  362 KRAATLAQELEKFNRD-QKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLegeltee 440
Cdd:COG4913   316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE------- 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  441 vemAKRRIDEINKELNQVMEQLGDARIDRQESSRQQR--KAEI--MESIKRLYPGSVY--------------------GR 496
Cdd:COG4913   389 ---AAALLEALEEELEALEEALAEAEAALRDLRRELRelEAEIasLERRKSNIPARLLalrdalaealgldeaelpfvGE 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  497 LIDLcQPTQKKYQIAVTKVLGKNMDAIIVDsEKTGRDCIQYIKEQRGEPEtflpLDYLEVKPTDEKLRELKG------AK 570
Cdd:COG4913   466 LIEV-RPEEERWRGAIERVLGGFALTLLVP-PEHYAAALRWVNRLHLRGR----LVYERVRTGLPDPERPRLdpdslaGK 539

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  571 LVIDVIRYEP---PHIKKALQYACgnalvCDNVEDARRiafggHQRHKTVA----LDGTLFQKsgvisggasDLKAKARR 643
Cdd:COG4913   540 LDFKPHPFRAwleAELGRRFDYVC-----VDSPEELRR-----HPRAITRAgqvkGNGTRHEK---------DDRRRIRS 600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  644 -----WD-EKAVDKLKEKKERLTEELKE-QMKAKRKEAELRQVQSQAHGLQMRLKYS--QSDLEQTKTRHLALNlQEKSK 714
Cdd:COG4913   601 ryvlgFDnRAKLAALEAELAELEEELAEaEERLEALEAELDALQERREALQRLAEYSwdEIDVASAEREIAELE-AELER 679

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  715 LE---SELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEvfeefcreigvrnIREFEEEKvkrqnEIAKKRLEFENQ 791
Cdd:COG4913   680 LDassDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKE-------------LEQAEEEL-----DELQDRLEAAED 741

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 527317371  792 KTRLGIQLDFEKNQLKEDQDKVhmwEQTVKKD-ENEIEKLKKEEQRHMKIIDETMAQ 847
Cdd:COG4913   742 LARLELRALLEERFAAALGDAV---ERELRENlEERIDALRARLNRAEEELERAMRA 795
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 637-1013 3.55e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 3.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  637 LKAKARRwdEKAVDKLKEKKERLT------EELKEQMKAKRKEAElrqVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ 710
Cdd:COG1196   168 SKYKERK--EEAERKLEATEENLErledilGELERQLEPLERQAE---KAERYRELKEELKELEAELLLLKLRELEAELE 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  711 EKSKLESELANfgpRINDIKRIIQSREREMKDLKEKMNQVEDEVfeefcreigvrnirefeEEKVKRQNEIAKKRLEFEN 790
Cdd:COG1196   243 ELEAELEELEA---ELEELEAELAELEAELEELRLELEELELEL-----------------EEAQAEEYELLAELARLEQ 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  791 QKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEME 870
Cdd:COG1196   303 DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  871 EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQgedsvsgsQRISSI 950
Cdd:COG1196   383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAA--------EEEAEL 454

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527317371  951 YAREALIEIdygdlcEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVR 1013
Cdd:COG1196   455 EEEEEALLE------LLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 173-486 4.07e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 57.83  E-value: 4.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   173 ERKEAKQEKEEADRYQRLKDEVVRAqvqlqlfklyhnevEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMM 252
Cdd:pfam17380  279 QHQKAVSERQQQEKFEKMEQERLRQ--------------EKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   253 REQQQIEK-EIKEKDSELNQKRPQYIKAKENTSHKIKKL--EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 329
Cdd:pfam17380  345 ERERELERiRQEERKRELERIRQEEIAMEISRMRELERLqmERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQ 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   330 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLaQELEKFNRDQKADQDRLDLEERKKVETEAK----IKQKLRE 405
Cdd:pfam17380  425 IRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQV-ERLRQQEEERKRKKLELEKEKRDRKRAEEQrrkiLEKELEE 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   406 -----IEENQKR--IEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRideinkelnQVMEQLGDARIDRQESSRQQRK 478
Cdd:pfam17380  504 rkqamIEEERKRklLEKEMEERQKAIYEEERRREAEEERRKQQEMEERR---------RIQEQMRKATEERSRLEAMERE 574


                   ....*...
gi 527317371   479 AEIMESIK 486
Cdd:pfam17380  575 REMMRQIV 582
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
134-486 6.22e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 6.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVE- 212
Cdd:PRK03918  384 LTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKr 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  213 IEKLNKELASKNKEIEKDKKRMDKVEDELKEkkkelgkmMREQQQIEKEIKEKDSELNQKRPQYIKAK----ENTSHKIK 288
Cdd:PRK03918  464 IEKELKEIEEKERKLRKELRELEKVLKKESE--------LIKLKELAEQLKELEEKLKKYNLEELEKKaeeyEKLKEKLI 535

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  289 KLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLkeeaskraatlA 368
Cdd:PRK03918  536 KLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNE-----------Y 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  369 QELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKL------EEYITTSKQSLEEQKKLEGeLTEEVE 442
Cdd:PRK03918  605 LELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELekkyseEEYEELREEYLELSRELAG-LRAELE 683

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 527317371  443 MAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 486
Cdd:PRK03918  684 ELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELR 727
PTZ00121 PTZ00121
MAEBL; Provisional
 265-901 1.20e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  265 KDSELNQKRPQyiKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEkEMLSVEKARQEFEERMEEESQSQGRDLT 344
Cdd:PTZ00121 1077 KDFDFDAKEDN--RADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAE-DARKAEEARKAEDARKAEEARKAEDAKR 1153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  345 LEENQVKKYHRLKEEASKraatlAQELEKFNRDQKADQDRlDLEERKKVETEAKIKQKLREieENQKRIEKLEEYitTSK 424
Cdd:PTZ00121 1154 VEIARKAEDARKAEEARK-----AEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAARKA--EEERKAEEARKA--EDA 1223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  425 QSLEEQKKLEgELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRlypgSVYGRLIDLCQPT 504
Cdd:PTZ00121 1224 KKAEAVKKAE-EAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK----AEEKKKADEAKKA 1298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  505 QKKYQIAVTKVLGKNMDAiIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIK 584
Cdd:PTZ00121 1299 EEKKKADEAKKKAEEAKK-ADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  585 KALQYACGNALVCDNVEDARRIAFGGHQRHKTValdgtlfQKSGVISGGASDLKAKARrwDEKAVDKLKEKKE--RLTEE 662
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADEAKKKAEEDKKKADEL-------KKAAAAKKKADEAKKKAE--EKKKADEAKKKAEeaKKADE 1448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  663 LKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRE-REMK 741
Cdd:PTZ00121 1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKaDEAK 1528

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  742 DLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQL-DFEKNQLKE-----DQDKVHM 815
Cdd:PTZ00121 1529 KAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAkKAEEARIEEvmklyEEEKKMK 1608

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  816 WEQTVKKDENEI--EKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDK------NHEMEEIRKKLGGANKEMTHLQ 887
Cdd:PTZ00121 1609 AEEAKKAEEAKIkaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikaaeeAKKAEEDKKKAEEAKKAEEDEK 1688

                         650
                  ....*....|....
gi 527317371  888 KEVTAIETKLEQKR 901
Cdd:PTZ00121 1689 KAAEALKKEAEEAK 1702
PTZ00121 PTZ00121
MAEBL; Provisional
 166-1019 1.96e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.92  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  166 RKKNIAAER-KEAKQEKEEADRYQRLKDEVVRaqvqlqlfklyhnEVEIEKLNKELASKNKEIEK--DKKRMDKVEDELK 242
Cdd:PTZ00121 1084 KEDNRADEAtEEAFGKAEEAKKTETGKAEEAR-------------KAEEAKKKAEDARKAEEARKaeDARKAEEARKAED 1150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  243 EKKKELGKMMREQQQIEKEIKEKDS---ELNQKRPQYIKAKE-NTSHKIKKLEAAKKSlQNAQKHYKKRKGDMDELEKEM 318
Cdd:PTZ00121 1151 AKRVEIARKAEDARKAEEARKAEDAkkaEAARKAEEVRKAEElRKAEDARKAEAARKA-EEERKAEEARKAEDAKKAEAV 1229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  319 LSVEKARQEFEERMEEESQSQGRDL-TLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRlDLEERKKVETEA 397
Cdd:PTZ00121 1230 KKAEEAKKDAEEAKKAEEERNNEEIrKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK-KAEEKKKADEAK 1308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  398 KIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKlegelteEVEMAKRRIDEINKELNQVMEQlgdARIDRQESSRQQR 477
Cdd:PTZ00121 1309 KKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKK-------AAEAAKAEAEAAADEAEAAEEK---AEAAEKKKEEAKK 1378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  478 KAEIMEsikrlypgsvygrlidlcqptQKKYQIAVTKVLGKNmdaiiVDSEKTGRDCIQYIKEQRGEPEtflpldylEVK 557
Cdd:PTZ00121 1379 KADAAK---------------------KKAEEKKKADEAKKK-----AEEDKKKADELKKAAAAKKKAD--------EAK 1424

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  558 PTDEKLRELKGAKLVIDVIRYEPPHIKKAlqyacgnalvcdnvEDARRIAFGGHQRHKTVALDGTlfQKSGVISGGASDL 637
Cdd:PTZ00121 1425 KKAEEKKKADEAKKKAEEAKKADEAKKKA--------------EEAKKAEEAKKKAEEAKKADEA--KKKAEEAKKADEA 1488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  638 KAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLES 717
Cdd:PTZ00121 1489 KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE 1568

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  718 ELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEvfeefcREIGVRNIREFEEEKVK----RQNEIAKKRLEFENQKT 793
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEE------KKMKAEEAKKAEEAKIKaeelKKAEEEKKKVEQLKKKE 1642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  794 RLGIQlDFEKNQLKEDQDKVHMWEQTVKKDEN--EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNhEMEE 871
Cdd:PTZ00121 1643 AEEKK-KAEELKKAEEENKIKAAEEAKKAEEDkkKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEE 1720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  872 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSD---RHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQR-I 947
Cdd:PTZ00121 1721 LKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDeeeKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKkI 1800

                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 527317371  948 SSIYAREALIEI--DYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQET 1019
Cdd:PTZ00121 1801 KDIFDNFANIIEggKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
PTZ00121 PTZ00121
MAEBL; Provisional
 134-455 2.55e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQlfklyhnevEI 213
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK---------KA 1589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  214 EKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKEntSHKIKKLEAA 293
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIKAAEEA 1667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  294 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARqefeermeeesqsqgrdltlEENQVKKYHRLKEEASKRAATLAQELEK 373
Cdd:PTZ00121 1668 KKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE--------------------EAKKAEELKKKEAEEKKKAEELKKAEEE 1727

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  374 fnRDQKADQDRLDLEERKKVETEAKIKqklrEIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINK 453
Cdd:PTZ00121 1728 --NKIKAEEAKKEAEEDKKKAEEAKKD----EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801


                  ..
gi 527317371  454 EL 455
Cdd:PTZ00121 1802 DI 1803
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
311-746 4.44e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.39  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  311 MDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRL---KEEASKRAATLAQELEKFNRD----QKADQD 383
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELqeeLEELEEELEELEAELEELREEleklEKLLQL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  384 RLDLEERKKVETE--------AKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEG--------ELTEEVEMAKRR 447
Cdd:COG4717   128 LPLYQELEALEAElaelperlEELEERLEELRELEEELEELEAELAELQEELEELLEQLSlateeelqDLAEELEELQQR 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  448 IDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGknMDAIIVds 527
Cdd:COG4717   208 LAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAG--VLFLVL-- 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  528 ektGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYAcgnalvcDNVEDARRIA 607
Cdd:COG4717   284 ---GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELL-------DRIEELQELL 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  608 FGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAvDKLKEKKERLtEELKEQMKAKRKEAELRQVQSQAHGLQ 687
Cdd:COG4717   354 REAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQA-EEYQELKEEL-EELEEQLEELLGELEELLEALDEEELE 431

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527317371  688 MRLKYSQSDLEQTKTRHLALnLQEKSKLESELANFGP--RINDIKRIIQSREREMKDLKEK 746
Cdd:COG4717   432 EELEELEEELEELEEELEEL-REELAELEAELEQLEEdgELAELLQELEELKAELRELAEE 491
ABC_Rad50 cd03240
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ...
 1100-1181 5.69e-07

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.


Pssm-ID: 213207 [Multi-domain]  Cd Length: 204  Bit Score: 51.45  E-value: 5.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1100 FRPMDNLSGGEKTVAALALLFAIHSYKPA--PFFVLDEIDAALDNTNI-GKVANYIKEQ-STCNFQAIVISLKEEFYTKA 1175
Cdd:cd03240   110 LDMRGRCSGGEKVLASLIIRLALAETFGSncGILALDEPTTNLDEENIeESLAEIIEERkSQKNFQLIVITHDEELVDAA 189


                  ....*.
gi 527317371 1176 ESLIGV 1181
Cdd:cd03240   190 DHIYRV 195
ABC_SMC6_euk cd03276
ATP-binding cassette domain of eukaryotic SM6 proteins; The structural maintenance of ...
 1097-1166 9.22e-07

ATP-binding cassette domain of eukaryotic SM6 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213243 [Multi-domain]  Cd Length: 198  Bit Score: 50.67  E-value: 9.22e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527317371 1097 GKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNiGKVA--NYIKE-QSTCNFQAIVIS 1166
Cdd:cd03276   101 KAAVRDVKTLSGGERSFSTVCLLLSLWEVMESPFRCLDEFDVFMDMVN-RKIStdLLVKEaKKQPGRQFIFIT 172
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
127-488 1.04e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  127 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNiaaERKEAKQEKEEA-DRYQRLKDEVVRAQVQLQLFK 205
Cdd:COG4717    53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQE---ELEELEEELEELeAELEELREELEKLEKLLQLLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  206 LYHnevEIEKLNKELASKNKEIEKDKKRMDKVEDelkekkkelgkMMREQQQIEKEIKEKDSELNQ--------KRPQYI 277
Cdd:COG4717   130 LYQ---ELEALEAELAELPERLEELEERLEELRE-----------LEEELEELEAELAELQEELEElleqlslaTEEELQ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  278 KAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS------------------- 338
Cdd:COG4717   196 DLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAallallglggsllslilti 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  339 -----------------QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRL-----DLEERKKVETE 396
Cdd:COG4717   276 agvlflvlgllallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELlelldRIEELQELLRE 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  397 AKIKQKLREIEENQKRIEKL-EEYITTSKQSLE---EQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQES 472
Cdd:COG4717   356 AEELEEELQLEELEQEIAALlAEAGVEDEEELRaalEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELE 435

                         410
                  ....*....|....*.
gi 527317371  473 SRQQRKAEIMESIKRL 488
Cdd:COG4717   436 ELEEELEELEEELEEL 451
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 259-481 1.12e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.13  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   259 EKEIKEKDSELNQKRPQYIKAKENT--SHKIKKLEAAKKSLQNAQKhykkrkgdMDELEKEMLSVEKARQEFEERMEEES 336
Cdd:TIGR00606  844 KIELNRKLIQDQQEQIQHLKSKTNElkSEKLQIGTNLQRRQQFEEQ--------LVELSTEVQSLIREIKDAKEQDSPLE 915

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   337 QSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRL-DLEERKKVETEAKIKQKLREIEENQKRIEK 415
Cdd:TIGR00606  916 TFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIqDGKDDYLKQKETELNTVNAQLEECEKHQEK 995

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 527317371   416 LEEYITTSKQSLEEQKKLEGELTEEVEMAKRR--IDEINKELNQVMEQLGDARIDRQESSRQQRKAEI 481
Cdd:TIGR00606  996 INEDMRLMRQDIDTQKIQERWLQDNLTLRKREneLKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENI 1063
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 141-417 1.13e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 52.82  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   141 ELAQEYDKRKKeMVKAEEDTQFNYHRKKNIAAERKEAKQEKE-EADRYQRLKDEVVRAQVQLQLFKLYHNEV-EIEKLNK 218
Cdd:pfam17380  307 EKAREVERRRK-LEEAEKARQAEMDRQAAIYAEQERMAMERErELERIRQEERKRELERIRQEEIAMEISRMrELERLQM 385

