NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|532164737|ref|NP_001269117|]
View 

cysteinyl leukotriene receptor 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606886)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
24-306 7.68e-180

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 498.89  E-value: 7.68e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15158    1 QVYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15158   81 YVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEPPQSNQQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15158  161 TKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKarKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15158  241 RKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
 
Name Accession Description Interval E-value
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
24-306 7.68e-180

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 498.89  E-value: 7.68e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15158    1 QVYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15158   81 YVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEPPQSNQQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15158  161 TKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKarKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15158  241 RKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-295 1.44e-47

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 160.93  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737   40 GNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMS 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  119 FFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM--AKPQKDEKNNTKCFePPQDNQTKNHVlVLHYVSLFV 196
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfgWTLTVPEGNVTVCF-IDFPEDLSKPV-SYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  197 GFIIPFVIIIVCYTMIILTLLKKSMKK----NLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihLHFLHNETKPCDSVLR 272
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQksseRTQRRRKALKTLAVVVVVFILCWLPYHI-----VNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 532164737  273 MQKSVVITLSLAASNCCFDPLLY 295
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
15-307 6.39e-40

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 143.38  E-value: 6.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  15 HDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKtYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDF 94
Cdd:PHA03087  32 LNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTK-TKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQ-WSFGEF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  95 LCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF 174
Cdd:PHA03087 110 ACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICC 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 ePPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLlkKSMKKNLSShKKAIGMIMVVTAAFLVSFMPYHIQRT 254
Cdd:PHA03087 190 -MFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITL--KGINKSKKN-KKAIKLVLIIVILFVIFWLPFNVSVF 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 255 IH-LHFLHNETKpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLS 307
Cdd:PHA03087 266 VYsLHILHFKSG-CKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKK 318
 
Name Accession Description Interval E-value
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
24-306 7.68e-180

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 498.89  E-value: 7.68e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15158    1 QVYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15158   81 YVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEPPQSNQQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15158  161 TKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKarKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15158  241 RKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
24-306 1.33e-135

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 386.86  E-value: 1.33e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15921    1 LFYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDnqTK 183
Cdd:cd15921   81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELAHD--AV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKS--MKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15921  159 DKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSpaLGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITER 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15921  239 QIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
25-306 3.50e-80

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 245.39  E-value: 3.50e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15157    2 IYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDeKNNTKCFEPPQDNQTKn 184
Cdd:cd15157   82 VNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKY-NSQTKCLDLHPSKIDK- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 hVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSM--KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHflhn 262
Cdd:cd15157  160 -LLILNYIVLVVGFILPFCTLSICYILIIKALLKPRVpqSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHLM---- 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 263 ETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15157  235 QWSEGQCNLRLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
24-306 8.43e-76

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 234.47  E-value: 8.43e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA-KPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLrSTIAKENNSTTCFEFLSEWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLhyVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHK-KAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd14982  161 SAAPIVL--IALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKrKALRMILIVLAVFLVCFLPYHVTRILYLLVRL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14982  239 SFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
30-306 1.86e-55

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 182.13  E-value: 1.86e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15168    7 YGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHV--- 186
Cdd:cd15168   87 SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELNDYViys 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHyVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLSSHK-KAIGMIMVVTAAFLVSFMPYHIQRTIHLHF-LHNET 264
Cdd:cd15168  167 MVLT-GLGFL---LPLLIILACYGLIVRALIRKLGEGVTSALRrKSIRLVIIVLALFAVCFLPFHVTRTINLAArLLSGT 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15168  243 ASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
25-306 6.85e-51

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 170.61  E-value: 6.85e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15159    2 LLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15159   82 INTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMEYPNFEKIKR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLhYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSS----HKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFL 260
Cdd:cd15159  162 LPLIL-LGACVIGFGVPVGIILFCYSQITLKLCRTAKENPLTEksghHKKACNVILLVLLVFVVCFSPYHLNIIQFMIRK 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 261 HNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15159  241 LLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
25-306 5.85e-50

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 167.96  E-value: 5.85e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15161    2 LFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNqTKN 184
Cdd:cd15161   82 LNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREK-ASR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLvlhyVSLFVGFIIPFVIIIVCYTMIILTLlkKSMKKNLSSHK-KAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15161  161 GAL----VSLAVAFTIPFVTTVTCYLLIIRSL--RTGKREEKPLKdKAIKMIILVLTIFLICFVPYHISRYIYILSHNGA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15161  235 GASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
28-306 4.66e-49

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 165.63  E-value: 4.66e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKD--EKNNTKCFEPPQDNQTKnh 185
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAieNLNKTACIMLYPHEAWH-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 vLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK--SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd14985  163 -FGLSLELNILGFVLPLLIILTCYFHIARSLRKRyeRTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGA 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14985  242 IRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
28-306 4.78e-49

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 165.47  E-value: 4.78e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNL 107
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSALYTINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC--FEPPQDNQTKNH 185
Cdd:cd14984   83 YSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICsyDYPEDTATTWKT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLhyVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLsshkKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHNET 264
Cdd:cd14984  163 LLRL--LQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKH----RALRVIFAVVVVFFLCWLPYNIVLLLDtLQLLGIIS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14984  237 RSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
30-306 1.89e-48

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 164.54  E-value: 1.89e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKK--SAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15147    7 YSIIFVLGLIANCYVLWVFARLYPSKklNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFINT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA----KPQKDEKNNTKCFEpPQDNQTK 183
Cdd:cd15147   87 YCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMdstnTVKIDSGNFTRCFE-GYEKDNS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHyVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKK--AIGMIMVVTAAFLVSFMPYHIqrtIHLHFLH 261
Cdd:cd15147  166 KPVLIIH-FIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVKrrALWMVCTVLAVFVICFVPHHV---VQGPWTL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 262 netkpcdSVLRMQKSVV------------ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15147  242 -------AVLQQWRYWDcqfrqalndahqITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-295 1.44e-47

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 160.93  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737   40 GNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMS 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  119 FFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM--AKPQKDEKNNTKCFePPQDNQTKNHVlVLHYVSLFV 196
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfgWTLTVPEGNVTVCF-IDFPEDLSKPV-SYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  197 GFIIPFVIIIVCYTMIILTLLKKSMKK----NLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihLHFLHNETKPCDSVLR 272
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQksseRTQRRRKALKTLAVVVVVFILCWLPYHI-----VNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 532164737  273 MQKSVVITLSLAASNCCFDPLLY 295
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
30-305 2.70e-47

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 161.10  E-value: 2.70e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15968    7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVL-- 187
Cdd:cd15968   87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFPHYVPyg 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 -VLHYVSLFVgfiiPFVIIIVCYTMIILTLLKKSMKKNLSS---HKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15968  167 mALTVSGFLL----PFSIILWCYCLVVRTLCRTLGPAEPPAqarRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15968  243 GVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
25-306 9.27e-47

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 159.77  E-value: 9.27e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd14970    2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPF-LMAKPQKDEKNNTKC-FEPPQDNQT 182
Cdd:cd14970   81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPViIFARTLQEEGGTISCnLQWPDPPDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHyvSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSS------HKKAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd14970  161 WGRVFTIY--TFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGArekrraRRKVTRLVLVVVAVFVVCWLPFHVFQIVR 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHFLHNETKPCDSVLRmqksVVITLSLAasNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14970  239 LLIDPPETLTVVGVFL----FCIALSYA--NSCLNPILYAFLDENFRKSF 282
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
26-297 1.22e-45

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 156.68  E-value: 1.22e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNH 185
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGfiiPFVIIIVCYTMIILTLLKKSMK-----------KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRT 254
Cdd:cd00637  161 YTIFLFVLLFLL---PLLVIIVCYVRIFRKLRRHRRRirssssnssrrRRRRRERKVTKTLLIVVVVFLLCWLPYFILLL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 255 IHLHFLHNETKPcdsvlrmQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd00637  238 LDVFGPDPSPLP-------RILYFLALLLAYLNSAINPIIYAF 273
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
28-306 5.01e-45

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 155.45  E-value: 5.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15377    5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNT-KCFEPPQDNQTKNHv 186
Cdd:cd15377   85 YGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTiTCYDTTSDEYLRSY- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSH----KKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHN 262
Cdd:cd15377  164 FIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNaplrRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLD 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 263 ETKP--CDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15377  244 FQTPamCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
30-306 5.85e-45

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 154.91  E-value: 5.85e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15373    7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVlVL 189
Cdd:cd15373   87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFV-VY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKpC 267
Cdd:cd15373  166 SSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGtsTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRSMDLS-C 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 268 DSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15373  245 GTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
25-298 2.31e-44

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 153.47  E-value: 2.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRN-WPFGDLLCKISVTLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP--FLMAKPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15156   81 TNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPasFFQSTNNQLNNNSETCFENFSSKTW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK-SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15156  161 KTYLSKIVIFIEIVGFFIPLILNVTCSTMVLKTLRRPnTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRT 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532164737 262 NETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFS 298
Cdd:cd15156  241 QTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFT 277
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
24-306 1.60e-43

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 151.42  E-value: 1.60e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15152    1 FIYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKS-WPFGKFLCMFCFYLK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQnINLVTQKKARFVCVGIWIFVILTSSPFLMAKpQKDEKNNTKCF-EPPQDNQT 182
Cdd:cd15152   80 YVNMYASIYFLVCISVRRCLYLIYPFR-YNDCKRKCDVYISIAGWLVVCVGCLPFPLLR-QSQDTNPTCCFaDLPLRNVG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK-SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLH 261
Cdd:cd15152  158 LTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKtPVLQDLGEKKKALKMILTCAVVFLICFAPYHI--SFPLDFLV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 262 NETKPCDSVLRMQKSVV--ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15152  236 KSNKIKSCTARKVILIFhpVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
29-306 2.64e-43

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 150.61  E-value: 2.64e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15180    6 LYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQninLVTQKKARFV---CVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15180   84 CGIFLLACISFDRYLSIVHAVQ---MYSRKKPMLVhlsCLIVWLFCLLLSIPdFIFLEATKDPRQNKTECVHNFPQSDTY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNlssHKKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHNE 263
Cdd:cd15180  161 WWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGFQ---KQRAIRVIVAVVVVFFLCWTPYNIALLVDtLIDLSVL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15180  238 DRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
30-306 6.24e-43

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 149.91  E-value: 6.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd16001    7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHvLVL 189
Cdd:cd16001   87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFGNY-FPY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSS--HKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPC 267
Cdd:cd16001  166 GMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKaaRAKSIRTILLVCGLFALCFVPFHITRTIYLFVRVYLVQDC 245
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 268 DSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd16001  246 PLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
29-306 5.12e-42

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 147.06  E-value: 5.12e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYhKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd14974    6 LYALIFLLGLPGNGLVIWVAGFKM-KRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKNHVL 187
Cdd:cd14974   85 ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPyFVFRDTVTHHNGRSCNLTCVEDYDLRRSRH 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFV-GFIIPFVIIIVCYTMIILTLLKKSMKKNlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKP 266
Cdd:cd14974  165 KALTVIRFLcGFLLPLLIIAICYSVIAVKLRRKRLAKS----SKPLRVLLAVVVAFFLCWLPYHVFALLELVAAAGLPEV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 267 cdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14974  241 ------VLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
29-306 1.87e-40

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 143.29  E-value: 1.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15160    6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA-KPQKDEKNNTKCFEPPQDNQtknHVL 187
Cdd:cd15160   86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHdELFRDEPNHTLCYEKYPMEG---WQA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVGFIIPFVIIIVCYTMiILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPC 267
Cdd:cd15160  163 SYNYARFLVGFLIPLSLILFFYRR-VLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGLC 241
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 268 DSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15160  242 GFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
35-295 2.29e-40

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 142.91  E-value: 2.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLI----KTYHkksAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15376   12 LVAVLGNGLALWLFVtrerRPWH---TGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKNHvlvL 189
Cdd:cd15376   89 IFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPvLSFSHLEVERHNKTECLGTAVDSRLPTY---L 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYvSLF---VGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIgMIMVVTAAFLVSFMPYHIQRTIHLHfLHNETKP 266
Cdd:cd15376  166 PY-SLFlavVGCGLPFLLTLASYLAIVWAVLRSPGITTLEKRKVAA-LVAVVVALYAVSFVPYHILRNLNLY-RRLQWLK 242
                        250       260
                 ....*....|....*....|....*....
gi 532164737 267 CDSVLRMQKSVVITLSLAASNCCFDPLLY 295
Cdd:cd15376  243 AAASLRIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
30-306 2.30e-40

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 143.02  E-value: 2.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15374    7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVlvl 189
Cdd:cd15374   87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFDHYV--- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFI--IPFVIIIVCYTMIILTLLKKSMKKNL----SSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15374  164 HYSSAVMVLLfgIPCLVIVVCYGLMARRLCKPRVGSSRqqgpSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLK 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15374  244 AD-CDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
15-307 6.39e-40

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 143.38  E-value: 6.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  15 HDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKtYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDF 94
Cdd:PHA03087  32 LNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTK-TKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQ-WSFGEF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  95 LCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF 174
Cdd:PHA03087 110 ACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICC 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 ePPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLlkKSMKKNLSShKKAIGMIMVVTAAFLVSFMPYHIQRT 254
Cdd:PHA03087 190 -MFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITL--KGINKSKKN-KKAIKLVLIIVILFVIFWLPFNVSVF 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 255 IH-LHFLHNETKpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLS 307
Cdd:PHA03087 266 VYsLHILHFKSG-CKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKK 318
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
27-305 9.78e-40

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 141.43  E-value: 9.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15193    4 PILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqKDEKNNTKCFEPPQDnqtknhv 186
Cdd:cd15193   84 RCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVY---RNLINESVCVEDSSS------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 lvlhyvSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSH-----------KKAIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15193  154 ------RFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHfhgakrtgrrrRNSLRIVFAIVTAFVLSWLPFNTLKAV 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 256 HLHF-LHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15193  228 RLLLeLGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
25-306 1.07e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 141.58  E-value: 1.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL--CVCtLPLRVVYYVHKGiWLFGDFLCRLSTYA 102
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLvsLFC-MPLTLLENVYRP-WVFGEVLCKAVPYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFL-------MAKPQKDEKNNTKCFE 175
Cdd:cd14993   80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLvvyeleeIISSEPGTITIYICTE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 P-PQDNQTKNHvLVLHYVSLFVGfiiPFVIIIVCYTMIILTLLKK------------SMKKNLSSHKKAIGMIMVVTAAF 242
Cdd:cd14993  160 DwPSPELRKAY-NVALFVVLYVL---PLLIISVAYSLIGRRLWRRkppgdrgsanstSSRRILRSKKKVARMLIVVVVLF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 243 LVSFMPYHIqrtIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14993  236 ALSWLPYYV---LSILLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
29-303 1.32e-39

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 141.05  E-value: 1.32e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15162    6 VYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP--QKDEKNNTKCFEPPQDNQTKNHV 186
Cdd:cd15162   86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQtiFLPALDITTCHDVLPEQLLVGDW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKP 266
Cdd:cd15162  166 FYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLISSSGTG 245
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532164737 267 cdsvlRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15162  246 -----HLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-306 4.32e-39

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 139.85  E-value: 4.32e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHkGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15378    4 PTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSN-GQWLFGDFLCKSNRYLLHAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHV 186
Cdd:cd15378   83 LYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDATNSL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETK- 265
Cdd:cd15378  163 IYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSIGv 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 266 -PCDSVLrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15378  243 sECTLII-IKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
27-304 9.29e-39

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 138.67  E-value: 9.29e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15375    4 PVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEpPQDNQTKNHV 186
Cdd:cd15375   84 LYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLD-FTSSDNLNTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMIILTlLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHF-LHNETk 265
Cdd:cd15375  163 WWYNWILTVLGFLLPLVIVTLCYTRIIYT-LAKGPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRIETrLPPVS- 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 266 pCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15375  241 -CCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
29-303 9.69e-39

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 138.73  E-value: 9.69e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15172    6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQ--WIFGNFSCKLLRGIYAINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKA--RFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEP--PQDNQTK 183
Cdd:cd15172   84 SGMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPtFIFSEVYDFGLEEQYVCEPkyPKNSTAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKksmKKNLSSHkKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLhNE 263
Cdd:cd15172  164 MWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQ---AQNSQRH-KAVRVVVAVVLVFLVCQVPYNIVLLIEAINL-GE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15172  239 QQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
25-306 4.02e-38

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 137.23  E-value: 4.02e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd15153    2 LYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHT-WPFGRFLCLLCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQninlVTQKKARF-VCVG--IWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQ 181
Cdd:cd15153   81 LNMYASICFLTCISIQRCFFLLHPFK----ARDWKRRYdVGISaaVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLV-LHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK-KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHF 259
Cdd:cd15153  157 LNFGAAIaMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQqQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 260 LHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15153  237 SESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
29-306 6.69e-38

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 136.42  E-value: 6.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15191    6 LYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINlVTQKKARFVCVGIWIFVILTSSPFLMAKPQK--DEKNNTKC--FEPPQDNQTKN 184
Cdd:cd15191   86 ASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYyiEELGVNACimAFPNEKYAQWS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLfvGFIIPFVIIIVCYTMIILTLLK-KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15191  165 AGLALMKNTL--GFLIPLIVIATCYFGIGRHLLKtKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15191  243 INNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
29-306 2.70e-37

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 134.89  E-value: 2.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVlIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15116    6 IYSVVFVLGVLGNGLVIFI-TGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAK--PQKDEKNNTKCF---------EPP 177
Cdd:cd15116   85 TSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRdtAPSQNNNKIICFnnfslsgdnSSP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QDNQTKNHVLVLHYVSLFV-GFIIPFVIIIVCYTMIILTLLKKSMKKNlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15116  165 EVNQLRNMRHQVMTITRFLlGFLIPFTIIICCYAAIVLKLKRNRLAKS----SKPFKIIAAVIVTFFLCWAPYHILNLLE 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHFLHNETKpcdsvlRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15116  241 MEATRSPAS------VFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
28-306 7.02e-37

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 133.71  E-value: 7.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP--QKDEKNNTKC-FEPPqdNQTKN 184
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDvfFIENTNITVCaFHYP--SQNST 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLK-KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15192  163 LLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKaYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15192  243 IQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
27-306 1.09e-35

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 130.66  E-value: 1.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15368    4 PVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYAN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKD--EKNNTKCFEPPQDNQTKN 184
Cdd:cd15368   84 MYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYvkELNITTCFDVLKWTMLPN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 hvlVLHYVSLFVGFIIPF-----VIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLhf 259
Cdd:cd15368  164 ---IAAWAAFLFTLFILLflipfIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHM-- 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 260 lhnetkpcDSVLRMQKSVV----ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15368  239 --------VSRLFYGKSLYhaykLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
25-306 1.62e-35

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 130.43  E-value: 1.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd15155    2 LYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRH-WPFGDSLCKISGTAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15155   81 TNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK-SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15155  161 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPaTLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 264 TKPCdSVLRMQKSVV-ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15155  241 IANC-GVERFARTMYpITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
28-306 2.06e-35

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 129.81  E-value: 2.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15967    5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpQKDEKNNTKCFEPPQDNQTKNHvL 187
Cdd:cd15967   85 YGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFF--SKTNSNGTKCFDTTFNDYLESY-L 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK-SMKKNLSShkKAIGMIMVVTAAFLVSFMPYHIQRTIHLHflhnetkp 266
Cdd:cd15967  162 TYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNnNVDKGLKQ--RCLKLVIILIVLFSVCYIPYHVFRNLNLL-------- 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 267 cDSVLRMQKSVV-----------ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15967  232 -SRILQKQGSCTqwfrgiyiahqVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
30-306 2.34e-35

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 129.88  E-value: 2.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHkGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15154    7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGSIFQMNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTK---CFEPPQDNQTKNh 185
Cdd:cd15154   86 SCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPaAIVHSSSDCLLHGEKvyrCFESFSDNDWKG- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLsSHKKAIGMIMVVTAAFLVSFMPYHiqRTIHLHFLHNETK 265
Cdd:cd15154  165 LLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQG-RRRKTVRLLLVNLVIFLICFVPYN--TTLAVYGLLRANL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 266 PCDSVL---RMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15154  242 VEDTWNikdTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
25-306 3.71e-35

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 129.10  E-value: 3.71e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTL-YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYAL 103
Cdd:cd15181    1 VFIPLaYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP--FLMAKPQKDEKNNTKCFEpPQDNQ 181
Cdd:cd15181   79 KLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnlVFLEVETSTNANRTSCSF-HQYGI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLVL-HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKknlSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHF 259
Cdd:cd15181  158 HESNWWLTsRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRR---LQKQKAIRVAILVTLVFCLCWLPYNIVIFLDtLDD 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 260 LHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15181  235 LKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
29-306 9.38e-35

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 128.16  E-value: 9.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15178    6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG--WIFGTFMCKLVSLLQEANFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNinlVTQKKA--RFVCVGIWIFVILTSSPFL----MAKPQKDEKnnTKCFEPPQDNQT 182
Cdd:cd15178   84 SGILLLACISVDRYLAIVHATRA---LTQKRHlvKFVCAGVWLLSLLLSLPALlnrdAFKPPNSGR--TVCYENLGNESA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLK-KSMKKnlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHF-- 259
Cdd:cd15178  159 DKWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQtRSFQK-----HRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMrt 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 260 -LHNETkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15178  234 kLITET--CELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
29-304 9.87e-34

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 125.35  E-value: 9.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15194    6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfeppQDNQTKNHVLV 188
Cdd:cd15194   86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYC----NEDAGTPSKVI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKP 266
Cdd:cd15194  162 FSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKsgKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVT 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 267 CDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15194  242 CLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
29-305 2.38e-33

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 124.11  E-value: 2.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVL-IKTyhKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15115    6 VLSLTFLLGVPGNGLVIWVAgLKM--KRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfeppqdnqTKNHVL 187
Cdd:cd15115   84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRC--------GYDFLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKnlsSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHflhnETKPC 267
Cdd:cd15115  156 AITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAK---SQSKTFRVIIAVVVAFFVCWAPYHIIGILSLY----GDPPL 228
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 268 DSVLRMQKSVVItlSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15115  229 SKVLMSWDHLSI--ALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
32-305 3.12e-33

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 124.11  E-value: 3.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIktYHKKS--AFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15381    9 IIFVLGTIENAFVLIVFC--LHKSSctVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP--QKDEKNNTKC-FEPPQDNQTKNHV 186
Cdd:cd15381   87 SIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTvmYFPEYNITACvLDYPSEGWHVALN 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLhyvsLFVGFIIPFVIIIVCYTMIILTLLKKSMK--KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNET 264
Cdd:cd15381  167 ILL----NVVGFLIPLSIITFCSTQIIQVLRNNKMQkfKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLI 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15381  243 SGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
31-304 1.13e-32

