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Conserved domains on  [gi|532524969|ref|NP_001269131|]
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zinc finger protein 630 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-454 8.88e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 8.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 205 SRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQrvhTREKPFECSECRKAFCEMSHLFIHQITHTGKKPYECTEC 284
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQ---NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 285 GKTFPRKTQLIIHQRTH----------TGEKPYKCGECGKTFCQQSHLIGHQR--IHTGE--KPYVCT--DCGKAFSQKS 348
Cdd:COG5048  258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 349 HLTGHQRLHTGEKPYMC--TECGKSFSQKSP-----LIIHQRIHTGEKPYQC--GECGKTFSQKSLLIIHLRVHTGEKPY 419
Cdd:COG5048  338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532524969 420 ECTECGRAFSLKSHLIL--HQRGHTGEKPYECSECGK 454
Cdd:COG5048  418 NCKNPPCSKSFNRHYNLipHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-454 8.88e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 8.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 205 SRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQrvhTREKPFECSECRKAFCEMSHLFIHQITHTGKKPYECTEC 284
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQ---NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 285 GKTFPRKTQLIIHQRTH----------TGEKPYKCGECGKTFCQQSHLIGHQR--IHTGE--KPYVCT--DCGKAFSQKS 348
Cdd:COG5048  258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 349 HLTGHQRLHTGEKPYMC--TECGKSFSQKSP-----LIIHQRIHTGEKPYQC--GECGKTFSQKSLLIIHLRVHTGEKPY 419
Cdd:COG5048  338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532524969 420 ECTECGRAFSLKSHLIL--HQRGHTGEKPYECSECGK 454
Cdd:COG5048  418 NCKNPPCSKSFNRHYNLipHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 5.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 532524969  321 HLIGHQRIHTGEKPYVCTDCGKAFSQ 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 361-413 8.90e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532524969 361 KPYmCTECGKSFSQKSPLIIHQRIHTgekpYQCGECGKTFSQKSLLIIH-LRVH 413
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-454 8.88e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 8.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 205 SRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQrvhTREKPFECSECRKAFCEMSHLFIHQITHTGKKPYECTEC 284
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQ---NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 285 GKTFPRKTQLIIHQRTH----------TGEKPYKCGECGKTFCQQSHLIGHQR--IHTGE--KPYVCT--DCGKAFSQKS 348
Cdd:COG5048  258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 349 HLTGHQRLHTGEKPYMC--TECGKSFSQKSP-----LIIHQRIHTGEKPYQC--GECGKTFSQKSLLIIHLRVHTGEKPY 419
Cdd:COG5048  338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 532524969 420 ECTECGRAFSLKSHLIL--HQRGHTGEKPYECSECGK 454
Cdd:COG5048  418 NCKNPPCSKSFNRHYNLipHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-512 1.96e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 165 KPYVCGDCRKAFSEKSHLIVHQRIHTGEKPYECTKYGRA--FSRKSPFTVHQRVHTGEKPYEC----------------F 226
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 227 ECPKAFSQKSHL---IIHQRVHTREKPFECSECRKAFCE---MSHLFIHQITHTGKK-PYECTECGKTFPRKTQLIIHQR 299
Cdd:COG5048  112 SSSSNSNDNNLLsshSLPPSSRDPQLPDLLSISNLRNNPlpgNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 300 THTGEKPYKCGECGKTFCQQSHLIGHQRIHTGEKPYVCTDCGKAF------SQKSHLTGHQRLHTGEKPYMCTECGKSFS 373
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 374 QKSPLIIHQRIHTG-EKPYQCGECGKTFSQKSLLIIHLR--VHTGE--KPYECTE--CGRAFSLKSHLILHQRGHTGEKP 446
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532524969 447 YECSEC------GKAFCGKSPLIIHQKTHPREKTPECAESGMTFFWKSQMITYQR---RHTGEKPS--RCSDCGKAF 512
Cdd:COG5048  352 AKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLhiiTHLSFRPYncKNPPCSKSF 428
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
46-405 1.18e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969  46 PLSQKFHKFDSCENSLKSNSDLLNYNRSYARKNptKRFRCGRPPKYNASCSVPEKEGFIHTGMEPYGDSqcEKVLSHKQA 125
Cdd:COG5048   76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLS--ISNLRNNPL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 126 HVQYKKFQAREKPN-------VCSMCGKAFIKKSQLIIHQRIHTGEKPYVCGDCRKaFSEKSHLIVHQRIHTGEKPYECT 198
Cdd:COG5048  152 PGNNSSSVNTPQSNslhpplpANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLT 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 199 KYGRAFSRKSP------FTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQRVHTR-EKPFECSECRKAFCEMSHLFIHQ- 270
Cdd:COG5048  231 TNSQLSPKSLLsqspssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLr 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 271 -ITHTGK--KPYECTE--CGKTFPRKTQLIIHQRTHTGEKPYKC--GECGKTF------CQQSHLIGHQRIHTgEKPYVC 337
Cdd:COG5048  311 sVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSET 389

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 532524969 338 TD--CGKAFSQKSHLTGHQRLHTGEKPYMCT--ECGKSFSQKSPLIIHQRIHTGEKPYQCGECGKTFSQKSL 405
Cdd:COG5048  390 LSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 5.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 532524969  321 HLIGHQRIHTGEKPYVCTDCGKAFSQ 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-523 5.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 276 KKPYECTECGKTFPRKTQLIIHQRTHTGEKPYKCG--ECGKTFCQQSHLIGHQRIHTGEKPYVCTD-CGKAFSQKSHLTG 352
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 353 HQRLHTGEKPYMCTECGKSFSQKSPLII--HQRIHTGEKPYQ-CGECGKTFSQKSLLI-------------------IHL 410
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532524969 411 RVHTGEKPYECTECGRAFSLKSHLILHQRGHTGEKPYECSECGKAFCGKSPLIIHQKTHPREKTPECAESGMTFFWKSQM 490
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 532524969 491 ITYQ------RRHTG-EKPSRCSDCGKAFCQHVYFTGHQN 523
Cdd:COG5048  271 QSSSpnesdsSSEKGfSLPIKSKQCNISFSRSSPLTRHLR 310
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-402 6.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|..
gi 532524969  381 HQRIHTGEKPYQCGECGKTFSQ 402
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 279-301 7.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.31e-03
                          10        20
                  ....*....|....*....|...
gi 532524969  279 YECTECGKTFPRKTQLIIHQRTH 301
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 391-413 7.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.83e-03
                          10        20
                  ....*....|....*....|...
gi 532524969  391 YQCGECGKTFSQKSLLIIHLRVH 413
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 8.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 532524969  349 HLTGHQRLHTGEKPYMCTECGKSFSQ 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 361-413 8.90e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 532524969 361 KPYmCTECGKSFSQKSPLIIHQRIHTgekpYQCGECGKTFSQKSLLIIH-LRVH 413
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-316 9.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.39e-03
                          10        20
                  ....*....|....*....|
gi 532524969  297 HQRTHTGEKPYKCGECGKTF 316
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-456 9.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.77e-03
                          10        20
                  ....*....|....*....|....
gi 532524969  433 HLILHQRGHTGEKPYECSECGKAF 456
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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