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   219 ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEiKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKK--S 296
Cdd:pfam17380  386 ERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAE-QEEARQREVRRLEEERAREMERVRLEEQERQQQveR 464

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   297 LQNAQKHYKKRKGDMDELEKEMLSVEKAR-----QEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQ-- 369
Cdd:pfam17380  465 LRQQEEERKRKKLELEKEKRDRKRAEEQRrkileKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERrk 544

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 527317371   370 ELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLE 417
Cdd:pfam17380  545 QQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYE 592
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 1106-1166 1.61e-06

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 49.17  E-value: 1.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527317371 1106 LSGGEKTVAALALLFAihsYKPaPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVIS 1166
Cdd:cd00267    81 LSGGQRQRVALARALL---LNP-DLLLLDEPTSGLDPASRERLLELLRELAEEGRTVIIVT 137
PTZ00121 PTZ00121
MAEBL; Provisional
 134-454 1.67e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQ-EKEEADRYQRLKDEVVRAQVQlQLFKLYHNEVE 212
Cdd:PTZ00121 1543 EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEEVMKLYEEEKKMKAE-EAKKAEEAKIK 1621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  213 IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQyiKAKENTSHKIKKLEA 292
Cdd:PTZ00121 1622 AEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE--EDEKKAAEALKKEAE 1699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  293 AKKSLQNAQKHYKKRKGDMDELEKEMlSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELE 372
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKKAEELKKAE-EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE 1778

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  373 KFNRD--QKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDE 450
Cdd:PTZ00121 1779 AVIEEelDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858


                  ....
gi 527317371  451 INKE 454
Cdd:PTZ00121 1859 ENGE 1862
ABC_SMC_head cd03239
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural ...
 15-62 1.77e-06

The SMC head domain belongs to the ATP-binding cassette superfamily; The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.


Pssm-ID: 213206 [Multi-domain]  Cd Length: 178  Bit Score: 49.61  E-value: 1.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 527317371   15 GKSNLMDAISFVLGEKTSNLRVKTLRDLIHGApvGKPAANRAFVSMVY 62
Cdd:cd03239    34 GKSNIVDAICFVLGGKAAKLRRGSLLFLAGGG--VKAGINSASVEITF 79
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 841-1036 2.57e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 2.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  841 IDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDiklpl 920
Cdd:COG3883    25 LSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSG----- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  921 skGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-EEIKQEMNTLQQKLNEQQSVLQRIA 999
Cdd:COG3883   100 --GSVSYLDVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAElEAKLAELEALKAELEAAKAELEAQQ 177

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 527317371 1000 APNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQA 1036
Cdd:COG3883   178 AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
ABC_SMC3_euk cd03272
ATP-binding cassette domain of eukaryotic SMC3 proteins; The structural maintenance of ...
 15-123 3.24e-06

ATP-binding cassette domain of eukaryotic SMC3 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213239 [Multi-domain]  Cd Length: 243  Bit Score: 49.95  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLGEKTSNLRVKTLRDLIH-GApvgKPAANRAFVSMVY--SEE----GAEDRTFARVIVGGSSEYKINN 87
Cdd:cd03272    35 GKSNFFAAIRFVLSDEYTHLREEQRQALLHeGS---GPSVMSAYVEIIFdnSDNrfpiDKEEVRLRRTIGLKKDEYFLDK 111

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 527317371   88 KVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAM 123
Cdd:cd03272   112 KNVTKNDVMNLLESAGFSRSNPYYIVPQGKINSLTN 147
ABC_SMC4_euk cd03274
ATP-binding cassette domain of eukaryotic SMC4 proteins; The structural maintenance of ...
 15-123 3.88e-06

ATP-binding cassette domain of eukaryotic SMC4 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213241 [Multi-domain]  Cd Length: 212  Bit Score: 49.22  E-value: 3.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPvGKPAANRAFVSMvyseegaedrTFARVIVggsseykinnkvvqlhe 94
Cdd:cd03274    37 GKSNVIDSMLFVFGFRASKMRQKKLSDLIHNSA-GHPNLDSCSVEV----------HFQEIID----------------- 88

                          90       100
                  ....*....|....*....|....*....
gi 527317371   95 ySEELEKLGILIKARNFLVFQGAVESIAM 123
Cdd:cd03274    89 -KPLLKSKGIDLDHNRFLILQGEVEQIAQ 116
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 253-479 8.35e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 8.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  253 REQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEK---ARQEFE 329
Cdd:COG4942    27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAeleAQKEEL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  330 ERMEEESQSQGRDLTLEenqvkkyHRLKEEASKRAATLAQELEKFNRDQKADQDRLdleerkkVETEAKIKQKLREIEEN 409
Cdd:COG4942   107 AELLRALYRLGRQPPLA-------LLLSPEDFLDAVRRLQYLKYLAPARREQAEEL-------RADLAELAALRAELEAE 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371  410 QKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKA 479
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAliARLEAEAAAAAERTP 244
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
134-488 9.48e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.06  E-value: 9.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  134 EEISRSGELAQEYDKRKKEMVKAEEdtqfnyhRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEI 213
Cdd:PRK03918  314 KRLSRLEEEINGIEERIKELEEKEE-------RLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTP 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  214 EKLNKELAS---KNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKenTSHKIKKL 290
Cdd:PRK03918  387 EKLEKELEElekAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE--YTAELKRI 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  291 EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEA---SKRAATL 367
Cdd:PRK03918  465 EKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLiklKGEIKSL 544

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  368 AQELEKFNrDQKADQDRLDLEERKKVETEAKIKQKLRE-----IEENQKRIEKLEEY------ITTSKQSLEEQKKLEGE 436
Cdd:PRK03918  545 KKELEKLE-ELKKKLAELEKKLDELEEELAELLKELEElgfesVEELEERLKELEPFyneyleLKDAEKELEREEKELKK 623

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 527317371  437 LTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRL 488
Cdd:PRK03918  624 LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSREL 675
PTZ00121 PTZ00121
MAEBL; Provisional
 119-904 2.57e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  119 ESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKdevvraq 198
Cdd:PTZ00121 1086 DNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIAR------- 1158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  199 vqlqlfklyhnevEIEKLNKELASKNKEiekDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK 278
Cdd:PTZ00121 1159 -------------KAEDARKAEEARKAE---DAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAED 1222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  279 AKEntSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSqgrDLTLEENQVKKYHRLKE 358
Cdd:PTZ00121 1223 AKK--AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKA---DELKKAEEKKKADEAKK 1297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  359 EASKRAATLAQEleKFNRDQKADQDRLDLEERKKVETEAKIKQ---------KLREIEENQKRIEKLEEYITTSKQSLEE 429
Cdd:PTZ00121 1298 AEEKKKADEAKK--KAEEAKKADEAKKKAEEAKKKADAAKKKAeeakkaaeaAKAEAEAAADEAEAAEEKAEAAEKKKEE 1375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  430 QKKLEGELTEEVEmAKRRIDEINK---ELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDlcqPTQK 506
Cdd:PTZ00121 1376 AKKKADAAKKKAE-EKKKADEAKKkaeEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD---EAKK 1451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  507 KyqiavtkvlgknmdaiiVDSEKTGRDCIQYIKEQRGEPEtfLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKA 586
Cdd:PTZ00121 1452 K-----------------AEEAKKAEEAKKKAEEAKKADE--AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA 1512

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  587 lqyacgnalvcDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRwdeKAVDKLKEKKERLTEELKEQ 666
Cdd:PTZ00121 1513 -----------DEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELK---KAEEKKKAEEAKKAEEDKNM 1578

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  667 mkAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHlalnlQEKSKLESELANfgpRINDIKRIIQSREREMKDLKEK 746
Cdd:PTZ00121 1579 --ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK-----AEEAKIKAEELK---KAEEEKKKVEQLKKKEAEEKKK 1648

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  747 MNQVEDEvfEEFCREIGVRNIREFEEEkvKRQNEIAKKRLEFENQKtrlgiqldfeKNQLKEDQDKVHMWEQTVKKDENE 826
Cdd:PTZ00121 1649 AEELKKA--EEENKIKAAEEAKKAEED--KKKAEEAKKAEEDEKKA----------AEALKKEAEEAKKAEELKKKEAEE 1714

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  827 I---EKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKN---HEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQK 900
Cdd:PTZ00121 1715 KkkaEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRM 1794


                  ....
gi 527317371  901 RSDR 904
Cdd:PTZ00121 1795 EVDK 1798
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 209-447 2.68e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  209 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRpqyikakentshkiK 288
Cdd:COG4942    25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE--------------K 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  289 KLEAAKKSLQNAQKHYKK------RKGDMDELeKEMLSVEKARQEFEERMEEESQSQGRdltleENQVKKYHRLKEEASK 362
Cdd:COG4942    91 EIAELRAELEAQKEELAEllralyRLGRQPPL-ALLLSPEDFLDAVRRLQYLKYLAPAR-----REQAEELRADLAELAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  363 RAATLAQE---LEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTE 439
Cdd:COG4942   165 LRAELEAEraeLEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                  ....*...
gi 527317371  440 EVEMAKRR 447
Cdd:COG4942   245 AAGFAALK 252
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 259-480 5.46e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  259 EKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEK---ARQEFEERMEEE 335
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAeieERREELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  336 SQSQGRDLTLEENQVkkyhrlkeeASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEK 415
Cdd:COG3883    95 LYRSGGSVSYLDVLL---------GSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAE 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  416 LEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAE 480
Cdd:COG3883   166 LEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 654-1073 6.15e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.41  E-value: 6.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   654 EKKERLTEELKEQMKAKRKEAELRQVQSQAHglQMRLKYSQSDLEQTKTRhlALNLQEKSKLESElanfgprinDIKRII 733
Cdd:pfam05483  222 EKIQHLEEEYKKEINDKEKQVSLLLIQITEK--ENKMKDLTFLLEESRDK--ANQLEEKTKLQDE---------NLKELI 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   734 QSRE---REMKDLKEKMNQ-VEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKR-------LEFENQKTRLGIQLDFE 802
Cdd:pfam05483  289 EKKDhltKELEDIKMSLQRsMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKaahsfvvTEFEATTCSLEELLRTE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   803 KNQLKEDQDKVHMWEQTVKKDENEIEKLkkeeqrhMKIIDETMAQLQDLKNQhLAKKSEVNDKNHEMEEIRKKLGGANKE 882
Cdd:pfam05483  369 QQRLEKNEDQLKIITMELQKKSSELEEM-------TKFKNNKEVELEELKKI-LAEDEKLLDEKKQFEKIAEELKGKEQE 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   883 MTHL----QKEVTAIETKLEQKRSDRHNLLQacKMQDIKLPLSKGTMDDISQEEGSsqgeDSVSGSQRISSIYAREALIE 958
Cdd:pfam05483  441 LIFLlqarEKEIHDLEIQLTAIKTSEEHYLK--EVEDLKTELEKEKLKNIELTAHC----DKLLLENKELTQEASDMTLE 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   959 IDYGDlcEDLKDAQAEEE-IKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAF 1037
Cdd:pfam05483  515 LKKHQ--EDIINCKKQEErMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 527317371  1038 EQikkeRFDRFNACFESVATNIDEIY---KALSRNSSAQ 1073
Cdd:pfam05483  593 EN----KCNNLKKQIENKNKNIEELHqenKALKKKGSAE 627
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 254-489 6.49e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.43  E-value: 6.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   254 EQQQIEKEIKEKDSELNQKRPqyIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERME 333
Cdd:pfam17380  297 EQERLRQEKEEKAREVERRRK--LEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEIAMEI 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   334 EESQSQGRdLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRI 413
Cdd:pfam17380  375 SRMRELER-LQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL 453

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 527317371   414 EKLE--EYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDrQESSRQQRKAEIMESIKRLY 489
Cdd:pfam17380  454 EEQErqQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIE-EERKRKLLEKEMEERQKAIY 530
PRK12704 PRK12704
phosphodiesterase; Provisional
 251-373 6.76e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.08  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  251 MMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEE 330
Cdd:PRK12704   66 IHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 527317371  331 RMEEESQSQGRDLTLEEnqvkkyhrLKEEASKRAATLAQELEK 373
Cdd:PRK12704  146 RISGLTAEEAKEILLEK--------VEEEARHEAAVLIKEIEE 180
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 391-497 7.24e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  391 KKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVmeqlgDARIDRQ 470
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAEL-----EKEIAEL 95

                          90       100
                  ....*....|....*....|....*..
gi 527317371  471 ESSRQQRKAEIMESIKRLYPGSVYGRL 497
Cdd:COG4942    96 RAELEAQKEELAELLRALYRLGRQPPL 122
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 638-906 7.25e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 7.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   638 KAKARRWDEKAVDKLKEKKERL-TEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLE 716
Cdd:pfam17380  282 KAVSERQQQEKFEKMEQERLRQeKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRE 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   717 SElanfgprindikriiQSREREMKDLKEKMNQVEDEVFEefcreigvrniREFEEEKVKRQNEIAKKRLEFENQKTRLG 796
Cdd:pfam17380  362 LE---------------RIRQEEIAMEISRMRELERLQME-----------RQQKNERVRQELEAARKVKILEEERQRKI 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   797 IQLDFEKNQLKEDQDKVHMWEQTVKKDEN--EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRK 874
Cdd:pfam17380  416 QQQKVEMEQIRAEQEEARQREVRRLEEERarEMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRK 495

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 527317371   875 KLggaNKEMTHLQKEVTAIETK---LEQKRSDRHN 906
Cdd:pfam17380  496 IL---EKELEERKQAMIEEERKrklLEKEMEERQK 527
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 91-488 7.41e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 47.04  E-value: 7.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    91 QLHEYSEELEKLGILIKARNFLVfQGAVES--IAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKk 168
Cdd:pfam15921  420 ELDDRNMEVQRLEALLKAMKSEC-QGQMERqmAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT- 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   169 niAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH----------NEVEIEKLNKELASKNKEIEKDKKRMDKVE 238
Cdd:pfam15921  498 --VSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHlknegdhlrnVQTECEALKLQMAEKDKVIEILRQQIENMT 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   239 DELKEKKKELGKMMREQQQIEKEIKEKDSELNqkrpQYIKAKENTSHKIKKLEA-------AKKSLQNAQKHYKKRKGDM 311
Cdd:pfam15921  576 QLVGQHGRTAGAMQVEKAQLEKEINDRRLELQ----EFKILKDKKDAKIRELEArvsdlelEKVKLVNAGSERLRAVKDI 651

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   312 DELEKEMLSVEKarqefeermeeESQSQGRDLTLEENQVKKYHRLK-EEASKRAATLAQELEKFNRDQKADQDRLDLEE- 389
Cdd:pfam15921  652 KQERDQLLNEVK-----------TSRNELNSLSEDYEVLKRNFRNKsEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEg 720

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   390 ------RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS----LEEQKKLEGEL----TEEVEMA----------- 444
Cdd:pfam15921  721 sdghamKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEkhflKEEKNKLSQELstvaTEKNKMAgelevlrsqer 800

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 527317371   445 --KRRIDEINKELNQVMEQLGDAR--IDRQESSRQQRKAEIMESIKRL 488
Cdd:pfam15921  801 rlKEKVANMEVALDKASLQFAECQdiIQRQEQESVRLKLQHTLDVKEL 848
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 349-489 9.40e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 9.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  349 QVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQK---------LREIEENQKRIEKLEEY 419
Cdd:COG1579    32 ELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnnkeyealQKEIESLKRRISDLEDE 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  420 ITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLgDARIDRQESSRQQRKAEIMESIKRLY 489
Cdd:COG1579   112 ILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAEL-EAELEELEAEREELAAKIPPELLALY 180
ABC_SMC5_euk cd03277
ATP-binding cassette domain of eukaryotic SMC5 proteins; The structural maintenance of ...
 1099-1152 1.11e-04

ATP-binding cassette domain of eukaryotic SMC5 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).


