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Conserved domains on  [gi|545478494|ref|NP_001269870|]
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rhotekin-2 isoform 2 [Homo sapiens]

Protein Classification

formin-binding protein 1; F-BAR dand HR1 domain-containing protein( domain architecture ID 10654329)

formin-binding protein 1 is involved in dynamin-mediated endocytosis; F-BAR (FES-CIP4 homology and Bin/Amphiphysin/Rvs) and HR1 (protein kinase C-related kinase homology region 1 Rho-binding) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anillin pfam08174
Cell division protein anillin; Anillin is a protein involved in septin organization during ...
 98-163 1.65e-29

Cell division protein anillin; Anillin is a protein involved in septin organization during cell division. It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localization of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.


:

Pssm-ID: 462393  Cd Length: 139  Bit Score: 105.05  E-value: 1.65e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545478494   98 CKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVV-NVDKT-ITDICFENVTIL 163
Cdd:pfam08174   1 CKGKVTISDIRIPLKWRFVDHFKNKGESRRYAFFCLLKCGTEIEATDLVsTLDRTdGTDICFGDPITF 68
Hr1 smart00742
Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical ...
 19-74 3.58e-10

Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain


:

Pssm-ID: 128981  Cd Length: 57  Bit Score: 52.58  E-value: 3.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 545478494    19 QQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVL-HAVKNLMVCNARLMAYTSELQK 74
Cdd:smart00742   1 LRLEDLRRKIEKELKVKEGAENMRKLTSNDRKVLsEAQSMLRESNQKLDLLKEELEK 57
 
Name Accession Description Interval E-value
Anillin pfam08174
Cell division protein anillin; Anillin is a protein involved in septin organization during ...
 98-163 1.65e-29

Cell division protein anillin; Anillin is a protein involved in septin organization during cell division. It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localization of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.


Pssm-ID: 462393  Cd Length: 139  Bit Score: 105.05  E-value: 1.65e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545478494   98 CKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVV-NVDKT-ITDICFENVTIL 163
Cdd:pfam08174   1 CKGKVTISDIRIPLKWRFVDHFKNKGESRRYAFFCLLKCGTEIEATDLVsTLDRTdGTDICFGDPITF 68
Hr1 smart00742
Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical ...
 19-74 3.58e-10

Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain


Pssm-ID: 128981  Cd Length: 57  Bit Score: 52.58  E-value: 3.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 545478494    19 QQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVL-HAVKNLMVCNARLMAYTSELQK 74
Cdd:smart00742   1 LRLEDLRRKIEKELKVKEGAENMRKLTSNDRKVLsEAQSMLRESNQKLDLLKEELEK 57
 
Name Accession Description Interval E-value
Anillin pfam08174
Cell division protein anillin; Anillin is a protein involved in septin organization during ...
 98-163 1.65e-29

Cell division protein anillin; Anillin is a protein involved in septin organization during cell division. It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localization of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.


Pssm-ID: 462393  Cd Length: 139  Bit Score: 105.05  E-value: 1.65e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545478494   98 CKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVV-NVDKT-ITDICFENVTIL 163
Cdd:pfam08174   1 CKGKVTISDIRIPLKWRFVDHFKNKGESRRYAFFCLLKCGTEIEATDLVsTLDRTdGTDICFGDPITF 68
Hr1 smart00742
Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical ...
 19-74 3.58e-10

Rho effector or protein kinase C-related kinase homology region 1 homologues; Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain


Pssm-ID: 128981  Cd Length: 57  Bit Score: 52.58  E-value: 3.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 545478494    19 QQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVL-HAVKNLMVCNARLMAYTSELQK 74
Cdd:smart00742   1 LRLEDLRRKIEKELKVKEGAENMRKLTSNDRKVLsEAQSMLRESNQKLDLLKEELEK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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