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Conserved domains on  [gi|544186128|ref|NP_001269623|]
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flavin-containing monooxygenase 1 isoform c [Homo sapiens]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-468 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 858.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFT------------------------------------- 44
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTenveegrasiyksvitntskemscfsdfpfpedypnf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   45 --------------------------TKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 98
Cdd:pfam00743  81 mhnskfleyfrmfakefdllkyiqfkTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   99 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 178
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  179 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 258
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  259 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 338
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  339 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 418
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 544186128  419 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 468
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-468 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 858.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFT------------------------------------- 44
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTenveegrasiyksvitntskemscfsdfpfpedypnf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   45 --------------------------TKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 98
Cdd:pfam00743  81 mhnskfleyfrmfakefdllkyiqfkTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   99 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 178
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  179 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 258
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  259 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 338
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  339 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 418
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 544186128  419 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 468
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-331 9.86e-61

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 203.94  E-value: 9.86e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTT----------KVCS------------------------ 49
Cdd:COG2072    8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRypglrldtpsHLYSlpffpnwsddpdfptgdeilayle 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  50 -----------------VTKCSDSAVSGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQ 112
Cdd:COG2072   88 ayadkfglrrpirfgteVTSARWDEADGRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGLEDFAGEQLHSAD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 113 YKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNMLRNSLPTPI---- 188
Cdd:COG2072  163 WRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYLGLEAPPALnrrd 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 189 VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDELPGRIITGKV-FIRPSIKEVKENSVIFNNtSKEEPIDIIVFAT 266
Cdd:COG2072  237 ARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-GTEHEVDVIVWAT 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544186128 267 GYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVLK 331
Cdd:COG2072  316 GFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 31-376 1.43e-23

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 103.02  E-value: 1.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  31 FERSDDLGGLWRFTTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAIFDAVMVCTGFLTNPYLPldSFPGINAFKGQYFH 109
Cdd:PLN02172 120 FAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEIFDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIH 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 110 SRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggwviSRIFDSGypwdmvfmtrfqnmLRNSLPTPiv 189
Cdd:PLN02172 193 SHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA--------SRASESD--------------TYEKLPVP-- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 190 twlmerkINNWLNHANYGLIPEDrtqlkefvlndelpgriitgkvfirpsikevkeNSVIFNNtSKEEPIDIIVFATGYT 269
Cdd:PLN02172 249 -------QNNLWMHSEIDTAHED---------------------------------GSIVFKN-GKVVYADTIVHCTGYK 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 270 FAFPFLDES-VVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEIN 347
Cdd:PLN02172 288 YHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDIN 365

                        330       340       350
                 ....*....|....*....|....*....|....
gi 544186128 348 ARKENKPSwFGLC--YCKAL---QSDYITYIDEL 376
Cdd:PLN02172 366 AWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-468 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 858.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFT------------------------------------- 44
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTenveegrasiyksvitntskemscfsdfpfpedypnf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   45 --------------------------TKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 98
Cdd:pfam00743  81 mhnskfleyfrmfakefdllkyiqfkTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   99 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 178
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  179 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 258
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  259 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 338
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  339 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 418
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 544186128  419 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 468
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-331 9.86e-61

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 203.94  E-value: 9.86e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTT----------KVCS------------------------ 49
Cdd:COG2072    8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRypglrldtpsHLYSlpffpnwsddpdfptgdeilayle 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  50 -----------------VTKCSDSAVSGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQ 112
Cdd:COG2072   88 ayadkfglrrpirfgteVTSARWDEADGRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGLEDFAGEQLHSAD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 113 YKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNMLRNSLPTPI---- 188
Cdd:COG2072  163 WRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYLGLEAPPALnrrd 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 189 VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDELPGRIITGKV-FIRPSIKEVKENSVIFNNtSKEEPIDIIVFAT 266
Cdd:COG2072  237 ARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-GTEHEVDVIVWAT 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544186128 267 GYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVLK 331
Cdd:COG2072  316 GFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 31-376 1.43e-23

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 103.02  E-value: 1.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  31 FERSDDLGGLWRFTTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAIFDAVMVCTGFLTNPYLPldSFPGINAFKGQYFH 109
Cdd:PLN02172 120 FAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEIFDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIH 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 110 SRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggwviSRIFDSGypwdmvfmtrfqnmLRNSLPTPiv 189
Cdd:PLN02172 193 SHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA--------SRASESD--------------TYEKLPVP-- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 190 twlmerkINNWLNHANYGLIPEDrtqlkefvlndelpgriitgkvfirpsikevkeNSVIFNNtSKEEPIDIIVFATGYT 269
Cdd:PLN02172 249 -------QNNLWMHSEIDTAHED---------------------------------GSIVFKN-GKVVYADTIVHCTGYK 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128 270 FAFPFLDES-VVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEIN 347
Cdd:PLN02172 288 YHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDIN 365

                        330       340       350
                 ....*....|....*....|....*....|....
gi 544186128 348 ARKENKPSwFGLC--YCKAL---QSDYITYIDEL 376
Cdd:PLN02172 366 AWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
45-289 3.70e-12