Pssm-ID: 213244 [Multi-domain]  Cd Length: 213  Bit Score: 44.89  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527317371 1099 RFRPMDNL--------SGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYI 1152
Cdd:cd03277   112 KFREGEQLqeldphhqSGGERSVSTMLYLLSLQELTRCPFRVVDEINQGMDPTNERKVFDML 173
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 1088-1186 1.14e-04

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 44.24  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1088 GINYncVAPGkrfRPMDNLSGGEKTVAALALLFAIHSykPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISL 1167
Cdd:cd03238    75 GLGY--LTLG---QKLSTLSGGELQRVKLASELFSEP--PGTLFILDEPSTGLHQQDINQLLEVIKGLIDLGNTVILIEH 147

                          90
                  ....*....|....*....
gi 527317371 1168 KEEFYTKAESLIGVYPEQG 1186
Cdd:cd03238   148 NLDVLSSADWIIDFGPGSG 166
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
349-488 1.26e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.45  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  349 QVKKYHRLKEEASKRAATLAQELEKFnrdQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE 428
Cdd:COG4913   236 DLERAHEALEDAREQIELLEPIRELA---ERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELE 312

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527317371  429 EQKKLEGELTEEVEMAKRRIDEI-NKELNQVMEQLGDARIDRQEssRQQRKAEIMESIKRL 488
Cdd:COG4913   313 RLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEE--RERRRARLEALLAAL 371
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 128-478 1.72e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.19  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  128 ERTALFEEISRSGELaQEYDKRKKEMVKaeEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLY 207
Cdd:PTZ00108 1012 SNKVRFIKHVINGEL-VITNAKKKDLVK--ELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSY 1088

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  208 H----------NEVEIEKLNKELASKNKEIEKDKKRmdkvedelkekkkELGKM-MREQQQIEKEIKEKDSELNQKRPQY 276
Cdd:PTZ00108 1089 DyllsmpiwslTKEKVEKLNAELEKKEKELEKLKNT-------------TPKDMwLEDLDKFEEALEEQEEVEEKEIAKE 1155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  277 IKAKENTSHKIKKLeaAKKSLQNAQKhyKKRKGDMDELEKEMLSVEKARQEFEERMEEESQ-------SQGRDLTLEENQ 349
Cdd:PTZ00108 1156 QRLKSKTKGKASKL--RKPKLKKKEK--KKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKpdnkksnSSGSDQEDDEEQ 1231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  350 VKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEE 429
Cdd:PTZ00108 1232 KTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVK 1311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 527317371  430 QKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK 478
Cdd:PTZ00108 1312 KRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKK 1360
PRK12704 PRK12704
phosphodiesterase; Provisional
 355-487 1.75e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.54  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  355 RLKEEASKRAATLAQELEkfnRDQKadqdrlDLEERKKVETEAKIKQKLREIEENQKRIEKLEE-------YITTSKQSL 427
Cdd:PRK12704   42 RILEEAKKEAEAIKKEAL---LEAK------EEIHKLRNEFEKELRERRNELQKLEKRLLQKEEnldrkleLLEKREEEL 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  428 EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLG-----DARIDRQESSRQQRKAEIMESIKR 487
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEEQLQELERISgltaeEAKEILLEKVEEEARHEAAVLIKE 177
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
314-463 2.27e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.23  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  314 LEKEMlsvEKARQEFEERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAqELEKFNRDQKADQDRLDLEE 389
Cdd:COG2433   382 LEELI---EKELPEEEPEAEREKEHEERELTEEEEEIRRLeeqvERLEAEVEELEAELE-EKDERIERLERELSEARSEE 457

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  390 RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKE-LNQVMEQLG 463
Cdd:COG2433   458 RREIRKDREISRLDREIERLERELEEERERIEELKRKLERLKELWKLEHSGELVPVKVVEKFTKEaIRRLEEEYG 532
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 818-1050 2.38e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  818 QTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKL 897
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  898 EQKRSDRHNLLQACKMQdiklplskGTMDDISQEEGSSQGEDSVSGSQRISSIY-AREALIEiDYGDLCEDLKDAQAE-E 975
Cdd:COG4942   100 EAQKEELAELLRALYRL--------GRQPPLALLLSPEDFLDAVRRLQYLKYLApARREQAE-ELRADLAELAALRAElE 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  976 EIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNA 1050
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 668-899 2.40e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  668 KAKRKEAELRQVQSQahglqmrLKYSQSDLEQTKtrhlalnlQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKM 747
Cdd:COG4942    21 AAAEAEAELEQLQQE-------IAELEKELAALK--------KEEKALLKQLAALERRIAALARRIRALEQELAALEAEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  748 NQVEDEvfeefcreigvrnIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEI 827
Cdd:COG4942    86 AELEKE-------------IAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQA 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 527317371  828 EKLKKE-------EQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQ 899
Cdd:COG4942   153 EELRADlaelaalRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
PRK01156 PRK01156
chromosome segregation protein; Provisional
 15-474 3.03e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 45.28  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   15 GKSNLMDAISFVLgekTSNLRVKTLRDLIhgapvgKPAANRAFVSMVYSEEGAEDRTFARVIVGG-----SSEYKINNKV 89
Cdd:PRK01156   35 GKSSIVDAIRFAL---FTDKRTEKIEDMI------KKGKNNLEVELEFRIGGHVYQIRRSIERRGkgsrrEAYIKKDGSI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   90 VQ--LHEYSEELEKLGILIKARNFL----VFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMvkaeedtqfn 163
Cdd:PRK01156  106 IAegFDDTTKYIEKNILGISKDVFLnsifVGQGEMDSLISGDPAQRKKILDEILEINSLERNYDKLKDVI---------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  164 yhrkKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLfKLYHNEVEIEKLNKELASKNKEIEKDKKRMDkvedelke 243
Cdd:PRK01156  176 ----DMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEK-SHSITLKEIERLSIEYNNAMDDYNNLKSALN-------- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  244 kkkELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELeKEMLSVEK 323
Cdd:PRK01156  243 ---ELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENK-KQILSNID 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  324 ArqefeermeeesqsqgrdltleenQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLE--ERKKVETEAKIKQ 401
Cdd:PRK01156  319 A------------------------EINKYHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEgyEMDYNSYLKSIES 374

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527317371  402 KLREIEENQKRIEKLEEYITtskQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSR 474
Cdd:PRK01156  375 LKKKIEEYSKNIERMSAFIS---EILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSR 444
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 356-486 3.66e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.82  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  356 LKEEASKRA-ATLAQELEKFNR-DQKADQDRLDLEERKKvETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEqkkl 433
Cdd:PRK00409  499 LPENIIEEAkKLIGEDKEKLNElIASLEELERELEQKAE-EAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEK---- 573

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 527317371  434 egELTEEVEMAKRRIDEINKELNQvMEQLGDARIDRQESSRQQRK----AEIMESIK 486
Cdd:PRK00409  574 --EAQQAIKEAKKEADEIIKELRQ-LQKGGYASVKAHELIEARKRlnkaNEKKEKKK 627
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 144-453 5.65e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.33  E-value: 5.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   144 QEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQrlkdEVVRAQVQLQLFKLYHNEVEIEKLNKELASK 223
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIA----EELKGKEQELIFLLQAREKEIHDLEIQLTAI 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   224 NKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 303
Cdd:pfam05483  463 KTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEK 542

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   304 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQD 383
Cdd:pfam05483  543 EMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKK 622

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   384 RLDLEERKKVETEAKIKQKLREIEENQkriEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINK 453
Cdd:pfam05483  623 KGSAENKQLNAYEIKVNKLELELASAK---QKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVK 689
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 213-455 7.11e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 7.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   213 IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQiekeikEKDsELNQKRPQYIKAKENtshKIKKLEA 292
Cdd:pfam12128  620 QAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQS------EKD-KKNKALAERKDSANE---RLNSLEA 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   293 AKKSLQNAQKHYKKR-KGDMDELEKEMLSVEKArqefeermeeesqsqgrdltLEENQVKKYHRLKEEASKRAATLAQEL 371
Cdd:pfam12128  690 QLKQLDKKHQAWLEEqKEQKREARTEKQAYWQV--------------------VEGALDAQLALLKAAIAARRSGAKAEL 749

