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Conserved domains on  [gi|540344569|ref|NP_001269341|]
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protein phosphatase 1 regulatory subunit 7 isoform 5 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 147-338 2.93e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 138.38  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 147 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 226
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 227 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 298
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 540344569 299 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 338
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-182 9.40e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 9.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  67 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 137
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 540344569 138 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 182
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 147-338 2.93e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 138.38  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 147 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 226
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 227 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 298
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 540344569 299 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 338
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-296 3.26e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 3.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  79 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 157
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 158 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 233
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 540344569 234 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 296
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-182 9.40e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 9.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  67 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 137
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 540344569 138 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 182
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
107-228 1.11e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.00  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  107 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 184
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 540344569  185 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 228
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-320 5.65e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 5.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  86 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 159
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 160 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 211
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 212 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 278
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 540344569 279 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 320
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 104-146 4.85e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 4.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344569  104 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 146
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 320-338 4.54e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 4.54e-03
                           10
                   ....*....|....*....
gi 540344569   320 DPQYRRKVMLALPSVRQID 338
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 147-338 2.93e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 138.38  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 147 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 226
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 227 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 298
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 540344569 299 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 338
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-296 3.26e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 3.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  79 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 157
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 158 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 233
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 540344569 234 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 296
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-315 1.85e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  89 LRQNLIKCIENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKI-EN 165
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 166 LSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYL 243
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDL 257

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 540344569 244 SHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 315
Cdd:COG4886  258 SNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-321 3.12e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  84 VKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNkiski 163
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 164 ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRE 240
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 241 LYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLeswSDLDELKGARSLETVYLERNPLQ 318
Cdd:COG4886  187 LDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNNQLT 263


                 ...
gi 540344569 319 KDP 321
Cdd:COG4886  264 DLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-323 5.13e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 5.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  66 DLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI- 141
Cdd:COG4886  142 DLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLp 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 142 EGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM 221
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 222 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDEL 301
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                        250       260
                 ....*....|....*....|..
gi 540344569 302 KGARSLETVYLERNPLQKDPQY 323
Cdd:COG4886  382 LALLLLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-317 4.17e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 4.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  85 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 164
Cdd:COG4886   11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 165 NLSNLHQLQMLELGSNriraiENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELY 242
Cdd:COG4886   91 DLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLD 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 540344569 243 LSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLESWSdlDELKGARSLETVYLERNPL 317
Cdd:COG4886  166 LSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-310 3.73e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 3.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  63 EDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLR 139
Cdd:COG4886  162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 140 NIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR--AIENIDTLTNLESLFLGKNKITKLQNLDALTNLT 217
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 218 VLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSD 297
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|...
gi 540344569 298 LDELKGARSLETV 310
Cdd:COG4886  402 LLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-229 4.54e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 4.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  71 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 150
Cdd:cd21340   35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 151 kklflvnnkiskIENLSNlhQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALTNLTVLSMQSNRL 226
Cdd:cd21340  115 ------------LAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180


                 ...
gi 540344569 227 TKI 229
Cdd:cd21340  181 CKK 183
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-182 9.40e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 9.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  67 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 137
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 540344569 138 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 182
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
107-228 1.11e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.00  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  107 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 184
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 540344569  185 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 228
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-324 1.14e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.34  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  53 METINLDRDAEDVDLNHYRIGKiEGFEVLKKVktlcLRQNlikcienleelQSLRELDLYDNQIKKiENLEALteleild 132
Cdd:COG5238  173 MAKALQNNSVETVYLGCNQIGD-EGIEELAEA----LTQN-----------TTVTTLWLKRNPIGD-EGAEIL------- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 133 isfnllrnIEGVDKLTRLKKLFLVNNKISK------IENLSNLHQLQMLELGSNRIRA------IENIDTLTNLESLFLG 200
Cdd:COG5238  229 --------AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLS 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 201 KNKITKlQNLDALtnltvlsmqsnrltkIEGLQNLVNLRELYLSHNGIEV------IEGLENNNKLTMLDIASNRI---- 270
Cdd:COG5238  301 VNRIGD-EGAIAL---------------AEGLQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgdeg 364

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 540344569 271 -----KKIENISHLTELQEFWMNDNLLESWSDLDELKGARsLETVYLERNPLQKDPQYR 324
Cdd:COG5238  365 aialaKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQR 422
LRR_9 pfam14580
Leucine-rich repeat;
175-338 1.68e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  175 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNgievi 251
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNN----- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  252 eglennnkltmldiasnrikkienisHLTELqefwmndnlleswSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 331
Cdd:pfam14580  99 --------------------------NLQEL-------------GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139


                  ....*..
gi 540344569  332 PSVRQID 338
Cdd:pfam14580 140 PQLRLLD 146
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-318 8.41e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 8.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 128 LEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL 207
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 208 QNLDALTNLTVLSMQSNrltkiEGLQNLVNLRELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEF 285
Cdd:COG4886   90 TDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                        170       180       190
                 ....*....|....*....|....*....|...
gi 540344569 286 WMNDNLLESWSdlDELKGARSLETVYLERNPLQ 318
Cdd:COG4886  165 DLSNNQLTDLP--EELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
214-270 2.66e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344569  214 TNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRI 270
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-320 5.65e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 5.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  86 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 159
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 160 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 211
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569 212 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 278
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 540344569 279 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 320
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_8 pfam13855
Leucine rich repeat;
192-248 6.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 6.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344569  192 TNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 248
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 214-246 2.93e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.93e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 540344569  214 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 246
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
126-182 3.29e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344569  126 TELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRI 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 104-146 4.85e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 4.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344569  104 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 146
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 192-234 4.94e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 4.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344569  192 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSN-RLTKIEGLQN 234
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
148-204 1.02e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344569  148 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 204
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
65-140 1.36e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 1.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 540344569   65 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-LQSLRELDLYDNQIKKIENLEALTELEILDiSFNLLRN 140
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 148-193 1.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 540344569  148 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIraIENIDTLTN 193
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
237-292 1.79e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344569  237 NLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLL 292
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 237-278 2.17e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 540344569  237 NLRELYLSHNGIEVIEGLENNNKLTMLDIASN-RIKKIENISH 278
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 126-168 3.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344569  126 TELEILDISFNLLRNIEGVDKLTRLKKLFLV-NNKISKIENLSN 168
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 320-338 4.54e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 4.54e-03
                           10
                   ....*....|....*....
gi 540344569   320 DPQYRRKVMLALPSVRQID 338
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_8 pfam13855
Leucine rich repeat;
104-160 6.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344569  104 QSLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKI 160
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 82-123 7.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 7.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 540344569   82 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDN-QIKKIENLE 123
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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