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Conserved domains on  [gi|528281411|ref|NP_001268441|]
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trifunctional enzyme subunit beta, mitochondrial isoform 2 precursor [Homo sapiens]

Protein Classification

thiolase family protein( domain architecture ID 10091456)

thiolase family protein may catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine; such as acetyl-CoA acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to another molecule of acetyl-CoA to form acetoacetyl-CoA

CATH:  3.40.47.10
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006635
PubMed:  16356722
SCOP:  4000245

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
55-456 6.86e-163

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


:

Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 464.64  E-value: 6.86e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  55 VVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTV 119
Cdd:cd00751    1 VIVSAVRTPIGRFGGAlkdvsaddlgaavikALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 120 TMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMgqrlsliskfRFNFLAPELPAV 199
Cdd:cd00751   81 NRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMSRAPYLLPKARRGGRLGLNTLDGM----------LDDGLTDPFTGL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 200 SefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK---DTVTKDNGIRP-SSLEQM 274
Cdd:cd00751  151 S-------MGITAENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDeIVPVEVPGRkgpVVVDRDEGPRPdTTLEKL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 275 AKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLT 354
Cdd:cd00751  224 AKLKPAF-KKDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDP-AIMGIGPVPAIPKALKRAGLT 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 355 MNDIDAFEFHEAFSGQILANFKAMDSDWfaenymgrktkvglpplEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEG 434
Cdd:cd00751  302 LDDIDLIEINEAFAAQALACLKELGLDP-----------------EKVNVNGGAIALGHPLGASGARIVVTLLHELKRRG 364
                        410       420
                 ....*....|....*....|..
gi 528281411 435 GQYGLVAACAAGGQGHAMIVEA 456
Cdd:cd00751  365 GRYGLATMCIGGGQGAAMVIER 386
 
Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
55-456 6.86e-163

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 464.64  E-value: 6.86e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  55 VVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTV 119
Cdd:cd00751    1 VIVSAVRTPIGRFGGAlkdvsaddlgaavikALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 120 TMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMgqrlsliskfRFNFLAPELPAV 199
Cdd:cd00751   81 NRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMSRAPYLLPKARRGGRLGLNTLDGM----------LDDGLTDPFTGL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 200 SefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK---DTVTKDNGIRP-SSLEQM 274
Cdd:cd00751  151 S-------MGITAENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDeIVPVEVPGRkgpVVVDRDEGPRPdTTLEKL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 275 AKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLT 354
Cdd:cd00751  224 AKLKPAF-KKDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDP-AIMGIGPVPAIPKALKRAGLT 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 355 MNDIDAFEFHEAFSGQILANFKAMDSDWfaenymgrktkvglpplEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEG 434
Cdd:cd00751  302 LDDIDLIEINEAFAAQALACLKELGLDP-----------------EKVNVNGGAIALGHPLGASGARIVVTLLHELKRRG 364
                        410       420
                 ....*....|....*....|..
gi 528281411 435 GQYGLVAACAAGGQGHAMIVEA 456
Cdd:cd00751  365 GRYGLATMCIGGGQGAAMVIER 386
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
56-455 4.38e-155

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 444.75  E-value: 4.38e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411   56 VVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVT 120
Cdd:TIGR01930   1 IVAAARTPIGKFGGSlkdvsaedlgaavikELLERNPLDPELIDDVIFGNVLQAGEQQNIARQAALLAGLPESVPAYTVN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  121 MACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKlMLDLNKAKSMGQRLSLiskfrfnflapelpaVS 200
Cdd:TIGR01930  81 RQCASGLQAVILAAQLIRAGEADVVVAGGVESMSRVPYGVPRSLRW-GVKPGNAELEDARLKD---------------LT 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  201 EFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK---DTVTKDNGIRP-SSLEQMA 275
Cdd:TIGR01930 145 DANTGLPMGVTAENLAKKYGISREEQDEYALRSHQRAAKAWEEGLFKDeIVPVTVKGRkgpVTVSSDEGIRPnTTLEKLA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  276 KLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLTM 355
Cdd:TIGR01930 225 KLKPAF-DPDGTVTAGNSSPLNDGAAALLLMSEEKAKELGLTPLARIVSFAVAGVDP-EIMGLGPVPAIPKALKKAGLSI 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  356 NDIDAFEFHEAFSGQILANFKAMDsdwfaenymgrktkvglPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGG 435
Cdd:TIGR01930 303 SDIDLFEINEAFAAQVLACIKELG-----------------LDLEKVNVNGGAIALGHPLGASGARIVTTLLHELKRRGG 365
                         410       420
                  ....*....|....*....|
gi 528281411  436 QYGLVAACAAGGQGHAMIVE 455
Cdd:TIGR01930 366 RYGLATMCIGGGQGAAVILE 385
fadI PRK08963
3-ketoacyl-CoA thiolase; Reviewed
52-456 1.73e-153

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181597 [Multi-domain]  Cd Length: 428  Bit Score: 442.50  E-value: 1.73e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPFLLSGT---------------SGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:PRK08963   5 DRIAIVSGLRTPFAKQATafhgipavdlgkmvvGELLARSEIDPELIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPEL 196
Cdd:PRK08963  85 YSVSRACATSFQAVANVAESIMAGTIDIGIAGGADSSSVLPIGVSKKLARALVDLNKARTLGQRLKLFSRLRLRDLLPVP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 PAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVV--PFKVPGKDTVTKDNGIRP-SSLEQ 273
Cdd:PRK08963 165 PAVAEYSTGLRMGDTAEQMAKTYGISREEQDALAHRSHQLAAQAWAEGKLDDEVmtAHVPPYKQPLEEDNNIRGdSTLED 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 274 MAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGL 353
Cdd:PRK08963 245 YAKLRPAFDRKHGTVTAANSTPLTDGAAAVLLMSESRAKALGLTPLGYLRSYAFAAIDVWQDMLLGPAYATPLALERAGL 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 354 TMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKE 433
Cdd:PRK08963 325 TLADLTLIDMHEAFAAQTLANLQMFASERFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGARMITQTLHELRRR 404
                        410       420
                 ....*....|....*....|...
gi 528281411 434 GGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK08963 405 GGGLGLTTACAAGGLGAAMVLEV 427
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
52-456 3.47e-144

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 417.55  E-value: 3.47e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF-----LLSGTS----------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:COG0183    2 REVVIVDAVRTPFgrfggALADVRaddlgaavikALLERAGLDPEAVDDVILGCVLQAGQGQNPARQAALLAGLPESVPA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGqrlsliskfrfnflapeL 196
Cdd:COG0183   82 VTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESMSRAPMLLPKARWGYRMNAKLVDPMI-----------------N 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 PAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD---TVTKDNGIRP-SSL 271
Cdd:COG0183  145 PGLTDPYTGLSMGETAENVAERYGISREEQDAFALRSHQRAAAAIAAGRFDDeIVPVEVPDRKgevVVDRDEGPRPdTTL 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 272 EQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDqLLLGPTYATPKVLEKA 351
Cdd:COG0183  225 EKLAKLKPAF-KKDGTVTAGNASGINDGAAALLLMSEEAAKELGLKPLARIVAYAVAGVDPEI-MGIGPVPATRKALARA 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 352 GLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLR 431
Cdd:COG0183  303 GLTLDDIDLIEINEAFAAQVLAVLREL----------------GLDP-DKVNVNGGAIALGHPLGASGARILVTLLHELE 365
                        410       420
                 ....*....|....*....|....*
gi 528281411 432 KEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:COG0183  366 RRGGRYGLATMCIGGGQGIALIIER 390
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
54-309 2.05e-86

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 264.94  E-value: 2.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411   54 VVVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHT 118
Cdd:pfam00108   1 VVIVSAARTPFGSFGGSlkdvsavelgaeaikAALERAGVDPEDVDEVIVGNVLQAGEGQNPARQAALKAGIPDSAPAVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  119 VTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRklmldlnkaksmgQRLSLISKFRFNFLAPElpA 198
Cdd:pfam00108  81 INKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDAR-------------SGLKHGDEKKHDLLIPD--G 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  199 VSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVP---GKDTVTKDNGIRP-SSLEQ 273
Cdd:pfam00108 146 LTDAFNGYHMGLTAENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKFKDeIVPVTVKgrkGKPTVDKDEGIRPpTTAEP 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 528281411  274 MAKLKPAFIKPyGTVTAANSSFLTDGASAMLIMAEE 309
Cdd:pfam00108 226 LAKLKPAFDKE-GTVTAGNASPINDGAAAVLLMSES 260
 
Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
55-456 6.86e-163

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 464.64  E-value: 6.86e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  55 VVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTV 119
Cdd:cd00751    1 VIVSAVRTPIGRFGGAlkdvsaddlgaavikALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 120 TMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMgqrlsliskfRFNFLAPELPAV 199
Cdd:cd00751   81 NRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMSRAPYLLPKARRGGRLGLNTLDGM----------LDDGLTDPFTGL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 200 SefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK---DTVTKDNGIRP-SSLEQM 274
Cdd:cd00751  151 S-------MGITAENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDeIVPVEVPGRkgpVVVDRDEGPRPdTTLEKL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 275 AKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLT 354
Cdd:cd00751  224 AKLKPAF-KKDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDP-AIMGIGPVPAIPKALKRAGLT 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 355 MNDIDAFEFHEAFSGQILANFKAMDSDWfaenymgrktkvglpplEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEG 434
Cdd:cd00751  302 LDDIDLIEINEAFAAQALACLKELGLDP-----------------EKVNVNGGAIALGHPLGASGARIVVTLLHELKRRG 364
                        410       420
                 ....*....|....*....|..
gi 528281411 435 GQYGLVAACAAGGQGHAMIVEA 456
Cdd:cd00751  365 GRYGLATMCIGGGQGAAMVIER 386
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
56-455 4.38e-155