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   372 EKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEY---------------ITTSKQSLEEQKKLEGE 436
Cdd:pfam12128  750 KALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYfdwyqetwlqrrprlATQLSNIERAISELQQQ 829

                          250
                   ....*....|....*....
gi 527317371   437 LTEEVEMAKRRIDEINKEL 455
Cdd:pfam12128  830 LARLIADTKLRRAKLEMER 848
PRK01156 PRK01156
chromosome segregation protein; Provisional
 625-1191 7.13e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.12  E-value: 7.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  625 QKSGVISGGASDLKAKARRWDE--KAVDKLKEKKERLTEELK--EQMKAKRKEAELRQVQSQAHgLQMRLKYSQSDLEQT 700
Cdd:PRK01156  329 KKLSVLQKDYNDYIKKKSRYDDlnNQILELEGYEMDYNSYLKsiESLKKKIEEYSKNIERMSAF-ISEILKIQEIDPDAI 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  701 KTRHLALNlQEKSKLESELANFGPRINDIkriiqsREREMkDLKEKMNQVEDEVFEEFCR----EIGVRNIRE------- 769
Cdd:PRK01156  408 KKELNEIN-VKLQDISSKVSSLNQRIRAL------RENLD-ELSRNMEMLNGQSVCPVCGttlgEEKSNHIINhynekks 479

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  770 -FEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMA-Q 847
Cdd:PRK01156  480 rLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSlK 559

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  848 LQDL--KNQHLAKKSEVNDkNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRS-----------------DRHNLL 908
Cdd:PRK01156  560 LEDLdsKRTSWLNALAVIS-LIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSyidksireieneannlnNKYNEI 638

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  909 QACKMQDIKLplsKGTMDDISQEegsSQGEDSVSGSQriSSIYAREALIEIDYGDLCEDLKDAQAE--------EEIKQE 980
Cdd:PRK01156  639 QENKILIEKL---RGKIDNYKKQ---IAEIDSIIPDL--KEITSRINDIEDNLKKSRKALDDAKANrarlestiEILRTR 710

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  981 MNTLQQKLNEQQSVLQRiaapnMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVatNID 1060
Cdd:PRK01156  711 INELSDRINDINETLES-----MKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTSLTRKYLFEFNLDFDDI--DVD 783

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1061 EIYK-ALSRNSSAQAflgpenpeepyldginyncvapgkrfrpMDNLSGGEKTVAALALLFAIHSY--KPAPFFVLDEID 1137
Cdd:PRK01156  784 QDFNiTVSRGGMVEG----------------------------IDSLSGGEKTAVAFALRVAVAQFlnNDKSLLIMDEPT 835

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 527317371 1138 AALDN---TNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVIS 1191
Cdd:PRK01156  836 AFLDEdrrTNLKDIIEYSLKDSSDIPQVIMISHHRELLSVADVAYEVKKSSGSSKVI 892
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
127-472 8.01e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  127 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEE-ADRYQRLKDEVVRAQVQLQLFK 205
Cdd:PRK03918  221 EELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEElEEKVKELKELKEKAEEYIKLSE 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  206 LYHN-EVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKkKELGKMMREQQQIEKEIKEKDSELNQKRP-----QYIKA 279
Cdd:PRK03918  301 FYEEyLDELREIEKRLSRLEEEINGIEERIKELEEKEERL-EELKKKLKELEKRLEELEERHELYEEAKAkkeelERLKK 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  280 K------ENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMD----ELEKEMLSVEKA--------RQEFEERMEEESQSQGR 341
Cdd:PRK03918  380 RltgltpEKLEKELEELEKAKEEIEEEISKITARIGELKkeikELKKAIEELKKAkgkcpvcgRELTEEHRKELLEEYTA 459

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  342 DLTLEENQVKKYHRLKEEASKRAATLAQELEKFNR----DQKADQDRlDLEERKKVETEAKIKQKLREIEENQKRIEKLE 417
Cdd:PRK03918  460 ELKRIEKELKEIEEKERKLRKELRELEKVLKKESEliklKELAEQLK-ELEEKLKKYNLEELEKKAEEYEKLKEKLIKLK 538

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  418 EYITTSKQSLEEQKKLEGELtEEVEMAKRRIDEINKELNQVMEQLGDARIDRQES 472
Cdd:PRK03918  539 GEIKSLKKELEKLEELKKKL-AELEKKLDELEEELAELLKELEELGFESVEELEE 592
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 96-440 8.68e-04

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 43.69  E-value: 8.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   96 SEELEKLGILiKARNFLVFQGA--VESIAMKNPKERTALFeeiSRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE 173
Cdd:PLN03229  390 TEELLKHRML-KFRKIGGFQEGvpVDPERKVNMKKREAVK---TPVRELEGEVEKLKEQILKAKESSSKPSELALNEMIE 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  174 R--KEAKQEKEEA-------DRYQRLKDEVVRAQVQLQLFklyhNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEK 244
Cdd:PLN03229  466 KlkKEIDLEYTEAviamglqERLENLREEFSKANSQDQLM----HPVLMEKIEKLKDEFNKRLSRAPNYLSLKYKLDMLN 541

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  245 KKELGKMMREQQQIEKEIKekdSELNQKRPQYIKAKEntshkIK-KLEAAKKSLQNAQKHykkRKGDMDELEKEmlSVEK 323
Cdd:PLN03229  542 EFSRAKALSEKKSKAEKLK---AEINKKFKEVMDRPE-----IKeKMEALKAEVASSGAS---SGDELDDDLKE--KVEK 608

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  324 ARQEFEERMEEESQSQGRDL-------------TLEENQVKKYHRLKEEASK------RAATLAQELEKFNRDQKADQDR 384
Cdd:PLN03229  609 MKKEIELELAGVLKSMGLEVigvtkknkdtaeqTPPPNLQEKIESLNEEINKkierviRSSDLKSKIELLKLEVAKASKT 688

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 527317371  385 LDLEERKKVET-EAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEE 440
Cdd:PLN03229  689 PDVTEKEKIEAlEQQIKQKIAEALNSSELKEKFEELEAELAAARETAAESNGSLKND 745
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 171-412 8.74e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  171 AAERKEAKQEKEEadryqrlkdevVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGK 250
Cdd:COG4942    19 ADAAAEAEAELEQ-----------LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  251 MMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKI----KKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQ 326
Cdd:COG4942    88 LEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  327 EFEERMEEESQsqgrdltLEENQVKKYHRLKEEASKRAATLAQelekFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 406
Cdd:COG4942   168 ELEAERAELEA-------LLAELEEERAALEALKAERQKLLAR----LEKELAELAAELAELQQEAEELEALIARLEAEA 236


                  ....*.
gi 527317371  407 EENQKR 412
Cdd:COG4942   237 AAAAER 242
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
257-488 8.87e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.49  E-value: 8.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  257 QIE-KEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQ---KHYKKRKGDMDELEKEMLSV-EKARQEFEER 331
Cdd:PRK02224  195 QIEeKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADevlEEHEERREELETLEAEIEDLrETIAETERER 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  332 MEEESQSQGRDLTLEEnqvkkyhrLKEEASKRAATLAQElekfNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQK 411
Cdd:PRK02224  275 EELAEEVRDLRERLEE--------LEEERDDLLAEAGLD----DADAEAVEARREELEDRDEELRDRLEECRVAAQAHNE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  412 RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKR-------RIDEINKELNQVMEQLGDARIDRQES-----SRQQRKA 479
Cdd:PRK02224  343 EAESLREDADDLEERAEELREEAAELESELEEAREavedrreEIEELEEEIEELRERFGDAPVDLGNAedfleELREERD 422


                  ....*....
gi 527317371  480 EIMESIKRL 488
Cdd:PRK02224  423 ELREREAEL 431
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
635-856 9.44e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  635 SDLKAKARRWDEKAVDKlkekkeRLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSK 714
Cdd:COG4913   255 EPIRELAERYAAARERL------AELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDEL 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  715 LESELANFGPRINDIKRIIQSREREMKDLKEKMNQvedevFEEFCREIGVrnirefeeekvkrqnEIAKKRLEFENQKTR 794
Cdd:COG4913   329 EAQIRGNGGDRLEQLEREIERLERELEERERRRAR-----LEALLAALGL---------------PLPASAEEFAALRAE 388

