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Conserved domains on  [gi|528078355|ref|NP_001268458|]
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proteasome activator complex subunit 1 isoform 4 [Homo sapiens]

Protein Classification

PA28_alpha and PA28_beta domain-containing protein( domain architecture ID 10491457)

PA28_alpha and PA28_beta domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 103-234 3.78e-72

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


:

Pssm-ID: 460508  Cd Length: 145  Bit Score: 216.23  E-value: 3.78e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078355  103 PVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQLE-------------GFHTQISKYFSERG 169
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEvlaeltrveesaaNFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528078355  170 DAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGM 234
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha pfam02251
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 8-68 6.87e-25

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


:

Pssm-ID: 460507  Cd Length: 61  Bit Score: 93.02  E-value: 6.87e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528078355    8 PEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDP 68
Cdd:pfam02251   1 SEAKKKVDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNIPVPDP 61
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 103-234 3.78e-72

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 216.23  E-value: 3.78e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078355  103 PVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQLE-------------GFHTQISKYFSERG 169
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEvlaeltrveesaaNFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528078355  170 DAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGM 234
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha pfam02251
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 8-68 6.87e-25

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460507  Cd Length: 61  Bit Score: 93.02  E-value: 6.87e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528078355    8 PEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDP 68
Cdd:pfam02251   1 SEAKKKVDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNIPVPDP 61
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 103-234 3.78e-72

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 216.23  E-value: 3.78e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078355  103 PVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQLE-------------GFHTQISKYFSERG 169
Cdd:pfam02252   1 LVPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEvlaeltrveesaaNFLDQISKYFLSRA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528078355  170 DAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGM 234
Cdd:pfam02252  81 KIVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha pfam02251
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 8-68 6.87e-25

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460507  Cd Length: 61  Bit Score: 93.02  E-value: 6.87e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528078355    8 PEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDP 68
Cdd:pfam02251   1 SEAKKKVDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNIPVPDP 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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