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Conserved domains on  [gi|544710825|ref|NP_001269848|]
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DNA repair-scaffolding protein isoform 3 [Homo sapiens]

Protein Classification

DUF4502 and DUF4503 domain-containing protein( domain architecture ID 10633128)

DUF4502 and DUF4503 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
461-790 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


:

Pssm-ID: 464397  Cd Length: 385  Bit Score: 634.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  461 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 540
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  541 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 620
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  621 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 700
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  701 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 780
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330
                  ....*....|
gi 544710825  781 SRPQCRVKVK 790
Cdd:pfam14951 321 SRPQCTVKVK 330
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
3-309 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


:

Pssm-ID: 464396  Cd Length: 384  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825    3 QSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQR---------------------- 60
Cdd:pfam14950  53 PSLTAEKKTITEKHLELSPRPKKETTTSKSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedga 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825   61 --DELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVL 138
Cdd:pfam14950 133 seDELQVIDWEIDSDREDASECSEFEDDESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVL 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  139 LIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAI 217
Cdd:pfam14950 213 FIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAI 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  218 SLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQ 297
Cdd:pfam14950 293 SLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQ 372
                         330
                  ....*....|..
gi 544710825  298 DTVRIFPPWQKL 309
Cdd:pfam14950 373 DIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
461-790 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 634.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  461 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 540
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  541 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 620
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  621 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 700
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  701 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 780
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330
                  ....*....|
gi 544710825  781 SRPQCRVKVK 790
Cdd:pfam14951 321 SRPQCTVKVK 330
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
3-309 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825    3 QSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQR---------------------- 60
Cdd:pfam14950  53 PSLTAEKKTITEKHLELSPRPKKETTTSKSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedga 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825   61 --DELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVL 138
Cdd:pfam14950 133 seDELQVIDWEIDSDREDASECSEFEDDESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVL 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  139 LIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAI 217
Cdd:pfam14950 213 FIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAI 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  218 SLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQ 297
Cdd:pfam14950 293 SLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQ 372
                         330
                  ....*....|..
gi 544710825  298 DTVRIFPPWQKL 309
Cdd:pfam14950 373 DIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
461-790 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 634.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  461 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 540
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  541 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 620
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  621 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 700
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  701 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 780
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330
                  ....*....|
gi 544710825  781 SRPQCRVKVK 790
Cdd:pfam14951 321 SRPQCTVKVK 330
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
3-309 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 560.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825    3 QSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQR---------------------- 60
Cdd:pfam14950  53 PSLTAEKKTITEKHLELSPRPKKETTTSKSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedga 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825   61 --DELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVL 138
Cdd:pfam14950 133 seDELQVIDWEIDSDREDASECSEFEDDESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVL 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  139 LIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAI 217
Cdd:pfam14950 213 FIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAI 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544710825  218 SLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQ 297
Cdd:pfam14950 293 SLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQ 372
                         330
                  ....*....|..
gi 544710825  298 DTVRIFPPWQKL 309
Cdd:pfam14950 373 DIIHIYPPWQKL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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