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Conserved domains on  [gi|527498299|ref|NP_001268432|]
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SLIT and NTRK-like protein 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-530 8.51e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 8.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKShFVDYKNLILLDLGNNNIATVENNtFKNLLDLRWLYMDSNYLDT 437
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LSREkFAGLQNLEYLNVEYNAIQlILPGTFNAMPKLRILILNNNLLRSLPvDVFAGVSLSKLSLHNNYFMYLPVAGVLDQ 517
Cdd:COG4886  197 LPEP-LGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN 273

                        170
                 ....*....|...
gi 527498299 518 LTSiiqIDLHGNP 530
Cdd:COG4886  274 LKT---LDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-212 2.88e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 2.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  63 LFLHGNSLTRLfPNEFANFYNAVSLHMENNGLHEIvPGAFLGLQLVKRLHINNNKIKSFRKqTFLGLDDLEYLQADFNLL 142
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 143 RDIdPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYeevLEQIPGIAEILLEDN 212
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
212-250 5.91e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 527498299   212 NPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGK 250
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
529-579 1.85e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 527498299   529 NPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-530 8.51e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 8.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKShFVDYKNLILLDLGNNNIATVENNtFKNLLDLRWLYMDSNYLDT 437
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LSREkFAGLQNLEYLNVEYNAIQlILPGTFNAMPKLRILILNNNLLRSLPvDVFAGVSLSKLSLHNNYFMYLPVAGVLDQ 517
Cdd:COG4886  197 LPEP-LGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN 273

                        170
                 ....*....|...
gi 527498299 518 LTSiiqIDLHGNP 530
Cdd:COG4886  274 LKT---LDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-212 2.88e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 2.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  63 LFLHGNSLTRLfPNEFANFYNAVSLHMENNGLHEIvPGAFLGLQLVKRLHINNNKIKSFRKqTFLGLDDLEYLQADFNLL 142
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 143 RDIdPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYeevLEQIPGIAEILLEDN 212
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-530 2.24e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPkLSNVQELFLRDNKIHSIRKSHFvdYKNLILLDLGNNNIATVENntFKNLLDLRWLYMDSNYLDT 437
Cdd:cd21340    8 YLNDKNITKIDNLSL-CKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LsrEKFAGLQNLEYLNVEYNAIQ-----LILPGTFNAM-PKLRILILNNNLLRSLpvDVFAG-VSLSKLSLHNNYFMYL- 509
Cdd:cd21340   83 V--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPlRNLEQLDASNNQISDLe 158

                        170       180
                 ....*....|....*....|.
gi 527498299 510 PVAGVLDQLTSIIQIDLHGNP 530
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
375-435 6.03e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 6.03e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527498299  375 SNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYL 435
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
108-166 1.62e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.62e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 527498299  108 VKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLI 166
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
212-250 5.91e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 527498299   212 NPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGK 250
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.85e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 527498299   529 NPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-189 2.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  62 HLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNL 141
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 527498299 142 LRDIDPGAFQDLNKLEVLILNDNLIS-TLPANVFQYVPITHLDLRGNRL 189
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 365-504 4.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 365 SSLADLKpklsNVQELFLRDNKIH-SIRKSHFvDYKNLILLDLGNNniatvenntfknlldlrwlymdsnYLDTLSREKF 443
Cdd:PLN00113 254 SSLGNLK----NLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDN------------------------SLSGEIPELV 304

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527498299 444 AGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILIL-NNNLLRSLPVDVFAGVSLSKLSLHNN 504
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLSTN 366
LRR smart00370
Leucine-rich repeats, outliers;
470-493 6.64e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 527498299   470 MPKLRILILNNNLLRSLPVDVFAG 493
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-530 8.51e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 8.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKShFVDYKNLILLDLGNNNIATVENNtFKNLLDLRWLYMDSNYLDT 437
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LSREkFAGLQNLEYLNVEYNAIQlILPGTFNAMPKLRILILNNNLLRSLPvDVFAGVSLSKLSLHNNYFMYLPVAGVLDQ 517
Cdd:COG4886  197 LPEP-LGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTN 273

                        170
                 ....*....|...
gi 527498299 518 LTSiiqIDLHGNP 530
Cdd:COG4886  274 LKT---LDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
373-529 1.29e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 373 KLSNVQELFLRDNKIHSIRKShFVDYKNLILLDLGNNNIATVeNNTFKNLLDLRWLYMDSNYLDTLSREkFAGLQNLEYL 452
Cdd:COG4886  111 NLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKEL 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 527498299 453 NVEYNAIQlILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPvagVLDQLTSIIQIDLHGN 529
Cdd:COG4886  188 DLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-212 2.88e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 2.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  63 LFLHGNSLTRLfPNEFANFYNAVSLHMENNGLHEIvPGAFLGLQLVKRLHINNNKIKSFRKqTFLGLDDLEYLQADFNLL 142
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 143 RDIdPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYeevLEQIPGIAEILLEDN 212
Cdd:COG4886  195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-530 2.24e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPkLSNVQELFLRDNKIHSIRKSHFvdYKNLILLDLGNNNIATVENntFKNLLDLRWLYMDSNYLDT 437
Cdd:cd21340    8 YLNDKNITKIDNLSL-CKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LsrEKFAGLQNLEYLNVEYNAIQ-----LILPGTFNAM-PKLRILILNNNLLRSLpvDVFAG-VSLSKLSLHNNYFMYL- 509
Cdd:cd21340   83 V--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPlRNLEQLDASNNQISDLe 158