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 444.75  E-value: 4.38e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411   56 VVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVT 120
Cdd:TIGR01930   1 IVAAARTPIGKFGGSlkdvsaedlgaavikELLERNPLDPELIDDVIFGNVLQAGEQQNIARQAALLAGLPESVPAYTVN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  121 MACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKlMLDLNKAKSMGQRLSLiskfrfnflapelpaVS 200
Cdd:TIGR01930  81 RQCASGLQAVILAAQLIRAGEADVVVAGGVESMSRVPYGVPRSLRW-GVKPGNAELEDARLKD---------------LT 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  201 EFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK---DTVTKDNGIRP-SSLEQMA 275
Cdd:TIGR01930 145 DANTGLPMGVTAENLAKKYGISREEQDEYALRSHQRAAKAWEEGLFKDeIVPVTVKGRkgpVTVSSDEGIRPnTTLEKLA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  276 KLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLTM 355
Cdd:TIGR01930 225 KLKPAF-DPDGTVTAGNSSPLNDGAAALLLMSEEKAKELGLTPLARIVSFAVAGVDP-EIMGLGPVPAIPKALKKAGLSI 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  356 NDIDAFEFHEAFSGQILANFKAMDsdwfaenymgrktkvglPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGG 435
Cdd:TIGR01930 303 SDIDLFEINEAFAAQVLACIKELG-----------------LDLEKVNVNGGAIALGHPLGASGARIVTTLLHELKRRGG 365
                         410       420
                  ....*....|....*....|
gi 528281411  436 QYGLVAACAAGGQGHAMIVE 455
Cdd:TIGR01930 366 RYGLATMCIGGGQGAAVILE 385
fadI PRK08963
3-ketoacyl-CoA thiolase; Reviewed
52-456 1.73e-153

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181597 [Multi-domain]  Cd Length: 428  Bit Score: 442.50  E-value: 1.73e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPFLLSGT---------------SGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:PRK08963   5 DRIAIVSGLRTPFAKQATafhgipavdlgkmvvGELLARSEIDPELIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPEL 196
Cdd:PRK08963  85 YSVSRACATSFQAVANVAESIMAGTIDIGIAGGADSSSVLPIGVSKKLARALVDLNKARTLGQRLKLFSRLRLRDLLPVP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 PAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVV--PFKVPGKDTVTKDNGIRP-SSLEQ 273
Cdd:PRK08963 165 PAVAEYSTGLRMGDTAEQMAKTYGISREEQDALAHRSHQLAAQAWAEGKLDDEVmtAHVPPYKQPLEEDNNIRGdSTLED 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 274 MAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGL 353
Cdd:PRK08963 245 YAKLRPAFDRKHGTVTAANSTPLTDGAAAVLLMSESRAKALGLTPLGYLRSYAFAAIDVWQDMLLGPAYATPLALERAGL 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 354 TMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKE 433
Cdd:PRK08963 325 TLADLTLIDMHEAFAAQTLANLQMFASERFAREKLGRSQAIGEVDMSKFNVLGGSIAYGHPFAATGARMITQTLHELRRR 404
                        410       420
                 ....*....|....*....|...
gi 528281411 434 GGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK08963 405 GGGLGLTTACAAGGLGAAMVLEV 427
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
52-456 3.47e-144

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 417.55  E-value: 3.47e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF-----LLSGTS----------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:COG0183    2 REVVIVDAVRTPFgrfggALADVRaddlgaavikALLERAGLDPEAVDDVILGCVLQAGQGQNPARQAALLAGLPESVPA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGqrlsliskfrfnflapeL 196
Cdd:COG0183   82 VTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESMSRAPMLLPKARWGYRMNAKLVDPMI-----------------N 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 PAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD---TVTKDNGIRP-SSL 271
Cdd:COG0183  145 PGLTDPYTGLSMGETAENVAERYGISREEQDAFALRSHQRAAAAIAAGRFDDeIVPVEVPDRKgevVVDRDEGPRPdTTL 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 272 EQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDqLLLGPTYATPKVLEKA 351
Cdd:COG0183  225 EKLAKLKPAF-KKDGTVTAGNASGINDGAAALLLMSEEAAKELGLKPLARIVAYAVAGVDPEI-MGIGPVPATRKALARA 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 352 GLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLR 431
Cdd:COG0183  303 GLTLDDIDLIEINEAFAAQVLAVLREL----------------GLDP-DKVNVNGGAIALGHPLGASGARILVTLLHELE 365
                        410       420
                 ....*....|....*....|....*
gi 528281411 432 KEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:COG0183  366 RRGGRYGLATMCIGGGQGIALIIER 390
PRK09268 PRK09268
acetyl-CoA C-acetyltransferase;
46-456 1.73e-114

acetyl-CoA C-acetyltransferase;


Pssm-ID: 236440 [Multi-domain]  Cd Length: 427  Bit Score: 343.04  E-value: 1.73e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  46 LAKPNIRNVVVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGF 110
Cdd:PRK09268   1 MTMPTVRRVAILGGNRIPFARSNGAyadasnqdmltaaldGLVDRFGLQGERLGEVVAGAVLKHSRDFNLTRECVLGSAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 111 SDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFN 190
Cdd:PRK09268  81 SPYTPAYDLQQACGTGLEAAILVANKIALGQIDSGIAGGVDTTSDAPIAVNEGLRKILLELNRAKTTGDRLKALGKLRPK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 191 FLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKvpgkdTVTKDNGIRP- 268
Cdd:PRK09268 161 HLAPEIPRNGEPRTGLSMGEHAAITAKEWGISREAQDELAAASHQNLAAAYDRGFFDDlITPFL-----GLTRDNNLRPd 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 269 SSLEQMAKLKPAFIK-PYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQD---PKDQLLLGPTYAT 344
Cdd:PRK09268 236 SSLEKLAKLKPVFGKgGRATMTAGNSTPLTDGASVVLLASEEWAAEHGLPVLAYLVDAETAAVDfvhGKEGLLMAPAYAV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 345 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVM 424
Cdd:PRK09268 316 PRLLARNGLTLQDFDFYEIHEAFASQVLATLKAWEDEEYCRERLGLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRIVA 395
                        410       420       430
                 ....*....|....*....|....*....|..
gi 528281411 425 AAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK09268 396 TLAKLLAEKGSGRGLISICAAGGQGVTAILER 427
PRK08170 PRK08170
acetyl-CoA C-acetyltransferase;
52-456 1.38e-108

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181265 [Multi-domain]  Cd Length: 426  Bit Score: 327.74  E-value: 1.38e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPFL-------------LSGTSG--LLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:PRK08170   3 RPVYIVDGARTPFLkarggpgpfsasdLAVAAGraLLNRQPFAPDDLDEVILGCAMPSPDEANIARVVALRLGCGEKVPA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPE- 195
Cdd:PRK08170  83 WTVQRNCASGMQALDSAAANIALGRADLVLAGGVEAMSHAPLLFSEKMVRWLAGWYAAKSIGQKLAALGKLRPSYLAPVi 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 196 --LPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFkVPGKDTV-TKDNGIRP-SSL 271
Cdd:PRK08170 163 glLRGLTDPVVGLNMGQTAEVLAHRFGITREQMDAYAARSHQRLAAAQAEGRLKEVVPL-FDRDGKFyDHDDGVRPdSSM 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 272 EQMAKLKPAFIKPYGTVTAANSSFLTDGAsAMLIMAEEKALAM-GYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEK 350
Cdd:PRK08170 242 EKLAKLKPFFDRPYGRVTAGNSSQITDGA-CWLLLASEEAVKKyGLPPLGRIVDSQWAALDP-SQMGLGPVHAATPLLQR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 351 AGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRL 430
Cdd:PRK08170 320 HGLTLEDLDLWEINEAFAAQVLACLAAWADEEYCREQLGLDGALGELDRERLNVDGGAIALGHPVGASGARIVLHLLHAL 399
                        410       420
                 ....*....|....*....|....*.
gi 528281411 431 RKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK08170 400 KRRGTKRGIAAICIGGGQGGAMLLER 425
PRK05790 PRK05790
putative acyltransferase; Provisional
52-456 2.06e-99

putative acyltransferase; Provisional


Pssm-ID: 180261 [Multi-domain]  Cd Length: 393  Bit Score: 303.23  E-value: 2.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF-----LLSGTS----------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:PRK05790   2 KDVVIVSAARTPIgkfggALKDVSavelgaivikAALERAGVPPEQVDEVIMGQVLQAGAGQNPARQAALKAGLPVEVPA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVP--IRHSR---KMRKL-MLDlnkaksmgqrlSLISkfrfn 190
Cdd:PRK05790  82 LTINKVCGSGLKAVALAAQAIRAGDADIVVAGGQESMSQAPhvLPGSRwgqKMGDVeLVD-----------TMIH----- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 191 flapelPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD----TVTKDNG 265
Cdd:PRK05790 146 ------DGLTDAFNGYHMGITAENLAEQYGITREEQDEFALASQQKAEAAIKAGRFKDeIVPVTIKQRKgdpvVVDTDEH 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 266 IRP-SSLEQMAKLKPAFIKPyGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYAT 344
Cdd:PRK05790 220 PRPdTTAESLAKLRPAFDKD-GTVTAGNASGINDGAAAVVVMSEAKAKELGLTPLARIVSYAVAGVDPA-IMGIGPVPAI 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 345 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPPlEKFNNWGGSLSLGHPFGATGCRLVM 424
Cdd:PRK05790 298 RKALEKAGWSLADLDLIEINEAFAAQALAVEKEL----------------GLDP-EKVNVNGGAIALGHPIGASGARILV 360
                        410       420       430
                 ....*....|....*....|....*....|..
gi 528281411 425 AAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK05790 361 TLLHEMKRRGAKKGLATLCIGGGQGVALIVER 392
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
54-309 2.05e-86

