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Conserved domains on  [gi|544063432|ref|NP_001269605|]
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inactive serine protease PAMR1 isoform d precursor [Homo sapiens]

Protein Classification

CCP and Tryp_SPc domain-containing protein( domain architecture ID 10041905)

protein containing domains EGF_CA, CCP, and Tryp_SPc

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 350-607 1.85e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 149.73  E-value: 1.85e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 350 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 429
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 430 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 509
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 510 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 588
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                        250
                 ....*....|....*....
gi 544063432 589 RLSTAFTKVLPFKDWIERN 607
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 169-232 1.98e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 1.98e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063432 169 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 232
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 129-161 3.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 3.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063432 129 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 161
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 297-332 2.41e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.37  E-value: 2.41e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063432 297 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 332
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 350-607 1.85e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 149.73  E-value: 1.85e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 350 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 429
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 430 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 509
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 510 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 588
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                        250
                 ....*....|....*....
gi 544063432 589 RLSTAFTKVLPFKDWIERN 607
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 350-604 6.74e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 142.82  E-value: 6.74e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   350 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 429
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   430 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 509
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   510 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 588
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213

                          250
                   ....*....|....*.
gi 544063432   589 RLSTAFTKVLPFKDWI 604
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 351-608 9.50e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 135.16  E-value: 9.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 351 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 430
Cdd:COG5640   42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 431 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 510
Cdd:COG5640  102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 511 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 590
Cdd:COG5640  175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240

                        250
                 ....*....|....*...
gi 544063432 591 STAFTKVLPFKDWIERNM 608
Cdd:COG5640  241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
351-604 1.39e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 130.64  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  351 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 430
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  431 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 509
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  510 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 588
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203

                         250
                  ....*....|....*.
gi 544063432  589 RLSTAFTKVLPFKDWI 604
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 169-232 1.98e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 1.98e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063432 169 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 232
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 169-231 7.64e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.84  E-value: 7.64e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063432   169 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 231
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
169-231 1.18e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063432  169 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 231
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 145-242 1.98e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 49.65  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 145 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 218
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190

                         90       100
                 ....*....|....*....|....
gi 544063432 219 qQNGEWSGKQPICIKACREPKISD 242
Cdd:PHA02927 191 -SGGEWSDPPTCQIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 129-161 3.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 3.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063432 129 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 161
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
129-161 1.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544063432   129 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 161
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 128-159 1.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.09e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 544063432  128 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 159
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 297-332 2.41e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.37  E-value: 2.41e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063432 297 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 332
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 297-331 4.22e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 4.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 544063432   297 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 331
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
296-331 9.37e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.48  E-value: 9.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 544063432  296 HTQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 331
Cdd:pfam00084  22 GASVSYECDPG-YRLVGSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 350-607 1.85e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 149.73  E-value: 1.85e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 350 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 429
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 430 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 509
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 510 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 588
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                        250
                 ....*....|....*....
gi 544063432 589 RLSTAFTKVLPFKDWIERN 607
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 350-604 6.74e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 142.82  E-value: 6.74e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   350 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 429
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   430 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 509
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432   510 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 588
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213

                          250
                   ....*....|....*.
gi 544063432   589 RLSTAFTKVLPFKDWI 604
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 351-608 9.50e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 135.16  E-value: 9.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 351 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 430
Cdd:COG5640   42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 431 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 510
Cdd:COG5640  102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 511 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 590
Cdd:COG5640  175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240

                        250
                 ....*....|....*...
gi 544063432 591 STAFTKVLPFKDWIERNM 608
Cdd:COG5640  241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
351-604 1.39e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 130.64  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  351 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 430
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  431 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 509
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432  510 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 588
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203

                         250
                  ....*....|....*.
gi 544063432  589 RLSTAFTKVLPFKDWI 604
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 169-232 1.98e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 1.98e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063432 169 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 232
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 169-231 7.64e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.84  E-value: 7.64e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063432   169 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 231
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
169-231 1.18e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063432  169 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 231
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 145-242 1.98e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 49.65  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 145 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 218
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190

                         90       100
                 ....*....|....*....|....
gi 544063432 219 qQNGEWSGKQPICIKACREPKISD 242
Cdd:PHA02927 191 -SGGEWSDPPTCQIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 129-161 3.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 3.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063432 129 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 161
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 377-489 1.03e-05

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 46.59  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 377 VCSGALVNERTVVVAAHCVTDLGKVTmiKTADLKVVLGkfYRDDDRdektiQSLQISAIILHPNYDP-ILLDADIAILKL 455
Cdd:COG3591   13 VCTGTLIGPNLVLTAGHCVYDGAGGG--WATNIVFVPG--YNGGPY-----GTATATRFRVPPGWVAsGDAGYDYALLRL 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 544063432 456 ldKARISTRVQPICLAASRDLSTsfqESHITVAG 489
Cdd:COG3591   84 --DEPLGDTTGWLGLAFNDAPLA---GEPVTIIG 112
EGF_CA smart00179
Calcium-binding EGF-like domain;
129-161 1.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544063432   129 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 161
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 128-159 1.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.09e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 544063432  128 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 159
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 297-332 2.41e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.37  E-value: 2.41e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063432 297 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 332
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 167-242 4.08e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 42.73  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063432 167 RNCSDPGGPVNGyqkitggpGLINGRHA-KIGTVVSFFCNN----SYVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKI 240
Cdd:PHA02639  83 KECNDPPSIING--------KIYNKREMyKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPDPPICkMINCRFPAL 154


                 ..
gi 544063432 241 SD 242
Cdd:PHA02639 155 QN 156
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 297-331 4.22e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 4.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 544063432   297 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 331
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 195-238 8.89e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.57  E-value: 8.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 544063432 195 KIGTVVSFFCNNSYVLSGNEKRTC---QQNGEWSGKQPIC-IKACREP 238
Cdd:PHA02639  41 EIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFCmLKECNDP 88
Sushi pfam00084
Sushi repeat (SCR repeat);
296-331 9.37e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.48  E-value: 9.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 544063432  296 HTQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 331
Cdd:pfam00084  22 GASVSYECDPG-YRLVGSPTITCQEDGTWSPPFPEC 56
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 127-161 1.83e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 1.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 544063432 127 PCS-SSPCFHDGTCVlDKAGSYKCACLAGYTGQ-RCE 161
Cdd:cd00053    1 ECAaSNPCSNGGTCV-NTPGSYRCVCPPGYTGDrSCE 36
PHA02817 PHA02817
EEV Host range protein; Provisional
 196-242 2.56e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 2.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 544063432 196 IGTVVSFFCNNS-----YVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKISD 242
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCkIIRCRFPALQN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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