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Conserved domains on  [gi|528078341|ref|NP_001268451|]
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DNA helicase MCM8 isoform 4 [Homo sapiens]

Protein Classification

minichromosome maintenance protein MCM( domain architecture ID 1000350)

minichromosome maintenance protein MCM is one of the highly conserved MCM complex proteins, the complex may have helicase activity and is essential for the initiation of DNA replication

Gene Ontology:  GO:0005524|GO:0004386|GO:0003682

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-790 3.12e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 468.12  E-value: 3.12e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 400 ENLFKLIVNSLCPVIFGHEA---------------------------------------------ACNVAPRGVYVCGnt 434
Cdd:COG1241  270 PDIYEKIIASIAPSIYGYEEikeaialqlfggvpkvlpdgsrirgdihillvgdpgtaksqllryAARLAPRGVYTSG-- 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 435 tttsgltvtlsKDSSS--------------GDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGV 499
Cdd:COG1241  348 -----------KGSTAagltaaavrddfgtGRWTLEAGALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGI 416

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 500 VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatva 579
Cdd:COG1241  417 VATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARH------------------ 478

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 580 rmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNS 658
Cdd:COG1241  479 ----------ILKVHRAGELLEQEIEEETEEVKPeIDPDLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDS 548

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 659 S-PITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISAL 736
Cdd:COG1241  549 PvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDII 628

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528078341 737 NNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQL 790
Cdd:COG1241  629 KELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKLKRKGEIYEPKPGHYKK 681
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-790 3.12e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 468.12  E-value: 3.12e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 400 ENLFKLIVNSLCPVIFGHEA---------------------------------------------ACNVAPRGVYVCGnt 434
Cdd:COG1241  270 PDIYEKIIASIAPSIYGYEEikeaialqlfggvpkvlpdgsrirgdihillvgdpgtaksqllryAARLAPRGVYTSG-- 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 435 tttsgltvtlsKDSSS--------------GDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGV 499
Cdd:COG1241  348 -----------KGSTAagltaaavrddfgtGRWTLEAGALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGI 416

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 500 VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatva 579
Cdd:COG1241  417 VATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARH------------------ 478

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 580 rmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNS 658
Cdd:COG1241  479 ----------ILKVHRAGELLEQEIEEETEEVKPeIDPDLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDS 548

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 659 S-PITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISAL 736
Cdd:COG1241  549 PvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDII 628

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528078341 737 NNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQL 790
Cdd:COG1241  629 KELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKLKRKGEIYEPKPGHYKK 681
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 405-700 1.65e-134

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 400.37  E-value: 1.65e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 405 LIVNSLCPVIFGHE-----------------------------------------------AACNVAPRGVYVCGNTTTT 437
Cdd:cd17759    1 LIVNSLCPAIYGHElvkaglllslfggkqkyaddknripirgdphvlivgdpglgksqmlqAACNIAPRGVYVCGNTTTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 438 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 517
Cdd:cd17759   81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 518 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsvlevvsek 597
Cdd:cd17759  161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 598 plserlkvvpgetidpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARA 677
Cdd:cd17759  205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266

                        330       340
                 ....*....|....*....|...
gi 528078341 678 RLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17759  267 RLELREEATKEDAEDVIEIMKES 289
MCM smart00350
minichromosome maintenance proteins;
207-702 5.38e-126

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 386.62  E-value: 5.38e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   207 LKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSpLTVTM 286
Cdd:smart00350   5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   287 DWQSIKIQElmSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSIsnsK 366
Cdd:smart00350  84 DFQKIKLQE--SPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHV---R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   367 GQKTKSSEDGCkHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHE---------------------------- 418
Cdd:smart00350 159 KLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEdikkaillllfggvhknlpdgmkirgdi 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   419 -----------------AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ 481
Cdd:smart00350 238 nillcgdpgtaksqllkYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDR 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   482 -ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSE 560
Cdd:smart00350 318 tAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAK 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   561 HVIAIragkqrtissatvaRMNSQDSNTSVLEVvsekplserlkvvpgetidPIPHQLLRKYIGYARQYVYPRLSTEAAR 640
Cdd:smart00350 398 HVVDL--------------HRYSHPEEDEAFEP-------------------PLSQEKLRKYIAYAREKIKPKLSEEAAD 444

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528078341   641 VLQDFYLELRK---QSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSML 702
Cdd:smart00350 445 KLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
MCM pfam00493
MCM P-loop domain;
389-566 2.74e-72

