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Conserved domains on  [gi|528078339|ref|NP_001268450|]
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DNA helicase MCM8 isoform 3 [Homo sapiens]

Protein Classification

minichromosome maintenance protein MCM( domain architecture ID 1000350)

minichromosome maintenance protein MCM is one of the highly conserved MCM complex proteins, the complex may have helicase activity and is essential for the initiation of DNA replication

Gene Ontology:  GO:0005524|GO:0004386|GO:0003682

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-877 4.43e-176

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 524.75  E-value: 4.43e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 400 ENLFKLIVKwSLAlsprleysgaisahcnlhlPSsnssptsacrvagTTGMRHqtqllllVKAGLALALFGGSQKYADDK 479
Cdd:COG1241  270 PDIYEKIIA-SIA-------------------PS-------------IYGYEE-------IKEAIALQLFGGVPKVLPDG 309

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 480 NRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGnttttsgltvtlsKDSSS--------------GDFALEAG 545
Cdd:COG1241  310 SRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSG-------------KGSTAagltaaavrddfgtGRWTLEAG 374

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 546 ALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 624
Cdd:COG1241  375 ALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLL 454

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 625 SRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPH 703
Cdd:COG1241  455 SRFDLIFVLRDKPDEERDRELARH----------------------------ILKVHRAGELLEQEIEEETEEVKPeIDP 506

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 704 QLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSS-PITTRQLESLIRLTEARARLELREEATKEDAEDIVE 782
Cdd:COG1241  507 DLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIR 586

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 783 IMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSL 861
Cdd:COG1241  587 LVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKL 665

                        810
                 ....*....|....*.
gi 528078339 862 NDQGYLLKKGPKVYQL 877
Cdd:COG1241  666 KRKGEIYEPKPGHYKK 681
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-877 4.43e-176

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 524.75  E-value: 4.43e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 400 ENLFKLIVKwSLAlsprleysgaisahcnlhlPSsnssptsacrvagTTGMRHqtqllllVKAGLALALFGGSQKYADDK 479
Cdd:COG1241  270 PDIYEKIIA-SIA-------------------PS-------------IYGYEE-------IKEAIALQLFGGVPKVLPDG 309

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 480 NRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGnttttsgltvtlsKDSSS--------------GDFALEAG 545
Cdd:COG1241  310 SRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSG-------------KGSTAagltaaavrddfgtGRWTLEAG 374

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 546 ALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 624
Cdd:COG1241  375 ALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLL 454

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 625 SRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPH 703
Cdd:COG1241  455 SRFDLIFVLRDKPDEERDRELARH----------------------------ILKVHRAGELLEQEIEEETEEVKPeIDP 506

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 704 QLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSS-PITTRQLESLIRLTEARARLELREEATKEDAEDIVE 782
Cdd:COG1241  507 DLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIR 586

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 783 IMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSL 861
Cdd:COG1241  587 LVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKL 665

                        810
                 ....*....|....*.
gi 528078339 862 NDQGYLLKKGPKVYQL 877
Cdd:COG1241  666 KRKGEIYEPKPGHYKK 681
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 459-787 2.32e-166

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 485.11  E-value: 2.32e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 459 LVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSG 538
Cdd:cd17759   15 LVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTSGLTVTLTKDGRSG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 539 DFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17759   95 DFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVGGHYNKGKTVSENLK 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsvlevvsekplserlkvvpgeti 698
Cdd:cd17759  175 MGPALLSRFDLVFILLDTPSEEHDHLLSEH-------------------------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 dpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAE 778
Cdd:cd17759  205 ----HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARARLELREEATKEDAE 280


                 ....*....
gi 528078339 779 DIVEIMKYS 787
Cdd:cd17759  281 DVIEIMKES 289
MCM smart00350
minichromosome maintenance proteins;
207-789 4.68e-141