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527317371  795 LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKE----EQRHmKIIDETMAQLQDLKNQHL 856
Cdd:COG4913   389 AAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiaslERRK-SNIPARLLALRDALAEAL 453
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 369-488 1.01e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  369 QELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE---------LTE 439
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvrnnkeyeaLQK 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 527317371  440 EVEMAKRRIDEINKELNQVMEQLGDAR--IDRQESSRQQRKAEIMESIKRL 488
Cdd:COG1579    97 EIESLKRRISDLEDEILELMERIEELEeeLAELEAELAELEAELEEKKAEL 147
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
771-1000 2.07e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  771 EEEKVKRQNEIAKKRLEFENQKTRLGIqLDFEKNQLK--EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL 848
Cdd:COG4913   247 AREQIELLEPIRELAERYAAARERLAE-LEYLRAALRlwFAQRRLELLEAELEELRAELARLEAELERLEARLDALREEL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  849 QDLKNQHLAkksevndknhemeeirkkLGGANKEmtHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDI 928
Cdd:COG4913   326 DELEAQIRG------------------NGGDRLE--QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAAL 385

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 527317371  929 SQEegssqgedsvsGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-EEIKQEMNTLQQ-KLN---EQQSVLQRIAA 1000
Cdd:COG4913   386 RAE-----------AAALLEALEEELEALEEALAEAEAALRDLRRElRELEAEIASLERrKSNipaRLLALRDALAE 451
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
650-909 2.09e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 42.36  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  650 DKLKEKKERLTEELKEqmkAKRKEAELRQVQSQAHGLQMRLKysqsDLEQTKTRhlalnlqekskleselanfgprINDI 729
Cdd:PRK03918  193 ELIKEKEKELEEVLRE---INEISSELPELREELEKLEKEVK----ELEELKEE----------------------IEEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  730 KRIIQSREREMKDLKEKMNQVEDEVFEEfcreigVRNIREFeEEKVKRQNEIAKKRLEFENQKtRLGIQLDFEKNQLKED 809
Cdd:PRK03918  244 EKELESLEGSKRKLEEKIRELEERIEEL------KKEIEEL-EEKVKELKELKEKAEEYIKLS-EFYEEYLDELREIEKR 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  810 QDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKsEVNDKNHEMEEIRKKLGGANKEmtHLQKE 889
Cdd:PRK03918  316 LSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE-EAKAKKEELERLKKRLTGLTPE--KLEKE 392

                         250       260
                  ....*....|....*....|
gi 527317371  890 VTAIETKLEQKRSDRHNLLQ 909
Cdd:PRK03918  393 LEELEKAKEEIEEEISKITA 412
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 173-455 2.41e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   173 ERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMM 252
Cdd:TIGR04523  402 NQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIK 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   253 REQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM 332
Cdd:TIGR04523  482 QNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEK 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   333 EEESQSQgrdltlEENQVKKYHRLKEEASKRAATLAQELEKfnrdqkaDQDRLDLEERKKVETEAKIKQKLREIEENQKR 412
Cdd:TIGR04523  562 EIDEKNK------EIEELKQTQKSLKKKQEEKQELIDQKEK-------EKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 527317371   413 IEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKEL 455
Cdd:TIGR04523  629 LSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKES 671
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
657-854 2.43e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  657 ERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSR 736
Cdd:COG4717    49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  737 E--REMKDLKEKMNQVEDEVfEEFCREIgvRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQldfEKNQLKEDQDKVH 814
Cdd:COG4717   129 PlyQELEALEAELAELPERL-EELEERL--EELRELEEELEELEAELAELQEELEELLEQLSLA---TEEELQDLAEELE 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 527317371  815 MWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQ 854
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE 242
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 357-488 3.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  357 KEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 436
Cdd:COG4942    29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAE 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  437 LT---------------------EEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRL 488
Cdd:COG4942   109 LLralyrlgrqpplalllspedfLDAVRRLQYLKYLAPARREQAEELRAdlAELAALRAELEAERAELEALLAEL 183
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 15-858 3.66e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.49  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    15 GKSNLMDAISFVLGEKTSNLR--VKTLRDLIHGAPVGKPA---------ANRAFVSMVYSEEGAEDRTFARVIVG--GSS 81
Cdd:TIGR00618   38 GKTTLLDAITYALYGKLPRRSevIRSLNSLYAAPSEAAFAelefslgtkIYRVHRTLRCTRSHRKTEQPEQLYLEqkKGR 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371    82 EYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFE----------------EISRSGELAQE 145
Cdd:TIGR00618  118 GRILAAKKSETEEVIHDLLKLDYKTFTRVVLLPQGEFAQFLKAKSKEKKELLMnlfpldqytqlalmefAKKKSLHGKAE 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   146 YDKRKKEMVK--AEEDTQFNYHRKKNIAAERK---EAKQEKEEADRYQRLKDEVVRAQVQLQ--LFKLYHNEVEIEKLNK 218
Cdd:TIGR00618  198 LLTLRSQLLTlcTPCMPDTYHERKQVLEKELKhlrEALQQTQQSHAYLTQKREAQEEQLKKQqlLKQLRARIEELRAQEA 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   219 ELASKNKEIEKDKKrmdkvEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTShKIKKLEAAKKSLQ 298
Cdd:TIGR00618  278 VLEETQERINRARK-----AAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQS-SIEEQRRLLQTLH 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   299 NAQKHYK----KRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAatLAQELEKF 374
Cdd:TIGR00618  352 SQEIHIRdaheVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRD--LQGQLAHA 429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   375 NRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE---EQKKLEGELTEEVEMAKRRIDEI 451
Cdd:TIGR00618  430 KKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLqetRKKAVVLARLLELQEEPCPLCGS 509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   452 NKELNQVMEQLGDARIDRQESSR-QQRKAEIMESIKRLYpgsvygrliDLCQPTQKKYQIAvtkvlgKNMDAIIVDSEKT 530
Cdd:TIGR00618  510 CIHPNPARQDIDNPGPLTRRMQRgEQTYAQLETSEEDVY---------HQLTSERKQRASL------KEQMQEIQQSFSI 574

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   531 GRDCIQYIKEQRgePETFLPLDylEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGG 610
Cdd:TIGR00618  575 LTQCDNRSKEDI--PNLQNITV--RLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHA 650

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   611 ------HQRHKTVALDGTLFQKSgviSGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQA- 683
Cdd:TIGR00618  651 lqltltQERVREHALSIRVLPKE---LLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENAs 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   684 HGLQMRLKYSQSDLEQ----------TKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDE 753
Cdd:TIGR00618  728 SSLGSDLAAREDALNQslkelmhqarTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAE 807

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   754 VFEEfcreigvrnIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKK- 832
Cdd:TIGR00618  808 IGQE---------IPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKl 878

                          890       900       910
                   ....*....|....*....|....*....|....*..
gi 527317371   833 ----------EEQRHMKIIDETMAQ-LQDLKNQHLAK 858
Cdd:TIGR00618  879 nginqikiqfDGDALIKFLHEITLYaNVRLANQSEGR 915
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 686-899 4.82e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.03  E-value: 4.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   686 LQMRLKYSQsdleqtKTRHLALNLQEKSKLESELANfgpriNDIKRIIQSREREMKDLKEKMNQVEDEVfeefcreigvR 765
Cdd:pfam07888   32 LQNRLEECL------QERAELLQAQEAANRQREKEK-----ERYKRDREQWERQRRELESRVAELKEEL----------R 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   766 NIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETM 845
Cdd:pfam07888   91 QSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEE 170

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 527317371   846 AQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQ 899
Cdd:pfam07888  171 AERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTT 224
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 644-909 5.22e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   644 WDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAhgLQMRLKYSQSDLEQTKTRHLalnlQEKSKLESELANFG 723
Cdd:pfam05483  422 DEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTA--IKTSEEHYLKEVEDLKTELE----KEKLKNIELTAHCD 495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   724 PRINDIKRIIQSREREMKDLKekmNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEK 803
Cdd:pfam05483  496 KLLLENKELTQEASDMTLELK---KHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSE 572