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 235.50  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  389 DLYAIQEIQAEENLFKLIVNSLCPVIFGHEA---------------------------------------------ACNV 423
Cdd:pfam00493   1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDvkkaillqlfggvkkilpdgtrlrgdinvllvgdpgtaksqllkyVEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  424 APRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVVCS 502
Cdd:pfam00493  81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIVAT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528078341  503 LPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIR 566
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 75-720 4.63e-60

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 219.48  E-value: 4.63e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  75 YKGWKL--YFSEVYSDSSPLIEKIQAFEKFFTrHIDLYDKdeierkgsilVDFKELTEggevtnlipdiatelrdAPEKT 152
Cdd:PTZ00111 122 YYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDK----------VLYKLLVT-----------------FPADC 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 153 LACMGLAIHQVLTKDLERHAAELQAQEglsndgetmvNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIK 232
Cdd:PTZ00111 174 IAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFSGTVVRQTWIV 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 233 PLCTKMAF---------------------------------LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRS 279
Cdd:PTZ00111 244 PEITMACFrcrgqkkiglndyqpctcehyeyviqgevneplLCNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPD 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 280 SP-LTVTMDWQSIKIQELMSDDQreagriprTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIE 358
Cdd:PTZ00111 324 KDgLDNSVDNSGLNGEIYMKDNE--------VINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLYTYFVN 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 359 ANSI----SNSKGQKTKSSEdgcKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEA----------ACN-- 422
Cdd:PTZ00111 396 VIHVkvinSTNANQPEKGLK---YLGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNvkigllcqlfSGNkn 472

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 423 ------------------------------------------VAPRGVYVCGNTTTTSGLTVTLS-KDSSSGDFALEAGA 459
Cdd:PTZ00111 473 ssdfnkspdacykvdnfrgiinvllcgdpgtaksqllhythlLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGA 552

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 460 LVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS 538
Cdd:PTZ00111 553 VVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFT 632

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 539 RFDLVFILLDTPNEHHDHLLSEhVIAiragKQRTISSATVARMNS---QDSNTSVLEvvsekplSERLKvvPGETIDPIP 615
Cdd:PTZ00111 633 RFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMTGSGNDEdtyDRSNTMHVE-------DESLR--SEKDYNKND 698

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 616 HQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK------------------------QSQRLNSSPITTRQLESLIR 671
Cdd:PTZ00111 699 LDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnfqtsnldelehaqedddddlyyQSSGTRMIYVSSRMISSIIR 778

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 528078341 672 LTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEF-GNLDFERSQHG 720
Cdd:PTZ00111 779 ISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 88-790 3.12e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 468.12  E-value: 3.12e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  88 DSSPLIEKiqaFEKFFTRHIdlYdKDEI-------ERKGSILVDFKELTEGGevtnliPDIATELRDAPEKTLACMGLAI 160
Cdd:COG1241    1 EESDLVDK---FEEFLRRYK--Y-RDEIlelaqeyPEKRSLVVDYNDLYSFD------PDLADDLLENPDEVLEAAEEAL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 161 HQVLTKDLErhaaelqaqeglsndgetmVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF 240
Cdd:COG1241   69 REIDLEPYD-------------------VSLGDAHVRITNLPETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 241 LCAACGEIQSFPLPDGKYSLPTKCPVpvC-RGRSFTALRSSplTVTMDWQSIKIQELMSDdqREAGRIPRTIECELVHDL 319
Cdd:COG1241  130 ECPRCGTETYVPQTGEKLQEPHECPG--CgRQGPFKLLPEK--SEFIDAQKIRIQEPPED--LPGGQQPQSIDVILEDDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 320 VDSCVPGDTVTITGIVKVsnaEEGSRNKNDKCMFLLYIEANSISNSkgqkTKSSEDgckhgmlMEFSLKDLYAIQEIQAE 399
Cdd:COG1241  204 VGEVRPGDRVTVTGILRI---EQRTSGRGKSTIFDLYLEANSIEVE----EKEFEE-------IEITEEDEEKIKELSKD 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 400 ENLFKLIVNSLCPVIFGHEA---------------------------------------------ACNVAPRGVYVCGnt 434
Cdd:COG1241  270 PDIYEKIIASIAPSIYGYEEikeaialqlfggvpkvlpdgsrirgdihillvgdpgtaksqllryAARLAPRGVYTSG-- 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 435 tttsgltvtlsKDSSS--------------GDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGV 499
Cdd:COG1241  348 -----------KGSTAagltaaavrddfgtGRWTLEAGALVLADGGLACIDELDKMREEDRsALHEAMEQQTISIAKAGI 416

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 500 VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatva 579
Cdd:COG1241  417 VATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARH------------------ 478

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 580 rmnsqdsntsVLEVVSEKPLSERLKVVPGETIDP-IPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNS 658
Cdd:COG1241  479 ----------ILKVHRAGELLEQEIEEETEEVKPeIDPDLLRKYIAYARRNVFPVLTEEAKDLIEDFYVDMRKKGEDEDS 548

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 659 S-PITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSD-EFGNLDFERSQHGSGMSNRSTAKRFISAL 736
Cdd:COG1241  549 PvPITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLKDVGVDpETGKFDIDVIETGTSKSQRDKMKLIKDII 628

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528078341 737 NNVAERtYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQL 790
Cdd:COG1241  629 KELEEE-SSGGAPIEDVIEEAEEEGIDREKAEELIEKLKRKGEIYEPKPGHYKK 681
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 405-700 1.65e-134

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 400.37  E-value: 1.65e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 405 LIVNSLCPVIFGHE-----------------------------------------------AACNVAPRGVYVCGNTTTT 437
Cdd:cd17759    1 LIVNSLCPAIYGHElvkaglllslfggkqkyaddknripirgdphvlivgdpglgksqmlqAACNIAPRGVYVCGNTTTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 438 SGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG 517
Cdd:cd17759   81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 518 GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarmnsqdsntsvlevvsek 597
Cdd:cd17759  161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH------------------------------------ 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 598 plserlkvvpgetidpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARA 677
Cdd:cd17759  205 ------------------HQLLRKYISYARQYVNPVLSKDASEALQEFYLELRKQNQLADSSPITTRQLESLIRLTEARA 266

                        330       340
                 ....*....|....*....|...
gi 528078341 678 RLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17759  267 RLELREEATKEDAEDVIEIMKES 289
MCM smart00350
minichromosome maintenance proteins;
207-702 5.38e-126

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 386.62  E-value: 5.38e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   207 LKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSpLTVTM 286
Cdd:smart00350   5 IRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPFSLNHE-RSTFI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   287 DWQSIKIQElmSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSIsnsK 366
Cdd:smart00350  84 DFQKIKLQE--SPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVPYGFKLNTVKGLPVFATYIEANHV---R 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   367 GQKTKSSEDGCkHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHE---------------------------- 418
Cdd:smart00350 159 KLDYKRSFEDS-SFSVQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEdikkaillllfggvhknlpdgmkirgdi 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   419 -----------------AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ 481
Cdd:smart00350 238 nillcgdpgtaksqllkYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDR 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   482 -ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSE 560
Cdd:smart00350 318 tAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAK 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341   561 HVIAIragkqrtissatvaRMNSQDSNTSVLEVvsekplserlkvvpgetidPIPHQLLRKYIGYARQYVYPRLSTEAAR 640
Cdd:smart00350 398 HVVDL--------------HRYSHPEEDEAFEP-------------------PLSQEKLRKYIAYAREKIKPKLSEEAAD 444

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528078341   641 VLQDFYLELRK---QSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSML 702
Cdd:smart00350 445 KLVKAYVDLRKedsQTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 405-700 3.05e-111

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 341.24  E-value: 3.05e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 405 LIVNSLCPVIFGHEA---------------------------------------------ACNVAPRGVYVCGNTTTTSG 439
Cdd:cd17706    1 ILADSIAPSIYGHEDvkkavllqlfggvqkiledgtrirgdihillvgdpgtaksqilkyVLKIAPRGVYTSGKGSSGAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 440 LTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGG 518
Cdd:cd17706   81 LTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRtALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 519 HYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTIssatvarmnsqdsntsvlevvsekp 598
Cdd:cd17706  161 RYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEE------------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 599 lserlKVVPGETIDPIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARAR 678
Cdd:cd17706  216 -----QVKPEEDGIPIDIELLRKYILYARQ-IHPKISEEAREKLVRWYVELRKESERRSTIPITARQLESVIRLAEAHAK 289

                        330       340
                 ....*....|....*....|..
gi 528078341 679 LELREEATKEDAEDIVEIMKYS 700
Cdd:cd17706  290 MRLSEVVTEEDVEEAIRLVRHS 311
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 423-697 1.93e-81

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 263.16  E-value: 1.93e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 423 VAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVC 501
Cdd:cd17761   65 VAPRAVYTTGKGSTAAGLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRsALHEAMEQQTISIAKAGIVA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 502 SLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHviairagkqrtissatvarm 581
Cdd:cd17761  145 TLNARAAVLAAANPKFGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANH-------------------- 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 582 nsqdsntsVLEVVSEKPLSErlkVVPgeTIDPiphQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSS-P 660
Cdd:cd17761  205 --------ILDTHSGGEMRE---IKP--EIDP---DLLRKYIAYARKNVRPVLTEEAKQLIKDFYVEMRKSGQETPSPvP 268

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 528078341 661 ITTRQLESLIRLTEARARLELREEATKEDAEDIVEIM 697
Cdd:cd17761  269 ITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 423-697 2.41e-73

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 241.97  E-value: 2.41e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 423 VAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVC 501
Cdd:cd17753   64 TAHRAVFTTGQGASAVGLTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRtSIHEAMEQQSISISKAGIVT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 502 SLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtisSATVARM 581
Cdd:cd17753  144 SLQARCSVIAAANPIGGRYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVV-----------GSHVRSH 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 582 NSQDSNTSVLEVVSEKPLSERLKVvpgetiDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPI 661
Cdd:cd17753  213 PENDEDREGEEEKNQRQRPKETKV------EPIPQELLRKYIHYAREKVRPKLNQMDMDKVSRVYADLRKESMATGSLPI 286

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 528078341 662 TTRQLESLIRLTEARARLELREEATKEDAEDIVEIM 697
Cdd:cd17753  287 TVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRVM 322
MCM pfam00493
MCM P-loop domain;
389-566 2.74e-72

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 235.50  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  389 DLYAIQEIQAEENLFKLIVNSLCPVIFGHEA---------------------------------------------ACNV 423
Cdd:pfam00493   1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDvkkaillqlfggvkkilpdgtrlrgdinvllvgdpgtaksqllkyVEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  424 APRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ-HQALLEAMEQQSISLAKAGVVCS 502
Cdd:pfam00493  81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEdRVALHEAMEQQTISIAKAGIVAT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528078341  503 LPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIR 566
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 406-700 5.52e-71

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 235.34  E-value: 5.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 406 IVNSLCPVIFGHEA---------------------------------------------ACNVAPRGVYVCGNTTTTSGL 440
Cdd:cd17757    2 LVRSIAPSIYGHEEvkkgillmllggvhkitregislrgdinvcivgdpstaksqflkyVEEFSPRAVYTSGKASSAAGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 441 TVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGH 519
Cdd:cd17757   82 TAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQvAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 520 YNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSatvarmnsqdsntsvlevvsekpl 599
Cdd:cd17757  162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEP------------------------ 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 600 serlkvvpgetidPIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYLELRKQSQRLNSSP---ITTRQLESLIRLTEAR 676
Cdd:cd17757  218 -------------PFTAEQLKRYIAYART-FKPKLTKEAKDELVEQYKELRQDDASGSTRSsyrITVRQLESLIRLSEAI 283

                        330       340
                 ....*....|....*....|....
gi 528078341 677 ARLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17757  284 ARLHCSDEVTPEHVEEAARLLKKS 307
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 423-700 6.22e-71

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 235.35  E-value: 6.22e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 423 VAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMgNQHQ--ALLEAMEQQSISLAKAGVV 500
Cdd:cd17756   64 VAPIGVYTSGKGSSAAGLTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKM-REDDrvAIHEAMEQQTISIAKAGIT 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 501 CSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSatvar 580
Cdd:cd17756  143 TTLNSRTSVLAAANPVFGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQS----- 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 581 mnsqdsntsvlevvsekplserlkvvpGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQ-------S 653
Cdd:cd17756  218 ---------------------------QENEGEIPISKLKRYIAYCRAKCAPRLSEEAAEKLSNHYVTIRKDvrqneleS 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 528078341 654 QRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17756  271 DNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 422-698 1.21e-69

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 231.56  E-value: 1.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 422 NVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVV 500
Cdd:cd17755   64 KISPRGVYTSGKGSSAVGLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLhEVMEQQTLSIAKAGII 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 501 CSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAiragkqrtissatvar 580
Cdd:cd17755  144 TTLNARTSILASANPIGSRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVS---------------- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 581 MNSQDSNTSvlevvsekplserlkvvpgETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK-QSQRLNSS 659
Cdd:cd17755  208 LYLEDTPEH-------------------IQDEVLDVEVLTDYISYAREHIHPKLSEEAAQELVQAYVDMRKmGSDARKRI 268

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 528078341 660 PITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMK 698
Cdd:cd17755  269 TATPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIR 307
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 421-700 1.21e-63

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 215.35  E-value: 1.21e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 421 CNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGV 499
Cdd:cd17758   61 CRIAPRSVYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRtAIHEVMEQQTISIAKAGI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 500 VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHViairagkqrtissaTVA 579
Cdd:cd17758  141 TTTLNARTSILAAANPAYGRYNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHV--------------TYV 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 580 RMNSQDsntsvlevvsekplserlkvvPGETIDPIPHQLLRKYIGYARQYvYPRLSTEAARVLQDFYLELRKQSQRLNSS 659
Cdd:cd17758  207 HQHNKQ---------------------PDSDFEPLDPKLLRAYIALAKRK-RPTVPPALADYIVQAYVEMRQEAKRSKDF 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528078341 660 PITT-RQLESLIRLTEARARLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17758  265 TFTTpRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 75-720 4.63e-60

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 219.48  E-value: 4.63e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  75 YKGWKL--YFSEVYSDSSPLIEKIQAFEKFFTrHIDLYDKdeierkgsilVDFKELTEggevtnlipdiatelrdAPEKT 152
Cdd:PTZ00111 122 YYLWKLmnFIKENLRDHSTGYSRILPFEVDLM-HVYSFDK----------VLYKLLVT-----------------FPADC 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 153 LACMGLAIHQVLTKDLERHAAELQAQEglsndgetmvNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIK 232
Cdd:PTZ00111 174 IAELDKVLVKLFNELLSKHYSDLSLEN----------NSFFPRARLMNKPVSDCVGNLEPSMADSLVQFSGTVVRQTWIV 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 233 PLCTKMAF---------------------------------LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRS 279
Cdd:PTZ00111 244 PEITMACFrcrgqkkiglndyqpctcehyeyviqgevneplLCNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPD 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 280 SP-LTVTMDWQSIKIQELMSDDQreagriprTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIE 358
Cdd:PTZ00111 324 KDgLDNSVDNSGLNGEIYMKDNE--------VINLNLYDDLIDSVKTGDRVTVVGILKVTPIRTSTTRRTLKSLYTYFVN 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 359 ANSI----SNSKGQKTKSSEdgcKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEA----------ACN-- 422
Cdd:PTZ00111 396 VIHVkvinSTNANQPEKGLK---YLGNENDFSDLQVYKILELSRNPMIYRILLDSFAPSIKARNNvkigllcqlfSGNkn 472

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 423 ------------------------------------------VAPRGVYVCGNTTTTSGLTVTLS-KDSSSGDFALEAGA 459
Cdd:PTZ00111 473 ssdfnkspdacykvdnfrgiinvllcgdpgtaksqllhythlLSPRSIYTSGKSSSSVGLTASIKfNESDNGRAMIQPGA 552

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 460 LVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS 538
Cdd:PTZ00111 553 VVLANGGVCCIDELDKCHNESRLSLyEVMEQQTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFT 632

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 539 RFDLVFILLDTPNEHHDHLLSEhVIAiragKQRTISSATVARMNS---QDSNTSVLEvvsekplSERLKvvPGETIDPIP 615
Cdd:PTZ00111 633 RFDLIYLVLDHIDQDTDQLISL-SIA----KDFLLPHMTGSGNDEdtyDRSNTMHVE-------DESLR--SEKDYNKND 698

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 616 HQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRK------------------------QSQRLNSSPITTRQLESLIR 671
Cdd:PTZ00111 699 LDMLRMYIKFSKLHCFPKLSDEAKKVITREYVKMRQgnfqtsnldelehaqedddddlyyQSSGTRMIYVSSRMISSIIR 778

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 528078341 672 LTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEF-GNLDFERSQHG 720
Cdd:PTZ00111 779 ISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVDPTtGKIDFDQLHQG 828
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 450-700 1.47e-56

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 195.84  E-value: 1.47e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 450 SGDFALEAGALVLGDQGICGIDEFDKMG-NQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPvGGHYNKAKTVSE 528
Cdd:cd17760   89 GGEWNLEAGALVLADGGLCCIDEFNSLKeHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPNESISV 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 529 NLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtissatvarmnSQDSNTSVLEVVsekplserlkvvpg 608
Cdd:cd17760  168 NIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL-------------------ENKGEPSKSSKL-------------- 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 609 etidpIPHQLLRKYIGYARQyVYPRLSTEAARVLQDFYlELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKE 688
Cdd:cd17760  215 -----WSMEKMRTYFCLIKN-LRPVLSDEANAILLRYY-QLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEE 287