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 428.22  E-value: 4.68e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   207 LKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSpLTVTM 286
Cdd:smart00350   5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   287 DWQSIKIQElmSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSIsnsK 366
Cdd:smart00350  84 DFQKIKLQE--SPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHV---R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   367 GQKTKSSEDGCkHGMLMEFSLKDLYAIQEIQAEENLFKLIVKwSLALSprleysgaISAHCNlhlpssnssptsacrvag 446
Cdd:smart00350 159 KLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLAR-SLAPS--------IYGHED------------------ 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   447 ttgmrhqtqllllVKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSG 526
Cdd:smart00350 211 -------------IKKAILLLLFGGVHKNLPDGMKI--RGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   527 LTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGG 605
Cdd:smart00350 276 LTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGG 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   606 HYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIragkqrtissatvaRMNSQDSNTSVLEVvsekp 685
Cdd:smart00350 356 RYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDL--------------HRYSHPEEDEAFEP----- 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   686 lserlkvvpgetidPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK---QSQRLNSSPITTRQLESLIRLTEA 762
Cdd:smart00350 417 --------------PLSQEKLRKYIAYAREKIKPKLSEEAADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEA 482

                          570       580
                   ....*....|....*....|....*..
gi 528078339   763 RARLELREEATKEDAEDIVEIMKYSML 789
Cdd:smart00350 483 HAKMRLSDVVEEADVEEAIRLLRESII 509
MCM pfam00493
MCM P-loop domain;
460-653 2.69e-93

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 292.90  E-value: 2.69e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  460 VKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:pfam00493  32 VKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDPVTGE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  540 FALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:pfam00493 110 FVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIFGRYDPKKSIAENIN 189

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 528078339  619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIR 653
Cdd:pfam00493 190 LPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 75-832 6.97e-71

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 252.22  E-value: 6.97e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  75 YKGWKL--YFSEVYSDSSPLIEKIQAFEKFFTrHIDLYDKdeierkgsilVDFKELTEggevtnlipdiatelrdAPEKT 152
Cdd:PTZ00111 122 YYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDK----------VLYKLLVT-----------------FPADC 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 153 LACMGLAIHQVLTKDLERHAAELQAQEglsndgetmvNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIK 232
Cdd:PTZ00111 174 IAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFSGTVVRQTWIV 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 233 PLCTKMAF---------------------------------LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRS 279
Cdd:PTZ00111 244 PEITMACFrcrgqkkiglndyqpctcehyeyviqgevneplLCNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPD 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 280 SP-LTVTMDWQSIKIQELMSDDQreagriprTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIE 358
Cdd:PTZ00111 324 KDgLDNSVDNSGLNGEIYMKDNE--------VINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLYTYFVN 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 359 ANSI----SNSKGQKTKSSEdgcKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKwSLALSprleysgaISAHCNlhlpss 434
Cdd:PTZ00111 396 VIHVkvinSTNANQPEKGLK---YLGNENDFSDLQVYKILELSRNPMIYRILLD-SFAPS--------IKARNN------ 457

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 435 nssptsacrvagttgmrhqtqllllVKAGLALALFGGSqKYADDKNRIP--------IRGDPHILVVGDPGLGKSQMLQA 506
Cdd:PTZ00111 458 -------------------------VKIGLLCQLFSGN-KNSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHY 511

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 507 ACNVAPRGVYVCGNTTTTSGLTVTLS-KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKA 584
Cdd:PTZ00111 512 THLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKA 591

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 585 GVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEhVIAiragKQRTISSAT 664
Cdd:PTZ00111 592 GIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMT 666

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 665 VARMNS---QDSNTSVLEvvsekplSERLKvvPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK--- 738
Cdd:PTZ00111 667 GSGNDEdtyDRSNTMHVE-------DESLR--SEKDYNKNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnf 737

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 739 ---------------------QSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEF- 796
Cdd:PTZ00111 738 qtsnldelehaqedddddlyyQSSGTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTt 817

                        810       820       830
                 ....*....|....*....|....*....|....*.
gi 528078339 797 GNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYN 832
Cdd:PTZ00111 818 GKIDFDQLHQGITTNKMQQLNQMYEQVLSVLTRSSN 853
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-877 4.43e-176