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   804 NQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEM 883
Cdd:pfam05483  573 ENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKF 652

                          250       260
                   ....*....|....*....|....*.
gi 527317371   884 THLqkeVTAIETKLEQKRSDRHNLLQ 909
Cdd:pfam05483  653 EEI---IDNYQKEIEDKKISEEKLLE 675
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 340-480 5.27e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 40.76  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   340 GRDLTLEENQVKKYHRLKEEASKRAATLAQELEKfnrdqkaDQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEY 419
Cdd:pfam05262  191 EKGVNFRRDMTDLKERESQEDAKRAQQLKEELDK-------KQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKNLPKP 263

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527317371   420 ITTskQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAE 480
Cdd:pfam05262  264 ADT--SSPKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHKAFdlKQESKASEKEAEDKEL 324
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 165-297 5.28e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  165 HRKKNIAAERKEAKQEKEEA-DRYQRLKDEVVRAQVQLQLFKLYHNEVE--IEKL---------NKELASKNKEIEKDKK 232
Cdd:COG1579    24 HRLKELPAELAELEDELAALeARLEAAKTELEDLEKEIKRLELEIEEVEarIKKYeeqlgnvrnNKEYEALQKEIESLKR 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527317371  233 RMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSL 297
Cdd:COG1579   104 RISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 205-487 6.62e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.77  E-value: 6.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   205 KLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTS 284
Cdd:TIGR04523   90 KLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   285 HKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKE------ 358
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEktteis 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   359 EASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKriEKLEEYITTSKQSLEEQKKLEGELT 438
Cdd:TIGR04523  250 NTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNN--QKEQDWNKELKSELKNQEKKLEEIQ 327

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 527317371   439 EEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ-QRKAEIMESIKR 487
Cdd:TIGR04523  328 NQISQNNKIISQLNEQISQLKKELTNSESENSEKQRElEEKQNEIEKLKK 377
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 291-488 6.98e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   291 EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRdLTLEENQ----VKKYHRLKEEASKRAAT 366
Cdd:pfam17380  291 EKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQER-MAMERERelerIRQEERKRELERIRQEE 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371   367 LAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREiEENQKRIekleeyittsKQSLEEQKKLEGELTEEVEMAKR 446
Cdd:pfam17380  370 IAMEISRMRELERLQMERQQKNERVRQELEAARKVKILE-EERQRKI----------QQQKVEMEQIRAEQEEARQREVR 438

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 527317371   447 RIDEinkELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRL 488
Cdd:pfam17380  439 RLEE---ERAREMERVRLEEQERQQQVERLRQQEEERKRKKL 477
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 358-465 7.18e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.05  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  358 EEASKRAATLAQELEKFNRDQKADQDRLDLEERK---KVETEAKIKQKlREIEENQKRIEKL-EEYITTSKQSLEEQKKL 433
Cdd:cd22656   131 KKYQDKAAKVVDKLTDFENQTEKDQTALETLEKAlkdLLTDEGGAIAR-KEIKDLQKELEKLnEEYAAKLKAKIDELKAL 209

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 527317371  434 EGELTEEVEMAKR---RIDEINKELNQVMEQLGDA 465
Cdd:cd22656   210 IADDEAKLAAALRliaDLTAADTDLDNLLALIGPA 244
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 191-445 7.58e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 40.30  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  191 KDEVVRAqvqLQLFKLYH-NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMR-EQQQIEKEIKEKDSE 268
Cdd:PRK05771   18 KDEVLEA---LHELGVVHiEDLKEELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKvSVKSLEELIKDVEEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  269 LNQKRPQyIKAKENtshKIKKLEAAKKSLQNAQKHYKKRKG-DMD---ELEKEMLSVEKARQEFEERMEEESQSQGRDLt 344
Cdd:PRK05771   95 LEKIEKE-IKELEE---EISELENEIKELEQEIERLEPWGNfDLDlslLLGFKYVSVFVGTVPEDKLEELKLESDVENV- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  345 LEENQVKKYHR-----LKEEASKRAATLAqelekfnrdqKADQDRLDLEERKKVETEakIKQKLREIEENQKRIEKLEEY 419
Cdd:PRK05771  170 EYISTDKGYVYvvvvvLKELSDEVEEELK----------KLGFERLELEEEGTPSEL--IREIKEELEEIEKERESLLEE 237

                         250       260
                  ....*....|....*....|....*..
gi 527317371  420 ITTSKQSLEE-QKKLEGELTEEVEMAK 445
Cdd:PRK05771  238 LKELAKKYLEeLLALYEYLEIELERAE 264
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
657-1156 8.71e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  657 ERLTEELKEqmkAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLAL--------NLQEKSKLESELANFGPRIND 728
Cdd:COG4717    74 KELEEELKE---AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekllqllpLYQELEALEAELAELPERLEE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  729 IKRIIQSREREMKDLKEKMNQVED--EVFEEFCREIGVRNIREFEEeKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQL 806
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAElqEELEELLEQLSLATEEELQD-LAEELEELQQRLAELEEELEEAQEELEELEEEL 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  807 KEDQDKVHMWEQTVKKDENEI----------------------------------------EKLKKEEQRHMKIIDETma 846
Cdd:COG4717   230 EQLENELEAAALEERLKEARLllliaaallallglggsllsliltiagvlflvlgllallfLLLAREKASLGKEAEEL-- 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  847 qlqdlknQHLAKKSEVNDKnhEMEEIRKKLG----GANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSK 922
Cdd:COG4717   308 -------QALPALEELEEE--ELEELLAALGlppdLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAE 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  923 GTMDDISQ-EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAP 1001
Cdd:COG4717   379 AGVEDEEElRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAEL 458

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1002 N------------MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNAcfesvatNIDEIYKALSRN 1069
Cdd:COG4717   459 EaeleqleedgelAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLE-------RASEYFSRLTDG 531

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1070 SSAQAFLgpenPEEPYLDGINYNCvapgkRFRPMDNLSGGEKTVAALALLFA-IHSYKPAPF-FVLDEIDAALDNTNIGK 1147
Cdd:COG4717   532 RYRLIRI----DEDLSLKVDTEDG-----RTRPVEELSRGTREQLYLALRLAlAELLAGEPLpLILDDAFVNFDDERLRA 602


                  ....*....
gi 527317371 1148 VANYIKEQS 1156
Cdd:COG4717   603 ALELLAELA 611
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
646-901 9.14e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  646 EKAVDKLKEKKERLTE----ELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS------DLEQTKTRHLALN------L 709
Cdd:PRK03918  227 EKEVKELEELKEEIEElekeLESLEGSKRKLEEKIRELEERIEELKKEIEELEEkvkelkELKEKAEEYIKLSefyeeyL 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  710 QEKSKLESELANFGPRINDIKRIIQ---SREREMKDLKEKMNQVEDEVfeefcreigvrnirEFEEEKVKRQNEIAKKRL 786
Cdd:PRK03918  307 DELREIEKRLSRLEEEINGIEERIKeleEKEERLEELKKKLKELEKRL--------------EELEERHELYEEAKAKKE 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371  787 EFENQKTRLGiqlDFEKNQLKEDQDKVhmwEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLA--------- 857
Cdd:PRK03918  373 ELERLKKRLT---GLTPEKLEKELEEL---EKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrelt 446

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 527317371  858 ---KKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKR 901
Cdd:PRK03918  447 eehRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKES 493
ABC_sbcCD cd03279
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ...
 1101-1176 9.34e-03

ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.


Pssm-ID: 213246 [Multi-domain]  Cd Length: 213  Bit Score: 38.79  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317371 1101 RPMDNLSGGEKTVAALALLFAIHSY------KPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVIS----LKEE 1170
Cdd:cd03279   119 RPVSTLSGGETFLASLSLALALSEVlqnrggARLEALFIDEGFGTLDPEALEAVATALELIRTENRMVGVIShveeLKER 198


                  ....*.
gi 527317371 1171 FYTKAE 1176
Cdd:cd03279   199 IPQRLE 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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