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 264.94  E-value: 2.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411   54 VVVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHT 118
Cdd:pfam00108   1 VVIVSAARTPFGSFGGSlkdvsavelgaeaikAALERAGVDPEDVDEVIVGNVLQAGEGQNPARQAALKAGIPDSAPAVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  119 VTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRklmldlnkaksmgQRLSLISKFRFNFLAPElpA 198
Cdd:pfam00108  81 INKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDAR-------------SGLKHGDEKKHDLLIPD--G 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  199 VSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVP---GKDTVTKDNGIRP-SSLEQ 273
Cdd:pfam00108 146 LTDAFNGYHMGLTAENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKFKDeIVPVTVKgrkGKPTVDKDEGIRPpTTAEP 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 528281411  274 MAKLKPAFIKPyGTVTAANSSFLTDGASAMLIMAEE 309
Cdd:pfam00108 226 LAKLKPAFDKE-GTVTAGNASPINDGAAAVLLMSES 260
PRK08235 PRK08235
acetyl-CoA C-acetyltransferase;
51-457 2.26e-79

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181311 [Multi-domain]  Cd Length: 393  Bit Score: 251.56  E-value: 2.26e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  51 IRNVVVVDGVRTPFLLSGTS----------GL-----LHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTP 115
Cdd:PRK08235   1 MSKTVIVSAARTPFGKFGGSlkdvkatelgGIaikeaLERANVSAEDVEEVIMGTVLQGGQGQIPSRQAARAAGIPWEVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 116 AHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPI-----RHSRKM-RKLMLDLNKAKSmgqrlsLISKFrf 189
Cdd:PRK08235  81 TETVNKVCASGLRAVTLADQIIRAGDASVIVAGGMESMSNAPYilpgaRWGYRMgDNEVIDLMVADG------LTCAF-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 190 nflapelpavsefsTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD----TVTKDN 264
Cdd:PRK08235 153 --------------SGVHMGVYGGEVAKELGISREAQDEWAYRSHQRAVSAHEEGRFEEeIVPVTIPQRKgdpiVVAKDE 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 265 GIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDqLLLGPTYA 343
Cdd:PRK08235 219 APRKdTTIEKLAKLKPVF-DKTGTITAGNAPGVNDGAAALVLMSEDRAKQEGRKPLATILAHTAIAVEAKD-FPRTPGYA 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 344 TPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAmdsdwfaenymgrktkVGLPPlEKFNNWGGSLSLGHPFGATGCRLV 423
Cdd:PRK08235 297 INALLEKTGKTVEDIDLFEINEAFAAVALASTEI----------------AGIDP-EKVNVNGGAVALGHPIGASGARII 359
                        410       420       430
                 ....*....|....*....|....*....|....
gi 528281411 424 MAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAY 457
Cdd:PRK08235 360 VTLIHELKRRGGGIGIAAICSGGGQGDAVLIEVH 393
PRK06205 PRK06205
acetyl-CoA C-acetyltransferase;
52-458 1.53e-78

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235741 [Multi-domain]  Cd Length: 404  Bit Score: 249.91  E-value: 1.53e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF-----LLSGTS----------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPA 116
Cdd:PRK06205   2 RDAVICEPVRTPVgrfggAFKDVPaeelaatvirALVERTGIDPARIDDVIFGQGYPNGEAPAIGRVAALDAGLPVTVPG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIrHSRKMRK--------LM--LDLNKAKSMGQRLSLISK 186
Cdd:PRK06205  82 MQLDRRCGSGLQAVITAAMQVQTGAADVVIAGGAESMSNVEF-YTTDMRWgvrgggvqLHdrLARGRETAGGRRFPVPGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 187 frfnflapelpavsefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD----TVT 261
Cdd:PRK06205 161 ---------------------MIETAENLRREYGISREEQDALAVRSHQRAVAAQEAGRFDDeIVPVTVPQRKgdptVVD 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 262 KDNGIRP-SSLEQMAKLKPAFIK--PYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLL 338
Cdd:PRK06205 220 RDEHPRAdTTLESLAKLRPIMGKqdPEATVTAGNASGQNDAAAACLVTTEDKAEELGLRPLARLVSWAVAGVEP-SRMGI 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 339 GPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAEnymgrktkvglpplEKFNNWGGSLSLGHPFGAT 418
Cdd:PRK06205 299 GPVPATEKALARAGLTLDDIDLIELNEAFAAQVLAVLKEWGFGADDE--------------ERLNVNGSGISLGHPVGAT 364
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 528281411 419 GCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYP 458
Cdd:PRK06205 365 GGRILATLLRELQRRQARYGLETMCIGGGQGLAAVFERVN 404
PRK06445 PRK06445
acetyl-CoA C-acetyltransferase;
51-457 1.27e-76

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180563 [Multi-domain]  Cd Length: 394  Bit Score: 244.63  E-value: 1.27e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  51 IRNVVVVDGVRTPFL-------------------LSGT--SGLLHRTSVPKEVVDYIIFGTVIQEVKT-SNVAREAALGA 108
Cdd:PRK06445   1 LEDVYLVDFARTAFSrfrpkdpqkdvfnnirpeeLAAMliNRLIEKTGIKPEEIDDIITGCALQVGENwLYGGRHPIFLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 109 GFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIR---HSRKMRKLMLDlnkaksmgqrlslis 185
Cdd:PRK06445  81 RLPYNIPAMAVDRQCASSLTTVSIGAMEIATGMADIVIAGGVEHMTRTPMGdnpHIEPNPKLLTD--------------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 186 kfrfnflaPELpAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVP---GKDTVT 261
Cdd:PRK06445 146 --------PKY-IEYDLTTGYVMGLTAEKLAEEAGIKREEMDRWSLRSHQLAAKAIQEGYFKDeILPIEVEvegKKKVVD 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 262 KDNGIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGP 340
Cdd:PRK06445 217 VDQSVRPdTSLEKLAKLPPAF-KPDGVITAGNSSPLNSGASYVLLMSKKAVKKYGLKPMAKIRSFGFAGVPP-AIMGKGP 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 341 TYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKamdsdwfaenymgrktKVGLPPlEKFNNWGGSLSLGHPFGATGC 420
Cdd:PRK06445 295 VPASKKALEKAGLSVKDIDLWEINEAFAVVVLYAIK----------------ELGLDP-ETVNIKGGAIAIGHPLGATGA 357
                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 528281411 421 RLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAY 457
Cdd:PRK06445 358 RIVGTLARQLQIKGKDYGVATLCVGGGQGGAVVLERV 394
fadA PRK08947
3-ketoacyl-CoA thiolase; Reviewed
52-455 4.36e-76

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181592 [Multi-domain]  Cd Length: 387  Bit Score: 242.95  E-value: 4.36e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF--------------LLSGT--SGLLHRTS--VPKEVVDyIIFGTVIQEVKTS-NVAREAALGAGFSD 112
Cdd:PRK08947   2 EDVVIVDAIRTPMgrskggafrnvraeDLSAHlmRSLLARNPalDPAEIDD-IIWGCVQQTLEQGfNIARNAALLAGIPH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 113 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSrkmrklmLDLNkaksmgqrlsliskfrfnfl 192
Cdd:PRK08947  81 SVPAVTVNRLCGSSMQALHDAARAIMTGDGDVFLIGGVEHMGHVPMNHG-------VDFH-------------------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 193 apelPAVSEFST--SETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPfkVPGKD------TVTKD 263
Cdd:PRK08947 134 ----PGLSKNVAkaAGMMGLTAEMLGKMHGISREQQDAFAARSHQRAWAATQEGRFKNeIIP--TEGHDadgvlkLFDYD 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 264 NGIRP-SSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTY 342
Cdd:PRK08947 208 EVIRPeTTVEALAALRPAFDPVNGTVTAGTSSALSDGASAMLVMSESRAKELGLKPRARIRSMAVAGCDPS-IMGYGPVP 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 343 ATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaeNYMGRKTkvglpplEKFNNWGGSLSLGHPFGATGCRL 422
Cdd:PRK08947 287 ATQKALKRAGLSISDIDVFELNEAFAAQSLPCLKDL-------GLLDKMD-------EKVNLNGGAIALGHPLGCSGARI 352
                        410       420       430
                 ....*....|....*....|....*....|...
gi 528281411 423 VMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK08947 353 STTLLNLMERKDAQFGLATMCIGLGQGIATVFE 385
PLN02644 PLN02644
acetyl-CoA C-acetyltransferase
52-458 1.04e-75

acetyl-CoA C-acetyltransferase


Pssm-ID: 215347 [Multi-domain]  Cd Length: 394  Bit Score: 242.31  E-value: 1.04e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTP---FL-----LSGTS-------GLLHRTSVPKEVVDYIIFGTVIqevkTSNV----AREAALGAGFSD 112
Cdd:PLN02644   1 RDVCIVGVARTPiggFLgslssLSATElgsiaiqAALERAGVDPALVQEVFFGNVL----SANLgqapARQAALGAGLPP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 113 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPirhsrkmrKLMLDLNKAKSMGQrLSLISkfrfNFL 192
Cdd:PLN02644  77 STICTTVNKVCASGMKAVMLAAQSIQLGINDVVVAGGMESMSNAP--------KYLPEARKGSRLGH-DTVVD----GML 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 193 APELPAV-SEFStsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGK-----DTVTKDNG 265
Cdd:PLN02644 144 KDGLWDVyNDFG----MGVCAELCADQYSISREEQDAYAIQSYERAIAAQEAGAFAWeIVPVEVPGGrgrpsVIVDKDEG 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 266 IRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATP 345
Cdd:PLN02644 220 LGKFDPAKLRKLRPSFKEDGGSVTAGNASSISDGAAALVLVSGEKALELGLQVIAKIRGYADAAQAP-ELFTTAPALAIP 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 346 KVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPPlEKFNNWGGSLSLGHPFGATGCRLVMA 425
Cdd:PLN02644 299 KALKHAGLEASQVDYYEINEAFSVVALANQKLL----------------GLDP-EKVNVHGGAVSLGHPIGCSGARILVT 361
                        410       420       430
                 ....*....|....*....|....*....|...
gi 528281411 426 AANRLRKEGGQYGLVAACAAGGQGHAMIVEAYP 458
Cdd:PLN02644 362 LLGVLRSKNGKYGVAGICNGGGGASAIVVELMQ 394
PRK09051 PRK09051
beta-ketothiolase BktB;
52-455 6.74e-72

beta-ketothiolase BktB;


