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Conserved domains on  [gi|538260592|ref|NP_001269311|]
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securin [Homo sapiens]

Protein Classification

Securin domain-containing protein( domain architecture ID 10522101)

Securin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Securin pfam04856
Securin sister-chromatid separation inhibitor; Securin is also known as pituitary ...
1-191 4.08e-70

Securin sister-chromatid separation inhibitor; Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss.


:

Pssm-ID: 461456  Cd Length: 197  Bit Score: 211.67  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592    1 MATLIYVDKENG--EPGTRVVAKDGLK------LGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNrate 72
Cdd:pfam04856   1 MNTIISVGKENGgaTPGTLLKRTDSLKlkgrapLGSKDNNKTSSGSSSVKLPRYGSVAGAGLNLPKPRTKSLVLKD---- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592   73 KSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMI--LD 150
Cdd:pfam04856  77 ISVKSKTELESESDSESDKKIFPLGKKLKSSLEADIEYAPERQKELPYQPLGYEPFDLPEENDIEKLKLRNSPLMIeyLD 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 538260592  151 EERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDV 191
Cdd:pfam04856 157 EDREQEPPLDLDELSPLESLDEESESDTRESPLSGLSTLDV 197
 
Name Accession Description Interval E-value
Securin pfam04856
Securin sister-chromatid separation inhibitor; Securin is also known as pituitary ...
1-191 4.08e-70

Securin sister-chromatid separation inhibitor; Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss.


Pssm-ID: 461456  Cd Length: 197  Bit Score: 211.67  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592    1 MATLIYVDKENG--EPGTRVVAKDGLK------LGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNrate 72
Cdd:pfam04856   1 MNTIISVGKENGgaTPGTLLKRTDSLKlkgrapLGSKDNNKTSSGSSSVKLPRYGSVAGAGLNLPKPRTKSLVLKD---- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592   73 KSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMI--LD 150
Cdd:pfam04856  77 ISVKSKTELESESDSESDKKIFPLGKKLKSSLEADIEYAPERQKELPYQPLGYEPFDLPEENDIEKLKLRNSPLMIeyLD 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 538260592  151 EERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDV 191
Cdd:pfam04856 157 EDREQEPPLDLDELSPLESLDEESESDTRESPLSGLSTLDV 197
 
Name Accession Description Interval E-value
Securin pfam04856
Securin sister-chromatid separation inhibitor; Securin is also known as pituitary ...
1-191 4.08e-70

Securin sister-chromatid separation inhibitor; Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss.


Pssm-ID: 461456  Cd Length: 197  Bit Score: 211.67  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592    1 MATLIYVDKENG--EPGTRVVAKDGLK------LGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNrate 72
Cdd:pfam04856   1 MNTIISVGKENGgaTPGTLLKRTDSLKlkgrapLGSKDNNKTSSGSSSVKLPRYGSVAGAGLNLPKPRTKSLVLKD---- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260592   73 KSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMI--LD 150
Cdd:pfam04856  77 ISVKSKTELESESDSESDKKIFPLGKKLKSSLEADIEYAPERQKELPYQPLGYEPFDLPEENDIEKLKLRNSPLMIeyLD 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 538260592  151 EERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDV 191
Cdd:pfam04856 157 EDREQEPPLDLDELSPLESLDEESESDTRESPLSGLSTLDV 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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