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 122.90  E-value: 1.13e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15922    8 SLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHvLVLH 190
Cdd:cd15922   88 IYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSLLY-FVWN 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 191 YVSLFVGFIIPFVIIIVCYTMIILTLLK--KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCD 268
Cdd:cd15922  167 FVLLILGFLLPFGVSLTCYALLGASIAKmnSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCT 246
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 532164737 269 SVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15922  247 LLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
29-305 1.19e-32

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 122.68  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15379    6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTNLH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARF-VCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFE--PPQdnqtknh 185
Cdd:cd15379   86 GSILFLTCISVQRYLGICHPLASWHKKKGKKLTWlVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDlsPPA------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 vLVLHY----VSLFV-GFIIPFVIIIVCYTMI--ILTLLKKSMKKNLSSHKK---AIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15379  159 -RSTAYfpygITLTRtGFLLPFAARLACYCSMatILCRVVIAVAVVAAPGEKrgkAARMIIVVAAVFLISFLPFHYTKTR 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 256 HLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15379  238 YLQVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-306 2.02e-32

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 121.70  E-value: 2.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVN 106
Cdd:cd15182    4 PVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSG--WIFGEILCKAVTSIFYIG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEppqDNQTKNH 185
Cdd:cd15182   82 FYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPeLILSTVMKSDEDGSLCEY---SSIKWKL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNlsshKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHNETK 265
Cdd:cd15182  159 GYYYQQNLFFL---IPLGIIVYCYVRILQTLMRTRTMRK----HRTVKLIFVIVLVFFLSWAPYNI--VIFLRSLKDLTI 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 266 P-CDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15182  230 PiCECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-305 3.66e-32

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 121.79  E-value: 3.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKS-AFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15190   15 VIYMLVFVLGLSGNGLVLWTVFRSKRKRRrSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVN 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC-----FEPPQDNQ 181
Cdd:cd15190   95 MYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVicdmdYSGVVSNE 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLV-LHYVSLFVGFIIPFVIIIVCYTMIILTL---LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIH- 256
Cdd:cd15190  175 SEWAWIAgLGLSSTVLGFLLPFLIMLTCYFFIGRTVarhFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYa 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 257 ---LHFLHNetkPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15190  255 lmyLGILPF---SCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
29-306 5.55e-32

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 120.63  E-value: 5.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15174    6 LYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSG--WVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQK--KARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC---FEPPQDNQTK 183
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCtmvYPSNESNRFK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHyvsLFVGFIIPFVIIIVCYTMIILTLLKksmKKNLSSHkKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15174  164 VAVLALK---VTVGFFLPFVVMVICYTLIIHTLLQ---AKRFQKH-KALKVIIAVVTVFVLSQLPYNSILLIKTINAYNI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 264 T-KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15174  237 TiTDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
28-306 1.28e-31

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 119.87  E-value: 1.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15369    5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP--QKDEKNNTKCFEPPQDNQTKNH 185
Cdd:cd15369   85 YCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQtiQIPDLGITTCHDVLNEQLLMGY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETK 265
Cdd:cd15369  165 YVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSKKTRALFMAVAVFCVFVICFGPTNVLLLAHYVRFAYTST 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 266 PCDSVLrmqkSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15369  245 NDASYF----AYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
29-304 1.29e-31

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 119.49  E-value: 1.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15173    6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE--WIFGTVMCKITNGLYTINLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKK--ARFVCVGIWIFVILTSSPFLMAKPQKDeKNNTKCFEPPQDNQTKNHV 186
Cdd:cd15173   84 SSMLILTCITVDRFIVIVQATKAHNCHAKKMrwGKVVCTLVWVISLLLSLPQFIYSEVRN-LSSKICSMVYPPDAIEVVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHyvsLFVGFIIPFVIIIVCYTMIILTLLKksmKKNLSSHkKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKp 266
Cdd:cd15173  163 NIIQ---MTVGFFLPLLAMIICYSVIIKTLLH---AKGFQKH-KSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDS- 234
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 267 cdsvLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15173  235 ----TNFKYAILITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-304 2.72e-31

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 119.06  E-value: 2.72e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKK--SAFQVYMINLAVADLL----CVctlPLRVVYYVHKGiWLFGDFLCRLSTYA 102
Cdd:cd15098    6 VFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFfllfCV---PFQATIYSLPE-WVFGAFMCKFVHYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPF-----LMAKPQKDekNNTKCFEPP 177
Cdd:cd15098   82 FTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVavhqdLVHHWTAS--NQTFCWENW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QDNQTKnHVLVLhyVSLFVGFIIPFVIIIVCYTMIILTLLKKS---MKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrt 254
Cdd:cd15098  160 PEKQQK-PVYVV--CTFVFGYLLPLLLITFCYAKVLNHLHKKLknmSKKSERSKKKTAQTVLVVVVVFGISWLPHHI--- 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 255 IHL--HFLHNETKPCDSVLRmqksvVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15098  234 IHLwvEFGDFPLTQASFVLR-----ITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-304 3.73e-31

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 118.05  E-value: 3.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHkGIWLFGDFLCRLSTYAL 103
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLL-GYWPFGPVLCRFWIALD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNqtK 183
Cdd:cd14967   80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPN--K 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVL----HYVSLFVgfiipfviIIVCYTMIILTLLKksmkknlssHKKAIGMIMVVTAAFLVSFMPYHIqrtIHLHF 259
Cdd:cd14967  158 IYVLVSsvisFFIPLLI--------MIVLYARIFRVARR---------ELKAAKTLAIIVGAFLLCWLPFFI---IYLVS 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 260 LHNETKPCDSVLRMqksvvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd14967  218 AFCPPDCVPPILYA-----VFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
29-297 5.30e-31

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 117.75  E-value: 5.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVvyYVHKGIWlFGDFLCRLSTYALYVNLY 108
Cdd:cd15164    6 IYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVL--YFLKHSW-PDDELCLVLQSIYFINRY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSpflmAKPQKDEKNNTKCFeppQDNQTKNHVLV 188
Cdd:cd15164   83 MSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIISVS----LRLAWEEQEENFCF---GKTSTRPSKRT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LhyVSLFVGFIIPFVIIIVCYTMIILTLLKKsMKKNLSSHK---KAIGMIMVVTAAFLVSFMPYHIQRTIHLhFLHNETK 265
Cdd:cd15164  156 L--IFSLLGFFIPLIILSFCSIQVIRSLKKK-KKTNPHEEKliqKAIYIVSANLIVFIVCFLPLHIGLLVRF-VMESNKA 231
                        250       260       270
                 ....*....|....*....|....*....|..
gi 532164737 266 PCDSVLRMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd15164  232 SCSLIQNIRNFIYVASCLANANCCLDAICYYF 263
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
28-306 6.15e-31

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 117.93  E-value: 6.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIkTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15372    5 SLYTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK--DEKNNTKCFEPPQDNQTKNH 185
Cdd:cd15372   84 YCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYplERLNITLCHDVLPLDEQDTY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVlHYVSLFV-GFIIPFVIIIVCYTMIILTLLKKSMKknlssHKKAIGMIMVVTAAFLVSFMPYHIQRTIHlhflHNET 264
Cdd:cd15372  164 LFY-YFACLAVlGFLLPLVVILFCYGSVLHTLLRSGQR-----YGHAMKLTVLVLVSFVLCFTPSNLLLLLH----YSDP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 265 KPcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15372  234 TL-DDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
25-306 8.19e-31

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 117.55  E-value: 8.19e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15088    2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKC---FEPPQDn 180
Cdd:cd15088   82 NNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPvWVYSSLIYFPDGTTFCyvsLPSPDD- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 qtknhVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIG----MIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15088  161 -----LYWFTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKrvtkMVILIVVVFIVCWLPFHVVQLVN 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LhflhNETKPcdsVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15088  236 L----AMNRP---TLAFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
35-304 1.60e-30

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 116.67  E-value: 1.60e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHkgIWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd15165   12 VLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKK--QWPLGRTLCSFLESLYFVNMYGSILII 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPflMAKPQKDEKNNTKCFEpPQDNQTKNHVLVLhyVSL 194
Cdd:cd15165   90 VCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIP--IYSFHDKPTNNTRCFH-GFSNKTWSKKVIV--VVE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 195 FVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKA-IGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRM 273
Cdd:cd15165  165 EFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKsVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIINDCSTKQSI 244
                        250       260       270
                 ....*....|....*....|....*....|.
gi 532164737 274 QKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15165  245 RLFVQVSMCLANVNCCLDAICYYFILKEFRE 275
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
28-304 3.62e-30

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 116.02  E-value: 3.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVlyVLIKTYHKK--SAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYV 105
Cdd:cd15179    5 TVYSIIFLLGIVGNGLV--ILVMGYQKKsrTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN--WYFGNFLCKAVHVIYTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNH 185
Cdd:cd15179   81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLlkkSMKKNLSShKKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHNET 264
Cdd:cd15179  161 VVAFRFQHILVGLVLPGLVILTCYCIIISKL---SHSKGHQK-RKALKTTVILILAFFACWLPYYIGISIDtFMLLEIIK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15179  237 QSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
27-304 3.82e-30

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 115.95  E-value: 3.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15148    4 AVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMakPQKDEKNNTKCFEPPQDNQTK--- 183
Cdd:cd15148   84 MYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIV--LTEKNEESTKCFQYKDRKNAKgka 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 --NHVLVLHYVSLFVgfiipfvIIIVCYTMIILTLLKKSMKK----NLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd15148  162 ifNFLIVAMFWLVFL-------LLILSYGKIAKKLLRISRDKpdfpNAAKYNRTARKSFFVLFIFTVCFVPYHAFRIFYI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 258 hFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15148  235 -TSQLQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
29-304 4.88e-30

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 115.48  E-value: 4.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15090    6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGNILCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC---FEPPQ---DNQT 182
Cdd:cd15090   85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCtltFSHPSwywENLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVslfvgfiIPFVIIIVCYTMIILTLLKKSM----KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLH 258
Cdd:cd15090  165 KICVFIFAFI-------MPVLIITVCYGLMILRLKSVRMlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 259 FLHNETkpcdsvLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15090  238 VTIPET------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
28-306 1.17e-29

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 114.69  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLaFLVCCVPFTAALYATPS-WVFGDFMCKFVNYMMQVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpQKDEKNNTK-----CFEP-PQDN 180
Cdd:cd15095   84 VQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIY--YRLEEGYWYgpqtyCREVwPSKA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNH----VLVLHYVSLFVGfiipfviiIVCYTMIILTLLKKSMKKNLSSH----------KKAIGMIMVVTAAFLVSF 246
Cdd:cd15095  162 FQKAYmiytVLLTYVIPLAII--------AVCYGLILRRLWRRSVDGNNQSEqlseralrqkRKVTRMVIVVVVLFAICW 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 247 MPYHIqrtIHLHFLHNETKPCDSVLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15095  234 LPNHV---LNLWQRFDPNFPETYATYALKIAALCLSYA--NSAVNPFVYAFMGENFRKYF 288
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
35-304 1.49e-29

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 114.38  E-value: 1.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIktYHKKS--AFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIF 112
Cdd:cd15201   12 VLGLLGNGLALWIFC--FHLKSwkSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 113 FMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfEPPQDNQTKNHVLVLHYV 192
Cdd:cd15201   90 FLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQC-ESFNICTGTDSSSNWHEA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 193 SLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNlSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLR 272
Cdd:cd15201  169 MFLLEFFLPLAIILYCSVRIIWQLRGRQLDRH-AKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNEDCQYYRS 247
                        250       260       270
                 ....*....|....*....|....*....|..
gi 532164737 273 MQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15201  248 VDLAFYITISFTYFNSMLDPVVYYFSSPSFKN 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
28-304 2.81e-29

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 113.54  E-value: 2.81e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL----CVctlPLRVVYYVhKGIWLFGDFLCRLSTYAL 103
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLfvvfCV---PFTATDYV-LPTWPFGDVWCKIVQYLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA----KPQKDEKNNTKCFEPPQD 179
Cdd:cd15096   81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLhgvvSYGFSSEAYSYCTFLTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQTKNHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLSS------HKKAIGMIMVVTAAFLVSFMPyhiqr 253
Cdd:cd15096  161 GTAAQTFFTSFFLFSYL---IPLTLICVLYMLMLRRLRRQKSPGGRRSaesqrgKRRVTRLVVVVVVVFAICWLP----- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 254 tIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15096  233 -IHIILLLKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
35-306 4.15e-29

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 112.93  E-value: 4.15e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd14991   12 VLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF------EPPQDNQTKNHVLV 188
Cdd:cd14991   92 TAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHsfssytKPSLSIRWHNALFL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFvgfiipfVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCD 268
Cdd:cd14991  172 LEFFLPL-------GLIVFCSVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCL 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 269 SVLRMQKSvvITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14991  245 NSVAQLFH--ISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
24-306 7.39e-29

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 112.54  E-value: 7.39e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYAL 103
Cdd:cd15184    1 RLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNAMCKLLTGLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNInlvtqkKARFVCVGI------WIFVILTSSPFLMAKPQKDEKNNTKC--FE 175
Cdd:cd15184   79 HIGFFSGIFFIILLTIDRYLAIVHAVFAL------KARTVTFGVvtsvvtWVVAVFASLPGIIFTKSQKEGSHYTCspHF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 PPQDNQTKNHVLVLHYVSLfvGFIIPFVIIIVCYTMIILTLLKksmKKNLSSHKKAIGMIMVVTAAFLVSFMPYHI---Q 252
Cdd:cd15184  153 PPSQYQFWKNFQTLKMNIL--GLVLPLLVMIICYSGILKTLLR---CRNEKKRHKAVRLIFTIMIVYFLFWAPYNIvllL 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 253 RTIHLHFLHNEtkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15184  228 NTFQEFFGLNN---CSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
29-306 1.21e-28

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 111.73  E-value: 1.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYhKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15114    6 LYAVVFLVGVPGNALVAWVTGFEA-KRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLV 188
Cdd:cd15114   85 ASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVDYGGSTGVEWA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVGFIIPFVIIIVCYTMiiltLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhlhfLHNETKPCD 268
Cdd:cd15114  165 VAIIRFLLGFLGPLVVIASCHGV----LLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLI----IAASAPNSR 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 269 SVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15114  237 LLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-306 1.91e-28

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 111.53  E-value: 1.91e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHkGIWLFGDFLCRLSTYAL 103
Cdd:cd14969    2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLmSVVGYPLSFYSNLS-GRWSFGDPGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVILTSSPFLM--AKPQKdEKNNTKCfEPPQDNQ 181
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLFgwSSYVP-EGGGTSC-SVDWYSK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLVLhyVSLFV-GFIIPFVIIIVCYTMIILTLLKKS-----------MKKNLSSHKKAIGMIMVVTAAFLVSFMPY 249
Cdd:cd14969  158 DPNSLSYI--VSLFVfCFFLPLAIIIFCYYKIYRTLRKMSkraarrknsaiTKRTKKAEKKVAKMVLVMIVAFLIAWTPY 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 250 HIQRTIHLhFLHNETKPcdsvlrmQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14969  236 AVVSLYVS-FGGESTIP-------PLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
27-304 1.93e-28

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 111.16  E-value: 1.93e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15970    4 SFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGSLLCRLVLSVDAIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM-AKPQKDEKNNTKC-FEPPQDNQTKN 184
Cdd:cd15970   83 MFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIfSNTAPNSDGSVACnMQMPEPSQRWL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHyvSLFVGFIIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhlhfl 260
Cdd:cd15970  163 AVFVVY--TFLMGFLLPVIAICLCYILIIVKMrvvaLKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLV----- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 261 hnetkpcDSVLRMQKSVVITLS--LAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15970  236 -------SVFVGQHDATVSQLSviLGYANSCANPILYGFLSDNFKR 274
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
29-306 2.76e-28

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 110.64  E-value: 2.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIK-TYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNL 107
Cdd:cd15188    6 FYTLVFLLGLAGNLLLFVVLLLyVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWH--WVFGSFLCKFVSTLYTINF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVL 187
Cdd:cd15188   84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHTIWKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMkknlSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHN--ETK 265
Cdd:cd15188  164 VFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRP----PGQGRALRFVAALVVVFFVLWFPYNL--TLFLHSLQDlhVIG 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 266 PCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15188  238 NCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
27-306 2.78e-28

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 110.69  E-value: 2.78e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVN 106
Cdd:cd15186    4 SIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE--WGLHNAMCKLTTAFFFIG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDeknnTKCF-EPPQDNQTKNH 185
Cdd:cd15186   82 FFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKE----NECLgDYPEVLQEIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSlFVGFIIPFVIIIVCYTMIILTLLK-KSMKKnlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNET 264
Cdd:cd15186  158 VLRNVELN-FLGFLLPLLIMSYCYFRIIQTLFScKNHKK-----ARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFF 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15186  232 PSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
26-306 2.82e-28

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 110.44  E-value: 2.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALY 104
Cdd:cd15001    2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLlLVFCVPLKTAEYF-SPTWSLGAFLCKAVAYLQL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15001   81 LSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVlvlhYVSLFVGFIIPFVIIIVCYTMIILTLLKKSmkknlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLhFLHNET 264
Cdd:cd15001  161 TL----YSRLYVVYLAIVIFFIPLIVMTFAYARDTR--------KQVIKMLISVVVLFAVCWGPLLIDNLLVS-FDVIST 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 265 KPCDSVlrmqKSVVITLS-LAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15001  228 LHTQAL----KYMRIAFHlLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
29-304 4.34e-28

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 110.27  E-value: 4.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFgdflCRLSTYALYVNLY 108
Cdd:cd15920    6 MYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAYQNTAGPLSF----CKIVGAFFYLNMY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNtKCFEPPQDNQTKNHVLV 188
Cdd:cd15920   82 ASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDN-KCFHFRSKGLTAGGINL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVgfiiPFVIIIVCYTMIILTLLKKSMKK----NLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNET 264
Cdd:cd15920  161 TAVVIFYI----LSLLFLYFYAKISHKLYKVSLGNaqqqIKKASKRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15920  237 SSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
29-306 6.71e-28

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 109.87  E-value: 6.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15364    6 VYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkPQKDEKNNTKCFEPPQDNQtknHVLV 188
Cdd:cd15364   86 ISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIM-REGQTEGSHTCFETLQMDT---QVAG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVGfiipfviiiVCYTMIILTLLKKSMKKN------LSSHKKAI--GMIMVVTAAFLVSFMPYHIQRTIH-LHF 259
Cdd:cd15364  162 FYYARFCIG---------FAIPLAILIFTNYRIFRSiqtstsLTPHQKAKvkYLAIAVIVIFLICFAPYHLVLLVRaIAF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 260 LHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15364  233 SLYPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
29-306 6.97e-28

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 109.89  E-value: 6.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15187    6 LYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQ--WVFGNAMCKIVSGAYYIGFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFE--PPQDNQTKnhv 186
Cdd:cd15187   84 SSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPfyPGQGNSWK--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMiILTLLKKSMKKNlssHKKAIGMIMVVTAAFLVSFMPYHIQRTI-HLHFLHnETK 265
Cdd:cd15187  161 VFTNFEVNILGLLIPFSILIFCYHN-ILRNLRRCHNQN---KTKAIKLVFIVVIVFFLFWTPFNVVLFLdSLHSLH-IID 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 266 PCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15187  236 GCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
24-306 8.48e-28

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 109.58  E-value: 8.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYAL 103
Cdd:cd15183    1 TLLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKL-KDDWIFGDAMCKFLSGFY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFL-MAKPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15183   80 YLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLyFFKSQWEFTHHTCSAHFPRKSLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFvGFIIPFVIIIVCYTMIILTLLKKSMKKNLsshkKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHN 262
Cdd:cd15183  160 RWKRFQALKLNLL-GLILPLLVMIICYTGIINILLRRPNEKKA----KAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 263 ETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15183  235 FTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
27-304 8.71e-28

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 109.65  E-value: 8.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15089    4 TALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYL-METWPFGELLCKAVLSIDYYN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFL-MAKPQKDEKNNTKC---FEPPQ---D 179
Cdd:cd15089   83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMvMAVTKTPRDGAVVCmlqFPSPSwywD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQTKNHVLVLHYVslfvgfiIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15089  163 TVTKICVFIFAFV-------VPILVITVCYGLMILRLrsvrLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 256 HLHFLHNETKPCdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15089  236 WTLVDIDRRNPL-----VVAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
28-297 8.76e-28

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 109.50  E-value: 8.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15366    5 TLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-PFLMAKPQKDEKNNTKCFE--PPQDnqtkn 184
Cdd:cd15366   85 YISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSaPLFHDELFRDRYNHTFCFEkyPMED----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIIltllkKSMKKNLSSHKK--------AIGMIMVVtaafLVSFMPYHIQRTIH 256
Cdd:cd15366  160 WVAWMNLYRVFVGFLFPWVLMLFSYRGIL-----RAVRGNVSTEQQekakikrlALSLIAIV----LLCFAPYHVLLLSR 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 257 LHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd15366  231 SVVYLGKPCDCGFEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
25-304 9.48e-28

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 109.49  E-value: 9.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd15094    2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLTS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPqDNQTK 183
Cdd:cd15094   81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPiILYASTVPDSGRYSCTIVWP-DSSAV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRtIHLHF 259
Cdd:cd15094  160 NGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLrtvgPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQ-VHLIF 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 260 LHNETKPCDSVLRMqkSVVITLsLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15094  239 LPPGTDMPKWEILM--FLLLTV-LSYANSMVNPLLYAFLSENFRK 280
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
24-306 1.01e-27

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 109.15  E-value: 1.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRvVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15185    1 QFLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFW-IHYVRWNNWVFGHGMCKLLSGFY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF----EPPQD 179
Cdd:cd15185   80 YLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSplypEDTED 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQTKNHVLVLHyvslFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLsshkKAIGMIMVVTAAFLVSFMPYHIQ---RTIH 256
Cdd:cd15185  160 SWKRFHALRMN----IFGLALPLLIMVICYTGIIKTLLRCPSKKKY----KAIRLIFVIMVVFFIFWTPYNLVlllSAFQ 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHFLHNEtkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15185  232 SIFFETD---CERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
27-306 1.48e-27

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 109.08  E-value: 1.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd14987    4 SFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP--FLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd14987   84 LFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPdtYFLKTVTSPSNNETYCRSFYPEESFKE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKkaigMIMVVTAAFLVSFMPYHIQRTIH-LHFLHNE 263
Cdd:cd14987  164 WLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRK----IIFSYVVVFLVCWLPYHTVVLLDiLSFLHLI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14987  240 PFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
29-306 1.57e-27