                        170       180
                 ....*....|....*....|.
gi 527498299 510 PVAGVLDQLTSIIQIDLHGNP 530
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
375-435 6.03e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 6.03e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527498299  375 SNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYL 435
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
425-483 9.45e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 9.45e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 527498299  425 LRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLL 483
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
108-166 1.62e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.62e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 527498299  108 VKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLI 166
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
132-189 6.12e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 6.12e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 527498299  132 LEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVP-ITHLDLRGNRL 189
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-304 1.11e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  62 HLFLHGNSLTRLfPNEFANFYNAVSLHMENNGLHEIvPGAFLGLQLVKRLHINNNKIKSFrKQTFLGLDDLEYLQADFNL 141
Cdd:COG4886  163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 142 LRDIDpgAFQDLNKLEVLILNDNLISTLPANvFQYVPITHLDLRGNRLKTLPYEEvLEQIPGIAEILLEDNPWDCTCDLL 221
Cdd:COG4886  240 LTDLP--ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKE-LELLLGLNSLLLLLLLLNLLELLI 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 222 SLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATP 301
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 ...
gi 527498299 302 GSA 304
Cdd:COG4886  396 TTA 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-591 2.83e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 358 NCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKShFVDYKNLILLDLGNNNIATVENnTFKNLLDLRWLYMDSNYLDT 437
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 438 LSREkFAGLQNLEYLNVEYNAIQLI---------------------LPGTFNaMPKLRILILNNNLLRSLPVDVFA--GV 494
Cdd:COG4886  220 LPEP-LANLTNLETLDLSNNQLTDLpelgnltnleeldlsnnqltdLPPLAN-LTNLKTLDLSNNQLTDLKLKELEllLG 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 495 SLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSN 574
Cdd:COG4886  298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377

                        250
                 ....*....|....*..
gi 527498299 575 DEICPQLYARISPTLTS 591
Cdd:COG4886  378 TLLTLALLLLTLLLLLL 394
LRR_8 pfam13855
Leucine rich repeat;
400-459 5.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.81e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  400 NLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAI 459
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-142 1.21e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 527498299   86 SLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLL 142
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
447-506 1.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 527498299  447 QNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAG-VSLSKLSLHNNYF 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
399-532 2.18e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 399 KNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNyldtlsrEKFAGLQNLEYLNVEYNAIQLiLPGTFNAMPKLRILIL 478
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDL 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 527498299 479 NNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAgvLDQLTSIIQIDLHGNPWE 532
Cdd:COG4886  144 SNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-213 2.53e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 2.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  91 NNGLHEIVPGAFLGLQLVKRLHINNNKiksfrkqTFLGLDDLEYLQADFNLLRDIdPGAFQDLNKLEVLILNDNLISTLP 170
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 527498299 171 ANVFQYVPITHLDLRGNRLKTLPyeEVLEQIPGIAEILLEDNP 213
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNNQ 193
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-529 9.35e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 365 SSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFA 444
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 445 GLQNLEYLNVEYNAiqlilpgTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAgvLDQLTSIIQI 524
Cdd:COG4886   94 DLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSL 164


                 ....*
gi 527498299 525 DLHGN 529
Cdd:COG4886  165 DLSNN 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
212-250 5.91e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.18  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 527498299   212 NPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGK 250
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.85e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 527498299   529 NPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-189 2.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  62 HLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNL 141
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 527498299 142 LRDIDPGAFQDLNKLEVLILNDNLIS-TLPANVFQYVPITHLDLRGNRL 189
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
LRR_8 pfam13855
Leucine rich repeat;
155-213 3.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299  155 KLEVLILNDNLISTLPANVFQYVPI-THLDLRGNRLKTLPyEEVLEQIPGIAEILLEDNP 213
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNlKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 365-504 4.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498299 365 SSLADLKpklsNVQELFLRDNKIH-SIRKSHFvDYKNLILLDLGNNniatvenntfknlldlrwlymdsnYLDTLSREKF 443
Cdd:PLN00113 254 SSLGNLK----NLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDN------------------------SLSGEIPELV 304

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527498299 444 AGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILIL-NNNLLRSLPVDVFAGVSLSKLSLHNN 504
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLSTN 366
LRR smart00370
Leucine-rich repeats, outliers;
470-493 6.64e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 527498299   470 MPKLRILILNNNLLRSLPVDVFAG 493
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
470-493 6.64e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 527498299   470 MPKLRILILNNNLLRSLPVDVFAG 493
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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