Pssm-ID: 181625 [Multi-domain]  Cd Length: 394  Bit Score: 232.16  E-value: 6.74e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRT-------------PFLLSGT--SGLLHRTSVPKEVVDYIIFGTVIQ-EVKTSNVAREAALGAGFSDKTP 115
Cdd:PRK09051   3 REVVVVSGVRTaigtfggslkdvaPTDLGATvvREALARAGVDPDQVGHVVFGHVIPtEPRDMYLSRVAAINAGVPQETP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 116 AHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVP-----IRHSRKMrklmldlNKAKSMGQRLSLISkfrfn 190
Cdd:PRK09051  83 AFNVNRLCGSGLQAIVSAAQAILLGDADVAIGGGAESMSRAPyllpaARWGARM-------GDAKLVDMMVGALH----- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 191 flapelpavSEFSTSEtMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPG-KDTVT--KDNGI 266
Cdd:PRK09051 151 ---------DPFGTIH-MGVTAENVAAKYGISREAQDALALESHRRAAAAIAAGYFKDqIVPVEIKTrKGEVVfdTDEHV 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 267 RPS-SLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATP 345
Cdd:PRK09051 221 RADtTLEDLAKLKPVFKKENGTVTAGNASGINDGAAAVVLAEADAAEARGLKPLARLVGYAHAGVDP-EYMGIGPVPATQ 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 346 KVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPPlEKFNNWGGSLSLGHPFGATGCRLVMA 425
Cdd:PRK09051 300 KALERAGLTVADLDVIEANEAFAAQACAVTREL----------------GLDP-AKVNPNGSGISLGHPVGATGAIITVK 362
                        410       420       430
                 ....*....|....*....|....*....|
gi 528281411 426 AANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK09051 363 ALYELQRIGGRYALVTMCIGGGQGIAAIFE 392
PRK07801 PRK07801
acetyl-CoA C-acetyltransferase;
56-455 9.28e-72

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181123 [Multi-domain]  Cd Length: 382  Bit Score: 231.52  E-value: 9.28e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  56 VVDGVRTPF-----LLSGT----------SGLLHRTSVPKEVVDYIIFGTVIQ-EVKTSNVAREAALGAGFSDKTPAHTV 119
Cdd:PRK07801   6 IVDAVRTPVgkrkgGLAGVhpadlgahvlKGLVDRTGIDPAAVDDVIFGCVDTiGPQAGNIARTSWLAAGLPEEVPGVTV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 120 TMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIrhsrkmrklmldlNKAKSMGQRLSLISKF--------RFNf 191
Cdd:PRK07801  86 DRQCGSSQQAIHFAAQAVMSGTQDLVVAGGVQNMSQIPI-------------SSAMTAGEQLGFTSPFaeskgwlhRYG- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 192 lapELPaVSEFstsetmgHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFkvpgkDTVTKDNGIRPSS 270
Cdd:PRK07801 152 ---DQE-VSQF-------RGAELIAEKWGISREEMERFALESHRRAFAAIRAGRFDNeIVPV-----GGVTVDEGPRETS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 271 LEQMAKLKPafIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVLEK 350
Cdd:PRK07801 216 LEKMAGLKP--LVEGGRLTAAVASQISDGASAVLLASERAVKRHGLTPRARIHHLSVRGDDPV-FMLTAPIPATRYALEK 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 351 AGLTMNDIDAFEFHEAFSGQILAnfkamdsdWFAEnymgrktkVGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRL 430
Cdd:PRK07801 293 TGLSIDDIDVVEINEAFAPVVLA--------WLKE--------TGADP-AKVNPNGGAIALGHPLGATGAKLMTTLLHEL 355
                        410       420
                 ....*....|....*....|....*
gi 528281411 431 RKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK07801 356 ERTGGRYGLQTMCEGGGTANVTIIE 380
PRK07850 PRK07850
steroid 3-ketoacyl-CoA thiolase;
53-455 1.01e-71

steroid 3-ketoacyl-CoA thiolase;


Pssm-ID: 181145 [Multi-domain]  Cd Length: 387  Bit Score: 231.53  E-value: 1.01e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  53 NVVVVDGVRTPF-----LLSG----------TSGLLHRTSVPKEVVDYIIFGTVIQEVKTS-NVAREAALGAGFSDKTPA 116
Cdd:PRK07850   3 NPVIVEAVRTPIgkrngWLSGlhaaellgavQRAVLDRAGIDPGDVEQVIGGCVTQAGEQSnNITRTAWLHAGLPYHVGA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRhsrkmrklmldlnkaKSMGQRLSLISKFRFNFlapEL 196
Cdd:PRK07850  83 TTIDCQCGSAQQANHLVAGLIAAGAIDVGIACGVEAMSRVPLG---------------ANAGPGRGLPRPDSWDI---DM 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 PAVSEfstsetmghSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLL-SDVVPFKVPGKD----------TVTKDNG 265
Cdd:PRK07850 145 PNQFE---------AAERIAKRRGITREDVDAFGLRSQRRAAQAWAEGRFdREISPVQAPVLDeegqptgetrLVTRDQG 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 266 IRPSSLEQMAKLKPafIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATP 345
Cdd:PRK07850 216 LRDTTMEGLAGLKP--VLEGGIHTAGTSSQISDGAAAVLWMDEDRARALGLRPRARIVAQALVGAEPY-YHLDGPVQATA 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 346 KVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDwfaenymgrktkvglppLEKFNNWGGSLSLGHPFGATGCRLVMA 425
Cdd:PRK07850 293 KVLEKAGMKIGDIDLVEINEAFASVVLSWAQVHEPD-----------------MDKVNVNGGAIALGHPVGSTGARLITT 355
                        410       420       430
                 ....*....|....*....|....*....|
gi 528281411 426 AANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK07850 356 ALHELERTDKSTALITMCAGGALSTGTIIE 385
PRK09050 PRK09050
beta-ketoadipyl CoA thiolase; Validated
52-455 2.56e-67

beta-ketoadipyl CoA thiolase; Validated


Pssm-ID: 181624 [Multi-domain]  Cd Length: 401  Bit Score: 220.60  E-value: 2.56e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  52 RNVVVVDGVRTPF-----LLSGTSG----------LLHRT-SVPKEVVDYIIFGTVIQEVKTS-NVAREAALGAGFSDKT 114
Cdd:PRK09050   2 TEAFICDAIRTPIgryggALSSVRAddlgavplkaLMARNpGVDWEAVDDVIYGCANQAGEDNrNVARMSALLAGLPVSV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 115 PAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPirhsrkmrklmLDLNKAKSMGQRLSLI--SKFRFNFL 192
Cdd:PRK09050  82 PGTTINRLCGSGMDAVGTAARAIKAGEAELMIAGGVESMSRAP-----------FVMGKADSAFSRQAEIfdTTIGWRFV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 193 APELPAvsEFSTsETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD----TVTKDNGIR 267
Cdd:PRK09050 151 NPLMKA--QYGV-DSMPETAENVAEDYNISRADQDAFALRSQQRAAAAQAAGFLAEeIVPVTIPQKKgdpvVVDRDEHPR 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 268 PS-SLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPK 346
Cdd:PRK09050 228 PEtTLEALAKLKPVF-RPDGTVTAGNASGVNDGAAALLLASEAAAKKHGLTPRARILGMATAGVEPR-IMGIGPAPATRK 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 347 VLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPP-LEKFNNWGGSLSLGHPFGATGCRLVMA 425
Cdd:PRK09050 306 LLARLGLTIDQFDVIELNEAFAAQGLAVLRQL----------------GLADdDARVNPNGGAIALGHPLGMSGARLVLT 369
                        410       420       430
                 ....*....|....*....|....*....|
gi 528281411 426 AANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK09050 370 ALHQLERTGGRYALCTMCIGVGQGIALAIE 399
PRK07661 PRK07661
acetyl-CoA C-acetyltransferase;
51-455 9.80e-65

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181072 [Multi-domain]  Cd Length: 391  Bit Score: 213.46  E-value: 9.80e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  51 IRNVVVVDGVRTPFLLSGTSGL----------------LHRTSVPKEVVDYIIFGTVIQEVKTS-NVAREAALGAGFSDK 113
Cdd:PRK07661   1 MREAVIVAGARTPVGKAKKGSLktvrpddlgalvvketLKRAGNYEGPIDDLIIGCAMPEAEQGlNMARNIGALAGLPYT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 114 TPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIrhsrkmrklmldlnkaksMGQRLSLISKfrfnfLA 193
Cdd:PRK07661  81 VPAITINRYCSSGLQSIAYGAERIMLGHSEAVIAGGAESMSLVPM------------------MGHVVRPNPR-----LV 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 194 PELPavsEFSTSetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVP----GKD--------TV 260
Cdd:PRK07661 138 EAAP---EYYMG--MGHTAEQVAVKYGISREDQDAFAVRSHQRAAKALAEGKFADeIVPVDVTlrtvGENnklqeetiTF 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 261 TKDNGIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMyVSQDPKDQLLLG 339
Cdd:PRK07661 213 SQDEGVRAdTTLEILGKLRPAF-NVKGSVTAGNSSQMSDGAAAVLLMDREKAESDGLKPLAKFRSFA-VAGVPPEVMGIG 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 340 PTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWfaenymgrktkvglpplEKFNNWGGSLSLGHPFGATG 419
Cdd:PRK07661 291 PIAAIPKALKLAGLELSDIGLFELNEAFASQSIQVIRELGLDE-----------------EKVNVNGGAIALGHPLGCTG 353
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 528281411 420 CRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK07661 354 AKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFE 389
PLN02287 PLN02287
3-ketoacyl-CoA thiolase
23-456 1.12e-62

3-ketoacyl-CoA thiolase


Pssm-ID: 215161 [Multi-domain]  Cd Length: 452  Bit Score: 210.01  E-value: 1.12e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  23 IRPLSCSSQLRAAPAVQTKTKKTLAKPNI--RNVVVVDGVRTP----------------FLLSGTSGLLHRTSV-PKEVV 83
Cdd:PLN02287  15 LRPSSSEPSSLSASACAAGDSAAYHRTTAfgDDVVIVAAYRTPickakrggfkdtypddLLAPVLKAVVEKTGLnPSEVG 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  84 DyIIFGTVIQE-VKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRhsr 162
Cdd:PLN02287  95 D-IVVGTVLAPgSQRANECRMAAFYAGFPETVPVRTVNRQCSSGLQAVADVAAAIKAGFYDIGIGAGVESMTTNPMA--- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 163 kmrklmldlnkaksmgqrlsliSKFRFNflapelPAVSEFSTSET----MGHSADRLAAAFAVSRLEQDEYALRSHSLAK 238
Cdd:PLN02287 171 ----------------------WEGGVN------PRVESFSQAQDcllpMGITSENVAERFGVTREEQDQAAVESHRKAA 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 239 KAQDEGLLSD-VVPFKVPGKD---------TVTKDNGIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMA 307
Cdd:PLN02287 223 AATASGKFKDeIVPVHTKIVDpktgeekpiVISVDDGIRPnTTLADLAKLKPVF-KKNGTTTAGNSSQVSDGAGAVLLMK 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 308 EEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQilanfkamdsdwfaenY 387
Cdd:PLN02287 302 RSVAMQKGLPILGVFRSFAAVGVDPA-VMGIGPAVAIPAAVKAAGLELDDIDLFEINEAFASQ----------------F 364
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528281411 388 MGRKTKVGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEG--GQYGLVAACAAGGQGHAMIVEA 456
Cdd:PLN02287 365 VYCCKKLGLDP-EKVNVNGGAIALGHPLGATGARCVATLLHEMKRRGkdCRFGVVSMCIGTGMGAAAVFER 434
PRK09052 PRK09052
acetyl-CoA C-acyltransferase;
79-456 3.05e-61

acetyl-CoA C-acyltransferase;


Pssm-ID: 181626 [Multi-domain]  Cd Length: 399  Bit Score: 204.47  E-value: 3.05e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  79 PKEVVDYIIfGTVIQEVKTS-NVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVP 157
Cdd:PRK09052  51 PKLIEDAIV-GCAMPEAEQGlNVARIGALLAGLPNSVGGVTVNRFCASGLQAVAMAADRIRVGEADVMIAAGVESMSMVP 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 158 IrhsrkmrklmldlnkaksMGQRLSLiskfrfnflAPELPAVSE-FSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSL 236
Cdd:PRK09052 130 M------------------MGNKPSM---------SPAIFARDEnVGIAYGMGLTAEKVAEQWKVSREDQDAFALESHQK 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 237 AKKAQDEGLLSD-VVPFKV----PG---------KDTVTKDNGIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGAS 301
Cdd:PRK09052 183 AIAAQQAGEFKDeITPYEIterfPDlatgevdvkTRTVDLDEGPRAdTSLEGLAKLKPVF-ANKGSVTAGNSSQTSDGAG 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 302 AmLIMAEEKAL-AMGYKPKAYLRDFMyVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKamds 380
Cdd:PRK09052 262 A-VILVSEKALkQFNLTPLARFVSFA-VAGVPPEIMGIGPIEAIPAALKQAGLKQDDLDWIELNEAFAAQSLAVIR---- 335
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528281411 381 dwfaenymgrktKVGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK09052 336 ------------DLGLDP-SKVNPLGGAIALGHPLGATGAIRTATVVHGLRRTNLKYGMVTMCVGTGMGAAGIFER 398
PRK07851 PRK07851
acetyl-CoA C-acetyltransferase;
98-455 9.61e-60

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181146 [Multi-domain]  Cd Length: 406  Bit Score: 201.00  E-value: 9.61e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  98 SNVAREAALGAGFsDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM---RKLMLDLNKA 174
Cdd:PRK07851  66 FNMARVVAVLLGY-DFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDVFISAGVETVSRFAKGNSDSLpdtKNPLFAEAQA 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 175 KSMGQRLSLISKFRFNFLAPELPAVSEfstseTMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLS-DVVPFK 253
Cdd:PRK07851 145 RTAARAEGGAEAWHDPREDGLLPDVYI-----AMGQTAENVAQLTGISREEQDEWGVRSQNRAEEAIANGFFErEITPVT 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 254 VPGKDTVTKDNGIRP-SSLEQMAKLKPAFiKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDfMYVSQDP 332
Cdd:PRK07851 220 LPDGTVVSTDDGPRAgTTYEKVSQLKPVF-RPDGTVTAGNACPLNDGAAAVVIMSDTKARELGLTPLARIVS-TGVSGLS 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 333 KDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDwfaenymgrktkvglppLEKFNNWGGSLSLG 412
Cdd:PRK07851 298 PEIMGLGPVEASKQALARAGMSIDDIDLVEINEAFAAQVLPSARELGID-----------------EDKLNVSGGAIALG 360
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 528281411 413 HPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK07851 361 HPFGMTGARITTTLLNNLQTHDKTFGLETMCVGGGQGMAMVLE 403
PRK08242 PRK08242
acetyl-CoA C-acetyltransferase;
56-455 8.83e-59

acetyl-CoA C-acetyltransferase;


Pssm-ID: 236197 [Multi-domain]  Cd Length: 402  Bit Score: 198.18  E-value: 8.83e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  56 VVDGVRTPFLLSGTSGLLH-----------------RTSVPKEVVDYIIFGTVIQeV--KTSNVAREAALGAGFSDKTPA 116
Cdd:PRK08242   6 IYDAVRTPRGKGKKDGSLHevkpvrlaagllealrdRNGLDTAAVDDVVLGCVTP-VgdQGADIARTAVLAAGLPETVPG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPirhsrkmrklMLDLNKAKSMGQRLSLISKFrfnflAPEl 196
Cdd:PRK08242  85 VQINRFCASGLEAVNLAAAKVRSGWDDLVIAGGVESMSRVP----------MGSDGGAWAMDPSTNFPTYF-----VPQ- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 pavsefstsetmGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLS-DVVPFK-VPGKDTVTKDNGIRP-SSLEQ 273
Cdd:PRK08242 149 ------------GISADLIATKYGFSREDVDAYAVESQQRAAAAWAEGYFAkSVVPVKdQNGLTILDHDEHMRPgTTMES 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 274 MAKLKPAF-------------IKPYGTV-------TAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPK 333
Cdd:PRK08242 217 LAKLKPSFammgemggfdavaLQKYPEVerinhvhHAGNSSGIVDGAAAVLIGSEEAGKALGLKPRARIVATATIGSDPT 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 334 dQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSdwfaenymgrktkvglpPLEKFNNWGGSLSLGH 413
Cdd:PRK08242 297 -IMLTGPVPATRKALAKAGLTVDDIDLFELNEAFASVVLRFMQALDI-----------------PHDKVNVNGGAIAMGH 358
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 528281411 414 PFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK08242 359 PLGATGAMILGTVLDELERRGKRTALITLCVGGGMGIATIIE 400
Thiolase_C pfam02803
Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
316-456 9.27e-58

Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 397094 [Multi-domain]  Cd Length: 123  Bit Score: 186.31  E-value: 9.27e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  316 YKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWfaenymgrktkvg 395
Cdd:pfam02803   1 LKPLARIRSYATAGVDP-AIMGIGPAYAIPKALKKAGLTVNDIDLFEINEAFAAQALAVAKDLGIDP------------- 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528281411  396 lpplEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:pfam02803  67 ----EKVNVNGGAIALGHPLGASGARILVTLLHELKRRGGKYGLASLCIGGGQGVAMIIER 123
PRK06504 PRK06504
acetyl-CoA C-acetyltransferase;
72-456 5.51e-57

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180595 [Multi-domain]  Cd Length: 390  Bit Score: 193.02  E-value: 5.51e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  72 LLHRTSVPKEVVDYIIFGTVIQE-VKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGV 150
Cdd:PRK06504  37 LVDRSGADPALIEDVIMGCVSQVgEQATNVARNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMSGTMDIVIAAGV 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 151 ELMSDVPirhsrkmrklmldlnkaksMGQRLSLISKFRF-NFLAPEL----PAVsEFStsETMGhsADRLAAAFAVSRLE 225
Cdd:PRK06504 117 ESMTRVP-------------------MGSPSTLPAKNGLgHYKSPGMeeryPGI-QFS--QFTG--AEMMAKKYGLSKDQ 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 226 QDEYALRSHSLAKKAQDEGLLSD-VVPFKVPG----KDTVTKDNGIR-PSSLEQMAKLKPafIKPYGTVTAANSSFLTDG 299
Cdd:PRK06504 173 LDEFALQSHQRAIAATQAGKFKAeIVPLEITRadgsGEMHTVDEGIRfDATLEGIAGVKL--IAEGGRLTAATASQICDG 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 300 ASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMD 379
Cdd:PRK06504 251 ASGVMVVNERGLKALGVKPLARIHHMTVIGGDPV-IMLEAPLPATERALKKAGMKIDDIDLYEVNEAFASVPLAWLKATG 329
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528281411 380 SDwfaenymgrktkvglpPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK06504 330 AD----------------P-ERLNVNGGAIALGHPLGASGTKLMTTLVHALKQRGKRYGLQTMCEGGGMANVTIVER 389
PRK07108 PRK07108
acetyl-CoA C-acyltransferase;
79-455 8.57e-57

acetyl-CoA C-acyltransferase;