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 109.05  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVliKTYH-KKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15117    6 IYSSAFVLGTLGNGLVIWV--TGFRmTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF-------EPPQDN 180
Cdd:cd15117   84 FASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYlnfdpwnETAEDP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSL-----FVGFIIPFVIIIVCYTMIILTLLKKSMKKnlSSHKKAIgmIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15117  164 VLWLETVVQRLSAQvitrfVLGFLVPLVIIGGCYGLIAARLWREGWVH--SSRPFRV--LTAVVAAFFLCWFPFHLVSLL 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 256 HLHFLHNETKpcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15117  240 ELVVILNQKE--DLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
24-306 2.48e-27

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 108.30  E-value: 2.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15924    1 QLFPVLYTVIFFAGILLNGLAMWIFFHI-PSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15924   80 YFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPnMILTNQQPREKNVKKCSFLKSELGL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHY-VSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLSS---HKKAIGMIMVVTAAFLVSFMPYHIQRTIHLH 258
Cdd:cd15924  160 KWHEIVNYIcQVIFW---IVFLLMIVCYTAITKKVYRSYRRVFRSSssrRKKSNVKIFIIVAVFFVCFVPYHFARIPYTL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 259 FLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15924  237 SQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
35-303 2.77e-27

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 107.93  E-value: 2.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd15923   12 VLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRE--SAGLQKLCNFVLSLYYINMYVSIFTI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMakpQKDEKNNTKCFEPPQDNQTKNHVLVLhyvsL 194
Cdd:cd15923   90 TAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFL---LDSSNEKTMCFQRTKQTESLKVFLLL----E 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 195 FVGFIIPFVIIIVCYTMIILTLLK-KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTihLHFLHNETKPCDSVLRM 273
Cdd:cd15923  163 IFGFLLPLIIMTFCSARVIHTLQKrLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFF--VKFIVGKSYSCDSKLII 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 532164737 274 QKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15923  241 HFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
25-304 4.38e-27

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 108.08  E-value: 4.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKgIWLFGDFLCRLSTYAL 103
Cdd:cd15203    2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLlLCLVSLPFTLIYTLTK-NWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNInlVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTK------CFEP- 176
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILpycgyfCTESw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 PQDNQTKNH---VLVLHYV-SLFVgfiipfviIIVCYTMIILTL-----LKKSMKKNLSSHKKAIG--------MIMVVT 239
Cdd:cd15203  159 PSSSSRLIYtisVLVLQFViPLLI--------ISFCYFRISLKLrkrvkKKRGKRTLSSRRRRSELrrkrrtnrLLIAMV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 240 AAFLVSFMPYHIqrtihLHFLhNETKPCDSVLRMQKSVV--ITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15203  231 VVFAVCWLPLNL-----FNLL-RDFEPLPQIDGRHFYLIflICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-305 5.44e-27

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 107.55  E-value: 5.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIF 112
Cdd:cd15189   10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 113 FMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKD--EKNNTKC-FEPPQDNQTKNHVLVL 189
Cdd:cd15189   90 LLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACvLLYPHEAWHFAHIVLL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFViiivcYTMIILTLLKK---SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHN--ET 264
Cdd:cd15189  170 NIVGFLLPLLVITF-----CNYNILQALRTreeSTRCEDRNDSKATALVLAVTLLFLVCWGPYHF--FTFLDFLFDvgVL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15189  243 DECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
28-306 8.10e-27

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 106.81  E-value: 8.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNinlvTQKKARF---VCVGIWIFVILTSSPFLMAKP--QKDEKNNTKCFEPPQDNQT 182
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIVNPMSH----SRKKANIaigISLAIWLLILLVTIPLYLVKQtvFIPALDITTCHDVLPEQLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 kNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHK--KAIGMIMVVTAAFLVSFMPYHIQRTIHLHFL 260
Cdd:cd15370  161 -VGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSINDESIEKKrkRAIKLIVTVLVMYLICFTPSNLLLVVHYFLL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 261 HNETKPcdsvlRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15370  240 KNQGQS-----SVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
25-304 3.41e-26

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 105.24  E-value: 3.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCV-CTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd14971    2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLlFCVPFTATIYPLPG-WVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEK--NNTKCFEPPQDNQ 181
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTpgNRTVCSEAWPSRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLS-----SHKKAIGMIMVVTAAFLVSFMPYHIqrtIH 256
Cdd:cd14971  161 HRRAFALCTFLFGYL---LPLLLICVCYAAMLRHLWRVAVRPVLSegsrrAKRKVTRLVLVVVVLFAACWGPIHA---IL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 L--HFLHNETKPCDSVLRMQKSVvitlsLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd14971  235 LlvALGPFPLTYATYALRIWAHC-----LAYSNSAVNPVLYAFLSEHFRK 279
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
29-303 3.85e-26

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 104.95  E-value: 3.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYyVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15092    6 VYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTD-IFLGFWPFGNALCKTVIAIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF---EPPQDNQTKNH 185
Cdd:cd15092   85 TSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLveiPTPQDYWDPVF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVgfiiPFVIIIVCYTMIILTLLK-------KSMKKNLsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLH 258
Cdd:cd15092  165 GICVFLFSFII----PVLIISVCYSLMIRRLRGvrllsgsKEKDRNL---RRITRLVLVVVAVFVGCWTPIQIFVLAQGL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 259 FLHNETKPCDSVLRMqksvviTLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15092  238 GVQPSSETAVAILRF------CTALGYVNSSLNPVLYAFLDENFK 276
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
25-297 5.18e-26

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 104.48  E-value: 5.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15365    2 LFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN-TKCFE--PPQDNQ 181
Cdd:cd15365   82 TNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSShTLCYDkfPLEDWQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKnhvlvLHYVSLFVGFIIPFVIIIVCYTMIIltllkKSMKKNLSS----HKKAIGMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd15365  162 AR-----LNLFRICLGYLLPLLIILFCYWKIY-----QAVRSNQATedqeKKKIFKLLLLITVTFVICFTPYHVVLLIRS 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 258 HFlhnETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd15365  232 IV---EPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCF 268
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
24-306 6.33e-26

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 104.54  E-value: 6.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSaFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15149    1 RVIPVFYSLVFIVGILLNGVNFWIFFYVPSNKS-FIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK-DEKNNTKCFEPP----- 177
Cdd:cd15149   80 YLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSfHEANYTKCARLKselgi 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QDNQTKNHVlvlhYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd15149  160 QWHKASNYI----CVSIFWVVFLLLIIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 258 HFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15149  236 LSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-304 6.51e-26

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 104.47  E-value: 6.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15093    6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPF-LAASNALRHWPFGSVLCRLVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKC-FEPPQDNQTKNHV 186
Cdd:cd15093   85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPvVVFAGTRENQDGSSACnMQWPEPAAAWSAG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHyvSLFVGFIIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHN 262
Cdd:cd15093  165 FIIY--TFVLGFLLPLLIICLCYLLIVIKVksagLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 263 ETkpcdSVLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRK 304
Cdd:cd15093  243 ET----PALVGVYHFVVILSYA--NSCANPILYGFLSDNFKK 278
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
29-306 1.90e-25

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 103.28  E-value: 1.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYhKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15119    6 IYIVAFVLGVPGNAIVIWVTGFKW-KKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKD-EKNNTKCFEPPQDNQ-----T 182
Cdd:cd15119   85 ASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMElSINVTICFNNFHKHDgdlivM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLhyVSLFVGFIIPFVIIIVCYTMIILtllkKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHN 262
Cdd:cd15119  165 RHTILVW--VRFFFGFLFPLLTMVVCYSLLAI----KVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHS 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 263 EtkpcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15119  239 S----YLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
26-303 2.28e-25

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 103.14  E-value: 2.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15390    3 WSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFL-----MAKPQKDEKNNTKCFEPPQDN 180
Cdd:cd15390   83 TVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLlysttETYYYYTGSERTVCFIAWPDG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSM--------KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIq 252
Cdd:cd15390  161 PNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTigentprqLESVRAKRKVVKMMIVVVVIFAICWLPYHL- 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 253 rtihLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15390  240 ----YFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFR 286
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
25-304 2.36e-25

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 103.11  E-value: 2.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALY 104
Cdd:cd15091    2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF--VILTSSPFLMAKPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15091   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLssSVGISAIVLGGTKVREDVDSTECSLQFPDDDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTL-----LKKSMKKNlSSHKKAIGMIMVVTAAFLVSFMPyhiqrtIHL 257
Cdd:cd15091  161 SWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLksvrlLSGSREKD-RNLRRITRLVLVVVAVFVVCWTP------IHI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 258 HFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15091  234 FILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
28-306 3.08e-25

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 102.54  E-value: 3.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLsTYALY-VN 106
Cdd:cd15175    5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKA-VYCLYkMS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKK--ARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15175   82 FFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVfiSKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHyvSLFVGFIIPFVIIIVCYTMIILTLLK-KSMKKNlsshkKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHN 262
Cdd:cd15175  162 VKIQIS--QMVLGFLVPLVVMSFCYSVIIKTLLQaRNFEKN-----KAIKVIIAVVVVFVVFQLPYNSVMLVStLSSFKG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 263 ETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15175  235 NTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
29-303 4.42e-25

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 102.43  E-value: 4.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEACT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPF--------LMAKPQKDEKNNTKCFEPPQD 179
Cdd:cd14979   86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPIlflmgiqyLNGPLPGPVPDSAVCTLVVDR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQtknhVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNL---------------SSHKKAIGMIMVVTAAFLV 244
Cdd:cd14979  166 ST----FKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGtraqgtrnvelslsqQARRQVVKMLGAVVIAFFV 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 245 SFMPYHIQRTIHLHFlhneTKPCDSVLRMQKSV-VITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd14979  242 CWLPFHAQRLMFSYA----SKEDTFLFDFYQYLyPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
28-297 4.65e-25

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 102.18  E-value: 4.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIktYHKKS-AFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15371    5 AVYIIVVVLGVPSNAIILWMLF--FRLRSvCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK--DEKNNTKCFEPPQDNQTKN 184
Cdd:cd15371   83 MYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYylKELNITTCHDVLPECEQNS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFV-GFIIPFVIIIVCYTMIILTLlkksmkkNLSSHKKA--IGMIMVVTAAFLVSFMPYHIQRTIHlHFLH 261
Cdd:cd15371  163 NFQFYYFISMAVfGFLIPLVITIFCYISIIRTL-------NAYEHKWFwyVKITALVLIIFTICFAPSNVILIIH-HFNY 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 532164737 262 NETKPCDsvlrMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd15371  235 YYFNNDN----LYSIYLIALCLGSLNSCLDPFLYFL 266
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
28-303 1.05e-24

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 101.02  E-value: 1.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd14975    5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPV-WIYFLATGTWDFGLAACKGCVYVCAVSM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFepPQDNQTKNHVL 187
Cdd:cd14975   84 YASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCK--YRHYSDGQLVF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLfVGFIIPFVIIIVCYTMIiltlLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYH----IQRTIHLHFLHNE 263
Cdd:cd14975  162 HLLLETV-VGFAVPFTAVVLCYSCL----LRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHvgnlLEVVSELIGGSKM 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 264 TKPCDSVLRMQKSVVITLSLAASncCFDPLLYFFSG-GNFR 303
Cdd:cd14975  237 AGTLGKVAEAGRPIAGALAFLSS--SINPLLYAFAArGLFR 275
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
29-306 1.11e-24

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 100.97  E-value: 1.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15087    6 IYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSIDHYNIF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLV--TQKKARFVCVGIWIFVILTSSPF-LMAKPQKDEKNNTKC---FEPPQDNQT 182
Cdd:cd15087   85 SSIYFLTVMSVDRYLVVLATVRSRRMPyrTYRAAKIVSLCVWLLVTIIVLPFtVFAGVYSNELGRKSCvlsFPSPESLWF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLvlhyVSLFVGFIIPFVIIIVCYTMiiltLLKKSMKKNLSSHKKAIG--------MIMVVTAAFLVSFMPYHIQRT 254
Cdd:cd15087  165 KASRI----YTLVLGFAIPVSTICILYTM----MLYKLRNMRLNSNAKALDkakkkvtlMVLVVLAVCLFCWTPFHLSTV 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 255 IHLhflhnETKPCDSVLRMQKSVVITlSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15087  237 VAL-----TTDLPQTPLVIGISYFIT-SLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
25-303 1.40e-24

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 101.04  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVHKgIWLFGDFLCRLSTYAL 103
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADiMITLFNTPFTFVRAVNN-TWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEP------- 176
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSlcledwp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 -PQDNQTKNHVLVLHYVSLFVGFIIPFVIiivcYTMIILTLLKKSMKKN---------LSSHKKAIGMIMVVTAAFLVSF 246
Cdd:cd15202  159 eRADLFWKYYDLALFILQYFLPLLVISFA----YARVGIKLWASNMPGDatteryfalRRKKKKVIKMLMVVVVLFALCW 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 247 MPYHIqrtihlHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15202  235 LPFNI------YVLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
26-306 1.65e-24

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 100.61  E-value: 1.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15167    3 FTYFYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFlMAKPQKD--EKNNTKCFEPPQDNQTK 183
Cdd:cd15167   83 NMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPN-MAIPIKTieEKPGVGCADFKTEFGRH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLvlhyvSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSH---KKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFL 260
Cdd:cd15167  162 WHVL-----TNFICMAIFLNFSAIILISNFLVIRKLYRNKDSEEYrnaRQALVNILLVTAGYVICFVPYHIVRIPYTLSQ 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 261 HNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15167  237 SEVITDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
25-301 1.75e-24

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 100.61  E-value: 1.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15367    2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP-QKDEKNNTKCFE--PPQDNQ 181
Cdd:cd15367   82 ENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEiSKDKENHSVCFEhyPIKAWE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKnhvlvLHYVSLFVGFIIPFVIIIVCYTMiILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15367  162 HN-----INYYRFYAGFLFPIFLLSFSYCR-ILRAVRKSHGTQKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFER 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 262 NetkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGN 301
Cdd:cd15367  236 D----CNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASES 271
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
29-303 1.77e-24

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 100.59  E-value: 1.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVlyVLIKTYHK--KSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVN 106
Cdd:cd15176    6 FYTIALVVGLAGNSLV--VAIYAYYKklKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSALYTMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINlvTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC---FEPPQDNQTK 183
Cdd:cd15176   82 FSCGMQFLACISVDRYVAITKATSRQF--TGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRClpvFPPSLVTSAK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHN 262
Cdd:cd15176  160 ATIQILEVLLGFV---LPFLVMVFCYSRVARALSRTPNVKK----SRALKVLLAVVGVFIVTQLPYNVVKFYRaIDVIYL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 263 ETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15176  233 LITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
25-306 3.62e-24

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 99.88  E-value: 3.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVL--IKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYA 102
Cdd:cd14976    2 LVSVVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFE--PPQD 179
Cdd:cd14976   82 TKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeAIFSTDTWSSVNHTLCLLrfPKNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQTKNHVLVLHYVSLFV--GFIIPFVIIIVCYTMIILTLLKKSMKKNLSShKKAIGMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd14976  162 SVTRWYNWLGMYQLQKVvlGFFLPLGIITLSYLLLLRFLQRKRGGSKRRK-SRVTKSVFIVVLSFFICWLPNQALSLWSA 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 258 HFLHNETKPCDSVLRMQKSVV-ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14976  241 LIKFDDVPFSDAFFAFQTYAFpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
29-251 8.87e-24

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 98.36  E-value: 8.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYvHKGIWLFGDFLCRLSTyALYVNLY 108
Cdd:cd15166    6 FYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYY-AKDEWPFGDYFCRILG-ALTVFYP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAM-SFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVL 187
Cdd:cd15166   84 SIALWLLAFiSADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTCLKMLDIIHLKEVN 163
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 188 VLHYVSLFVGFIIPFVIIIVCYTMIILTLLK-KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd15166  164 VLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHgRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHI 228
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
25-306 1.51e-23

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 97.96  E-value: 1.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15339    2 ILPSFIGILCSTGLVGNILVLFTIIRS-RKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWI-FVILTSSPFLMAKPQKDEKNNTKC-FEPPQDNQT 182
Cdd:cd15339   81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAaSFILVLPVWVYAKVIKFRDGLESCaFNLTSPDDV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFV--IIIVCYTMIILTLLKKSMKKNLSSHK----KAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15339  161 LWYTLYQTITTFFFPLPLILIcyILILCYTWEMYRKNKKAGRYNTSIPRqrvmRLTKMVLVLVGVFLVSAAPYHVIQLVN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHfLHNETkpcdsvLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15339  241 LS-VSQPT------LAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
28-306 2.70e-23

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 97.15  E-value: 2.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNL 107
Cdd:cd15177    5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG--WIFGNAMCKLIQGLYAINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIV--FPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNH 185
Cdd:cd15177   83 YSGFLFLTCISVDRYVVIVraTSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKksmKKNLSSHkKAIGMIMVVTAAFLVSFMPYHIQRTIHL-HFLHNET 264
Cdd:cd15177  163 KGATALTQVVLGFAIPLIVMAVCYAAIGRTLLA---ARGWERH-RALRVIAALVVAFVLFQLPYSVVLLLDTaDLLATLE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15177  239 LSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
27-306 3.97e-23

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 96.77  E-value: 3.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLiKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15120    4 AVALFVTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK-DEKNNTKC---------FEP 176
Cdd:cd15120   83 MFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRlDEKGKTICqnnyalstnWES 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 PQDNQTKNHVLVLHYVSLFV-GFIIPFVIIIVCYTMIILtllkKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15120  163 AEVQASRQWIHVAMFVFRFLlGFLLPFLIITFCYVRMAL----KMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 256 HLhflhneTKPCDSVLrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15120  239 VL------TRGRPPSL-TDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
25-304 1.36e-22

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 95.31  E-value: 1.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15973    2 VIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPF-LAASAALQHWPFGSAMCRTVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd15973   81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHyvSLFVGFIIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHfl 260
Cdd:cd15973  161 AAFVIY--TFLLGFLLPVLAIGLCYILIIGKMravaLKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLF-- 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 532164737 261 hnetkpcdsVLRMQKSVV-ITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15973  237 ---------LPRLDATVNhASLILSYANSCANPILYGFLSDNFRR 272
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
29-316 1.60e-22

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 97.39  E-value: 1.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLiktYHKK--SAFQVYMINLAVADLLCVCTLPLrvVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:PHA02638 104 FYIIIFILGLFGNAAIIMIL---FCKKikTITDIYIFNLAISDLIFVIDFPF--IIYNEFDQWIFGDFMCKVISASYYIG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP----------FLMAKPQKDEKNNTKCfEP 176
Cdd:PHA02638 179 FFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPayfifeasniIFSAQDSNETISNYQC-TL 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 PQDNQTKNHVL---VLHYVSLFVGFIIPFVIIIVCYTMIILTLlkKSMKKnlSSHKKAIGMIMVVTAAFLVSFMPYHIQR 253
Cdd:PHA02638 258 IEDNEKNNISFlgrILQFEINILGMFIPIIIFAFCYIKIILKL--KQLKK--SKKTKSIIIVSIIIICSLICWIPLNIVI 333
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 254 TIHLHFLHNETKPCDS-----VLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL------------STFRKHSLSS 316
Cdd:PHA02638 334 LFATMYSFKGFNSIISehicgFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLlmifrniftnakFSFRKSSISS 413
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
33-305 2.04e-22

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 94.87  E-value: 2.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIF 112
Cdd:cd15380   10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 113 FMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK--DEKNNTKC-FEPPQDNQTKNHVLVL 189
Cdd:cd15380   90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKhvPDLNISACiLLFPHEAWHFARRVEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFViiivcYTMIILTLLKKSMKKNLSSHK-----KAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNET 264
Cdd:cd15380  170 NIVGFLLPLAAIVF-----FNFHIIASLRERTEESRKRCGglkdtKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVI 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 265 KPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15380  245 QGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
29-306 2.93e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 94.46  E-value: 2.93e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd14988    6 LYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKnHVLV 188
Cdd:cd14988   86 SSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFETYDE-WALA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNlsshKKAIGMIMVVTAAFLVSFMPYHIQR---TIHL--HFLHne 263
Cdd:cd14988  165 VSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPES----RRHCLLIYAYILVFVVCWLPYHVTLlllTLHGshISLH-- 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 tkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14988  239 ---CNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
24-304 3.67e-22

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 94.25  E-value: 3.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKK-SAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYA 102
Cdd:cd15170    1 WLVLAVYIITFLIGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-----PFLMAKPQKDEKNNTKCFEPP 177
Cdd:cd15170   81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHCSivyivEYHIDSENTSVTNNSRCYDNF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QDNQTK-------NHVLVLHYVSLFVgfiipfviIIVCYTMIILTLLKKSmkkNLSSHKK--AIGMIMVVTAAFLVSFMP 248
Cdd:cd15170  161 TPEQLKillpvrlELFLVLFCIPFLI--------TCFCYINFIRILSSLP---HISRQRKqrAIGLAVATLLNFIVCFAP 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 249 YHIQrtiHL-HFLHNETKPcdsvLRMqksvvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15170  230 YNIS---HVvGFIQRKSPE----WRM-----YALLLSTLNACLDPIIFYFSSSAVRR 274
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
28-302 4.52e-22

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 93.73  E-value: 4.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15121    5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPF-FLHFLSGGGWEFGSVVCKLCHYVCGVSM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPpqDNQTKNHvL 187
Cdd:cd15121   84 YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIP--YHPSVGH-E 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYV-SLFVGFIIPFVIIIVCYTMIILTLLKKSMKknlsSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHL-HFLHNETK 265
Cdd:cd15121  161 AFQYLfETITGFLLPFTAIVTCYSTIGRRLRSARFR----RKRRTNRLVVLIIATFALFWLPYHVVNLIQVaGALQNQAG 236
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532164737 266 PCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNF 302
Cdd:cd15121  237 NASVLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSL 273
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
25-306 4.68e-22

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 94.08  E-value: 4.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15151    2 VFPVLYTVLFLVGLILNSVAAWIFFHI-PSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15151   81 ITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPnMILSNKPATPISVKKCASLKSPLGLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVS-LFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLhfLHN 262
Cdd:cd15151  161 WHEVVNYICQfIFWGVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYT--LSQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 263 ETKPCDSVLRMQKSVV--ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15151  239 TGKITDCQLQNLLYIAkeITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
25-303 1.54e-21

