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Conserved domains on  [gi|1844083954|ref|NP_001269602|]
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Fanconi anemia core complex-associated protein 20 isoform 8 [Homo sapiens]

Protein Classification

FANCA_interact and UBZ_FAAP20 domain-containing protein( domain architecture ID 12174456)

FANCA_interact and UBZ_FAAP20 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FANCA_interact pfam15751
FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi ...
 35-139 1.76e-42

FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi anemia-associated protein of 20 kDa (FAAP20), where it is responsible for interaction with Fanconi anemia group A protein (FANCA).


:

Pssm-ID: 464845  Cd Length: 108  Bit Score: 137.22  E-value: 1.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083954  35 ERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPT---EVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHL 111
Cdd:pfam15751   1 ESARLWAELLRTVSADLTLDGELPPLPAFPGQEPRRSPERTappEVFTVGSKTFSWTPFPPAPGGSGRSYRLLRGTGGPL 80

                          90       100
                  ....*....|....*....|....*...
gi 1844083954 112 ESPARSLPQRPAPDPCRAPRVEQQPSVE 139
Cdd:pfam15751  81 GSPTRSPQGCPAPDPRGTPSAEEQPSVE 108
UBZ_FAAP20 super family cl24348
Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi ...
 144-158 1.16e-03

Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi anaemia-associated protein of 20 kDa.


The actual alignment was detected with superfamily member pfam15750:

Pssm-ID: 464844  Cd Length: 35  Bit Score: 35.14  E-value: 1.16e-03
                          10
                  ....*....|....*
gi 1844083954 144 LRSCPMCQKEFAPRY 158
Cdd:pfam15750   1 LQSCPMCQKEFPPGL 15
 
Name Accession Description Interval E-value
FANCA_interact pfam15751
FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi ...
 35-139 1.76e-42

FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi anemia-associated protein of 20 kDa (FAAP20), where it is responsible for interaction with Fanconi anemia group A protein (FANCA).


Pssm-ID: 464845  Cd Length: 108  Bit Score: 137.22  E-value: 1.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083954  35 ERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPT---EVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHL 111
Cdd:pfam15751   1 ESARLWAELLRTVSADLTLDGELPPLPAFPGQEPRRSPERTappEVFTVGSKTFSWTPFPPAPGGSGRSYRLLRGTGGPL 80

                          90       100
                  ....*....|....*....|....*...
gi 1844083954 112 ESPARSLPQRPAPDPCRAPRVEQQPSVE 139
Cdd:pfam15751  81 GSPTRSPQGCPAPDPRGTPSAEEQPSVE 108
UBZ_FAAP20 pfam15750
Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi ...
 144-158 1.16e-03

Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi anaemia-associated protein of 20 kDa.


Pssm-ID: 464844  Cd Length: 35  Bit Score: 35.14  E-value: 1.16e-03
                          10
                  ....*....|....*
gi 1844083954 144 LRSCPMCQKEFAPRY 158
Cdd:pfam15750   1 LQSCPMCQKEFPPGL 15
 
Name Accession Description Interval E-value
FANCA_interact pfam15751
FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi ...
 35-139 1.76e-42

FAAP20 FANCA interaction domain; This domain is found at the N-terminus of Fanconi anemia-associated protein of 20 kDa (FAAP20), where it is responsible for interaction with Fanconi anemia group A protein (FANCA).


Pssm-ID: 464845  Cd Length: 108  Bit Score: 137.22  E-value: 1.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083954  35 ERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPT---EVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHL 111
Cdd:pfam15751   1 ESARLWAELLRTVSADLTLDGELPPLPAFPGQEPRRSPERTappEVFTVGSKTFSWTPFPPAPGGSGRSYRLLRGTGGPL 80

                          90       100
                  ....*....|....*....|....*...
gi 1844083954 112 ESPARSLPQRPAPDPCRAPRVEQQPSVE 139
Cdd:pfam15751  81 GSPTRSPQGCPAPDPRGTPSAEEQPSVE 108
UBZ_FAAP20 pfam15750
Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi ...
 144-158 1.16e-03

Ubiquitin-binding zinc-finger; This domain is the ubiquitin-binding zinc-finger of the Fanconi anaemia-associated protein of 20 kDa.


Pssm-ID: 464844  Cd Length: 35  Bit Score: 35.14  E-value: 1.16e-03
                          10
                  ....*....|....*
gi 1844083954 144 LRSCPMCQKEFAPRY 158
Cdd:pfam15750   1 LQSCPMCQKEFPPGL 15
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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