                        250
                 ....*....|..
gi 528078341 689 DAEDIVEIMKYS 700
Cdd:cd17760  288 DAITVVSVMESS 299
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 422-700 4.13e-56

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 194.61  E-value: 4.13e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 422 NVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVV 500
Cdd:cd17754   63 NTAPLAIATTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRvAIHEVMEQQTVTIAKAGIH 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 501 CSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIairagkqrtissatvaR 580
Cdd:cd17754  143 ASLNARCSVLAAANPVYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVL----------------R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 581 MNSQdsntsvlevvsekplserlkvvpgetidpipHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQ----SQRL 656
Cdd:cd17754  207 MHRY-------------------------------IKFLRKYIHYAKERIKPKLTQEAAEYIAEEYADLRNDdntkTDKA 255

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 528078341 657 NSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYS 700
Cdd:cd17754  256 RTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 617-701 1.01e-32

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 121.11  E-value: 1.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  617 QLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQS-QRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVE 695
Cdd:pfam17855   1 ELLRKYIAYAREKIKPKLSEEAREKLVDAYVELRKEStGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIR 80


                  ....*.
gi 528078341  696 IMKYSM 701
Cdd:pfam17855  81 LLKESL 86
MCM8_WHD cd22247
winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; ...
 726-791 6.95e-31

winged-helix domain (WHD) found in minichromosome maintenance 8 (MCM8) and similar proteins; MCM8 is a DNA helicase that is a component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is also required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting its nuclease activity. This model corresponds to the C-terminal winged-helix domain (WHD) of MCM8, which mediates protein-nucleic acid interaction, as well as protein-protein interaction.


Pssm-ID: 439328 [Multi-domain]  Cd Length: 66  Bit Score: 115.27  E-value: 6.95e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528078341 726 RSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQ 791
Cdd:cd22247    1 RKQAKRFVSALQREAERKGNNLFTVDELKQIAKELGLQVDDFDDFIESLNNQGYLLKKGPNLYQLQ 66
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 206-337 1.13e-30

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 116.81  E-value: 1.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341  206 QLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFplpdgKYSLPTKCPVPVCRGR-SFTALRSspLTV 284
Cdd:pfam17207   1 SIRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGV-----KITEPTKCPNPECGNKdPFKLVHE--KSK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528078341  285 TMDWQSIKIQElMSDDQReAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKV 337
Cdd:pfam17207  74 FVDFQKIKIQE-SPEEVP-AGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRV 124
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 482-713 6.34e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 42.46  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 482 ALLEAMEQQSISLakAGVVCSLPARTSIIAAANPVggHYNKAKTVSEnlkmgsALLSRFdLVFILLDTPNEhhdhllsEH 561
Cdd:COG0714  113 ALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPI--EQEGTYPLPE------AQLDRF-LLKLYIGYPDA-------EE 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 562 VIAIRAGKQRTiSSATVARMNSQDSNTSVLEVVSEKPLSERLKvvpgetidpiphqllrkyiGYARQYVYprlsteAARV 641
Cdd:COG0714  175 EREILRRHTGR-HLAEVEPVLSPEELLALQELVRQVHVSEAVL-------------------DYIVDLVR------ATRE 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528078341 642 LQDFylelrkqsqRLNSSPittRQLESLIRLTEARARLELREEATKEDAEDI-VEIMKYSMLGTYSDEFGNLD 713
Cdd:COG0714  229 HPDL---------RKGPSP---RASIALLRAARALALLDGRDYVTPDDVKAVaGPVLKHRLILSPEADAEGVT 289
PRK09862 PRK09862
ATP-dependent protease;
456-575 6.97e-04

ATP-dependent protease;


Pssm-ID: 182120 [Multi-domain]  Cd Length: 506  Bit Score: 43.04  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078341 456 EAGALVLGDQGICGIDEFDKMGNQH-QALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPV-GGHY--NKAKTVSENL- 530
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTlDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPSpTGHYqgNHNRCTPEQTl 365

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528078341 531 ----KMGSALLSRFDLVF-ILLDTPNehhdhLLSEHVIAIRAG---KQRTISS 575
Cdd:PRK09862 366 rylnRLSGPFLDRFDLSLeIPLPPPG-----ILSKTVVPGESSatvKQRVMAA 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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