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 92.42  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL----CVCTLPLRVVYYVHkgiWLFGDFLCRLST 100
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmavfCVPFSFIALLILQY---WPFGEFMCPVVN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 101 YALYVNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLM----AKPQKDEKNNTKCFEP 176
Cdd:cd15392   79 YLQAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAItsrlFEDSNASCGQYICTES 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 -PQDNQTKNHVLVLHYVSLFVGFIIPFVIiivcYTMIILTLLKKSM---------KKNLSSHKKAIGMIMVVTAAFLVSF 246
Cdd:cd15392  157 wPSDTNRYIYSLVLMILQYFVPLAVLVFT----YTRIGIVVWAKRTpgeaennrdQRMAESKRKLVKMMITVVAIFALCW 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 247 MPYHIqrtihLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15392  233 LPLNI-----LNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFR 284
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
31-306 2.71e-21

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 92.05  E-value: 2.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYyVHKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd14986    8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvAFFTVLTQIIW-EATGEWVAGDVLCRIVKYLQVVGLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTK-CFEP-PQDNQTKNHVL 187
Cdd:cd14986   87 STYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVHqCWSSfYTPWQRKVYIT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVgfiiPFVIIIVCYTMIILTLLKKS------------MKKNLSSH------------KKAIGMIMVVTAAFL 243
Cdd:cd14986  165 WLATYVFVI----PLIILSYCYGRILRTIWIRSrqktdrpiaptaMSCRSVSCvssrvslisrakIKTIKMTLVIILAFI 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 244 VSFMPYHIqrtIHLHFLHNETKPCDSVlrmqkSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14986  241 LCWTPYFI---VQLLDVYAGMQQLEND-----AYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
29-304 3.72e-21

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 91.73  E-value: 3.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL--CVCTlPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd14992    6 ALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLmaLFCT-PFNFTYVVSLS-WEYGHFLCKIVNYLRTVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA---KPQKDEKNNTK---CFEPPQDN 180
Cdd:cd14992   84 VYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYattEVLFSVKNQEKifcCQIPPVDN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHV-LVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKK-----SMK----KNLSSHKKAIGMIMVVTAAFLVSFMPYH 250
Cdd:cd14992  164 KTYEKVyFLLIFVVIFV---LPLIVMTLAYARISRELWFRkvpgfSIKeverKRLKCKRRVIKMLVCVVVLFVICWLPFH 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 251 IQRTIHLHFLHNETKPcdsvlRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd14992  241 LFFLLRDFFPLIMKEK-----HTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
27-304 3.72e-21

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 91.40  E-value: 3.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15974    4 PVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPF-LATQNAISYWPFGSFLCRLVMTVDGVN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDekNNTKCFEPPQDNQTKNH 185
Cdd:cd15974   83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPvIIFSDVQPD--LNTCNISWPEPVSVWST 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLfvGFIIPFVIIIVCYTMIILTL----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFlh 261
Cdd:cd15974  161 AFIIYTAVL--GFFGPLLVICLCYLLIVIKVkssgLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIV-- 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 262 neTKPCDSVLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRK 304
Cdd:cd15974  237 --ILPEEPAFVGVYFFVVVLSYA--NSCANPILYGFLSDNFKQ 275
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
36-306 5.88e-21

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 90.66  E-value: 5.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  36 VGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTlPLRVVYYVHKGIWLFGdFLCRLSTYALYVNLYCSIFFMT 115
Cdd:cd14989   13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVAD-SLIEVFNLNEKYYDIA-VLCTFMSLFLQINMYSSIFFLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 116 AMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL-TSSPFLMAKPQKDEKnNTKCFEppqdnqtknHVLVLHYVSL 194
Cdd:cd14989   91 WMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISaTLLPFTAVQAQHTGE-VHFCFA---------DVREIQWLEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 195 FVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHK-KAIGMIMVVTAAFLVSFMPYHIQRTIH-LHFLHNETKPCDSVLR 272
Cdd:cd14989  161 TLGFIIPFSIIGLCYSLIVRVLVRAQKHRRLRPRRqKALRMILVVVLVFFICWLPENVFISIQlLQGTQEPSESYDESFR 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532164737 273 MQKSV---VITLSlAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14989  241 HNHPLtghIVNLA-AFSNSCLNPLIYSFLGETFRDKL 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
29-304 6.04e-21

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 90.67  E-value: 6.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15971    6 IYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPF-LAIQVALVHWPFGKAICRVVMTVDGINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM-AKPQKDEKNNTKCFEPPQDNQTKNHVL 187
Cdd:cd15971   85 TSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIyAGVQTKHGRSSCTIIWPGESSAWYTGF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHyvSLFVGFIIPFVIIIVCYTMIILTLLKKSMK----KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15971  165 IIY--TFILGFFVPLTIICLCYLFIIIKVKSSGIRvgssKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 264 TKpcdsVLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRK 304
Cdd:cd15971  243 TP----GLKGMFDFVVVLSYA--NSCANPILYAFLSDNFKK 277
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
25-306 7.69e-21

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 90.62  E-value: 7.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15969    2 VFPVLYLIIFIGSILLNGLAVWIFFHI-RNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15969   81 ASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPnIILTNGQPTEDNIHDCSKLKSPLGVK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLhYVSLFVgFIIPFVIIIVCYtMIILTLLKKSMKKNLSSHKKAIG---MIMVVTAAFLVSFMPYHIQRTI----H 256
Cdd:cd15969  161 WHTAVS-YINICI-FVAVLVILIVCY-ISISRYIYKSSKQFISSSSRTRKhnqSIRVVVAVFFVCFLPYHLCRIPftfsQ 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHFLHNETkpCDSVLRMQKSvvITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15969  238 LDKILDCT--IKTILYYCKE--ATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
28-312 1.21e-20

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 90.40  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLlLTCVPFTSTIYTLDS-WPFGEFLCKLSEFLKDTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-----FLMAKPQKDEKNNTKCFEPPQD-- 179
Cdd:cd15927   84 IGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPeaifsHVVTFTLTDNQTIQICYPYPQElg 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 -NQTKNHVLvLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSM----------KKNLSSHKKAIGMIMVVTAAFLVSFMP 248
Cdd:cd15927  164 pNYPKIMVL-LRFLVYYL---IPLLIIGVFYVLMARHLIRSTRnigsgqnqaaQRQIEARKKVAKTVLAFVVLFAVCWLP 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 249 YHIqRTIHLHFLHNETKPCDS---VLRmqksvVITLSLAASNCCFDPL-LYFFSGgnfrkrlsTFRKH 312
Cdd:cd15927  240 RHV-FMLWFHFAPNGLVDYNAfwhVLK-----IVGFCLSFINSCVNPVaLYLLSG--------SFRRH 293
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
25-306 1.46e-20

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 89.95  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYvLIKTYH--KKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYA 102
Cdd:cd15926    2 IISIVYSVVCALGLVGNLLVLY-LMKSKQgwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF-EPPQDNQ 181
Cdd:cd15926   81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLvKFPDNRG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLVL-HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMK-KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRT----I 255
Cdd:cd15926  161 NAQFWLGLyHAQKVLLGFLIPLGIISLCYLLLVRFITDKNITgSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTwgilI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 256 HLHFLHNETkpcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15926  241 KLNVVHFSY---EYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
28-305 2.33e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 89.38  E-value: 2.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15195    5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMvTFFNMPMDAVWNYTVE-WLAGDLMCRVMMFLKQFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVqNINLVTQKKARFVCVGiWIFVILTSSP----FLMAKPQKDEKNNTKCFEpPQDNQT 182
Cdd:cd15195   84 MYLSSFMLVVIALDRVFAILSPL-SANQARKRVKIMLTVA-WVLSALCSIPqsfiFSVLRKMPEQPGFHQCVD-FGSAPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK---------SMKKNLSSH------KKAIGMIMVVTAAFLVSFM 247
Cdd:cd15195  161 KKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMakrardtpiSNRRRSRTNslerarMRTLRMTALIVLTFIVCWG 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 248 PYHIQRTIHlHFLHNETKPCDSVLrmqksVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15195  241 PYYVLGLWY-WFDKESIKNLPPAL-----SHIMFLLGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-306 2.62e-20

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 89.04  E-value: 2.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd14999    3 GTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKK-WYFGDVGCRLLFSLDFLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPvqnINLVTQKK--ARFVCVGIWIFVILTSSPFLMA-----KPQKDEKNNTKCFEPPQD 179
Cdd:cd14999   82 MHASIFTLTVMSTERYLAVVKP---LDTVKRSKsyRKLLAGVIWLLSLLLTLPMAIMirlvtVEDKSGGSKRICLPTWSE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 180 NQTKNHVLVLHYVS-----LFVGFIIPFVIIIVCYTMiilTLLKKSMKKNLSSHKKAIgMIMVVTAAFLVSFMPYHIQRT 254
Cdd:cd14999  159 ESYKVYLTLLFSTSivipgLVIGYLYIRLARKYWLSQ---AAASNSSRKRLPKQKVLK-MIFTIVLVFWACFLPFWIWQL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 532164737 255 IHLHflHNETKPCDsvlRMQKSV-VITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14999  235 LYLY--SPSLSLSP---RTTTYVnYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
25-306 7.02e-20

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 87.95  E-value: 7.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15150    2 IFPLLYTVLFIVGLTMNGLAMRVFFQI-PSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15150   81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPnMILTNRQPTPKNVKKCSLLKSEFGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVgfIIPFVIIIVCYTMIILTLLK---KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFL 260
Cdd:cd15150  161 WHEIVNYICQVIF--WVNFLIVIVCYTLITKELYKsykRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 261 HNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15150  239 TRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
25-305 8.55e-20

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 87.57  E-value: 8.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHK-KSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYA 102
Cdd:cd15097    2 IVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLcFILFCVPFQATIYSLEG-WVFGSFLCKAVHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15097   81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWEEARR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KnhvlVLHYVSLFVGFIIPFVIIIVCYTMIILTLLK-----KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtIHL 257
Cdd:cd15097  161 K----AMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTavdplEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHV---VIL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 258 HFLHNE--TKPCDSVLRMqksvvITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15097  234 CYLYGDfpFNQATYAFRL-----LSHCMAYANSCLNPIVYALVSKHFRKG 278
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
29-304 6.11e-19

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 85.24  E-value: 6.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15972    6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALS-YWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWI--FVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKnhv 186
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWAlsFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRAG--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLfvGFIIPFVIIIVCYTMIILTL------LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFl 260
Cdd:cd15972  162 FIIYTATL--GFFCPLLVICLCYLLIVVKVrssgrrVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVC- 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 261 hneTKPCDSVLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRK 304
Cdd:cd15972  239 ---PLPEEPSLFGLYFFVVVLSYA--NSCANPIIYGFLSDNFKQ 277
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
29-262 6.72e-19

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 85.23  E-value: 6.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15928    6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM-----AKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15928   86 ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVlvgveHIQGQQTPRGFECTVVNVSSGLL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVgfiipfviiivcyTMIILTLLKKSMKKNLSS----------------HKKAIGMIMVVTAAFLVSFM 247
Cdd:cd15928  166 SVMLWVSTSFFFV-------------PMVCLSLLYGLIGRALWDrrqrsrtagasrrdnnHRQTVRMLAVIVLAFVLCWL 232
                        250       260
                 ....*....|....*....|....
gi 532164737 248 PYHIQRTI---------HLHFLHN 262
Cdd:cd15928  233 PFHVGRVIfnhsrastkHLHYVSQ 256
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
28-306 1.01e-18

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 84.70  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVC-TLPLRVVYYVHkGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15389    5 VAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVN-STWVFGKIMCHLSRFAQYCS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPF-----LMAKPQKDEKNNTKC---FEPPQ 178
Cdd:cd15389   84 VYVSTLTLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHaiyqkLVEFEYSNERTRSRClpsFPEPS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DnQTKNHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLSSH---------KKAIGMIMVVTAAFLVSFMP- 248
Cdd:cd15389  162 D-LFWKYLDLATFILQYV---LPLLIIGVAYTRVAKKLWLRNAIGDVTTEqyvaqrrkkKKTIKMLMLVVLLFAICWLPl 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 249 --YHIqrtihlhFLHNETKPCDSVLrmqksVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15389  238 ncYHV-------LLSSHPIRSNSAL-----FFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
28-306 1.26e-18

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 84.47  E-value: 1.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVlIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15118    5 CLHGIVSTLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAK---PQKDEK----NNTKCFEPPQDN 180
Cdd:cd15118   84 FVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRdviERKDGRklcyYNFALFSPSPDN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 Q---TKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKkaigMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd15118  164 NhpiCKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVR----LVVSVVVSFALCWAPYHIFSIIEV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 258 HfLHNETKPCDSVLRmqkSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15118  240 M-AHNQHSLRPLVIQ---GLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
29-304 1.44e-18

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 83.98  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNL 107
Cdd:cd15206    6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLlAVFCMPFTLVGQLLRN-FIFGEVMCKLIPYFQAVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP--QKDEKNNTKCFEPPQDNQTKNH 185
Cdd:cd15206   85 SVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNliPMSRPGGHKCREVWPNEIAEQA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKksmkknlsSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETK 265
Cdd:cd15206  165 WYVFLDLMLLV---IPGLVMSVAYGLISWTLLE--------AKKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAAR 233
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 266 PCDSVlrmqkSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15206  234 YVSST-----TISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-255 1.57e-18

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 84.08  E-value: 1.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNgfVLYVLIKTYHK--KSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15132   10 LFVVGVTGN--TMTVLIIRRYKdmRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYAT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP--FLMAKPQKDEKNNT----KCFEPPQDNQTKN 184
Cdd:cd15132   88 ILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPflFLVGVEQDNNIHPDdfsrECKHTPYAVSSGL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 -HVLVLHYVSLFVgfiipfviiivcYTMIILTLLKKSMKKNL----------------SSHKKAIGMIMVVTAAFLVSFM 247
Cdd:cd15132  168 lGIMIWVTTTYFF------------LPMLCLSFLYGFIGRKLwkskndlrgpnaaareRSHRQTVRILAVVVLAFIICWL 235

                 ....*...
gi 532164737 248 PYHIQRTI 255
Cdd:cd15132  236 PFHIGRIL 243
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
35-305 2.01e-18

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 83.67  E-value: 2.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd15200   12 VLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIVFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDeknNTKC--FEPPQDNQTKNHvlvLHYV 192
Cdd:cd15200   92 TAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQS---NSTClsYDHGTDPSASDR---WHRI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 193 SLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNlSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLhfLHNETKPCDSVLR 272
Cdd:cd15200  166 LFFLEFFLPLGIILFCIFSIILTLKQRKLAKQ-AGPQRAVKVLAVIVLVYTVCFLPSILFALASL--VAFKVSQCRSLDL 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 532164737 273 MQKSVVITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15200  243 CTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
27-251 2.25e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 81.18  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL--LCVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALY 104
Cdd:cd14997    4 SVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLlvLLVCMPVALVETWARE-PWLLGEFMCKLVPFVEL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFL-MAKPQKDEKNNTKCF---EPPQDN 180
Cdd:cd14997   83 TVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLfITEFKEEDFNDGTPVavcRTPADT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLK----------KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYH 250
Cdd:cd14997  163 FWKVAYILSTIVVFFV---VPLAILSGLYSVICRRLVGhpalesrradAANRHTLRSRRQVVYMLITVVVLFFVCLLPFR 239

                 .
gi 532164737 251 I 251
Cdd:cd14997  240 V 240
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
29-306 3.19e-17

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 80.40  E-value: 3.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVV-YYVHKgiWLFGDFLCRLSTYALYVN 106
Cdd:cd15074    6 YLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLgISVFGYPLAIIsAFAHR--WLFGDIGCVFYGFCGFLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPvQNINLVTQKKARFVCVGIWIFVIL-TSSPFLMAKPQKDEKNNTKCfeppqdnqTKNH 185
Cdd:cd15074   84 GCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFwAVAPLVGWGSYGPEPFGTSC--------SIDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVS--------LFVGFIIPFVIIIVCYTMIILTLLK---------KSMKKNLSSHKKAIGMIMVVTAAFLVSFMP 248
Cdd:cd15074  155 TGASASVGgmsyiisiFIFCYLLPVLIIVFSYVKIIRKVKSsrkrvagfdSRSKRQHKIERKVTKVAVLICAGFLIAWTP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 249 YHIqrtIHLHFLHNETKPCDSVLrmqkSVVITLsLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15074  235 YAV---VSMWSAFGSPDSVPILA----SILPAL-FAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
36-305 3.42e-17

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 80.23  E-value: 3.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  36 VGFFGNGFVLYVLIKTYHK--KSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFF 113
Cdd:cd15122   13 LGLPGNGFIIWSILWKMKArgRSVTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYYLCCLSMYASIFI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 114 MTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPqdNQTKNHVLVLHYV 192
Cdd:cd15122   92 IGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPaFVYRHVWKDEGMNDRICEPC--HASRGHAIFHYTF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 193 SLFVGFIIPFVIIIVCYTmIILTLLKKSMKKNLSSHKKAIGMIMVvtaAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLR 272
Cdd:cd15122  170 ETLVAFVLPFGVILFSYS-VILVRLKGARFRRRARVEKLIAAIVV---AFALLWVPYHVVNLLQVVANLAPGEVLEKLGG 245
                        250       260       270
                 ....*....|....*....|....*....|....
gi 532164737 273 MQKSV-VITLSLAASNCCFDPLLYFFSGGNFRKR 305
Cdd:cd15122  246 AAKAArAGATALAFFSSSVNPLLYVFAAGDLIKT 279
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
25-306 4.00e-17

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 80.45  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLrVVYYVHKGIWLFGDFLCRLstYAL 103
Cdd:cd15083    2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDfLMCILNCPL-MVISSFSGRWIFGKTGCDM--YGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLY--CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTKCfepPQDN 180
Cdd:cd15083   79 SGGLFgiMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYsLLWVLPPLFGWSRYVLEGLLTSC---SFDY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSLFV-GFIIPFVIIIVCYTMIILTLLK--KSMKKNLSSHKKAIGM---------------IMVVTAAF 242
Cdd:cd15083  156 LSRDDANRSYVICLLIfGFVLPLLIIIYCYSFIFRAVRRheKAMKEMAKRFSKSELSspkarrqaevktakiALLLVLLF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 243 LVSFMPYHIQRTIHLhflhneTKPCDSVLRMqkSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15083  236 CLAWTPYAVVALIGQ------FGYLEVLTPL--ATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
29-249 4.95e-17

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 79.74  E-value: 4.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT--LPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd14995    6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAagLPNEIESLLGPDSWIYGYAGCLLITYLQYLG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHV 186
Cdd:cd14995   86 INASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVSRHYY 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCYTMIILTLlkksmkknLSSHKKAIGMIMVVTAAFLVSFMPY 249
Cdd:cd14995  166 LPIYLADFVLFYVIPLLLAIVLYGLIGRIL--------FSSRKQVTKMLAVVVVLFALLWMPY 220
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
28-306 7.37e-17

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 79.38  E-value: 7.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYH--KKSAFQVYMINLAVADLL-CVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALY 104
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADLLlLLFSVPFRAAAYS-KGSWPLGWFVCKTADWFGH 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15002   83 ACMAAKSFTIAVLAKACYMYVVNPTKQVTI-KQRRITAVVASIWVPACLLPLPqWLFRTVKQSEGVYLCILCIPPLAHEF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYvsLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSS----HKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHF 259
Cdd:cd15002  162 MSAFVKLY--PLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRnqirSRKLTHMLLSVVLAFTILWLPEWVAWLWLIHI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 260 LHNETKPcdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15002  240 KSSGSSP------PQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-306 1.38e-16

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 78.64  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC--VCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYV 105
Cdd:cd15012    4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVgiFCVLQNLSIYLIPS--WPFGEVLCRMYQFVHSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqkdeKNNTKCFEPPQDNQTKNH 185
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVF------SQTVEILVTQDGQEEEIC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHY--------VSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKnlsSHKKAIGMIMVVTAAFLVSFMPYHIqRTIHL 257
Cdd:cd15012  156 VLDREMfnsklydtINFIVWYLIPLLIMTVLYSKISIVLWKSSSIE---ARRKVVRLLVAVVVSFALCNLPYHA-RKMWQ 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 258 HFlhNETKPCDSVLRMQKSvVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15012  232 YW--SEPYRCDSNWNALLT-PLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
30-295 1.50e-16

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 78.91  E-value: 1.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15134    7 YGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLlILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIfviltsSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLV 188
Cdd:cd15134   87 ASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWI------IAFVCALPFAIQTRIVYLEYPPTSGEALEESAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 ------------LHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSM-----------KKNLSSHKKAIGMIMVVTAAFLVS 245
Cdd:cd15134  161 camlneippitpVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLlrrgqrsvsggRRSSQSRRTVLRMLVAVVVAFFIC 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 246 FMPYHIQRTIHLHflhnETKPCDSVLRMQKSVV-ITLSLAASNCCFDPLLY 295
Cdd:cd15134  241 WAPFHAQRLLTVY----AKNMTPPYLFINRILFyISGVLYYVSSTVNPILY 287
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
25-306 2.55e-16

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 78.06  E-value: 2.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFqVYMINLAVADLL-CVCTLPLRVVYYvhkgiwLFGDFLCRLSTYAL 103
Cdd:cd14978    2 LYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTN-VYLAALAVSDILvLLSALPLFLLPY------IADYSSSFLSYFYA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLY----------CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMakpqkdEKNNTKC 173
Cdd:cd14978   75 YFLPYiyplantfqtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFF------EYEVVEC 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 174 FEPPQDNQTKN--HVLVLHYVSLFVGFIIPFVIIIV---CYTMIILTL-----LKKSMKKNLSSHKKAIG---------- 233
Cdd:cd14978  149 ENCNNNSYYYVipTLLRQNETYLLKYYFWLYAIFVVllpFILLLILNIlliraLRKSKKRRRLLRRRRRLlsrsqrrerr 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 234 ---MIMVVTAAFLVSFMPYHIqrtihLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14978  229 ttiMLIAVVIVFLICNLPAGI-----LNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
26-303 2.66e-16

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 77.91  E-value: 2.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15199    3 YASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqKDEKNNTKC--FEPPQDNQTK 183
Cdd:cd15199   83 SRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLA---SQPKNFTECnsFSPKDDEDFS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NhvlVLHYVSLFVGFIIPFVIIIVCyTMIILTLLKKSMKKNLSSHK--KAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLH 261
Cdd:cd15199  160 D---TWQEAVFFLQFLLPFGLIVFC-TVRIIRRLKKRLRDVGKQPKlqRAMALVTSVVVVFGFCFLPCFLARVLMLIFQN 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 262 NETkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15199  236 KES--CNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
31-306 3.21e-16

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 77.27  E-value: 3.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLcVC------TLPLRVVYYVHKgiwlfGDFLCRLSTYALY 104
Cdd:cd15196    8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLL-VAlfnvlpQLIWDITYRFYG-----GDLLCRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGiWIFVILTSSP----FLMAKPQKDEKNNTKCFEPPQDN 180
Cdd:cd15196   82 VGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIA-WVLSLLLSIPqlfiFSYQEVGSGVYDCWATFEPPWGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTknhvlvlhYVSLFVGFIIP--FVIIIVCYTMIILTLLKKSMkknlsshkKAIGMIMVVTAAFLVSFMPYHiqrTIHLH 258
Cdd:cd15196  161 RA--------YITWFTVAVFVvpLIILAFCYGRICYVVWRAKI--------KTVKLTLVVVACYIVCWTPFF---VVQMW 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 259 FLHNETKPCDSVlrmqkSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15196  222 AAWDPTAPIEGP-----AFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
29-306 4.05e-16

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 77.53  E-value: 4.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCR----LSTYALY 104
Cdd:cd14996    6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRianfFGTLVIH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFM--TAMSFF-------------RCIAIVFPVQNINLVTQKK-ARFVCVGIWIFVILTSSPF--LMAKPQKD 166
Cdd:cd14996   86 VSMCVSILILswIAISRYatlmkhdsatqkqSCYEKIFYGHFLKRFRQPKfARYLCIYIWGVVLCIIIPVvvYYSVREAD 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 167 EKNNTKCF-EPPQDNQTKNHVLVLHYVSLFvGFIIPFVIIIVCYTMIILTLLKKS---MKKNLsSHKKAIGMIMVVTAAF 242
Cdd:cd14996  166 EDGESLCYnRQVELGAKGSQIAGLIATTFF-FLFFLVVLLSYYSFVNHLRRIQKNtciSEKDL-IYRSVKRNILIIQALL 243
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 243 LVSFMPYHIQRTIHLHfLHNeTKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14996  244 VVCFLPYHIFKPVFYV-LHQ-REDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
27-295 5.97e-16

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 77.06  E-value: 5.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYV 105
Cdd:cd15393    4 SILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFQFQAALLQR-WVLPRFMCPFCPFVQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMA---KPQKDEKNN-TKCFEPPQDNQ 181
Cdd:cd15393   83 SVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVALAlrvEELTDKTNNgVKPFCLPVGPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHvLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKN---------LSSHKKAIGMIMVVTAAFLVSFMPYhiq 252
Cdd:cd15393  161 DDWW-KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNaqdvrddeiLKNKKKVIKMLIIVVALFALCWLPL--- 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 253 rtiHLHFLHNETKPcdSVLRMQKSVVITLS---LAASNCCFDPLLY 295
Cdd:cd15393  237 ---QTYNLLNEIKP--EINKYKYINIIWFCshwLAMSNSCYNPFIY 277
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
24-306 7.28e-16

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 76.32  E-value: 7.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSA-FQVYMINLAVADLLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYA 102
Cdd:cd14983    1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLRLTpNVIYMINLCLSDLVFILSLPIKIVEALSSA-WTLPAVLCPLYNLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-PFLMAKPQKDEKNNTK------CFE 175
Cdd:cd14983   80 HFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTlVFILETSGGTLDINTPvgnsstCYE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 PPQDNQTKNHV-------LVLHYVSLFVgfiipfviIIVCYTMIILTLLKKSMKKNLSshKKAIGMIMVVTAAFLVSFMP 248
Cdd:cd14983  160 NFTPEQLALLApvrlelsLVLFFLPLAI--------TAFCYVRCIRILVRSRLHERRK--RRAVRVAVSTLLTFVVCFGP 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 249 YHIQRTIhlHFLHNETkpcdsvLRMQKSVVITLSLAASnccFDPLLYFFSGGNFRKRL 306
Cdd:cd14983  230 YNISHVV--GFVRHES------VWWRKLALLTSTCNAF---LDPLIFYFLSSSMERGF 276
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
24-306 1.24e-15

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 76.02  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGiwLFGDFLCRLSTYAL 103
Cdd:cd15171    1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGG--SLGNPTCKVLVALS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFV-CVGIWIFVILTSSP-FLMAKPQKDEKNNtKCF--EP--- 176
Cdd:cd15171   79 SVGLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIaSVLAWLTAFLVTLPeFVFYKPQMDSQKS-KCAfsRPhfl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 PQDNQTKNHVLVLHYVslFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSshkkaiGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15171  158 PAEETFWKYFLTLKMN--IVVLVFPLLVFIICCVQLRKTQRFRERQRDLS------KLVFAIMVVFLLMWAPYNIALFLS 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 257 LHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15171  230 AFKEHFSLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
29-306 1.56e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 75.55  E-value: 1.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15394    6 LYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLmCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN--TKCfEPPQDNQTKNH 185
Cdd:cd15394   86 YVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLdfSIC-EEFWFGQEKQR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 vLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSS---------HKKAIGMIMVVTAAFLVSFMPYHI---QR 253
Cdd:cd15394  163 -LAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQsqaewdrarRRKTFRLLVVVVVAFAICWLPLHIfnvIR 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 532164737 254 TIHLHFLHnetKPCDSVLRmqksvVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15394  242 DIDIDLID---KQYFNLIQ-----LLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
32-304 2.94e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 74.22  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHkGIWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15210    9 VFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLfCAFNLPLAASTFLH-QAWIHGETLCRVFPLLRYGLVAVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK---DEKNNTKCFEPPQDNQTKNHVL 187
Cdd:cd15210   88 LLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRfglDPKVCSCSILRDKKGRSPKTFL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLfvgfiipfviiiVCYTMIILTLLKKSMKKNLsshkkaigMIMVVTAAFLVSFMPYHIqrtihLHFLHNETKPc 267
Cdd:cd15210  168 FVFGFVL------------PCLVIIICYARREDRRLTR--------MMLVIFLCFLVCYLPITL-----VNVFDDEVAP- 221
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532164737 268 dSVLRMQKSVVITLSlaasnCCFDPLLYFFSGGNFRK 304
Cdd:cd15210  222 -PVLHIIAYVLIWLS-----SCINPIIYVAMNRQYRQ 252
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
29-159 3.26e-15

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 74.92  E-value: 3.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLrVVYYVHKGIWLFGDFLCRLstYALYVNL- 107
Cdd:cd15079    6 IYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPI-FIYNSFYEGWALGPLGCQI--YAFLGSLs 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 108 -YCSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVIL-TSSPFL 159
Cdd:cd15079   83 gIGSIWTNAAIAYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPwALLPLL 135
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
25-306 4.02e-15

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 74.58  E-value: 4.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15207    2 LFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVgVFCMPFTLVDNILTG-WPFGDVMCKLSPLVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSP---FLMAKPQKDEKNNTK--CFEP-P 177
Cdd:cd15207   81 GVSVAASVFTLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPqalVLEVKEYQFFRGQTVhiCVEFwP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QDNQTKNHVLVLhYVSLFVGFIIPFVIIivcYTMIILTLLKKSMKKNLS---------SHKKA--IGMIMVVTAAFLVSF 246
Cdd:cd15207  159 SDEYRKAYTTSL-FVLCYVAPLLIIAVL---YVRIGYRLWFKPVPGGGSasreaqaavSKKKVrvIKMLIVVVVLFALSW 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 247 MPYHIqrTIHLHFLHNETKPcdsvlrmQKSVV------ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15207  235 LPLHT--VTMLDDFGNLSPN-------QREVLyvyiypIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-295 4.90e-15

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL--CVCTLPLRVVYYVHKgiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15384    8 AVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLvtFFCIPSEAIWAYTVA--WLAGNTMCKLVKYLQVFGLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLvtQKKARFVCVGIWIFVILTSSP----FLMAKPQKDEkNNTKCF------EPPQ 178
Cdd:cd15384   86 LSTYITVLISLDRCVAILYPMKRNQA--PERVRRMVTVAWILSPIFSIPqaviFHVERGPFVE-DFHQCVtygfytAEWQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DNQTKNHVLVLHYVSLFVgfiipfvIIIVCYTMIILTLLKKS-MKKNLSSH----------------KKAIGMIMVVTAA 241
Cdd:cd15384  163 EQLYNMLSLVFMFPIPLV-------IMVTCYVLIFITLSKSSrDFQGLEIYtrnrgpnrqrlfhkakVKSLRMSAVIVTA 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 242 FLVSFMPYHIQRTIHLHFLHNETKPcdsvlrmqKSVVITLSLAASNCCFDPLLY 295
Cdd:cd15384  236 FILCWTPYYVIMIWFLFFNPYPLND--------ILFDVIFFFGMSNSCVNPLIY 281
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
27-304 7.38e-15

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 73.61  E-value: 7.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15000    3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEK----NNTKCFEPPQDNQT 182
Cdd:cd15000   83 LLASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQwknfLETYCAENTQVLPI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVGfiipfvIIIVCYTMIILTL-------LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrti 255
Cdd:cd15000  161 YWHVIITVLVWLPLG------IMLICYSAIFWKLdkyerrvLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTA---- 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 256 hLHFLHNETKPCDSVLRMQKSVVITLSLAAS-----NCCFDPLLYFFSGGNFRK 304
Cdd:cd15000  231 -LIFYRYKLVPNDNTQNSVSGSFHILWFASKylmflNAAVNPLIYGFTNENFRK 283
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-303 1.42e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 73.04  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF----EPPQDN 180
Cdd:cd16003   82 TSVFASIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFvawpGGPDQH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKnHVLVLHYVSLFvgfiiPFVIIIVCYTMIILTLLKKSM--------KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIq 252
Cdd:cd16003  160 FTY-HIIVIVLVYCL-----PLLVMGITYTIVGITLWGGEIpgdtsdkyHEQLRAKRKVVKMMIIVVLTFAICWLPYHI- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 253 rtihLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd16003  233 ----YFIVTGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
25-304 1.83e-14

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 72.89  E-value: 1.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15205    2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLiTFFCIPFTLLQNISSN-WLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKD------EKNNTKCFE-- 175
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVkydflyEKRHVCCLErw 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 ---PPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCY-------TMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVS 245
Cdd:cd15205  161 yspTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWikkrvgdASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVC 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 246 FMPYHIQrTIHLHFLHNETKPCDSVLRMQKSVVITLSLaaSNCCFDPLLYFFSGGNFRK 304
Cdd:cd15205  241 WAPFHVV-HMMIEYSNLENKYDGVTIKLIFAIVQLIGF--SNSFNNPIVYAFMNENFKK 296
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
33-160 1.92e-14

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 72.44  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVHKGiWLFGDFLCRLstYALYVNLY--C 109
Cdd:cd15336   10 IGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDfLMSLTQSPIFFVNSLHKR-WIFGEKGCEL--YAFCGALFgiT 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM 160
Cdd:cd15336   87 SMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLF 137
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
32-303 3.11e-14

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 71.36  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFlcrLSTYALYVNLYCSI 111
Cdd:cd15163    9 LIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAGNCLTCSF---VHIFSYFVNMYCSI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 112 FFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFeppqdnqtknhvlvlhy 191
Cdd:cd15163   86 LFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASCCLSKLF----------------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 192 vSLFVGFIIPFVIIIVCYTMIILTLLKKS--MKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhlhFLHNETKPCDS 269
Cdd:cd15163  149 -ALTVFEFFLPLLIITFFTIRIMCALSRPglMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVA---VAFNPDIPHHT 224
                        250       260       270
                 ....*....|....*....|....*....|....
gi 532164737 270 VLRMQKsvvITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15163  225 SLIVYH---VTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
30-306 4.64e-14

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 71.57  E-value: 4.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSA-FQVYMINLAVADLLCVC-TLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNL 107
Cdd:cd15382    7 YSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFiMMPLEIGWAATVA-WLAGDFLCRLMLFFRAFGL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLvtQKKARFVCVGIWIFVILTSSPFLMAKPQKDE---KNNTKC----FEPpqdn 180
Cdd:cd15382   86 YLSSFVLVCISLDRYFAILKPLRLSDA--RRRGRIMLAVAWVISFLCSIPQSFIFHVESHpcvTWFSQCvtfnFFP---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 qTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIG--------------------MIMVVTA 240
Cdd:cd15382  160 -SHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSvrlrrssvgllerarsrtlkMTIVIVL 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 241 AFLVSFMPYHIQRTIHLhFLHNETKPCDSvlRMQKSVVItlsLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15382  239 VFIICWTPYFIMSLWYW-FDRESASKVDP--RIQKGLFL---FAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
27-306 5.69e-14

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 71.06  E-value: 5.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVL-IKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15925    4 ALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQtknH 185
Cdd:cd15925   84 NVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNY---W 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGM-IMVVTAAFLVSFMPYHIQrTIHLHFLHNET 264
Cdd:cd15925  161 LGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARsVRLVVASFFLCWFPNHVV-TFWGVLVKFRA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 265 KPCDSVLRMQKSVV--ITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15925  240 VPWNSTFYFIHTYVfpVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
35-253 6.30e-14

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 71.07  E-value: 6.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd15131   12 VVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMA-----KPQKDEKNNTKCfePPQDNQTKNHVLVL 189
Cdd:cd15131   92 TALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLvgvehENGTNPIDTNEC--KATEYAVRSGLLTI 169
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532164737 190 HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLS-------SHKKAIGMIMVVTAAFLVSFMPYHIQR 253
Cdd:cd15131  170 MVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPnashrdkNNRQTVKMLAVVVFAFVLCWLPFHVGR 240
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-251 6.71e-14

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 71.03  E-value: 6.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd16004    2 LWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:cd16004   82 TAMFVSIYSMTAIAADRYMAIIHPFK--PRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGK 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 185 HVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSM---------KKNLSSHKKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd16004  160 HQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVpghqahgayHRQLQAKKKFVKTMVVVVVTFAICWLPYHL 235
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-304 1.53e-13

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 70.11  E-value: 1.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKgIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15208    6 LYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTE-TWFFGQVLCKIIPYLQTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINlvTQKKARFVCVGIWIF---------VILTSSPFLMAKPQKDEKnnTKCFEPPQ 178
Cdd:cd15208   85 SVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVsllimipqaIVMECSRVVPLANKTILL--TVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DNQTKnhvLVLHYVSLFVGFIIPFVIIIVCYTMIILTL---------------LKKSMKKN-------LSSHKKAIGMIM 236
Cdd:cd15208  161 DSIYQ---KVYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkWNKPRKSAvaaeekqLRSRRKTAKMLI 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 532164737 237 VVTAAFLVSFMPYHI----QRTIHLHFLHNETkpcdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15208  238 VVVIMFAICYLPVHLlnilRYVFGLFTVDRET--------IYAWFLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
35-159 3.98e-13

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 68.81  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTY--HKKSAFQVYMINLAVADLLCVCTL-PLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSI 111
Cdd:cd14981   12 VFGVLGNLLALIVLARSSksHKWSVFYRLVAGLAITDLLGILLTsPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 112 FFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-PFL 159
Cdd:cd14981   92 LIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASlPLL 140
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
37-304 1.02e-12

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 67.23  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  37 GFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSIFFMT 115
Cdd:cd15325   14 GVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWAAVDVLCCTASIMSLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 116 AMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfeppQDNQTKNHVLVLHYVSLF 195
Cdd:cd15325   93 IISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETIC----QITEEPGYALFSALGSFY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 196 VGFIIPFVIIIVCYTMIIltllkksmkkNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFlhNETKPCDSVLRmqk 275
Cdd:cd15325  169 LPLAIILVMYCRVYVVAL----------KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIF--PAYKPSDTVFK--- 233
                        250       260
                 ....*....|....*....|....*....
gi 532164737 276 svvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15325  234 ---ITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
28-306 2.16e-12

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 66.69  E-value: 2.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYVN 106
Cdd:cd15397    5 VSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILvCLVCLPFTVVYTLMD-YWIFGEVLCKMTPFIQCMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQkkARFVCVGIWIFVILTSSPFLMAKPQKDE--KNNTKCFEPPQDNQ--- 181
Cdd:cd15397   84 VTVSILSLVLIALERHQLIINPTGWKPSVSQ--AYLAVVVIWMLACFISLPFLAFHILTDEpyKNLSHFFAPLADKAvct 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 ----TKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKK--------SMKKNLSSHKKAIGMIMVVTAAFLVSFMPY 249
Cdd:cd15397  162 eswpSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRkdmlerrgEYNRRAGHSKRINVMLVSLVAAFALCWLPL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 250 HIQRTIhLHFLHNETKPCdsvlrmQKSVVITLS--LAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15397  242 NVFNAI-ADWNHEAIPHC------QHNLIFSLChlAAMASTCVNPIIYGFLNSNFKKEV 293
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
25-314 5.87e-12

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 64.97  E-value: 5.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIkTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWlFGDFLCRLSTYALY 104
Cdd:cd14973    2 VIFSLTVLLSLCGLVGNGLVLWLLG-FRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTK-CFeppqdnqtk 183
Cdd:cd14973   80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESaCR--------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 nHVLVLHYVSLFVgfiipfviiiVCYTMII--LTLLKKSMKknlSSHKKA----IGMIMVVTAAFLVSFMPYHIQRTIHL 257
Cdd:cd14973  151 -TFNFLSALLFLL----------LFLVMCVssLTLLIRVQC---SSQRRPptrlYVVILLTVLVFLLCGLPLGIYWFLLL 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 258 HFLHNETKPCDSVLRMqksvvitlsLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSL 314
Cdd:cd14973  217 WFSNYLFHTFHPISDL---------LSCVNSSANPIIYFFVGSLRGRRLREPLRVVL 264
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
28-306 6.37e-12

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 65.22  E-value: 6.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYH---KKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15338    5 SVFGVICFLGIIGNSIVIYTIVKKSKfrcQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAK---PQKDEKNNTKCFEPPQDNQ 181
Cdd:cd15338   85 NSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAglmPLPDGSVGCALLLPNPETD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 182 TKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHL---- 257
Cdd:cd15338  165 TYWFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAHLsidr 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 258 -----HFLHNetkpcdsvlrmqksvvITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15338  245 pslafLYAYN----------------VAISMGYANSCINPFLYIMLSETFKRQF 282
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
29-308 1.02e-11

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 64.93  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKtyhKKSAF--QVYMINLAVADLLCVCTLPlrvvYYVHKGI--WLFGDFLCRLSTYALY 104
Cdd:PHA02834  34 FYILLFIFGLIGNVLVIAVLIV---KRFMFvvDVYLFNIAMSDLMLVFSFP----FIIHNDLneWIFGEFMCKLVLGVYF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQnINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKN 184
Cdd:PHA02834 107 VGFFSNMFFVTLISIDRYILVVNATK-IKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSW 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLHYVSLFvGFIIPFVIIIVCYTMIILTlLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNET 264
Cdd:PHA02834 186 SAFFNFEINIF-GIVIPLIILIYCYSKILYT-LKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLIDIG 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 532164737 265 kpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLST 308
Cdd:PHA02834 264 --CYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKN 305
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-304 1.07e-11

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 64.59  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15125    2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEE-WMFGTVGCKLIPVIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPvqnINLVTQKKARFVC---VGIWIFVILTSSP---FLMAKPQKDEKNN--TKCFE 175
Cdd:cd15125   81 LTSVGVSVFTLTALSADRYKAIVNP---MDIQTSSAVLRTClkaIAIWVVSVLLAVPeavFSEVAHIMPDDNTtfTACIP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 PPQDNQT--KNHVLVLHYVSLFVGFIIPFVIiivcYTMIILTLLKKS----------MKKNLSSHKKAIGMIMVVTAAFL 243
Cdd:cd15125  158 YPQTDEMhpKIHSVLIFLVYFLIPLAIISIY----YYHIAKTLIKSAhnipgeysehSKRQMETRKRLAKIVLVFVGLFA 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532164737 244 VSFMPYHIQrTIHLHFLHNETkpcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15125  234 FCWFPNHVL-YMYRSFNYNEI---DSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRR 290
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-304 1.92e-11

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 63.98  E-value: 1.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  40 GNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSF 119
Cdd:cd15197   17 GNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 120 FRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN-TKCF-EPPQDNQTKNHVLVLHyVSLFVg 197
Cdd:cd15197   97 DRYDAICHPMN--FSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNGeVQCWiLWPEPWYWKVYMTIVA-FLVFF- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 198 fiIPFVIIIVCYTMIILTLLKKSM-------------KKNLSSHK--------KAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15197  173 --IPATIISICYIIIVRTIWKKSKiqvtinkaglhdgSSRRSSSRgiiprakiKTIKMTFVIVTVFIICWSPYFVFDLLD 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 257 LHFLHNETKpcdsvLRMQKSVVITlSLAASNCCFDPLLY-FFSGGNFRK 304
Cdd:cd15197  251 VFGLLPRSK-----TKIAAATFIQ-SLAPLNSAINPLIYcLFSTHLCRP 293
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
26-258 1.98e-11

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 63.45  E-value: 1.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVC-TLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15310    3 YALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATlVMPWVVYLEVTGGVWNFSRICCDVFVTLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGI---WIFVILTSSPFLMAKPQKDEknntkcfepPQDNQ 181
Cdd:cd15310   83 MMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMItavWVLAFAVSCPLLFGFNTTGD---------PTVCS 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 182 TKNHVLVLHyvSLFVGFIIPFVIIIVCYTMIILTLLKKsmkknlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLH 258
Cdd:cd15310  154 ISNPDFVIY--SSVVSFYLPFGVTLLVYVRIYVVLLRE---------KKATQMLAIVLGAFIVCWLPFFLTHILNTH 219
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
29-303 2.34e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 63.35  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNL 107
Cdd:cd15978    6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmLCLFCMPFTLIPNLLKD-FIFGSAVCKTATYFMGISV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM-------AKPQKDEKNNTKCFEPPQDN 180
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIysnlvpfTRINNSTGNMCRLLWPNDVT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSLFVGfiipfVIIIVCYTMIILTLLKKSmkKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHfl 260
Cdd:cd15978  165 QQSWYIFLLLILFLIPG-----IVMMTAYGLISLELYRGI--KFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRAF-- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 261 hnETKPCDSVLRMQKSVVITLsLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15978  236 --DTRSADRLLSGAPISFIHL-LSYTSACVNPIIYCFMNKRFR 275
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-303 2.36e-11

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 63.35  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd16002    2 LWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEAsMSAFNTVINFTYAIHNE-WYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKArFVCVgIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKV-VICV-IWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHyVSLFVGFIIPFVIIIVC-YTMIILTLLKKSM--------KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRT 254
Cdd:cd16002  159 KYETVYH-VCVTVLIYFLPLLVIGCaYTVVGITLWASEIpgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 255 IHLHFLHNETKPCdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd16002  238 LQYFHPELYEQKF-----IQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
35-304 4.67e-11

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 62.22  E-value: 4.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSIFF 113
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEI-LGYWVFGRIFCDIWAAVDVLCCTASILS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 114 MTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVS 193
Cdd:cd15326   91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEITEEPFYALFSSLGSFYIP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 194 LFVgfiipfviIIVCYTMIILTLLKksmkknLSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHNETKPCDSVLRm 273
Cdd:cd15326  171 LIV--------ILVMYCRVYIVALK------FSREKKAAKTLGIVVGMFILCWLPFFI--ALPLGSLFSHLKPPETLFK- 233
                        250       260       270
                 ....*....|....*....|....*....|.
gi 532164737 274 qksvvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15326  234 -----IIFWLGYFNSCLNPIIYPCSSKEFKR 259
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
28-306 4.83e-11

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 62.52  E-value: 4.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmLAVFCMPFTLIPNL-MGTFIFGEVICKAVAYLMGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqkdekNNTKCFepPQDNQTKNHV 186
Cdd:cd15979   84 VSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVY-------SVTVPV--PVGDRPRGHQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFVGFIIPFVIIIVCY-----TMII-LTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYhiqrtihlhFL 260
Cdd:cd15979  155 CRHAWPSAQVRQAWYVLLLLILFfipgvVMIVaYGLISRELYRGLLAKKRVIRMLVVIVAMFFLCWLPI---------FS 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 261 HNETKPCD--SVLRMQKSVVITLS--LAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15979  226 ANTWRAFDplSAHRALSGAPISFIhlLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
27-304 6.31e-11

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 62.25  E-value: 6.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKGiWLFGDFLCRLSTYALYV 105
Cdd:cd15123    4 YVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADT-WLFGRIGCKLLSFIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPV--QNINLVTQKKARFVCVgiWIFVILTSSP-------FLMAKPqkdEKNNT--KCF 174
Cdd:cd15123   83 SVGVSVFTLTVLSADRYRAIVKPLelQTSDAVLKTCCKAGCV--WIVSMLFAIPeavfsdlYSFRDP---EKNTTfeACA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 EPPQDNQTKNHVLVLhyVSLFVGFIIPFVIIIVCYTMIILTLLKKSM----------KKNLSSHKKAIGMIMVVTAAFLV 244
Cdd:cd15123  158 PYPVSEKILQEIHSL--LCFLVFYIIPLSIISVYYFLIARTLYKSTFnmpaeehshaRKQIESRKRVAKTVLVLVALFAF 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 245 SFMPYHIQRTIHLHFLHNETkpcDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15123  236 CWLPNHILYLYRSFTYHTSV---DSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQ 292
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
28-306 7.24e-11

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 62.16  E-value: 7.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15396    5 IAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDvLVCVMCIPFTAVYTLMDH-WIFGETMCKLTSFVQSVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQkkARFVCVGIWIFVILTSSPFLMAKPQKDE------------KNNTKCF 174
Cdd:cd15396   84 VSVSIFSLVLIAIERYQLIVNPRGWKPSASH--AYWGIVLIWLFSLMISIPFLIFHQLTDEpfrnlsshsdfyKDKVVCI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 E--PPQDNQtknhvLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKS-----MKKN---LSSHKKAIGMIMVVTAAFLV 244
Cdd:cd15396  162 EawPSETER-----LIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNskidrMRENesrLSENKRINTMLISIVVTFAA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 245 SFMPYHIQRTIhLHFLHNETKPCdsvlrmQKSVVITLS--LAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15396  237 CWLPLNIFNVV-FDWNHEVLMSC------HHNLVFTLChlVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
33-155 1.11e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 61.45  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD------LLCVCT--LPLRVVYYVHKGIWL------FGDFLCRL 98
Cdd:cd15137   10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADflmgvyLLIIASvdLYYRGVYIKHDEEWRsswlctFAGFLATL 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737  99 STYAlyvnlycSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVILTS 155
Cdd:cd15137   90 SSEV-------SVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLA 138
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
25-304 1.50e-10

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 61.06  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15980    2 VFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPF-LMAKPQKDE--------KNNTKCF 174
Cdd:cd15980   81 GISVSASVFTLVAIAVDRFRCIVYPFK--QKLTISTAVVIIVIIWVLAIAIMCPSaVMLHVQEEKnyrvvlgsQNKTSPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 EPPQDNQTKNHVLVLHYVSLFVGFIIP-FVIIIVCYTMIILTLLKKSMKKNLSSH-----------KKAIGMIMVVTAAF 242
Cdd:cd15980  159 YWCREDWPNQEMRKIYTTVLFANIYLApLSLIVIMYARIGITLFKTAMPHTGKHNqeqrhvvsrkkQKVIKMLLIVALLF 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 243 LVSFMPYHIqrtihLHFLHNETKPCDSVLRMQKSVVITLS--LAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15980  239 ILSWLPLWT-----LMMLSDYANLSPNQLQIINIYIYPFAhwLAFFNSSVNPIIYGFFNENFRR 297
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-157 1.73e-10

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 61.03  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVlLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFET 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP 135
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
28-157 4.42e-10

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 59.78  E-value: 4.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVlLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETV 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15358   85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIP 135
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
29-304 4.54e-10

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 59.74  E-value: 4.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKGiWLFGDFLCRLSTYALYVNL 107
Cdd:cd14977    6 LSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKD-WLFGDVMCKLVPFIQVTSL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIV--FPVQNINLVTQKKARFvcVGIWIFVILTSSP-----FLMAKPQKDEKNNTKCFEPPQDN 180
Cdd:cd14977   85 GVTVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKL--AVIWVGSVLLAVPeavlsTVARESSLDNSSLTVCIMKPSTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 --QTKNHVLVLHYVSLFvgFIIPFVIIIVCYTMIILTLLKK------SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQ 252
Cdd:cd14977  163 faETYPKARSWWLFGCY--FCLPLAFTAVCYLLMARTLIRAakeytrGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHIS 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 253 RtIHLHFLHNETKpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd14977  241 N-ILRATLYNEVL-IDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
31-306 4.69e-10

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 59.64  E-value: 4.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL--CVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15337    8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGfsAVNGFPLKTISSFNK-KWIWGKVACELYGFAGGIFGF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTKC-FeppqDNQTKNHV 186
Cdd:cd15337   87 MSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWsLLWSIPPFFGWGRYVPEGFQTSCtF----DYLSRDLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYVSLFV-GFIIPFVIIIVCYTMIILTLLK--KSMKKNLSSHK---------------KAIGMIMVVTAAFLVSFMP 248
Cdd:cd15337  163 NRLFILGLFIfGFLCPLLIIIFCYVNIIRAVRNheKEMTQTAKSGMgkdtekndarkkaeiRIAKVAIILISLFLLSWTP 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 249 YHIQRTIHLHFLHNETKPCDSVLRMQksvvitlsLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15337  243 YAVVALLGQFGPAYWITPYVSELPVM--------FAKASAIYNPIIYALSHPKFRAAL 292
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-251 5.26e-10

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 59.60  E-value: 5.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYY-VHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLvAVFCLPFEMDYYvVRQRSWTHGDVLCAVVNYLRTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPvqNINLVTQKKARFVCVGIWIFVILTSSP---FLMAKPQKDeKNNTKCFEP-PQDNQ 181
Cdd:cd15204   85 SLYVSTNALLVIAIDRYLVIVHP--LKPRMKRRTACVVIALVWVVSLLLAIPsavYSKTTPYAN-QGKIFCGQIwPVDQQ 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 182 TKNHVlvlHYVSLFVGFIIP-FVIIIVCYTMIILTLLKK--------SMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd15204  162 AYYKA---YYLFLFVLEFVLpVLIMTLCYLRIVRKVWFRrvpgqqteQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
26-304 8.24e-10

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 58.51  E-value: 8.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15053    3 WALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLvAILVMPFAVYVEVNGGKWYLGPILCDIYIAMDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqkdeKNNTKCFEPpqdnqtkn 184
Cdd:cd15053   83 MCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFG------LNNVPYRDP-------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 185 HVLVLhYVSLFVGFIIPFVIIIVCYTMIIL-TLLKKSMKKnlssHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNE 263
Cdd:cd15053  149 EECRF-YNPDFIIYSSISSFYIPCIVMLLLyYRIFRALRR----EKKATKTLAIVLGVFLFCWLPFFTLNILNAICPKLQ 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 264 TKPCDSVLRMqksVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15053  224 NQSCHVGPAL---FSLTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
25-304 1.29e-09

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 57.83  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLyVLIKTYHKKSAFQVYMI-NLAVADL-LCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYA 102
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVI-LSVFTYRPLRIVQNFFIvSLAVADLaVAIFVLPLNVAYFL-LGKWLFGIHLCQMWLTC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15060   80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIG--WNDWPENFTETTPCTLTEE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVgfiipfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhLHFlhn 262
Cdd:cd15060  158 KGYVIYSSSGSFFI-------------PLLIMTIVYVKIFIATSKERRAARTLGIIMGVFVVCWLPFFLMYVI-LPF--- 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 532164737 263 etkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15060  221 ----CETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
27-304 1.70e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 57.92  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15008    3 SLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEkNNTKCFEPPQDNQTKNHV 186
Cdd:cd15008   83 PGVQIYVLLSICVDRFYTIVYPLS--FKVSREKAKKMIAASWLFDAAFVSPALFFYGSNWG-PHCNFFLPDSWDGAAYAI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 lvlhyVSLFVGFIIPFVIIIVCYTMIILTL---------LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHl 257
Cdd:cd15008  160 -----IHLLVGFLVPSILIILFYQKVIKYIwrigtdgrtVRRTMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWH- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 258 hflhnetkPCDSVLRMQKSVVITLSLAA-SNCCFDPLLYFFSGGNFRK 304
Cdd:cd15008  234 --------PRESDYRQSSLVFLAVTWISfSSSASKPTLYSVYNANFRR 273
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
40-306 2.31e-09

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 57.76  E-value: 2.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  40 GNGFVLYVLIKTYHKK-SAFQVYMINLAVADLLCVC-TLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFFMTAM 117
Cdd:cd15383   17 SNLAVLWSATRNRRRKlSHVRILILHLAAADLLVTFvVMPLDAAWNVTVQ-WYAGDLACRLLMFLKLFAMYSSAFVTVVI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 118 SFFRCIAIVFPVqNINLVTQKKARFVCVGiWIFVILTSSP----FLMAKPQKDEkNNTKC-----FEPPQDNQTKNhvlV 188
Cdd:cd15383   96 SLDRHAAILNPL-AIGSARRRNRIMLCAA-WGLSALLALPqlflFHTVTATPPV-NFTQCathgsFPAHWQETLYN---M 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 189 LHYVSLFVgfiIPFVIIIVCYTMIILTLLKKSMKKNLSSHK----------------KAIGMIMVVTAAFLVSFMPYHIQ 252
Cdd:cd15383  170 FTFFCLFL---LPLLIMIFCYTRILLEISRRMKEKKDSAKNevalrsssdnipkarmRTLKMTIVIVSSFIVCWTPYYLL 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 253 RTIHLHFlhnetkPCDSVLRMQKSVVITLSL-AASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15383  247 GLWYWFS------PEMLEQTVPESLSHILFLfGLLNACLDPLIYGLFTISFRRGL 295
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
25-166 2.85e-09

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 57.12  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKgIWLFGDFLCRLstyAL 103
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLD-VWIFGHTWCQI---WL 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 104 YVNLY---CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKD 166
Cdd:cd15063   78 AVDVWmctASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLsFVICFPPLVGWNDGKD 144
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
30-251 3.10e-09

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 57.14  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC--VCtLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15399    7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVntLC-LPFTLVYTL-LDEWKFGAVLCHLVPYAQALAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNinlVTQKKARFVCVGI-WIFVILTSSPFLMAKPQKDEK-----NNTKCFEpPQDNQ 181
Cdd:cd15399   85 HVSTVTLTVIALDRHRCIVYHLES---KISKKISFLIIGLtWAASALLASPLAIFREYSVIEispdfKIQACSE-KWPNG 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 182 TKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSH-----KKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd15399  161 TLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHyhqrrRKTTKMLVCVVVVFAVSWLPFHA 235
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-304 3.29e-09

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 56.88  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKT---YHKKSAFQVYMINLAVADLLCVCT---LPLRVVYYVHKGiWLFGDFLCRL 98
Cdd:cd15130    2 LVTAIYLALFVVGTVGNSVTLFTLARKkslQSLQSTVRYHLGSLALSDLLILLLampVELYNFIWVHHP-WAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  99 STYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN-----TKC 173
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDgthpgGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 174 FEPPQDNQTknhVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKksmkknlsSHKKAIGMIMVVTAAFLVSFMPYHIQR 253
Cdd:cd15130  161 CTPIVDTAT---LKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQ--------ALRRGVLVLRAVVIAFVVCWLPYHVRR 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 254 TIHLHFLHNE-TKPCDSVLRMQKSVVITLSLAASncCFDPLLYFFSGGNFRK 304
Cdd:cd15130  230 LMFCYISDEQwTTFLFDFYHYFYMLTNALFYVSS--AINPILYNLVSANFRQ 279
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
25-253 4.42e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 56.80  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKT---YHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYV-HKGIWLFGDFLCRLS 99
Cdd:cd15356    2 LFTAVYALIWALGAAGNALTIHLVLKKrslRGLQGTVHYHLVSLALSDLLIlLISVPIELYNFVwFHYPWVFGDLVCRGY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 100 TYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEkNNTKCFEPPQD 179
Cdd:cd15356   82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKYE-LETADGEPEPS 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 180 NQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKnLSSHKKAIGMIMVVTAAFLVSFMPYHIQR 253
Cdd:cd15356  161 SRVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLR-IQSLQHSVQVLRAIVIAYVICWLPYHARR 233
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-157 4.62e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 56.77  E-value: 4.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15133    4 CLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFET 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15133   84 VCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALP 135
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
32-306 5.30e-09

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 56.48  E-value: 5.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKK-SAFQVYMINLAVADLL--------CVCTLPLRVVYYVHKGIWL------FGDFLC 96
Cdd:cd14980    9 IIGILALIGNILVIIWHISSKKKKkKVPKLLIINLAIADFLmgiylliiAIADQYYRGRYAQYSEEWLrsppclLACFLV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  97 RLSTYAlyvnlycSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVIL-----TSSPFLMAKPQKDEKNNT 171
Cdd:cd14980   89 SLSSLM-------SVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIfaaipILYSINQPGDNRLYGYSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 172 KCFEPPQDNqtknhVLVLHYVSLFVGFIIPF-VIIIVCYTMIILTLLKKSMKKNLSSHKK----AIGMIMVVTAAfLVSF 246
Cdd:cd14980  161 ICMPSNVSN-----PYYRGWLIAYLLLTFIAwIIICILYILIFISVRKSRKSARRSSSKRdkriAIRLALILITD-LICW 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 247 MPYHI---QRTIHLHFLhnetkpcdSVLRMQKSVVITLSLaasNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd14980  235 LPYYIvifSGLLTSTEI--------DIHVLQFIAILALPL---NSAINPYLYTLTTPTFKRDF 286
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
27-177 7.45e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 56.31  E-value: 7.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYalyV 105
Cdd:cd15058    4 LLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVV-TGKWQLGNFWCELWTS---V 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 106 NLYC---SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS-SPFLMAKPQKDEKNNTKCFEPP 177
Cdd:cd15058   80 DVLCvtaSIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDCYQDP 155
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
29-306 1.00e-08

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 55.60  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYyVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15391    6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLiMALFCMPFTFTQ-IMLGHWVFPAPMCPIVLYVQLVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSS-PFLMAKPQK---DEKNNTKCFEP-PQDNQT 182
Cdd:cd15391   85 TASVLTNTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLSSvQLFAGRTQRygqYSEGRVLCGESwPGPDTS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KnhvlVLHYVSLFVGFIIP-FVIIIVCYTMIILTLLKKSMKKN---------LSSHKKAIGMIMVVTAAFLVSFMPYHIQ 252
Cdd:cd15391  163 R----SAYTVFVMLLTYIIpLLILTSTYGYVGFRLWNRTAPGNadkgrddmqIKSKRKVIKMLVFVVLMFGICWLPLHLF 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 253 RTIHLHFLHNETKPCDSVLRMQKSVVItlsLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15391  239 NLVQDFSTVFRNMPQHTTRLIYGACHW---IAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
28-306 1.16e-08

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 55.29  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVHKGiWLFGDFLCRLSTYALYVN 106
Cdd:cd15124    5 TVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADE-WLFGRVGCKLIPFIQLTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP---FLMAKPQKDEKNN---TKCFEPPQDN 180
Cdd:cd15124   84 VGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPeavFSDLHPFYDKSTNktfVSCAPYPHSN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTknHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKS----------MKKNLSSHKKAIGMIMVVTAAFLVSFMPYH 250
Cdd:cd15124  164 EL--HPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAynlpvegnvhVRRQIESRKRLAKTVLVFVGLFAFCWLPNH 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 251 IqrtIHLHFLHNETKPCDSVLRMQKSVVITLsLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15124  242 I---IYLYRSYHYSEVDTSMLHFVSSICARI-LAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
31-304 1.74e-08

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 54.80  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15062    8 GAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATLEV-LGYWAFGRIFCDVWAAVDVLCCTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfeppQDNQTKNHVLVL 189
Cdd:cd15062   87 SIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQAC----GVNEEPGYVLFS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFVIiivcYTMIILTLLKksmkknLSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHNETKPCDS 269
Cdd:cd15062  163 SLGSFYLPLAIILVM----YCRVYVVAFK------FSREKKAAKTLGIVVGAFVLCWFPFFV--VLPLGSLFSTLKPPEP 230
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 532164737 270 VLRmqksvvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15062  231 VFK------VVFWLGYFNSCLNPIIYPCSSREFKR 259
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-304 3.41e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 53.87  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15064    4 SVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLvAVLVMPLSAVYEL-TGRWILGQVLCDIWISLDVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEknntkcfEPPQDNQTKNH 185
Cdd:cd15064   83 CCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDS-------EDPSECLISQD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYvSLFVGFIIpfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYhiqrtihlhFLHNETK 265
Cdd:cd15064  156 IGYTIF-STFGAFYI---------PLLLMLILYWKIYRAAARERKAAKTLGIILGAFIVCWLPF---------FLVALIV 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532164737 266 PCDSVLRMQKSVV-ITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15064  217 PLCSHCWIPLALKsFFLWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-178 3.56e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 54.14  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15958    4 SLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVV-RGRWLYGSFFCELWTSVDVL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-PFLMAKPQKDEKNNTKCFEPPQ 178
Cdd:cd15958   83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFlPIMMHWWRDEDDQALKCYEDPG 156
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
30-306 3.85e-08

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 54.05  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15395    7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLmTIMCLPFTFVYTLMDH-WVFGEAMCKLNSMVQCISIT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQninlvTQKKARFVCVGI---WIFVILTSSPFLMAKPQKDE--KNNTKCFEP------- 176
Cdd:cd15395   86 VSIFSLVLIAIERHQLIINPRG-----WRPNNRHAYVGIaviWVLAVLTSLPFLIFQVLTDEpfKNVNVSLDAykgkyvc 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 177 ----PQDNQTKNH---VLVLHYVSLFVgfiipfvIIIVCYTMIILTLLKKS-----MKKN--LSSHKKAIG-MIMVVTAA 241
Cdd:cd15395  161 ldqfPSDTIRLSYttcLLVLQYFGPLC-------FIFICYLKIYIRLKRRNnmmdkMRDNkyRSSETKRINiMLISIVVA 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 242 FLVSFMPYHIQRTIhLHFLHNETKPCDSVLRMqksvVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15395  234 FAVCWLPLNIFNAV-FDWNHEAIATCNHNLLF----LICHLTAMISTCVNPIFYGFLNKNFQRDL 293
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
28-157 3.93e-08

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 53.85  E-value: 3.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVN 106
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTL-TGKWPFGKVFCKAWLVVDYTL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 532164737 107 LYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15048   84 CTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGP 134
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-157 4.04e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 53.67  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLcvctlpLRVVYYVHKGIW-----LFG-DFLCR 97
Cdd:cd15387    1 KVEVTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLV------VAVFQVLPQLIWditfrFYGpDFLCR 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  98 LSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINlvtQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15387   75 LVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLH---RRSDRVYVLFSWLLSLVFSIP 131
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
65-304 1.01e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 52.56  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  65 LAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKA-RF 142
Cdd:cd15055   42 LAVADFLVgLLVMPFSMIRSIETC-WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVkIC 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 143 VCVGiWIFVILTSSPFLMAK-PQKDEKNNTKCFeppqdnqtKNHVLVLHYVSLFVgfIIPFVIIIVCYTMIIL------- 214
Cdd:cd15055  121 ICLC-WFVSALYSSVLLYDNlNQPGLIRYNSCY--------GECVVVVNFIWGVV--DLVLTFILPCTVMIVLymrifvv 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 215 ---------------TLLKKSMKKNLSSHKKA---IGMIMVVtaaFLVSFMPYHIQRTIHLHFLHNETkpcdsvlrmqkS 276
Cdd:cd15055  190 arsqarairshtaqvSLEGSSKKVSKKSERKAaktLGIVVGV---FLLCWLPYYIVSLVDPYISTPSS-----------V 255
                        250       260
                 ....*....|....*....|....*...
gi 532164737 277 VVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15055  256 FDVLIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
24-162 1.37e-07

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 52.08  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYAL 103
Cdd:cd15388    1 QVEIAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQ 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGiWIFVILTSSP--FLMAK 162
Cdd:cd15388   81 VVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPqvFIFSK 140
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
33-317 1.43e-07

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 52.02  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYhKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS- 110
Cdd:cd15110   10 ICLLGLVGNGIVLWFLGFRI-RRNPFTVYILHLAIADFtFLLCIFILSIMYIGPFNFSHSRDYVAMLIFIILFLFGYNTg 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTkcfeppqdnqtknhvLVL 189
Cdd:cd15110   89 LYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALsVLMTSLEYLMCIDEGFHVRNE---------------CRA 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 190 HYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSShkKAIGMIMVVTAAFLVSFMPYHIQrtIHLHFLHNETkpcds 269
Cdd:cd15110  154 VLIFIGILTFLVFTPLMLISSLILFIKVRCNSQRRHPG--KLYIIIMLTVIFFLIFAMPMRVL--LLLNYLHHSS----- 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 270 vLRMQKSVVITLSLAasNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSV 317
Cdd:cd15110  225 -FLFSNPVPFLLSTV--NSSINPIVYFLVGSLRRKRIKKSLKVALQRV 269
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
25-303 2.59e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 51.39  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15085    2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVcVGIWIFVILTS-SPFLMAKPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15085   82 YFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGL-LFIWLFCLFWAvAPLFGWSSYGPEGVQTSCSIGWEERSWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NH-VLVLHYVSLFVgfiIPFVIIIVCYTMIILTL--LKKSM-----KKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15085  161 NYsYLILYFLMCFV---IPVAIIGFSYGNVLRSLhkLNKKIeqqggKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 256 HLHFLHNETKPCDSVLRMQksvvitlsLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15085  238 VVVNPELSISPLAATMPTY--------FAKTSPVYNPIIYIFLNKQFR 277
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
40-303 2.59e-07