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 66.86  E-value: 3.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   45 TKVCSVTKcsdsaVSGQWEVVTMHEEkqesaiFDA--VMVCTGFLTNPYLPLDSFPGInafkgqyfHSRQYKHPDIFKDK 122
Cdd:pfam13738  96 EEVTSVKK-----EDDGFVVTTSKGT------YQAryVIIATGEFDFPNKLGVPELPK--------HYSYVKDFHPYAGQ 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  123 RVLVIGMGNSGTDIAVEashLAEKvflsttgGGWVisRIFDSGYPWDmvfmtrfqnmlrnslptpivtwlmerkinNWLN 202
Cdd:pfam13738 157 KVVVIGGYNSAVDAALE---LVRK-------GARV--TVLYRGSEWE-----------------------------DRDS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  203 HANYGLIPEDRTQLKEFVLNdelpGRIitgKVFIRPSIKEVKENS----VIFNNTSKEEPIDIIVFATGYTFAFPFLDES 278
Cdd:pfam13738 196 DPSYSLSPDTLNRLEELVKN----GKI---KAHFNAEVKEITEVDvsykVHTEDGRKVTSNDDPILATGYHPDLSFLKKG 268

                         250
                  ....*....|..
gi 544186128  279 VVKV-EDGQASL 289
Cdd:pfam13738 269 LFELdEDGRPVL 280
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-140 1.74e-09

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 59.76  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   3 KRVAIVGAGVSGLAsikcC----LEEGLEPTCFERSDDLGGLWRFttkvcsvtkcsdsavsG-----------QWEV--- 64
Cdd:COG0493  122 KKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGLLRY----------------GipefrlpkdvlDREIeli 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  65 ----------------VTMHEEKQEsaiFDAVMVCTGFLTNPYLPLdsfPGINAfKGQYF------HSRQYKHPD--IFK 120
Cdd:COG0493  182 ealgvefrtnvevgkdITLDELLEE---FDAVFLATGAGKPRDLGI---PGEDL-KGVHSamdfltAVNLGEAPDtiLAV 254

                        170       180
                 ....*....|....*....|
gi 544186128 121 DKRVLVIGMGNSGTDIAVEA 140
Cdd:COG0493  255 GKRVVVIGGGNTAMDCARTA 274
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 3-150 3.20e-08

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 55.38  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   3 KRVAIVGAGVSGLAS---IKCcleEGLEPTCFERSDDLGGL-------WR---------------------FTTKV-CSV 50
Cdd:PRK12770  19 KKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLmlfgipeFRipiervregvkeleeagvvfhTRTKVcCGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  51 TKCSDSAVSGQWEVVTMHEEKQEsaiFDAVMVCTGF-----LTNP-------YLPLDSFPGINAFKgqYFHSRQYKHPDi 118
Cdd:PRK12770  96 PLHEEEGDEFVERIVSLEELVKK---YDAVLIATGTwksrkLGIPgedlpgvYSALEYLFRIRAAK--LGYLPWEKVPP- 169

                        170       180       190
                 ....*....|....*....|....*....|...
gi 544186128 119 FKDKRVLVIGMGNSGTDIAVEASHL-AEKVFLS 150
Cdd:PRK12770 170 VEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLA 202
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-135 5.89e-08

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 54.78  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   3 KRVAIVGAGVSGLAsikcCLEE----GLEPTCFERSDDLGGLWRF-----------------------TTKVCSVTKCSD 55
Cdd:PRK12810 144 KKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGLLRYgipdfklekevidrrielmeaegIEFRTNVEVGKD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  56 savsgqwevVTMHEEKQEsaiFDAVMVCTGfLTNP-YLPldsFPGINAfKGQYF-----------HSRQYKHPDI-FKDK 122
Cdd:PRK12810 220 ---------ITAEELLAE---YDAVFLGTG-AYKPrDLG---IPGRDL-DGVHFamdfliqntrrVLGDETEPFIsAKGK 282

                        170
                 ....*....|...
gi 544186128 123 RVLVIGMGNSGTD 135
Cdd:PRK12810 283 HVVVIGGGDTGMD 295
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 1.89e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 46.75  E-value: 1.89e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 544186128   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
5-149 2.37e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 46.27  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128   5 VAIVGAGVSGL-ASIKCCLEeGLEPTCFERsDDLGGlwRFTTkvcsvTKCSD------SAVSGQWEVVTMHEE------- 70
Cdd:COG0492    3 VVIIGAGPAGLtAAIYAARA-GLKTLVIEG-GEPGG--QLAT-----TKEIEnypgfpEGISGPELAERLREQaerfgae 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186128  71 ---------KQESAIF------------DAVMVCTGFltNP-YLPLdsfPGINAFKGQ----------YFhsrqykhpdi 118
Cdd:COG0492   74 illeevtsvDKDDGPFrvttddgteyeaKAVIIATGA--GPrKLGL---PGEEEFEGRgvsycatcdgFF---------- 138

                        170       180       190
                 ....*....|....*....|....*....|.
gi 544186128 119 FKDKRVLVIGMGNSGTDIAVEASHLAEKVFL 149
Cdd:COG0492  139 FRGKDVVVVGGGDSALEEALYLTKFASKVTL 169
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 4.46e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 45.65  E-value: 4.46e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 544186128   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 1.40e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 44.07  E-value: 1.40e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 544186128   1 MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGG 39
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-42 2.34e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.44  E-value: 2.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 544186128    7 IVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWR 42
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAY 36
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 3-43 3.66e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 3.66e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 544186128   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRF 43
Cdd:PRK12769 328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 2.40e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 40.06  E-value: 2.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 544186128   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDD 36
Cdd:COG0771    5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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