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Conserved domains on  [gi|541862241|ref|NP_001269403|]
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AP-1 complex subunit gamma-like 2 isoform 2 [Homo sapiens]

Protein Classification

AP-1 complex subunit gamma( domain architecture ID 13560716)

AP-1 complex subunit gamma is a subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 1-194 6.32e-45

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 162.79  E-value: 6.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241    1 MMQELQAFL-ESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRL 79
Cdd:pfam01602 337 IVKELLKYVhEIADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   80 YNALaEDISQQPLVQVAAWCIGEYGDLLLagnceeieplqvDEEEVLALLEKVLQSHMSLPA-TRGYALTALMKLSTRLC 158
Cdd:pfam01602 417 CELL-EDIESPEALAAALWILGEYGELIP------------NGSSPPDLLRSILEVFVLESAkVRAAALTALAKLGLTSP 483

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 541862241  159 GDN--NRIRQVVSIYG--SCLDVELQQRAVEYDTLFRKYD 194
Cdd:pfam01602 484 EETtqNLIIQLLLTLAtqDSLDLEVRDRAVEYLRLLSLAD 523
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
 291-399 2.83e-31

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


:

Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 115.03  E-value: 2.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   291 VFEREGVQLNLSFIRPPENpalLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGglPITQLFRILNPN 370
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGL---IRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSSPTLPPGG--QITQVLKVENPG 75

                           90       100
                   ....*....|....*....|....*....
gi 541862241   371 KAPLRLKLRLTYDHFHQSVQEIFEVNNLP 399
Cdd:smart00809  76 KFPLRLRLRLSYLLGGSAVTEQGDVLKFP 104
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 1-194 6.32e-45

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 162.79  E-value: 6.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241    1 MMQELQAFL-ESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRL 79
Cdd:pfam01602 337 IVKELLKYVhEIADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   80 YNALaEDISQQPLVQVAAWCIGEYGDLLLagnceeieplqvDEEEVLALLEKVLQSHMSLPA-TRGYALTALMKLSTRLC 158
Cdd:pfam01602 417 CELL-EDIESPEALAAALWILGEYGELIP------------NGSSPPDLLRSILEVFVLESAkVRAAALTALAKLGLTSP 483

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 541862241  159 GDN--NRIRQVVSIYG--SCLDVELQQRAVEYDTLFRKYD 194
Cdd:pfam01602 484 EETtqNLIIQLLLTLAtqDSLDLEVRDRAVEYLRLLSLAD 523
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
 291-399 2.83e-31

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 115.03  E-value: 2.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   291 VFEREGVQLNLSFIRPPENpalLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGglPITQLFRILNPN 370
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGL---IRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSSPTLPPGG--QITQVLKVENPG 75

                           90       100
                   ....*....|....*....|....*....
gi 541862241   371 KAPLRLKLRLTYDHFHQSVQEIFEVNNLP 399
Cdd:smart00809  76 KFPLRLRLRLSYLLGGSAVTEQGDVLKFP 104
Alpha_adaptinC2 pfam02883
Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud ...
 291-399 2.76e-29

Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.


Pssm-ID: 460735  Cd Length: 111  Bit Score: 109.72  E-value: 2.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241  291 VFEREGVQLNLSFIRPpENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPN 370
Cdd:pfam02883   5 LYESDGLQIGFSFERS-RRPGQIRITLTFTNKSSSPISNFSFQAAVPKSLKLQLQPPSSNVLPPNPGGQITQVLLIENPG 83

                          90       100
                  ....*....|....*....|....*....
gi 541862241  371 KAPLRLKLRLTYdHFHQSVQEIFEVNNLP 399
Cdd:pfam02883  84 KKPLRMRLKISY-LNGGAVQEQGDVLKFP 111
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 1-194 6.32e-45

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 162.79  E-value: 6.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241    1 MMQELQAFL-ESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRL 79
Cdd:pfam01602 337 IVKELLKYVhEIADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   80 YNALaEDISQQPLVQVAAWCIGEYGDLLLagnceeieplqvDEEEVLALLEKVLQSHMSLPA-TRGYALTALMKLSTRLC 158
Cdd:pfam01602 417 CELL-EDIESPEALAAALWILGEYGELIP------------NGSSPPDLLRSILEVFVLESAkVRAAALTALAKLGLTSP 483

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 541862241  159 GDN--NRIRQVVSIYG--SCLDVELQQRAVEYDTLFRKYD 194
Cdd:pfam01602 484 EETtqNLIIQLLLTLAtqDSLDLEVRDRAVEYLRLLSLAD 523
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
 291-399 2.83e-31

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 115.03  E-value: 2.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241   291 VFEREGVQLNLSFIRPPENpalLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGglPITQLFRILNPN 370
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGL---IRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSSPTLPPGG--QITQVLKVENPG 75

                           90       100
                   ....*....|....*....|....*....
gi 541862241   371 KAPLRLKLRLTYDHFHQSVQEIFEVNNLP 399
Cdd:smart00809  76 KFPLRLRLRLSYLLGGSAVTEQGDVLKFP 104
Alpha_adaptinC2 pfam02883
Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud ...
 291-399 2.76e-29

Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.


Pssm-ID: 460735  Cd Length: 111  Bit Score: 109.72  E-value: 2.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541862241  291 VFEREGVQLNLSFIRPpENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPN 370
Cdd:pfam02883   5 LYESDGLQIGFSFERS-RRPGQIRITLTFTNKSSSPISNFSFQAAVPKSLKLQLQPPSSNVLPPNPGGQITQVLLIENPG 83

                          90       100
                  ....*....|....*....|....*....
gi 541862241  371 KAPLRLKLRLTYdHFHQSVQEIFEVNNLP 399
Cdd:pfam02883  84 KKPLRMRLKISY-LNGGAVQEQGDVLKFP 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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