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 50.99  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  40 GNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMS 118
Cdd:cd15308   17 GNVLVCLSVCTERALKTTTNYFIVSLAVADLLlALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 119 FFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfePPQDNqtkNHVLVLHYVSLFVgf 198
Cdd:cd15308   97 VDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVC--KLEDN---NYVVYSSVCSFFI-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 199 iipfviiiVCYTMIILTLlkkSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihlhfLHNETKPCDSVLRMQKSVV 278
Cdd:cd15308  170 --------PCPVMLVLYC---AMFRGLGRERKAMRVLPVVVGAFLFCWTPFFV--------VHITRALCESCSIPPQLIS 230
                        250       260
                 ....*....|....*....|....*
gi 532164737 279 ITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15308  231 IVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
60-152 3.74e-07

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 50.78  E-value: 3.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  60 VYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKK 139
Cdd:cd15169   38 VYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCY 117
                         90
                 ....*....|...
gi 532164737 140 ARFVCVGIWIFVI 152
Cdd:cd15169  118 SWGVCAAIWALVL 130
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
27-308 4.58e-07

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 50.63  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLcvCTLPLRVVYYVHK--GIWLFGDFLCRLSTYALY 104
Cdd:cd15084   14 AVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLL--VTLFGSSVSFSNNivGFFVFGKTMCEFEGFMVS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIFVILTSSPFLMA-KPQKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15084   92 LTGIVGLWSLAILAFERYLVICKPMGDFRF-QQRHAVSGCAFTWGWSLLWTSPPLFGwSSYVPEGLRTSCGPNWYTGGTN 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLhyvSLFVGFIIP-FVIIIVCYTMIILTL-----LKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTihl 257
Cdd:cd15084  171 NNSYIL---ALFVTCFALpLSTIIFSYSNLLLTLravaaQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAM--- 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 258 hflhnetkpcdsVLRMQKSVVITLSLAA-------SNCCFDPLLYFFSGGNFRKRLST 308
Cdd:cd15084  245 ------------VVATNKDVVIQPTLASlpsyfskTATVYNPIIYVFMNKQFRSCLLE 290
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-177 4.70e-07

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 50.63  E-value: 4.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15957    6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMgLAVVPFGAAHILLK-TWTFGNFWCEFWTSIDVLCV 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS-PFLMAKPQKDEKNNTKCFEPP 177
Cdd:cd15957   85 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFlPIQMHWYRATHQEAINCYAEE 155
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
40-304 6.77e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 49.91  E-value: 6.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  40 GNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCT-LPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMS 118
Cdd:cd15327   17 GNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFSATLEV-LGFWAFGRVFCDIWAAVDVLCCTASILSLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 119 FFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVgf 198
Cdd:cd15327   96 VDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITEEPGYALFSSLFSFYLPLMV-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 199 iipfviIIVCYTMIILTLLKksmkknLSSHKKAIGMIMVVTAAFLVSFMPYHIqrTIHLHFLHNETKPCDSVLRmqksvv 278
Cdd:cd15327  174 ------ILVMYFRVYVVALK------FSREKKAAKTLAIVVGVFILCWFPFFF--VLPLGSFFPALKPSEMVFK------ 233
                        250       260
                 ....*....|....*....|....*.
gi 532164737 279 ITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15327  234 VIFWLGYFNSCVNPIIYPCSSKEFKR 259
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-304 7.54e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 49.67  E-value: 7.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHkGIWLFGDFLCRLSTYAL 103
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRQLL-GYWPLGSHLCDFWISLD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEppqdNQTK 183
Cdd:cd15061   80 VLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYY----TYDK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLFVgfiipfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihlhfLHNE 263
Cdd:cd15061  156 GYRIYSSMGSFFL-------------PLLLMLFVYLRIFRVIAKERKTAKTLAIVVGCFIVCWLPFFI--------MYLI 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 264 TKPCDSVLRMQKSVVITLsLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15061  215 EPFCDCQFSEALSTAFTW-LGYFNSVINPFIYAFYNKDFRR 254
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
27-304 7.68e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 49.56  E-value: 7.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15334    4 SLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLvAVLVMPFSIMYIV-KETWIMGQVVCDIWLSVDIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNtKCFeppqdnqTKNH 185
Cdd:cd15334   83 CCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRED-ECI-------IKHD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIpfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhlhflhneTK 265
Cdd:cd15334  155 HIVFTIYSTFGAFYI---------PLALILILYYKIYRAATRERKAATTLGLILGAFVICWLPFFVKEVI--------VN 217
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 266 PCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15334  218 TCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKK 256
7tmA_FP cd15145
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...
26-295 7.78e-07

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.


Pssm-ID: 320273 [Multi-domain]  Cd Length: 290  Bit Score: 49.82  E-value: 7.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISV-VGFFGNGFVLYVLIKTYHK-----KSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGD---FL 95
Cdd:cd15145    2 LSVFFSIIFMtVGILSNSLAIAILMKAYQRfrqksKASFLLLASGLVITDFFGhLINGTIAVFVYASDKDWIRFDqsnIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  96 CRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS-SPFLMAKPQKDEKNNTKCF 174
Cdd:cd15145   82 CSVFGICMVFFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVAlLPILGHRDYQIQASRTWCF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 ---EPPQDNQTKNHVLVLHYVSLFVgfiipFVIIIVCYTMIILTLLKKSMKKNLSSHKKA--IGMIMVVTAAFLVSFMPY 249
Cdd:cd15145  162 yktEHIEDWEDRFYLLLFSFLGLLA-----LAISFLCNAITGITLLRVKFRSQQHRQGRShhFEMVIQLLAIMCVSCICW 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 250 HIQRTIHLHFLHNETKPCDSVLRMqksvVITLSLAASNCCFDPLLY 295
Cdd:cd15145  237 SPFLVTMANIGINGRDSLESCETI----LFALRMATWNQILDPWVY 278
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
28-299 8.51e-07

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 49.79  E-value: 8.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTyHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd14994    6 FLYSVVLIGGVIGVILMSFLLVKM-NTRSVTTTAVINLIVVHSLFLLTVPFRIYYYA-SKTWKFGMPLCKMVSAMIHIHM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEpPQDNQTKNHV 186
Cdd:cd14994   84 HLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPvFVKEYGSSSSYNSDQCFK-FHKELEVHYV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 187 LVLHYvsLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHK------KAIGMIMVVtaafLVSFMPYHIQRTIHLhfl 260
Cdd:cd14994  163 KVLNY--IIICIVLIVTLALLGFQVFILGHVYRKLRASLLSHQefwaqmKSLFFIVVI----IVCFVPYNLFRIYYL--- 233
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 261 hNETKPCDSVLRMQKsvvITLSLAASNcCFDPLLYFFSG 299
Cdd:cd14994  234 -SQVIQNEKLDPYNE---IFLAVTALS-CLDLLTFVGRG 267
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
39-306 1.24e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 49.37  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  39 FGNGFVLYVL--IKTYHKKSAFQVYmiNLAVAD-LLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSIFFMT 115
Cdd:cd15317   16 SGNLVVIISIshFKQLHSPTNMLVL--SLATADfLLGLCVMPFSMIRTV-ETCWYFGDLFCKFHTGLDLLLCTTSIFHLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 116 AMSFFRCIAIVFPVQNINLVTQKKA-RFVCVGiWIFVILTSSPFLMAKPQKDEKNNT----KCFEPPQDNQTKNHVLvLH 190
Cdd:cd15317   93 FIAIDRYYAVCDPLRYPSKITVQVAwRFIAIG-WLVPGIYTFGLIYTGANDEGLEEYsseiSCVGGCQLLFNKIWVL-LD 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 191 YVSLFVgfiipfviiiVCYTMIIL-----------------------TLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFM 247
Cdd:cd15317  171 FLTFFI----------PCLIMIGLyakiflvarrqarkiqnmedkfrSSEENSSKASASRERKAAKTLAIVMGIFLFCWL 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 248 PYHIQRTIHlHFLHNETKPCdsvlrmqksVVITLS-LAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15317  241 PYFIDTIVD-EYSNFITPAI---------VFDAVIwLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
25-304 1.45e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.96  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHkGIWLFGDFLCRLstYAL 103
Cdd:cd15073    2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAASDLH-GSWKFGYAGCQW--YAF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLY--CSIFFMTAMSFFRCIAIVFPvQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTKCfeppQDN 180
Cdd:cd15073   79 LNIFFgmASIGLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNaFFWAAMPLVGWASYALDPTGATC----TIN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYV-SLF-VGFIIPFVIIIVCYTMIILTLLKKSMKKNLS------SHKKAIG-MIMVVTAAFLVSFMPYHI 251
Cdd:cd15073  154 WRKNDSSFVSYTmSVIvVNFIVPLAVMFYCYYNVSRFVKKVLASDCLEsvnidwTDQNDVTkMSVIMIVMFLVAWSPYSI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 532164737 252 qrtIHLHFLHNETKPCDSVLrmqksVVITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15073  234 ---VCLWASFGEPKKIPPWM-----AIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
42-309 1.52e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 48.75  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  42 GFVLYVLIKTYHKK--SAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMS 118
Cdd:cd15305   17 GNILVIMAVSLEKKlqNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 119 FFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEK--NNTKCFEppqdnQTKNHVLVLHYVSLFV 196
Cdd:cd15305   97 LDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKvfVNGTCVL-----NDENFVLIGSFVAFFI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 197 GFIIPFVIiivcYTMIILTLLKKSMKKNLSSHKKAIGMIMVVtaaFLVSFMPYHIqrTIHLHFLHNETkpCDSVLrMQKS 276
Cdd:cd15305  172 PLIIMVIT----YCLTIQVLQRQQAINNERRASKVLGIVFFL---FLIMWCPFFI--TNILSVLCKEA--CDQKL-MEEL 239
                        250       260       270
                 ....*....|....*....|....*....|...
gi 532164737 277 VVITLSLAASNCCFDPLLYFFSGGNFRKRLSTF 309
Cdd:cd15305  240 LNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNY 272
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
29-298 1.77e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 48.58  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd14964    4 ILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN---TKCFEPPQDNQTKNH 185
Cdd:cd14964   84 ASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTltgSCYLICTTIYLTWGF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFiipfviiivcYTMIILTLLKKSMK--------KNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihL 257
Cdd:cd14964  164 LLVSFLLPLVAFL----------VIFSRIVLRLRRRVrairsaasLNTDKNLKATKSLLILVITFLLCWLPFSI-----V 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 258 HFLHNETKPCDSVLRMqksVVITLSLAASNCCFDPLLYFFS 298
Cdd:cd14964  229 FILHALVAAGQGLNLL---SILANLLAVLASTLNPFIYCLG 266
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
32-160 3.16e-06

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 47.98  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737   32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-----CVCTLPLrVVYYVHKGIWLFGDFLCRLSTYALYVN 106
Cdd:pfam10328   2 LISLIGLVANLLVFIAFLKLPSLKNSFGILCLSQAIGNAIiclifLFYVVPM-TLFQNSFLPEWLNSHIIGLIAMGLYEI 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 532164737  107 LYCSIFFmtaMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM 160
Cdd:pfam10328  81 SPLSHLL---IALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCTVFYE 131
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-178 3.18e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 47.98  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLcvctLPLRVV----YYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLV----MGLLVVppgaTILLTGHWPLGTTVCELWTSVDV 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNN--TKCFEPPQ 178
Cdd:cd15959   82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEeaQRCYDNPR 157
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
29-305 3.95e-06

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 47.44  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKsAFQVYMINLAVADLLCVC----TLPLRVVYYVHkgIWLFGDFLCRLSTYALY 104
Cdd:cd15106    6 LTCIISLVGLTGNAVVLWLLGFRMRRN-AFSVYILNLAAADFLFLCchiiDSLLRLINIFH--IISIPKILTNVMTFPYF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYcsifFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS------SPFLMAkpqkdEKNNTKCfeppq 178
Cdd:cd15106   83 AGLS----MLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSilewkfCGFLFS-----GADSHWC----- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 dnQTKNHVLVLHYVSLFVgfiipfvIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVtaaFLVSFMPYHIQRTIHLH 258
Cdd:cd15106  149 --QTFDFITTAWLIFLFV-------VLCGSSLALLVRILCGSRKMPLTRLYVTILLTVLV---FLLCGLPFGIQWFLLLW 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 259 F-LHNETKPCDSVLrmqksvvITLSLAASNCCFDPLLYFFSgGNFRKR 305
Cdd:cd15106  217 IhIDLEVLFCHVYL-------VSVVLSCLNSSANPIIYFFV-GSFRQR 256
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
28-157 5.62e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 47.51  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15385    5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGM 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTqKKARFVCVGIWIFVILTSSP 157
Cdd:cd15385   85 FASTYMLVMMTADRYIAICHPLKTLQQPT-KRSYLMIGSAWALSFILSTP 133
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-253 5.65e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 47.53  E-value: 5.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIK---TYHKKSAFQVYMINLAVADLLcVCTLPLRVVYY----VHKGiWLFGDFLCRLSTY 101
Cdd:cd15355    6 IYLALFVVGTVGNSITLYTLARkksLQHLQSTVHYHLASLALSDLL-ILLLAMPVELYnfiwVHHP-WAFGDAACRGYYF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 102 ALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQK---DEKNNTKCFEPPQ 178
Cdd:cd15355   84 LRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQnrsGTHPGGLICTPIV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DNQTKNHVL----------------VLHYV---SLFVGFIIPFVIIIVCYTMIILTLLKKSMKKN-LSSHKKAIGMIMVV 238
Cdd:cd15355  164 DTSTLKVVIqvnaflsflfpmlvisVLNTLianQLTVMVNQAEQENQVCTIGGQRTVLSVSMEPGrVQSLRHGVLVLRAV 243
                        250
                 ....*....|....*
gi 532164737 239 TAAFLVSFMPYHIQR 253
Cdd:cd15355  244 VIAFVVCWLPYHVRR 258
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
29-251 6.02e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.85  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15304    6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADmLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNqtkNHVL 187
Cdd:cd15304   86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADE---NFVL 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737 188 VLHYVSLFVGFiipfviiivcyTMIILT--LLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd15304  163 IGSFVAFFIPL-----------TIMVITyfLTIKSLQQSISNEQKASKVLGIVFFLFVVMWCPFFI 217
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
31-304 7.74e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 46.65  E-value: 7.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15050    8 STISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLL-ESKWILGRPVCLFWLSMDYVASTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFL----MAKPQKDEKNNTKCfeppqdnQTKnh 185
Cdd:cd15050   87 SIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhhFARGGERVVLEDKC-------ETD-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 vlvLHYVSLFvgfIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIhLHFLHNEtk 265
Cdd:cd15050  158 ---FHDVTWF---KVLTAILNFYIPSLLMLWFYAKIFKAVNRERKAAKQLGFIMAAFILCWIPYFILFMV-IAFCKNC-- 228
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 266 pCDSVLRMqksvvITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15050  229 -CNENLHM-----FTIWLGYINSTLNPFIYPLCNENFKK 261
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
24-155 1.03e-05

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 46.24  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHKkSAFQVYMINLAVADLLCVCT------LPLRVVYYVHKGIWLFgdflcr 97
Cdd:cd15107    1 NTMNFLSIIIALVGLAGNAIVLWLLGFHMHR-NAFSVYILNLAGADFLFLCTqivfslEIVLQFHSIDIHIPLF------ 73
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737  98 lSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS 155
Cdd:cd15107   74 -LLTVTMFAYLAGLSMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLS 130
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-165 1.41e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 45.91  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFG 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQK 165
Cdd:cd15212   86 IVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSLPwYLLASAPE 142
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
31-194 1.43e-05

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 45.97  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLikTYHKK------SAFQVYMINLAVADLLCVCTL-PLRVVYYVHKGIWL---FGDFLCRLST 100
Cdd:cd15141    8 TLMFAAGVVGNLLALGIL--GVHRKerrtksSAFCVLVTGLAATDLLGTCFLsPMVFVSYAQNSSLLglaAGQPLCHLFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 101 YALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTKCF---EP 176
Cdd:cd15141   86 FAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFgALFCALPLLGVGRHKQYCPGTWCFirmTV 165
                        170
                 ....*....|....*...
gi 532164737 177 PQDNQTKNHVLVLHYVSL 194
Cdd:cd15141  166 PGHREPGSLAFSLLYASL 183
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
29-297 1.59e-05

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 45.92  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15398    6 LYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWI--FVILTSSPFLMAKPQKDE-------KNNTKCFEP-PQ 178
Cdd:cd15398   86 VSTLMLMSIAIVRYHMIKHPLS--NHLTANHGYFLLGTVWTlgFTICSPLPVFHKIVDLSEtfnleslKNKYLCIESwPS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DNQTKNHVLVLHYVSLFVgfiipfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIqrtihLH 258
Cdd:cd15398  164 DSYRIAFTISLLFVQYIL-------------PLVCLTVSHTSVCRSVKRSRSVFYRLTIVILAFAVSWMPLHL-----FH 225
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 532164737 259 FLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd15398  226 LVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGF 264
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
27-304 1.78e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 45.94  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLI----KTYHKKSAFQvYMINLAVADLLcVCTLPLRVVYYvhKGIWL-----FGDFLCR 97
Cdd:cd15135    4 TLLYSLILVAGILGNSATIKVTQvlqkKGYLQKSVTD-HMVSLACSDLL-VLLLGMPVELY--SAIWDpfatpSGNIACK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  98 LSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVgIWIFVILTSSPFLMAKPQKDEKNNTKCFE-- 175
Cdd:cd15135   80 IYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICF-VWLTSALVALPLLFAMGTEDPLEAFPSYRgt 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 176 -PPQDNQTKNHVL--------VLHYVSLF----VGFIIPFVIIIVCYTMIilTLLKKSMKKNL----------------- 225
Cdd:cd15135  159 rHHCQDQKSNLTIctslsskwTVFQASIFsafvLYLLVLASVAFMCRRMM--RALMGSKKGAVavkgpggsvqllrkhes 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 226 ----SSHKKAIGMIMVVTAAFLVSFMPYHIQRtihlhfLHNETKPCDSVLRMQKSVVITLsLAASNC------CFDPLLY 295
Cdd:cd15135  237 aegkTARKQTILFLGLIVGTLAVCWMPNQIRR------IMAAAKPKDDWTRSYFRAYIIL-LPIADTffylssVLNPLLY 309

                 ....*....
gi 532164737 296 FFSGGNFRK 304
Cdd:cd15135  310 NLSSQQFRS 318
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
30-157 1.80e-05

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 45.59  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  30 YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLY 108
Cdd:cd15981    7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITG-WPFDNAMCKMSGLVQGMSVS 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 109 CSIFFMTAMSFFRCIAIVFPVQniNLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15981   86 ASVFTLVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWVLALIIMCP 132
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
35-192 2.24e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 45.28  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFF 113
Cdd:cd15402   12 VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVvAIYPYPLVLTSIFHNG-WNLGYLHCQISGFLMGLSVIGSIFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 114 MTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP-QKDEKNNTKCFEPPQDNQTKNHVLVLHYV 192
Cdd:cd15402   91 ITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSlQYDPRIYSCTFAQSVSSAYTIAVVFFHFI 170
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
25-156 2.26e-05

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 45.28  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYhKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15109    2 VMNYIFLLLCLCGLVGNGLVLWFFGFSI-KRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSS 156
Cdd:cd15109   81 CTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTC 132
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
25-174 2.36e-05

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 45.13  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYvLIKTYHKKSAFQVYMINLAVADLL---CVCTLPLRVVYYVHKGIWLFGDFLCRLSTY 101
Cdd:cd15108    2 VLSALVMFTCVCGMAGNGLVVW-LLSCRGRRTPFCVYVLHLAVADLLfllCMASTLSLETSPLVITHDLAYEVVRRVKYF 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 102 ALYVNLYcsifFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCF 174
Cdd:cd15108   81 AYTASLS----LLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSEFWHPDEWQCF 149
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
35-303 2.97e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 44.82  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFM 114
Cdd:cd15077   12 IAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 115 TAMSFFRCIAIVFPVQNINLVTqKKARFVCVGIWIFVILTSSPFLMAKPQKDEKnNTKCFEPPQ----DNQTKNHVLVLH 190
Cdd:cd15077   92 AVVAFERFLVICKPLGNFTFRG-THAIIGCIATWVFGLAASLPPLFGWSRYIPE-GLQCSCGPDwyttNNKWNNESYVMF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 191 YVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHK---KAIGMIMVVTAAFLVSFMPYHIqrtIHLHFLHNETKPC 267
Cdd:cd15077  170 LFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKaerEVTKMVVVMVLGFLVCWLPYAS---FALWVVTNRGEPF 246
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 532164737 268 DSVLRMQKSVvitlsLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15077  247 DLRLASIPSV-----FSKASTVYNPVIYVFMNKQFR 277
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
31-157 3.09e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 44.65  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCR-------LSTYA 102
Cdd:cd15067    7 SLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDvwhsfdvLASTA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 103 LYVNLyCSIffmtamSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15067   87 SILNL-CVI------SLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFP 134
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
35-192 3.35e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 44.90  E-value: 3.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL-LCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFF 113
Cdd:cd15401   12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLvVAVYPYPLILLAIFHNG-WTLGNIHCQISGFLMGLSVIGSVFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 114 MTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYV 192
Cdd:cd15401   91 ITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPnFFVGSLQYDPRIYSCTFAQTVSSSYTITVVVVHFI 170
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
26-306 3.85e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 44.67  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKK-SAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15104    2 AGVILAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILT-SSPFLMAKPQKDEkNNTKC-FeppqDNQT 182
Cdd:cd15104   82 TSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIgFLPLISPQFQQTS-YKGKCsF----FAAF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVlvlHYVSLFVGFIIPFVIIIVCYTMIILT--------------LLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMP 248
Cdd:cd15104  157 HPRV---LLVLSCMVFFPALLLFVFCYCDILKIarvhsraiykvehaLARQIHPRRTLSDFKAARTVAVLIGCFLLSWLP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 249 YHIQRTIHLhflhnetkPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15104  234 FQITGLVQA--------LCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
31-256 5.52e-05

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 44.19  E-value: 5.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYC 109
Cdd:cd15297    8 GSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTV-IGYWPLGPVVCDLWLALDYVVSNA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 110 SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP------FLMAKPQKDEKnntKCfeppqdnqtk 183
Cdd:cd15297   87 SVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPailfwqFIVGGRTVPEG---EC---------- 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532164737 184 nhvlvlhYVSLFVGFIIPFVIIIVCYTM--IILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd15297  154 -------YIQFFSNAAVTFGTAIAAFYLpvIIMTVLYWQISRASSREKKVTRTILAILLAFIITWTPYNVMVLIN 221
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
25-128 7.89e-05