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 524.75  E-value: 4.43e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 400 ENLFKLIVKwSLAlsprleysgaisahcnlhlPSsnssptsacrvagTTGMRHqtqllllVKAGLALALFGGSQKYADDK 479
Cdd:COG1241  270 PDIYEKIIA-SIA-------------------PS-------------IYGYEE-------IKEAIALQLFGGVPKVLPDG 309

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 480 NRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGnttttsgltvtlsKDSSS--------------GDFALEAG 545
Cdd:COG1241  310 SRI--RGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSG-------------KGSTAagltaaavrddfgtGRWTLEAG 374

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 546 ALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 624
Cdd:COG1241  375 ALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLL 454

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 625 SRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPH 703
Cdd:COG1241  455 SRFDLIFVLRDKPDEERDRELARH----------------------------ILKVHRAGELLEQEIEEETEEVKPeIDP 506

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 704 QLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSS-PITTRQLESLIRLTEARARLELREEATKEDAEDIVE 782
Cdd:COG1241  507 DLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIR 586

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 783 IMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSL 861
Cdd:COG1241  587 LVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDIIKELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKL 665

                        810
                 ....*....|....*.
gi 528078339 862 NDQGYLLKKGPKVYQL 877
Cdd:COG1241  666 KRKGEIYEPKPGHYKK 681
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 459-787 2.32e-166

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 485.11  E-value: 2.32e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 459 LVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSG 538
Cdd:cd17759   15 LVKAGLLLSLFGGKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTSGLTVTLTKDGRSG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 539 DFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17759   95 DFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVGGHYNKGKTVSENLK 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsvlevvsekplserlkvvpgeti 698
Cdd:cd17759  175 MGPALLSRFDLVFILLDTPSEEHDHLLSEH-------------------------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 dpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAE 778
Cdd:cd17759  205 ----HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARARLELREEATKEDAE 280


                 ....*....
gi 528078339 779 DIVEIMKYS 787
Cdd:cd17759  281 DVIEIMKES 289
MCM smart00350
minichromosome maintenance proteins;
207-789 4.68e-141

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 428.22  E-value: 4.68e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   207 LKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSpLTVTM 286
Cdd:smart00350   5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   287 DWQSIKIQElmSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSIsnsK 366
Cdd:smart00350  84 DFQKIKLQE--SPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHV---R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   367 GQKTKSSEDGCkHGMLMEFSLKDLYAIQEIQAEENLFKLIVKwSLALSprleysgaISAHCNlhlpssnssptsacrvag 446
Cdd:smart00350 159 KLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLAR-SLAPS--------IYGHED------------------ 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   447 ttgmrhqtqllllVKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSG 526
Cdd:smart00350 211 -------------IKKAILLLLFGGVHKNLPDGMKI--RGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   527 LTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGG 605
Cdd:smart00350 276 LTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRtAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGG 355

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   606 HYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIragkqrtissatvaRMNSQDSNTSVLEVvsekp 685
Cdd:smart00350 356 RYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDL--------------HRYSHPEEDEAFEP----- 416

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339   686 lserlkvvpgetidPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK---QSQRLNSSPITTRQLESLIRLTEA 762
Cdd:smart00350 417 --------------PLSQEKLRKYIAYAREKIKPKLSEEAADKLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEA 482

                          570       580
                   ....*....|....*....|....*..
gi 528078339   763 RARLELREEATKEDAEDIVEIMKYSML 789
Cdd:smart00350 483 HAKMRLSDVVEEADVEEAIRLLRESII 509
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 460-787 9.85e-136

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 407.11  E-value: 9.85e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDknRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17706   16 VKKAVLLQLFGGVQKILED--GTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLTAAVVRDSETGE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17706   94 WYLEAGALVLADGGVCCIDEFDKMKELDRtALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGRYNPKLSPIENIN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRtissatvarmnsqdsntsvlevvsekplseRLKVVPGETI 698
Cdd:cd17706  174 LPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDP------------------------------EEQVKPEEDG 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 DPIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAE 778
Cdd:cd17706  224 IPIDIELLRKYILYARQ-IHPKISEEAREKLVRWYVELRKESERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVE 302


                 ....*....
gi 528078339 779 DIVEIMKYS 787
Cdd:cd17706  303 EAIRLVRHS 311
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 460-784 9.04e-104

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 323.63  E-value: 9.04e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17761   17 VKEAIALQLFGGVPKVLPDGTRI--RGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGLTAAVVRDEGTGE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17761   95 WYLEAGALVLADKGIAVVDEIDKMRKEDRsALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKFGRFDSYRPVAEQID 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsVLEVVSEKPLSErlkVVPgeTI 698
Cdd:cd17761  175 LPPTLLSRFDLIFVLKDTPNEEKDRRLANH----------------------------ILDTHSGGEMRE---IKP--EI 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 DPiphQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSS-PITTRQLESLIRLTEARARLELREEATKEDA 777
Cdd:cd17761  222 DP---DLLRKYIAYARKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPvPITARQLEALVRLSEASARMRLSQEVTLEDA 298


                 ....*..
gi 528078339 778 EDIVEIM 784
Cdd:cd17761  299 ERAIRIM 305
MCM pfam00493
MCM P-loop domain;
460-653 2.69e-93

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 292.90  E-value: 2.69e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  460 VKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:pfam00493  32 VKKAILLQLFGGVKKILPDGTRL--RGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDPVTGE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  540 FALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:pfam00493 110 FVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIFGRYDPKKSIAENIN 189

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 528078339  619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIR 653
Cdd:pfam00493 190 LPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 460-784 6.16e-92

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 293.20  E-value: 6.16e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17753   16 IKTAIALALFGGVAKNPGGKHRI--RGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTASVRKDPVTKE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17753   94 WTLEGGALVLADKGVCLIDEFDKMNDQDRtSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYNPTLTFAQNVN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtisSATVARMNSQDSNTSVLEVVSEKPLSERLKVvpgeti 698
Cdd:cd17753  174 LTEPILSRFDILCVVRDTVDPEEDERLAKFVV-----------GSHVRSHPENDEDREGEEEKNQRQRPKETKV------ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 DPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAE 778
Cdd:cd17753  237 EPIPQELLRKYIHYAREKVRPKLNQMDMDKVSRVYADLRKESMATGSLPITVRHLESIIRISEAHAKMHLREYVSEEDVD 316


                 ....*.
gi 528078339 779 DIVEIM 784
Cdd:cd17753  317 MAIRVM 322
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 460-785 9.17e-88

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 281.63  E-value: 9.17e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKyADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17755   16 VKKGILLQLFGGTRK-DFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVGLTAYVTRDPDTKQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17755   95 LVLESGALVLSDGGICCIDEFDKMSDSTRSVLhEVMEQQTLSIAKAGIITTLNARTSILASANPIGSRYNPKLTVVENID 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAiragkqrtissatvarMNSQDSNTSvlevvsekplserlkvvpgETI 698
Cdd:cd17755  175 LPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVS----------------LYLEDTPEH-------------------IQD 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 DPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQ-SQRLNSSPITTRQLESLIRLTEARARLELREEATKEDA 777
Cdd:cd17755  220 EVLDVEVLTDYISYAREHIHPKLSEEAAQELVQAYVDMRKMgSDARKRITATPRQLESLIRLAEAHAKMRLSNVVEAEDV 299


                 ....*...
gi 528078339 778 EDIVEIMK 785
Cdd:cd17755  300 EEAVRLIR 307
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 460-787 1.14e-87

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 281.18  E-value: 1.14e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDKnrIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17757   16 VKKGILLMLLGGVHKITREG--ISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGLTAAVVRDEETGD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17757   94 FVIEAGALMLADNGICCIDEFDKMDIKDQvAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGRYDRSKSLKQNIN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSatvarmnsqdsntsvlevvsekplserlkvvpgeti 698
Cdd:cd17757  174 ISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEP------------------------------------ 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 dPIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYLELRKQSQRLNSSP---ITTRQLESLIRLTEARARLELREEATKE 775
Cdd:cd17757  218 -PFTAEQLKRYIAYART-FKPKLTKEAKDELVEQYKELRQDDASGSTRSsyrITVRQLESLIRLSEAIARLHCSDEVTPE 295

                        330
                 ....*....|..
gi 528078339 776 DAEDIVEIMKYS 787
Cdd:cd17757  296 HVEEAARLLKKS 307
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 460-787 2.51e-87

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 280.81  E-value: 2.51e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17756   16 IKKAIACLLFGGSRKRLPDGMRL--RGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGLTASVMRDPSTRE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMgNQHQ--ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENL 617
Cdd:cd17756   94 FYLEGGAMVLADGGVVCIDEFDKM-REDDrvAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFGRYDDLKTPGDNI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 618 KMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSatvarmnsqdsntsvlevvsekplserlkvvpGET 697
Cdd:cd17756  173 DFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQS--------------------------------QEN 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 698 IDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQ-------SQRLNSSPITTRQLESLIRLTEARARLELRE 770
Cdd:cd17756  221 EGEIPISKLKRYIAYCRAKCAPRLSEEAAEKLSNHYVTIRKDvrqneleSDNRSSIPITVRQLEAIIRISESLAKMELSP 300

                        330
                 ....*....|....*..
gi 528078339 771 EATKEDAEDIVEIMKYS 787
Cdd:cd17756  301 IATEKHVEEAIRLFQVS 317
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 460-787 3.91e-80

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 261.19  E-value: 3.91e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKYADDknrIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17758   16 VKKALLLLLVGGVDKRGDG---MKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTAAVMKDPVTGE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17758   93 MTLEGGALVLADQGICCIDEFDKMDESDRtAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGRYNPRRSPEQNIN 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHViairagkqrtissaTVARMNSQDsntsvlevvsekplserlkvvPGETI 698
Cdd:cd17758  173 LPAALLSRFDLLFLILDKPDRDNDLRLAEHV--------------TYVHQHNKQ---------------------PDSDF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 DPIPHQLLRKYIGYARQYvYPRLSTEAARVLQDFYLELRKQSQRLNSSPITT-RQLESLIRLTEARARLELREEATKEDA 777
Cdd:cd17758  218 EPLDPKLLRAYIALAKRK-RPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTpRTLLAILRLSQALARLRLSDSVEIDDV 296

                        330
                 ....*....|
gi 528078339 778 EDIVEIMKYS 787
Cdd:cd17758  297 EEALRLMEMS 306
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 453-787 5.73e-75

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 247.07  E-value: 5.73e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 453 QTQLLLLVKAGLALALFGGSQKYADDKNRIpiRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLS 532
Cdd:cd17760    9 QVFGLYNVKLAVAMVLAGGVQRIDASGTRV--RGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 533 KDssSGDFALEAGALVLGDQGICGIDEFDKMG-NQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPvGGHYNKAK 611
Cdd:cd17760   87 KD--GGEWNLEAGALVLADGGLCCIDEFNSLKeHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPNE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 612 TVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtissatvarmnSQDSNTSVLEVVsekplserlk 691
Cdd:cd17760  164 SISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL-------------------ENKGEPSKSSKL---------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 692 vvpgetidpIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYlELRKQSQRLNSSPITTRQLESLIRLTEARARLELREE 771
Cdd:cd17760  215 ---------WSMEKMRTYFCLIKN-LRPVLSDEANAILLRYY-QLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRET 283

                        330
                 ....*....|....*.
gi 528078339 772 ATKEDAEDIVEIMKYS 787
Cdd:cd17760  284 VTEEDAITVVSVMESS 299
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 75-832 6.97e-71

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 252.22  E-value: 6.97e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  75 YKGWKL--YFSEVYSDSSPLIEKIQAFEKFFTrHIDLYDKdeierkgsilVDFKELTEggevtnlipdiatelrdAPEKT 152
Cdd:PTZ00111 122 YYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDK----------VLYKLLVT-----------------FPADC 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 153 LACMGLAIHQVLTKDLERHAAELQAQEglsndgetmvNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIK 232
Cdd:PTZ00111 174 IAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFSGTVVRQTWIV 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 233 PLCTKMAF---------------------------------LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRS 279
Cdd:PTZ00111 244 PEITMACFrcrgqkkiglndyqpctcehyeyviqgevneplLCNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPD 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 280 SP-LTVTMDWQSIKIQELMSDDQreagriprTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIE 358
Cdd:PTZ00111 324 KDgLDNSVDNSGLNGEIYMKDNE--------VINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLYTYFVN 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 359 ANSI----SNSKGQKTKSSEdgcKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKwSLALSprleysgaISAHCNlhlpss 434
Cdd:PTZ00111 396 VIHVkvinSTNANQPEKGLK---YLGNENDFSDLQVYKILELSRNPMIYRILLD-SFAPS--------IKARNN------ 457

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 435 nssptsacrvagttgmrhqtqllllVKAGLALALFGGSqKYADDKNRIP--------IRGDPHILVVGDPGLGKSQMLQA 506
Cdd:PTZ00111 458 -------------------------VKIGLLCQLFSGN-KNSSDFNKSPdacykvdnFRGIINVLLCGDPGTAKSQLLHY 511

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 507 ACNVAPRGVYVCGNTTTTSGLTVTLS-KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKA 584
Cdd:PTZ00111 512 THLLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKA 591

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 585 GVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEhVIAiragKQRTISSAT 664
Cdd:PTZ00111 592 GIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMT 666

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 665 VARMNS---QDSNTSVLEvvsekplSERLKvvPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK--- 738
Cdd:PTZ00111 667 GSGNDEdtyDRSNTMHVE-------DESLR--SEKDYNKNDLDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnf 737

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 739 ---------------------QSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEF- 796
Cdd:PTZ00111 738 qtsnldelehaqedddddlyyQSSGTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTt 817

                        810       820       830
                 ....*....|....*....|....*....|....*.
gi 528078339 797 GNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYN 832
Cdd:PTZ00111 818 GKIDFDQLHQGITTNKMQQLNQMYEQVLSVLTRSSN 853
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 460-787 2.72e-70

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 234.28  E-value: 2.72e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 460 VKAGLALALFGGSQKyaDDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGD 539
Cdd:cd17754   16 IKKAILLMLLGGVEK--NLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTAAVTTDQETGE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 540 FALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLK 618
Cdd:cd17754   94 RRLEAGAMVLADRGVVCIDEFDKMSDIDRvAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGRYDVYKTPMENIG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 619 MGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtissatvaRMNSQdsntsvlevvsekplserlkvvpgeti 698
Cdd:cd17754  174 LPDSLLSRFDLLFIVLDDIDEERDRSISEHVL----------------RMHRY--------------------------- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 699 dpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQ----SQRLNSSPITTRQLESLIRLTEARARLELREEATK 774
Cdd:cd17754  211 ----IKFLRKYIHYAKERIKPKLTQEAAEYIAEEYADLRNDdntkTDKARTSPITARTLETLIRLATAHAKARLSKTVDK 286

                        330
                 ....*....|...
gi 528078339 775 EDAEDIVEIMKYS 787
Cdd:cd17754  287 VDAEVALNLLRFA 299
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 704-788 8.53e-33

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 121.50  E-value: 8.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  704 QLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQS-QRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVE 782
Cdd:pfam17855   1 ELLRKYIAYAREKIKPKLSEEAREKLVDAYVELRKEStGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80


                  ....*.
gi 528078339  783 IMKYSM 788
Cdd:pfam17855  81 LLKESL 86
MCM8_WHD cd22247
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ...
 813-878 5.41e-31

winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.


Pssm-ID: 439328 [Multi-domain]  Cd Length: 66  Bit Score: 115.66  E-value: 5.41e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528078339 813 RSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQ 878
Cdd:cd22247    1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDDFDDFIESLNNQGYLLKKGPNLYQLQ 66
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 206-337 1.21e-30

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 116.81  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339  206 QLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFplpdgKYSLPTKCPVPVCRGR-SFTALRSspLTV 284
Cdd:pfam17207   1 SIRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGV-----KITEPTKCPNPECGNKdPFKLVHE--KSK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528078339  285 TMDWQSIKIQElMSDDQReAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKV 337
Cdd:pfam17207  74 FVDFQKIKIQE-SPEEVP-AGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRV 124
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 475-633 5.57e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 47.14  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 475 YADDKNRIPIRGDPHILVVGDPGLGKSQMLQA-ACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQG 553
Cdd:cd00009    7 IEALREALELPPPKNLLLYGPPGTGKTTLARAiANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 554 ICGIDEFDKMGNQ-HQALLEAMEQQSISLAKagvvcslPARTSIIAAANPvgghynkaktvSENLKMGSALLSRFDLVFI 632
Cdd:cd00009   87 VLFIDEIDSLSRGaQNALLRVLETLNDLRID-------RENVRVIGATNR-----------PLLGDLDRALYDRLDIRIV 148


                 .
gi 528078339 633 L 633
Cdd:cd00009  149 I 149
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 489-800 2.27e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 47.08  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 489 HILVVGDPGLGKSQMLQA---ACNVAPR--------------GVYVCgnttttsgltvtlskDSSSGDFALEAGAL---- 547
Cdd:COG0714   33 HLLLEGVPGVGKTTLAKAlarALGLPFIriqftpdllpsdilGTYIY---------------DQQTGEFEFRPGPLfanv 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 548 VLgdqgicgIDEFDKMGNQHQ-ALLEAMEQQSISLakAGVVCSLPARTSIIAAANPVggHYNKAKTVSEnlkmgsALLSR 626
Cdd:COG0714   98 LL-------ADEINRAPPKTQsALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPI--EQEGTYPLPE------AQLDR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 627 FdLVFILLDTPNEhhdhllsEHVIAIRAGKQRTiSSATVARMNSQDSNTSVLEVVSEKPLSERLKvvpgetidpiphqll 706
Cdd:COG0714  161 F-LLKLYIGYPDA-------EEEREILRRHTGR-HLAEVEPVLSPEELLALQELVRQVHVSEAVL--------------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 707 rkyiGYARQYVYprlsteAARVLQDFylelrkqsqRLNSSPittRQLESLIRLTEARARLELREEATKEDAEDI-VEIMK 785
Cdd:COG0714  217 ----DYIVDLVR------ATREHPDL---------RKGPSP---RASIALLRAARALALLDGRDYVTPDDVKAVaGPVLK 274

                        330
                 ....*....|....*
gi 528078339 786 YSMLGTYSDEFGNLD 800
Cdd:COG0714  275 HRLILSPEADAEGVT 289
PRK09862 PRK09862
ATP-dependent protease;
543-662 7.92e-04

ATP-dependent protease;


Pssm-ID: 182120 [Multi-domain]  Cd Length: 506  Bit Score: 43.04  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078339 543 EAGALVLGDQGICGIDEFDKMGNQH-QALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV-GGHY--NKAKTVSENL- 617
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTlDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPSpTGHYqgNHNRCTPEQTl 365

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528078339 618 ----KMGSALLSRFDLVF-ILLDTPNehhdhLLSEHVIAIRAG---KQRTISS 662
Cdd:PRK09862 366 rylnRLSGPFLDRFDLSLeIPLPPPG-----ILSKTVVPGESSatvKQRVMAA 413
RadA_SMS_N cd01121
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ...
 490-519 1.13e-03

bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.


Pssm-ID: 410866 [Multi-domain]  Cd Length: 268  Bit Score: 41.75  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528078339 490 ILVVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 519
Cdd:cd01121   85 VLIGGDPGIGKSTlLLQVAARLAQRGgkvLYVSG 118
Sms COG1066
DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and ...
 490-519 3.04e-03

DNA repair protein RadA/Sms, contains AAA+ ATPase domain [Replication, recombination and repair];


Pssm-ID: 440685 [Multi-domain]  Cd Length: 453  Bit Score: 41.19  E-value: 3.04e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528078339 490 ILVVGDPGLGKSQ-MLQAACNVAPRG---VYVCG 519
Cdd:COG1066   92 VLIGGEPGIGKSTlLLQVAARLAKKGgkvLYVSG 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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