Pssm-ID: 180843 [Multi-domain]  Cd Length: 392  Bit Score: 192.68  E-value: 8.57e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  79 PKEVVDyIIFGTVIQEVKT-SNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVp 157
Cdd:PRK07108  46 PAEVED-VIMGCANPEGATgANIARQIALRAGLPVTVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCV- 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 158 irhSRKMRKLMLD---LNKAKsmgqrlsliskfrfnflaPELpavsefstSETMGHSADRLAAAFAVSRLEQDEYALRSH 234
Cdd:PRK07108 124 ---QNEMNRHMLRegwLVEHK------------------PEI--------YWSMLQTAENVAKRYGISKERQDEYGVQSQ 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 235 SLAKKAQDEGLLSD-VVPF--------KVPG-----KDTVTKDNGIRP-SSLEQMAKLKPAFikPYGTVTAANSSFLTDG 299
Cdd:PRK07108 175 QRAAAAQAAGRFDDeIVPItvtagvadKATGrlftkEVTVSADEGIRPdTTLEGVSKIRSAL--PGGVITAGNASQFSDG 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 300 ASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPkDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILanfkamd 379
Cdd:PRK07108 253 ASACVVMNAKVAEREGLQPLGIFRGFAVAGCEP-DEMGIGPVFAVPKLLKQAGLKVDDIDLWELNEAFAVQVL------- 324
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528281411 380 sdwfaenYMgrKTKVGLPPlEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK07108 325 -------YC--RDTLGIPM-DRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFE 390
PRK06633 PRK06633
acetyl-CoA C-acetyltransferase;
72-456 6.05e-56

acetyl-CoA C-acetyltransferase;


Pssm-ID: 168632 [Multi-domain]  Cd Length: 392  Bit Score: 190.63  E-value: 6.05e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  72 LLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVE 151
Cdd:PRK06633  38 ILQNSKIDPALVNEVILGQVITGGSGQNPARQTLIHAGIPKEVPGYTINKVCGSGLKSVALAANSIMTGDNEIVIAGGQE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 152 LMS----DVPIRHSRKMRKL-MLDLNkaksmgQRLSLISKFRFNFlapelpavsefstsetMGHSADRLAAAFAVSRLEQ 226
Cdd:PRK06633 118 NMSlgmhGSYIRAGAKFGDIkMVDLM------QYDGLTDVFSGVF----------------MGITAENISKQFNISRQEQ 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 227 DEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKDTVT---KDNGIRP-SSLEQMAKLKPAFIKPyGTVTAANSSFLTDGAS 301
Cdd:PRK06633 176 DEFALSSHKKAAKAQLAGIFKDeILPIEVTIKKTTSlfdHDETVRPdTSLEILSKLRPAFDKN-GVVTAGNASSINDGAA 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 302 AMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdqlLLG--PTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILanfkamd 379
Cdd:PRK06633 255 CLMVVSEEALKKHNLTPLARIVSYASAGVDPS---IMGtaPVPASQKALSKAGWSVNDLEVIEVNEAFAAQSI------- 324
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528281411 380 sdwfaenYMGRKTKVGLpplEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK06633 325 -------YVNREMKWDM---EKVNINGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLCIGGGMGMAMCVEA 391
PRK08131 PRK08131
3-oxoadipyl-CoA thiolase;
53-455 1.27e-55

3-oxoadipyl-CoA thiolase;


Pssm-ID: 181242 [Multi-domain]  Cd Length: 401  Bit Score: 189.99  E-value: 1.27e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  53 NVVVVDGVRTPF--------------LLSGT-SGLLHRTSVPKEVVDYIIFGTVIQEVKTS-NVAREAALGAGFSDKTPA 116
Cdd:PRK08131   3 DAYIYDGLRSPFgrhagalasvrpddLAATViRRLLEKSGFPGDDIEDVILGCTNQAGEDSrNVARNALLLAGLPVTVPG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKS-MGQRlsliskfrfnFLAPE 195
Cdd:PRK08131  83 QTVNRLCASGLAAVIDAARAITCGEGDLYLAGGVESMSRAPFVMGKAESAFSRDAKVFDTtIGAR----------FPNPK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 196 LpaVSEFStSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFKVP--GKDT---VTKDNGIRPS 269
Cdd:PRK08131 153 I--VAQYG-NDSMPETGDNVAAEFGISREDADRFAAQSQAKYQAAKEEGFFADeITPIEVPqgRKLPpklVAEDEHPRPS 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 270 S-LEQMAKLKPAFIKpyGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVL 348
Cdd:PRK08131 230 StVEALTKLKPLFEG--GVVTAGNASGINDGAAALLIGSRAAGEKYGLKPMARILSSAAAGVEPR-IMGIGPVEAIKKAL 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 349 EKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDwFAEnymgrktkvglpplEKFNNWGGSLSLGHPFGATGCRLVMAAAN 428
Cdd:PRK08131 307 ARAGLTLDDMDIIEINEAFASQVLGCLKGLGVD-FDD--------------PRVNPNGGAIAVGHPLGASGARLALTAAR 371
                        410       420
                 ....*....|....*....|....*..
gi 528281411 429 RLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK08131 372 ELQRRGKRYAVVSLCIGVGQGLAMVIE 398
PRK06366 PRK06366
acetyl-CoA C-acetyltransferase;
51-455 1.34e-52

acetyl-CoA C-acetyltransferase;


Pssm-ID: 102340 [Multi-domain]  Cd Length: 388  Bit Score: 181.75  E-value: 1.34e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  51 IRNVVVVDGVRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTP 115
Cdd:PRK06366   1 MKDVYIVSAKRTAIGKFGRSfskikapqlggaaikAVIDDAKLDPALVQEVIMGNVIQAGVGQNPAGQAAYHAGLPFGVT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 116 AHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMR---KLMLDLN-KAKSMGQRLSLISKFRFnf 191
Cdd:PRK06366  81 KYTVNVVCASGMLAVESAAREIMLGERDLVIAGGMENMSNAPFLLPSDLRwgpKHLLHKNyKIDDAMLVDGLIDAFYF-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 192 lapelpavsefstsETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFkvpgkDTVTKDNGIRPSS 270
Cdd:PRK06366 159 --------------EHMGVSAERTARKYGITREMADEYSVQSYERAIRATESGEFRNeIVPF-----NDLDRDEGIRKTT 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 271 LEQMAKLKPAFIKPyGTVTAANSSFLTDGASAmLIMAEEKAL-AMGYKPKAYLRDFMYVSQDPKDqLLLGPTYATPKVLE 349
Cdd:PRK06366 220 MEDLAKLPPAFDKN-GILTAGNSAQLSDGGSA-LVMASEKAInEYGLKPIARITGYESASLDPLD-FVEAPIPATRKLLE 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 350 KAGLTMNDIDAFEFHEAFS--GQILANFKAMDSdwfaenymgrktkvglpplEKFNNWGGSLSLGHPFGATGCRLVMAAA 427
Cdd:PRK06366 297 KQNKSIDYYDLVEHNEAFSiaSIIVRDQLKIDN-------------------ERFNVNGGAVAIGHPIGNSGSRIIVTLI 357
                        410       420
                 ....*....|....*....|....*...
gi 528281411 428 NRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK06366 358 NALKTRHMKTGLATLCHGGGGAHTLTLE 385
PRK06954 PRK06954
acetyl-CoA C-acetyltransferase;
73-457 2.36e-50

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180775 [Multi-domain]  Cd Length: 397  Bit Score: 175.85  E-value: 2.36e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  73 LHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVEL 152
Cdd:PRK06954  43 VERAGLKPEQIDEVVMGCVLPAGQGQAPARQAALGAGLPLSVGCTTVNKMCGSGMRAAMFAHDMLVAGSVDVIVAGGMES 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 153 MSDVP-----------IRHSRKMRKLMLD-LNKAKSMGQrlsliskfrfnflapelpavsefstseTMGHSADRLAAAFA 220
Cdd:PRK06954 123 MTNAPyllpkarggmrMGHGQVLDHMFLDgLEDAYDKGR---------------------------LMGTFAEECAGEYG 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 221 VSRLEQDEYALRSHSLAKKAQDEGLLS-DVVPFKVPGKD---TVTKDNGIRPSSLEQMAKLKPAFIKPyGTVTAANSSFL 296
Cdd:PRK06954 176 FTREAQDAFAIESLARAKRANEDGSFAwEIAPVTVAGKKgdtVIDRDEQPFKANPEKIPTLKPAFSKT-GTVTAANSSSI 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 297 TDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFK 376
Cdd:PRK06954 255 SDGAAALVMMRASTAKRLGLAPLARVVGHSTFAQAPS-KFTTAPVGAIRKLFEKNGWRAAEVDLFEINEAFAVVTMAAMK 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 377 AMDSdwfaenymgrktkvglpPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEA 456
Cdd:PRK06954 334 EHGL-----------------PHEKVNVNGGACALGHPIGASGARILVTLIGALRARGGKRGVASLCIGGGEATAMGIEL 396

                 .
gi 528281411 457 Y 457
Cdd:PRK06954 397 I 397
PRK05656 PRK05656
acetyl-CoA C-acetyltransferase;
72-455 2.37e-49

acetyl-CoA C-acetyltransferase;


Pssm-ID: 168156  Cd Length: 393  Bit Score: 173.15  E-value: 2.37e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  72 LLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVE 151
Cdd:PRK05656  37 LLEQTGLDPAQVDEVILGQVLTAGAGQNPARQAAIKAGLPHSVPAMTLNKVCGSGLKALHLAAQAIRCGDAEVIIAGGQE 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 152 LMSDVPIRhsrkmrklmldLNKAKSmGQRL-------SLISKFRFNflapelpAVSEFStsetMGHSADRLAAAFAVSRL 224
Cdd:PRK05656 117 NMSLAPYV-----------LPGART-GLRMghaqlvdSMITDGLWD-------AFNDYH----MGITAENLVEKYGISRE 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 225 EQDEYALRSHSLAKKAQDEGLLSD-VVPFKVPGKD----TVTKDNGIRP-SSLEQMAKLKPAFIKPyGTVTAANSSFLTD 298
Cdd:PRK05656 174 AQDAFAAASQQKAVAAIEAGRFDDeITPILIPQRKgeplAFATDEQPRAgTTAESLAKLKPAFKKD-GSVTAGNASSLND 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 299 GASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKdQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAM 378
Cdd:PRK05656 253 GAAAVLLMSAAKAKALGLPVLAKIAAYANAGVDPA-IMGIGPVSATRRCLDKAGWSLAELDLIEANEAFAAQSLAVGKEL 331
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528281411 379 DSDwfaenymgrktkvglppLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK05656 332 GWD-----------------AAKVNVNGGAIALGHPIGASGCRVLVTLLHEMIRRDAKKGLATLCIGGGQGVALAIE 391
PRK06690 PRK06690
acetyl-CoA C-acyltransferase;
53-455 1.98e-46

acetyl-CoA C-acyltransferase;


Pssm-ID: 180659 [Multi-domain]  Cd Length: 361  Bit Score: 164.55  E-value: 1.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  53 NVVVVDGVRTPFllSGTSGLLHRTSVPK--------------EVVDYIIFGTVIQevKTSNVAREAALGAGFSDKTPAHT 118
Cdd:PRK06690   2 RAVIVEAKRTPI--GKKNGMLKDYEVQQlaaplltflskgmeREIDDVILGNVVG--PGGNVARLSALEAGLGLHIPGVT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 119 VTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRhsrkmrklmldlnkaksmgqrlsliSKFRFnflAPEL-- 196
Cdd:PRK06690  78 IDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSTSPFQ-------------------------NRARF---SPETig 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 197 -PAvsefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSD-VVPFkvpgkDTVTKDNGIRPSSLEQM 274
Cdd:PRK06690 130 dPD---------MGVAAEYVAERYNITREMQDEYACLSYKRTLQALEKGYIHEeILSF-----NGLLDESIKKEMNYERI 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 275 -AKLKPAFIKPyGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQlLLGPTYATPKVLEKAGL 353
Cdd:PRK06690 196 iKRTKPAFLHN-GTVTAGNSCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLP-GTGPIFAVNKLLNEMNM 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 354 TMNDIDAFEFHEAFSGQILANFKAMDSdwfaenymgrktkvglpPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKE 433
Cdd:PRK06690 274 KVEDIDYFEINEAFASKVVACAKELQI-----------------PYEKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRE 336
                        410       420
                 ....*....|....*....|..
gi 528281411 434 GGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK06690 337 DMKYGIATLGIGGGIGLALLFE 358
PRK06025 PRK06025
acetyl-CoA C-acetyltransferase;
56-455 4.39e-44

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235675 [Multi-domain]  Cd Length: 417  Bit Score: 159.56  E-value: 4.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  56 VVDGVRTPFLLS--GTSGLLH----------------RTSVPKEVVDYIIFGTVIQEVKTS-NVAREAALGAGFSDKTPA 116
Cdd:PRK06025   6 IIDAVRTPRGIGkvGKGALAHlhpqhlaatvlkalaeRNGLNTADVDDIIWSTSSQRGKQGgDLGRMAALDAGYDIKASG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 117 HTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRK----LMLDLNKAksmgqrlsliskfRFNFL 192
Cdd:PRK06025  86 VTLDRFCGGGITSVNLAAAQIMSGMEDLVIAGGTEMMSYTAAMAAEDMAAgkppLGMGSGNL-------------RLRAL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 193 APElpavsefstsETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLS-DVVPFKVP-GKDTVTKDNGIRP-S 269
Cdd:PRK06025 153 HPQ----------SHQGVCGDAIATMEGITREALDALGLESQRRAARAIKEGRFDkSLVPVYRDdGSVALDHEEFPRPqT 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 270 SLEQMAKLKPAF-------IKPYGTV------------------TAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRD 324
Cdd:PRK06025 223 TAEGLAALKPAFtaiadypLDDKGTTyrglinqkypdleikhvhHAGNSSGVVDGAAALLLASKAYAEKHGLKPRARIVA 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 325 FMYVSQDPKdQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSgqilanfkamdsdWFAENYMgRKTKVglpPLEKFNN 404
Cdd:PRK06025 303 MANMGDDPT-LMLNAPVPAAKKVLAKAGLTKDDIDLWEINEAFA-------------VVAEKFI-RDLDL---DRDKVNV 364
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528281411 405 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVE 455
Cdd:PRK06025 365 NGGAIALGHPIGATGSILIGTVLDELERRGLKRGLVTMCAAGGMAPAIIIE 415
nondecarbox_cond_enzymes cd00826
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic ...
70-455 7.77e-39

nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238422 [Multi-domain]  Cd Length: 393  Bit Score: 144.94  E-value: 7.77e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  70 SGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGG 149
Cdd:cd00826   32 AAALEPAGVAAGAVEEACLGQVLGAGEGQNCAQQAAMHAGGLQEAPAIGMNNLCGSGLRALALAMQLIAGGDANCILAGG 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 150 VELMSdVPIRHSRKMRKLMLDLNKAKSmgqrlsliskfrfnflapelpavsefstsetmghsadrlaaafavsRLEQDEY 229
Cdd:cd00826  112 FEKME-TSAENNAKEKHIDVLINKYGM----------------------------------------------RACPDAF 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 230 ALRSHSLAKKAQDEGLLSD-VVPFKVPGKD---TVTKDNGIR---PSSLEQMAKLKPAFIKPyGTVTAANSSFLTDGASA 302
Cdd:cd00826  145 ALAGQAGAEAAEKDGRFKDeFAKFGVKGRKgdiHSDADEYIQfgdEASLDEIAKLRPAFDKE-DFLTAGNACGLNDGAAA 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 303 MLIMAEEKA-------LAMGYKPKAYLRDFMYVSQDPKDQLLLG---PTYATPKVLEKAGLTMNDIDAFEFHEAFSGQIL 372
Cdd:cd00826  224 AILMSEAEAqkhglqsKAREIQALEMITDMASTFEDKKVIKMVGgdgPIEAARKALEKAGLGIGDLDLIEAHDAFAANAC 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 373 ANFKAMdsDWFAENYMGRKTKVGLPPLEK---FNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQY-----GLVAACA 444
Cdd:cd00826  304 ATNEAL--GLCPEGQGGALVDRGDNTYGGksiINPNGGAIAIGHPIGASGAAICAELCFELKGEAGKRqgagaGLALLCI 381
                        410
                 ....*....|.
gi 528281411 445 AGGQGHAMIVE 455
Cdd:cd00826  382 GGGGGAAMCIE 392
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
78-454 3.20e-17

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 83.08  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  78 VPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKtPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVP 157
Cdd:cd00829   33 LEPADIDAVVVGNAAGGRFQSFPGALIAEYLGLLGK-PATRVEAAGASGSAAVRAAAAAIASGLADVVLVVGAEKMSDVP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 158 irhsrkmrklmldlnKAKSMGQRLSLISKFRFN-FLAPELPAVsefstsetMGHSADRLAAAFAVSRLEQDEYALRSHSL 236
Cdd:cd00829  112 ---------------TGDEAGGRASDLEWEGPEpPGGLTPPAL--------YALAARRYMHRYGTTREDLAKVAVKNHRN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 237 AKK---AQdegllsdvvpFKVPgkDTVTKDNGIRPSSLeqmaklkpafikPYgtvTAANSSFLTDGASAMLIMAEEKALA 313
Cdd:cd00829  169 AARnpyAQ----------FRKP--ITVEDVLNSRMIAD------------PL---RLLDCCPVSDGAAAVVLASEERARE 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 314 MGYKPkAYLR------DFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAM------DSD 381
Cdd:cd00829  222 LTDRP-VWILgvgaasDTPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLgfcekgEGG 300
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528281411 382 WFAENymGRKTKVGLPPLekfNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQY-----GLVAACAAGGQGHAMIV 454
Cdd:cd00829  301 KLVRE--GDTAIGGDLPV---NTSGGLLSKGHPLGATGLAQAVEAVRQLRGEAGARqvpgaRVGLAHNIGGTGSAAVV 373
PRK06064 PRK06064
thiolase domain-containing protein;
83-454 6.24e-12

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 66.84  E-value: 6.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  83 VDYIIFGTVI--QEVKTSNVAREAALGAGFSDKtPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPirh 160
Cdd:PRK06064  44 IDAMYVGNMSagLFVSQEHIAALIADYAGLAPI-PATRVEAACASGGAALRQAYLAVASGEADVVLAAGVEKMTDVP--- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 161 srkmrklmldlnkaksmgqrlsliskfrfnflAPElpavsefsTSETMGHSADRLAAAFA----------VSRLEQDEYA 230
Cdd:PRK06064 120 --------------------------------TPD--------ATEAIARAGDYEWEEFFgatfpglyalIARRYMHKYG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 231 LRSHSLAK---KAQDEGLLSDVVPFKvpgkdtvtkdngiRPSSLEQMAKLKPAF--IKPYgtvtaaNSSFLTDGASAMLI 305
Cdd:PRK06064 160 TTEEDLALvavKNHYNGSKNPYAQFQ-------------KEITVEQVLNSPPVAdpLKLL------DCSPITDGAAAVIL 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 306 MAEEKAlamgykpKAYLRDFMYVS-----------QDPKDQLLLGPT-YATPKVLEKAGLTMNDIDAFEFHEAFSgqiLA 373
Cdd:PRK06064 221 ASEEKA-------KEYTDTPVWIKasgqasdtialHDRKDFTTLDAAvVAAEKAYKMAGIEPKDIDVAEVHDCFT---IA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 374 NFKAMDSDWFAENYMGRK------TKVG--LPplekFNNWGGSLSLGHPFGATGCRLVMAAANRLRKE---GGQ------ 436
Cdd:PRK06064 291 EILAYEDLGFAKKGEGGKlaregqTYIGgdIP----VNPSGGLKAKGHPVGATGVSQAVEIVWQLRGEaekGRQqvigag 366
                        410
                 ....*....|....*...
gi 528281411 437 YGLvaACAAGGQGHAMIV 454
Cdd:PRK06064 367 YGL--THNVGGTGHTAVV 382
PRK12578 PRK12578
thiolase domain-containing protein;
109-450 4.96e-11

thiolase domain-containing protein;


Pssm-ID: 183606 [Multi-domain]  Cd Length: 385  Bit Score: 64.10  E-value: 4.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 109 GFSDKTPAHtVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVpirhsrkmrklmlDLNKAKSMGQRlSLISKFR 188
Cdd:PRK12578  69 GLTGKVPLR-VEAMCATGLAASLTAYTAVASGLVDMAIAVGVDKMTEV-------------DTSTSLAIGGR-GGNYQWE 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 189 FNFLAPELPAVSEFSTSETMghsadrlaAAFAVSRLEQDEYALRSH---SLAKKAQdegllsdvvpFKvpgkdtvtkdng 265
Cdd:PRK12578 134 YHFYGTTFPTYYALYATRHM--------AVYGTTEEQMALVSVKAHkygAMNPKAH----------FQ------------ 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 266 iRPSSLEQMakLKPAFIK-PygtVTAANSSFLTDGASAMLIMAEEKALAMGY------KPKAYLRDFMYVSQDPKDQLLL 338
Cdd:PRK12578 184 -KPVTVEEV--LKSRAISwP---IKLLDSCPISDGSATAIFASEEKVKELKIdspvwiTGIGYANDYAYVARRGEWVGFK 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 339 GPTYATPKVLEKAGLTMNDIDAFEFHEAFSgqiLANFKAMDSDWFAENYMGRK----------TKVGLpplekfNNWGGS 408
Cdd:PRK12578 258 ATQLAARQAYNMAKVTPNDIEVATVHDAFT---IAEIMGYEDLGFTEKGKGGKfieegqsekgGKVGV------NLFGGL 328
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 528281411 409 LSLGHPFGATGCRLVMAAANRLRKEGGQY--------GLVAacAAGGQGH 450
Cdd:PRK12578 329 KAKGHPLGATGLSMIYEITKQLRDEAGKLqqplkkyiGLVH--NVGGTGH 376
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
290-454 6.35e-09

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 56.68  E-value: 6.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 290 AANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDfMYVSQDPKDQLLL----GPTYATPKVLEKAGLTMNDIDAFEFHE 365
Cdd:cd00327   94 GSEEFVFGDGAAAAVVESEEHALRRGAHPQAEIVS-TAATFDGASMVPAvsgeGLARAARKALEGAGLTPSDIDYVEAHG 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 366 AFSGQILANFKAMDSDWFaenymgrktKVGLPPLEkfnnwGGSLSLGHPFGATG-------CRLVMAAANRLRKEGGQYG 438
Cdd:cd00327  173 TGTPIGDAVELALGLDPD---------GVRSPAVS-----ATLIMTGHPLGAAGlaildelLLMLEHEFIPPTPREPRTV 238
                        170
                 ....*....|....*.
gi 528281411 439 LVAACAAGGQGHAMIV 454
Cdd:cd00327  239 LLLGFGLGGTNAAVVL 254
PTZ00455 PTZ00455
3-ketoacyl-CoA thiolase; Provisional
115-446 9.10e-08

3-ketoacyl-CoA thiolase; Provisional


Pssm-ID: 240424 [Multi-domain]  Cd Length: 438  Bit Score: 54.13  E-value: 9.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 115 PAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSmgqrlslISKFRFNFL-A 193
Cdd:PTZ00455 112 PAMRVEGACASGGLAVQSAWEALLAGTSDIALVVGVEVQTTVSARVGGDYLARAADYRRQRK-------LDDFTFPCLfA 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 194 PELPAVSEfSTSETMGHSADRLAAAFAVSrlEQDEYAlrsHSLAKKAQDEGLlsdvvpfkvpgkdtvtkdNGIRPSSLEQ 273
Cdd:PTZ00455 185 KRMKYIQE-HGHFTMEDTARVAAKAYANG--NKNPLA---HMHTRKLSLEFC------------------TGASDKNPKF 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 274 MAKlkpAFIKPYGTVTaaNSSFLTDGASAMLIMAEEKALAMGYKP--------KAYLRDFMYVSQDPKDQLLLGPTY-AT 344
Cdd:PTZ00455 241 LGN---ETYKPFLRMT--DCSQVSDGGAGLVLASEEGLQKMGLSPndsrlveiKSLACASGNLYEDPPDATRMFTSRaAA 315
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 345 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDsdwFAE-------NYMGRKTKVGLPPLekfNNWGGSLSLGHPFGA 417
Cdd:PTZ00455 316 QKALSMAGVKPSDLQVAEVHDCFTIAELLMYEALG---IAEyghakdlIRNGATALEGRIPV---NTGGGLLSFGHPVGA 389
                        330       340
                 ....*....|....*....|....*....
gi 528281411 418 TGCRLVMAAANRLRKEGGQYGLVAACAAG 446
Cdd:PTZ00455 390 TGVKQIMEVYRQMKGQCGEYQMKNIPALG 418
PRK07516 PRK07516
thiolase domain-containing protein;
294-426 5.16e-07

thiolase domain-containing protein;


Pssm-ID: 181013 [Multi-domain]  Cd Length: 389  Bit Score: 51.49  E-value: 5.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 294 SFLTDGASAMLIMAEEKALAM----GYKPKAYLRDFMYVSQdpKDQLLL-GPTYATPKVLEKAGLTMNDIDAFEFHEAFS 368
Cdd:PRK07516 213 SLVSDGAAALVLADAETARALqravRFRARAHVNDFLPLSR--RDPLAFeGPRRAWQRALAQAGVTLDDLSFVETHDCFT 290
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528281411 369 GQILANFKAM------------DSDWFAENymGRktkvgLPplekFNNWGGSLSLGHPFGATGCRL-VMAA 426
Cdd:PRK07516 291 IAELIEYEAMglappgqgaraiREGWTAKD--GK-----LP----VNPSGGLKAKGHPIGATGVSMhVLAA 350
KAS_I_II cd00834
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ...
97-151 2.30e-06

Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.


Pssm-ID: 238430 [Multi-domain]  Cd Length: 406  Bit Score: 49.46  E-value: 2.30e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528281411  97 TSNVAREAALGAGFsdKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVE 151
Cdd:cd00834  137 PNMAAGQVAIRLGL--RGPNYTVSTACASGAHAIGDAARLIRLGRADVVIAGGAE 189
FabB COG0304
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ...
115-151 2.70e-06

3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440073 [Multi-domain]  Cd Length: 409  Bit Score: 49.32  E-value: 2.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 528281411 115 PAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVE 151
Cdd:COG0304  153 PNYTVSTACASGAHAIGEAYRLIRRGRADVMIAGGAE 189
ketoacyl-synt pfam00109
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ...
115-153 1.58e-05

Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.


Pssm-ID: 425468 [Multi-domain]  Cd Length: 251  Bit Score: 46.09  E-value: 1.58e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528281411  115 PAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELM 153
Cdd:pfam00109 165 PSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVNLL 203
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
64-152 8.26e-05

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 43.97  E-value: 8.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411  64 FLLSGTSGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSdKTPAHTVTMACISANQAMTTGVGLIASGQCD 143
Cdd:cd00327   10 LGFEAAEQAIADAGLSKGPIVGVIVGTTGGSGEFSGAAGQLAYHLGIS-GGPAYSVNQACATGLTALALAVQQVQNGKAD 88

                 ....*....
gi 528281411 144 VIVAGGVEL 152
Cdd:cd00327   89 IVLAGGSEE 97
elong_cond_enzymes cd00828
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
115-177 2.54e-03

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.


Pssm-ID: 238424 [Multi-domain]  Cd Length: 407  Bit Score: 40.11  E-value: 2.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528281411 115 PAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSM 177
Cdd:cd00828  154 PIKTPVGACATALEALDLAVEAIRSGKADIVVVGGVEDPLEEGLSGFANMGALSTAEEEPEEM 216
PRK08256 PRK08256
lipid-transfer protein; Provisional
343-419 4.33e-03

lipid-transfer protein; Provisional


Pssm-ID: 181327 [Multi-domain]  Cd Length: 391  Bit Score: 39.11  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528281411 343 ATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMdsdwfaenymgrktkvGLPP---LEKF--------------NNW 405
Cdd:PRK08256 269 AAQQVYEQAGIGPEDIDVVELHDCFSANELLTYEAL----------------GLCPegeAEKFiddgdntyggrwvvNPS 332
                         90
                 ....*....|....
gi 528281411 406 GGSLSLGHPFGATG 419
Cdd:PRK08256 333 GGLLSKGHPLGATG 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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