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 43.63  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHkGIWLFGDFLCRLSTYAL 103
Cdd:cd15056    2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVaVLVMPFGAIELVN-NRWIYGETFCLVRTSLD 80
                         90       100
                 ....*....|....*....|....*
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFP 128
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQ 105
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
32-153 8.04e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 8.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADL--------LCVCTLPLRVVYYVHKGIWLFG------DFLCR 97
Cdd:cd15136    9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFcmgiylglLAIVDAKTLGEYYNYAIDWQTGagcktaGFLAV 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 532164737  98 LSTYAlyvnlycSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL 153
Cdd:cd15136   89 FSSEL-------SVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALI 137
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
35-162 9.22e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 43.31  E-value: 9.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVL--IKTYHKKSAFQVymINLAVAD-LLCVCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSI 111
Cdd:cd15318   12 LIIVLGNLFVVVTVshFKALHTPTNFLL--LSLALADmLLGLTVLPFSTIRSV-ESCWYFGDSFCRLHTCLDTLFCLTSI 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 112 FFMTAMSFFRCIAIVFPVQNINLVTQKKA-RFVCVGiWIFVILTSSPFLMAK 162
Cdd:cd15318   89 FHLCFISIDRHCAICDPLLYPSKFTIRVAcIFIAAG-WLVPTVYTSVFLYTK 139
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
33-153 9.52e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 43.35  E-value: 9.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD------LLCVCTLPL--RVVYYVHKGIWLFGDFlCRLSTYALY 104
Cdd:cd15964   10 VNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADfcmgiyLLLIASVDLhtRSEYYNHAIDWQTGPG-CNTAGFFTV 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL 153
Cdd:cd15964   89 FASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFL 137
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-153 1.07e-04

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 43.27  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  31 SMISVVGFFGNGFVLYVLIKTYHK-----KSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15143    8 TIFSAIGLASNLFAFIVLVKSSRKtksrsRSSFLIFLCGLVVTDFLgLLVTGTIVISFHLTNFNWRVVDPDCYLCNFMGL 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 105 VNLY---CSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL 153
Cdd:cd15143   88 SMVFyglCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFL 139
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
33-303 1.28e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 43.12  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVHKGiWLFGDFLCRLSTYaLYVNLYC-S 110
Cdd:cd15213   10 MIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDiMLSLVCMPFAAVTIITGR-WIFGDIFCRISAM-LYWFFVLeG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIvfpVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqkdeknNTKCFEPPQDNQ-----TKNH 185
Cdd:cd15213   88 VAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVG--------WGKYEFPPRAPQcvlgyTESP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKksmkknlSSHKKAIGMIMVVTAAFLVSFMPYHIQRtihlhFLHNETK 265
Cdd:cd15213  157 ADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVR-------SFKTRAFTTILILFIGFSVCWLPYTVYS-----LLSVFSR 224
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 532164737 266 PCDSVLRMQksvVITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15213  225 YSSSFYVIS---TCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
25-195 2.02e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 42.62  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGdflCRLSTYAL 103
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFAITISTGFCAACHG---CLFIACFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIF-VILTSSPFL---MAKPQKDEKNNTKCFEPPQD 179
Cdd:cd15068   79 LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLsFAIGLTPMLgwnNCGQPKEGKNHSQGCGEGQV 158
                        170
                 ....*....|....*.
gi 532164737 180 NQTKNHVLVLHYVSLF 195
Cdd:cd15068  159 ACLFEDVVPMNYMVYF 174
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
25-170 2.11e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 42.14  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKgIWLFGDFLCRLSTYAL 103
Cdd:cd15215    1 IRSVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLqTVLVMPWVIATSVPL-FWPLDSHLCTALVVLM 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM--AKPQKDEKNN 170
Cdd:cd15215   80 HLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYgwGQAAFDERNA 148
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
25-304 2.34e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 42.22  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLcVCTL--PLRVVYYVhKGIWLFGDFLCRLstYA 102
Cdd:cd15321    8 AIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADIL-VATLiiPFSLANEL-MGYWYFRKTWCEI--YL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 103 LYVNLYC--SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAK-PQKDEKNNT-KCfeppQ 178
Cdd:cd15321   84 ALDVLFCtsSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKgKQKDEQGGLpQC----K 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 179 DNQTKNHVLVLHYVSLFVgfiipfviiiVCYTMIILTLLKKSMKKNlsSHKKAIGMIMVVTAAFLVSFMPYhiqrtihlH 258
Cdd:cd15321  160 LNEEAWYILSSSIGSFFA----------PCLIMILVYLRIYLIAKN--REKRFTFVLAVVIGVFVLCWFPF--------F 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 259 FLHNETKPCDSVLRMQKSVV-ITLSLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15321  220 FSYSLGAICPELCKVPHSLFqFFFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
27-255 2.54e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 41.83  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKgIWLFGDFLCRLSTYALYV 105
Cdd:cd15335    4 VLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLvAVLVMPLSITYIVMD-TWTLGYFICEIWLSVDMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCfeppqdnqTKNH 185
Cdd:cd15335   83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQC--------IIQH 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 186 VLVLHYVSLFVGFIIPfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTI 255
Cdd:cd15335  155 DHVIYTIYSTFGAFYI--------PLTLILILYYRIYHAASRERKAARILGLILGAFILSWLPFFIKELI 216
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
25-304 2.72e-04

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 42.03  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHkGIWLFGDFLCRLSTYAL 103
Cdd:cd15086    2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLvCVLGTPFSFAASTQ-GRWLIGEHGCRWYGFAN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQnINLVTQKKARFVCVGIWIFVIL-TSSPFLMAKPQKDEKNNTKCfepPQDNQT 182
Cdd:cd15086   81 SLFGIVSLISLAVLSYERYCTLLRPTE-ADVSDYRKAWLGVGGSWLYSLLwTLPPLLGWSSYGPEGPGTTC---SVQWTS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFV-GFIIPFVIIIVCYTMiILTLLKKSMKKNLSSHKK----AIGMIMVVTAAFLVSFMPYHIqrtihL 257
Cdd:cd15086  157 RSANSISYIICLFIfCLLLPFLVMVYCYGR-LLYAIKQVGKINKSTARKreqhVLLMVVTMVICYLLCWLPYGV-----M 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 532164737 258 HFLHNETKPcdSVLRMQKSVVITLsLAASNCCFDPLLYFFSGGNFRK 304
Cdd:cd15086  231 ALLATFGKP--GLVTPVASIVPSI-LAKSSTVVNPIIYVFMNKQFYR 274
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
25-303 2.81e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 42.23  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADllcVCTLPLRVVYYVHKGIWLFGDFL-CRLSTYAL 103
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAAD---VAVGLFAIPFAITISLGFCTDFHsCLFLACFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFV-ILTSSPFLmakPQKDEKNNTKCFEPPQDNQT 182
Cdd:cd15069   79 LVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAfGIGLTPFL---GWNKAMSATNNSTNPADHGT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLH-------------YVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKK--------AIGMIMVVTAA 241
Cdd:cd15069  156 NHSCCLISclfenvvpmsymvYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRttlqreihAAKSLAIIVGI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 242 FLVSFMPYHIQRTI-HLHFLHNETKPcdsvlRMQKSVVITLSLAasNCCFDPLLYFFSGGNFR 303
Cdd:cd15069  236 FALCWLPVHILNCItLFQPEFSKSKP-----KWAMNVAILLSHA--NSVVNPIVYAYRNRDFR 291
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
32-251 2.94e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 41.92  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15052    9 LLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLvGLLVMPLSILTELFGGVWPLPLVLCLLWVTLDVLFCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEK--NNTKCFEPpqdnqTKNHVLV 188
Cdd:cd15052   89 IMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNvlNNGTCVLF-----NPNFVIY 163
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532164737 189 LHYVSLFVgfiiPFVIIIVCYTMIIltllkksmkKNLSSHKKAIGMIMVVTAAFLVSFMPYHI 251
Cdd:cd15052  164 GSIVAFFI----PLLIMVVTYALTI---------RLLSNEQKASKVLGIVFAVFVICWCPFFI 213
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
61-304 3.19e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 41.73  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  61 YMINLAVADL-LCVCTLPLRVVYYVHkGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKK 139
Cdd:cd15301   38 FLFSLAVADFaIGVISMPLFTVYTAL-GYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKK 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 140 ARFVCVGIWIFVILTSSPFLMAKPQKDEKnntkcFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIvcyTMIIL--TLL 217
Cdd:cd15301  117 AAVMIASAWIISLLLWPPWIYSWPYIEGK-----RTVPAGTCYIQFLETNPYVTFGTALAAFYVPVT---IMCILywRIW 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 218 KKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPcdsvlrmqkSVVITLS--LAASNCCFDPLLY 295
Cdd:cd15301  189 RETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIP---------TELWDFSyyLCYINSTINPLCY 259

                 ....*....
gi 532164737 296 FFSGGNFRK 304
Cdd:cd15301  260 ALCNAAFRR 268
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
26-258 3.66e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 41.56  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  26 YSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15309    3 YAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFP-VQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKnntKCFeppqdnqTKN 184
Cdd:cd15309   83 MCTASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQN---ECI-------IAN 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532164737 185 HVLVLHyvSLFVGFIIPFVIIIVCYTMIILTLLKKsmkknlsshKKAIGMIMVVTAAFLVSFMPYHIQRTIHLH 258
Cdd:cd15309  153 PAFVVY--SSIVSFYVPFIVTLLVYVQIYIVLQKE---------KKATQMLAIVLGVFIICWLPFFITHILNMH 215
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
33-297 6.53e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 40.74  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL--CVCTLPLRVVYYVHKGIWLFGDFLcRLStyALYVNLYCS 110
Cdd:cd14972    8 LGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagIAFVFTFLSVLLVSLTPSPATWLL-RKG--SLVLSLLAS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAkpqkdeKNNTKCFEP---PQDNQTKNHVL 187
Cdd:cd14972   85 AYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLG------WNCVLCDQEscsPLGPGLPKSYL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 188 VLHYVSLFVgfiiPFVIIIVCYtMIILTLLKKSMK-----------KNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIH 256
Cdd:cd14972  159 VLILVFFFI----ALVIIVFLY-VRIFWCLWRHANaiaarqeaavpAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLD 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 532164737 257 LHflhnetkpCDSVLRMQKSVVITLSLAASNCCFDPLLYFF 297
Cdd:cd14972  234 VL--------CPSVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
29-306 6.72e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 40.88  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNL 107
Cdd:cd15302    6 ITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGDYWPLGWVLCDLWLSVDYTVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 108 YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKP----QKDEKNNTKCFEPPQDNQTK 183
Cdd:cd15302   86 LVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQyftgQGRSLPEGECYVQFMTDPYF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 184 NHVLVLHYVSLfvgfiipfviiivcyTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHlHFLHNE 263
Cdd:cd15302  166 NMGMYIGYYWT---------------TLIVMLILYAGIYRAANRARKALRTITFILGAFVICWTPYHILATIY-GFCEAP 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 532164737 264 TkPCDSVLRMqksvvITLSLAASNCCFDPLLYFFSGGNFRKRL 306
Cdd:cd15302  230 P-CVNETLYT-----ISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
28-295 7.61e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 40.70  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVL--IKTYHKKSAFQVymINLAVADLLCVC-TLPLRVVYYVHKGIWLFGDFLCRLSTYALY 104
Cdd:cd15328    5 TLLAMLVVATFLWNLLVLVTIlrVRTFHRVPHNLV--ASMAVSDVLVAAlVMPLSLVHELSGRRWQLGRSLCQVWISFDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 105 VNLYCSIFFMTAMSFFRCIAIVFPVQnINLVTQKKARFVCVGI-WIFVILTS-SPFLMAKPQKDEKNNTKCfeppQDNQT 182
Cdd:cd15328   83 LCCTASIWNVTAIALDRYWSITRHLE-YTLRTRRRISNVMIALtWALSAVISlAPLLFGWGETYSEDSEEC----QVSQE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 183 KNHVLVLHYVSLFVgfiipfviiIVCYTMIILTLLKKSMKKnlssHKKAIGMIMVVTAAFLVSFMPYHIQRTIhlhflhN 262
Cdd:cd15328  158 PSYTVFSTFGAFYL---------PLCVVLFVYWKIYKAAQK----EKRAALMVGILIGVFVLCWIPFFLTELI------S 218
                        250       260       270
                 ....*....|....*....|....*....|...
gi 532164737 263 ETKPCDsVLRMQKSvvITLSLAASNCCFDPLLY 295
Cdd:cd15328  219 PLCSCD-IPPIWKS--IFLWLGYSNSFFNPLIY 248
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
33-249 7.87e-04

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 40.65  E-value: 7.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737   33 ISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLlcvCTLPLRVVYYVHKGIWLFGDFLCR--LSTYALYVNLY-- 108
Cdd:pfam10324   6 LSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDI---ITMLLTIYNFIPEFIISYENSECIppDSYLKVLLDWIle 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  109 --------CSIFFMTAMSFFRCIAIVFPVQNI--NLVTQKKARFVCVGIWIFVILTSSPFLMA----KPQKDEKNNTKCF 174
Cdd:pfam10324  83 slqdysrrCSTWLGVFMALIRTLVVKNPMSNKiqKLSKPKFGLIIIIIVFILSLPISIFYYFRyeivEVGGIWKPPPNCA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  175 EPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIV---------CYTMIILTL-----LKKSMK--KNLSSHK-----KAIG 233
Cdd:pfam10324 163 GFPPNYTETRYVLVVSELFTANDGLLLKIFLLIdgifskiipCILLPILTIlliieLRKAKKsrKNLSSSSknksdRTTK 242
                         250
                  ....*....|....*.
gi 532164737  234 MIMVVTAAFLVSFMPY 249
Cdd:pfam10324 243 LVIFMTISFFIAEFPL 258
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
35-153 9.05e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 40.56  E-value: 9.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTY--HKKSAFQVYMINLAVADLLCVC-TLPLRVVYYVhKGIWLFGDFLCRLSTYALYVNLYCSI 111
Cdd:cd15142   12 IFGVVGNLIAIVVLCKSRkeQKETTFYTLVCGLAVTDLLGTClASPVTIATYL-KGRWPGGQPLCEYFSFILLFFSLSGL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 532164737 112 FFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL 153
Cdd:cd15142   91 SIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNIL 132
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
35-153 9.92e-04

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 40.25  E-value: 9.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHK-----KSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGD---FLCRLSTYALYV 105
Cdd:cd15146   12 ITGMVGNALAMLLVYRSYRKkenkrKRSFLLCIGSLALTDLFGqLLTSPIVISVYLSDRKWERVDpsgRLCPFFGLCMTV 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVIL 153
Cdd:cd15146   92 FGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLA 139
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
25-149 1.53e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 39.55  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVHKGIWLFGdflCRLSTYAL 103
Cdd:cd14968    2 VYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPLAILISLGLPTNFHG---CLFMACLV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 104 YVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWI 149
Cdd:cd14968   79 LVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWV 124
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
35-157 1.84e-03

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 39.45  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVAD-LLCVCTLPLRVVYYVhKGIWLFGDFLCRLST--YALYVNLYCSI 111
Cdd:cd15403   12 AIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTII-TVDWHFGAHFCRISAmlYWFFVLEGVAI 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 532164737 112 FFMTAMSFFRCIaivfpVQNINLVTQKKARFVCVGIWIFVILTSSP 157
Cdd:cd15403   91 LLIISVDRFLII-----VQRQDKLNPHRAKVMIAISWVLSFCISFP 131
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
28-155 2.14e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 39.24  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLstyalYVN 106
Cdd:cd15051    5 VVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYEL-RGEWPLGPVFCNI-----YIS 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532164737 107 L-----YCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS 155
Cdd:cd15051   79 LdvmlcTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVS 132
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
32-305 2.27e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 39.41  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  32 MISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKG-IWLFGDFLCRLSTYALYVNLYCS 110
Cdd:cd15198    9 VILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGdRWMAGDVACRLLKLLQASARGAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 111 IFFMTAMSFFRCIAIVFPvqninLVTQKKARFVCVGIWIFVILTSSPFLM-------AKPQKDEKNNTKC---FEPpqdn 180
Cdd:cd15198   89 ANLVVLLALDRHQAIRAP-----LGQPLRAWKLAALGWLLALLLALPQAYvfrvdfpDDPASAWPGHTLCrgiFAP---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 181 QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIIL---------TLLKKSMKKNLSSHK-------------KAIGMIMVV 238
Cdd:cd15198  160 LPRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLkwweranqaPGAKKPWKKPSKSHLratapsalprakvKTLKMTLVI 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 532164737 239 TAAFLVSFMPYHIQRTIHLHFLHN-ETKPCDSVLRMqksvvitlsLAASNCCFDPLLY-FFSGGNFRKR 305
Cdd:cd15198  240 ALLFVGCSLPYFIAELAAAFGSGDwEPEKVAAALGV---------MAVANSATNPFVFlFFNAGDCRLR 299
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
35-192 2.40e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 38.99  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  35 VVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIFF 113
Cdd:cd15209   12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvAIYPYPLILHAIFHNG-WTLGQLHCQASGFIMGLSVIGSIFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 114 MTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYV 192
Cdd:cd15209   91 ITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPnFFIGSLQYDPRIYSCTFAQTVSTVYTITVVVIHFL 170
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
27-173 2.50e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 39.01  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  27 STLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15333    8 AVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVsILVMPISIVYTV-TGTWTLGQVVCDIWLSSDIT 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKC 173
Cdd:cd15333   87 CCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSEC 154
7tmA_MAS1L cd15113
mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of ...
24-129 2.61e-03

mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of seven-transmembrane G protein-coupled receptors; MAS1L is also called MAS1 oncogene-like (MAS1-like) or mas-related G-protein coupled receptor MRG. MAS1L is a G protein-coupled receptor that only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L. The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320241  Cd Length: 265  Bit Score: 39.05  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  24 QVYSTLYSMISVVGFFGNGFVLYVLIkTYHKKSAFQVYMINLAVAD---LLCVCTLPLRVVYYVHKGIWLF-GDFLCRLS 99
Cdd:cd15113    1 NVVFPLAVLVSLCGLVGNGVVFWLLC-CGVRSNPYMVYILNLAAADvinLSCSAVILLEVTLLLYHGVTLFvADFLEPVS 79
                         90       100       110
                 ....*....|....*....|....*....|
gi 532164737 100 TYALYVNLycsiFFMTAMSFFRCIAIVFPV 129
Cdd:cd15113   80 YFSDTVGL----CLLVAISTESCLCVLFPI 105
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
29-168 2.67e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 38.79  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  29 LYSMISVVGFFGNGFVLY--VLIKTYHKKSAFQVymINLAVADLLC-VCTLPLRVVYYVhKGIWLFGDFLCRLSTYALYV 105
Cdd:cd15329    6 VLLIIILGTVVGNALVIIavCLVKKLRTPSNYLI--VSLAVSDLLVaLLVMPLAIIYEL-SGYWPFGEILCDVWISFDVL 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532164737 106 NLYCSIFFMTAMSFFRCIAIVFPVQNInlVTQKKAR-FVCVGI-WIFVILTSSP--FLMAKPQKDEK 168
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTYA--VKRTPKRmALMIAIvWLLSALISIPplFGWKNKVNDPG 147
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
16-249 3.64e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 38.62  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  16 DTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFL 95
Cdd:cd15082    6 KSIAPWNFTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  96 CRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLvTQKKARFVCVGIWIF-VILTSSPFLMAKPQKDEKNNTKCf 174
Cdd:cd15082   86 CVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRL-QGKHAALGLLFVWTFsFIWTIPPVLGWSSYTVSKIGTTC- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 175 EPP--QDNQTKNHVLVLHYVSLFVgfiIPFVIIIVCYTMIILTLLKKS-MKKNLSSHKKA----IGMIMVVTAAFLVSFM 247
Cdd:cd15082  164 EPNwySGNMHDHTYIITFFTTCFI---LPLGVIFVSYGKLLQKLRKVSnTQGRLGNARKPerqvTRMVVVMIVAFMVCWT 240

                 ..
gi 532164737 248 PY 249
Cdd:cd15082  241 PY 242
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
28-155 3.71e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.49  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  28 TLYSMISVVGFFGNGFVLYVLIK--TYHKKSAFqvYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCrlSTYALYV 105
Cdd:cd15065    4 IFLSLIIVLAIFGNVLVCLAIFTdrRLRKKSNL--FIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFC--NIWISFD 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 532164737 106 NLYC--SIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTS 155
Cdd:cd15065   80 VMCStaSILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALIS 131
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-303 3.84e-03

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 38.73  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  25 VYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYAL 103
Cdd:cd15977    2 VNTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLyILIAIPINVIKLIAED-WPFGVHVCKLYPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 104 YVNLYCSIFFMTAMSF--FRCIAIVFPVQNINLVTQKKARFVCvgIWIFVILTSSP----FLMAKPQKDEKNNTKCFEPP 177
Cdd:cd15977   81 KASVGITVLSLCALSIdrYRAVASWSRIRGIGIPVWKAVEVTL--IWAVAIIVAVPeaiaFDMVEIDYRGQTLLVCMLPM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 178 QdnQTKNHVLVLHYVSLFVGFIIPFVIIIVC----YTMIILTLL--KKSMKKNLSSHKK----AIGMIMVVTAAFLVSFM 247
Cdd:cd15977  159 E--QTSSFMRFYQDVKDWWLFGFYFCLPLACtgvfYTLMSCEMLsiKNGMRIALNDHMKqrreVAKTVFCLVVIFALCWL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 532164737 248 PYHIQRtIHLHFLHNETKPCDSVLRMQKSVV--ITLSLAASNCCFDPLLYFFSGGNFR 303
Cdd:cd15977  237 PLHLSR-ILKKTIYDVKDPQRCELLSFLLVMdyTGINMASLNSCINPVALYFVSRKFK 293
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-192 4.31e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 38.29  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737  34 SVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLL-CVCTLPLRVVYYVHKGiWLFGDFLCRLSTYALYVNLYCSIF 112
Cdd:cd15400   11 TVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVvALYPYPLVLVAIFHNG-WALGEMHCKVSGFVMGLSVIGSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532164737 113 FMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSP-FLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHY 191
Cdd:cd15400   90 NITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPnFFVGSLEYDPRIYSCTFVQTASSSYTIAVVVIHF 169

                 .
gi 532164737 192 V 192
Cdd:cd15400  170 I 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH