NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|546231733|ref|NP_001271235|]
View 

zinc finger protein 106 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 710-987 1.03e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  710 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 787
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  788 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 864
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  865 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 940
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 546231733  941 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 987
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 710-987 1.03e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  710 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 787
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  788 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 864
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  865 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 940
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 546231733  941 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 987
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
712-988 1.79e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 1.79e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  712 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 789
Cdd:COG2319   116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  790 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 864
Cdd:COG2319   193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  865 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 940
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 546231733  941 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 988
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 745-787 4.88e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 4.88e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 546231733    745 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 787
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
710-742 3.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 546231733   710 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 742
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 710-987 1.03e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  710 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 787
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  788 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 864
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  865 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 940
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 546231733  941 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 987
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
712-988 1.79e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 1.79e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  712 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 789
Cdd:COG2319   116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  790 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 864
Cdd:COG2319   193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  865 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 940
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 546231733  941 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 988
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
703-988 1.85e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 1.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  703 DDDEPTEGSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKnaALYTGSSD 780
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGK--TLASGSAD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  781 HTIRCYNVKSRECVeqlqledRVLCLHSRW----------RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATA 850
Cdd:COG2319   142 GTVRLWDLATGKLL-------RTLTGHSGAvtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  851 QEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAV 928
Cdd:COG2319   214 PDG--KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 546231733  929 TVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIH--KSMIYTGCYDGSIQ 988
Cdd:COG2319   292 NSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-951 7.70e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.70e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  711 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGknaALYTGSSDHTIRCYNV 788
Cdd:cd00200    46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  789 KSRECVEQLQL-EDRVLCL--HSRWRILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGARklLVVGSYDC 865
Cdd:cd00200   123 ETGKCLTTLRGhTDWVNSVafSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSSDG 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  866 TISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVTA 941
Cdd:cd00200   200 TIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASG 279

                         250
                  ....*....|
gi 546231733  942 CLDKFVRVYE 951
Cdd:cd00200   280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
711-954 1.28e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 1.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  711 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKNAAlyTGSSDHTIRCYNV 788
Cdd:COG2319   157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLA--SGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  789 KSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFEcHGPRAVSCLATAQEGarKLLVVGSY 863
Cdd:COG2319   234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  864 DCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 939
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                         250
                  ....*....|....*
gi 546231733  940 TACLDKFVRVYELQS 954
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 748-987 4.38e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.38e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  748 CIGVFEGHTSKVNCLlvtQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLE----DRVLCLHSRWRILYAGLaNGTVV 823
Cdd:cd00200     1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADGTYLASGSS-DKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  824 TFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSG 901
Cdd:cd00200    77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  902 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--M 977
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                         250
                  ....*....|
gi 546231733  978 IYTGCYDGSI 987
Cdd:cd00200   234 LASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
839-988 5.75e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 5.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733  839 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGE 916
Cdd:COG2319    34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 546231733  917 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 988
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 745-787 4.88e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 4.88e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 546231733    745 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 787
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 711-742 8.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.79e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 546231733    711 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 742
Cdd:smart00320    7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
710-742 3.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 546231733   710 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 742
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
746-787 4.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 546231733   746 RKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYN 787
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 844-919 5.71e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.06  E-value: 5.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231733   844 VSCLATAQEGArkLLVVGSYDCTISV-------------RDARNGLL----------LRTLEGHSKTILCMKVVN--DLV 898
Cdd:pfam20426  127 VSCVAVTSDGS--ILATGSYDTTVMVwevlrgrssekrsRNTQTEFPrkdhviaetpFHILCGHDDIITCLYVSVelDIV 204

                           90       100
                   ....*....|....*....|.
gi 546231733   899 FSGSSDQSVHAHNIHTGELVR 919
Cdd:pfam20426  205 ISGSKDGTCIFHTLREGRYVR 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH