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Conserved domains on  [gi|548923952|ref|NP_001271359|]
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U3 small nucleolar RNA-associated protein 15 homolog isoform 2 [Homo sapiens]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 324-471 4.64e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 201.94  E-value: 4.64e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  324 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 403
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923952  404 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 471
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
31-288 3.98e-55

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 3.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  31 PPYNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHT 108
Cdd:COG2319   88 PDGRLLASASAdgTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 109 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLSVE- 185
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLATGKLLRTLTg 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 186 HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVV 264
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260
                 ....*....|....*....|....*
gi 548923952 265 HSFD-YAASILSLALAHEDETIVVG 288
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 324-471 4.64e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 201.94  E-value: 4.64e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  324 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 403
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923952  404 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 471
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
31-288 3.98e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 3.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  31 PPYNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHT 108
Cdd:COG2319   88 PDGRLLASASAdgTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 109 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLSVE- 185
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLATGKLLRTLTg 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 186 HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVV 264
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260
                 ....*....|....*....|....*
gi 548923952 265 HSFD-YAASILSLALAHEDETIVVG 288
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-296 1.56e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.66  E-value: 1.56e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  53 PIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 132
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 133 PNSKEILTFKEHSDYVRCgCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYV 210
Cdd:cd00200   81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 211 KVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGM 289
Cdd:cd00200  160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                 ....*..
gi 548923952 290 TNGILSV 296
Cdd:cd00200  239 EDGTIRV 245
PTZ00421 PTZ00421
coronin; Provisional
 72-217 4.82e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 4.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  72 DGRLLVAGSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEILTFKE 143
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 144 HSDYVrCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDML 216
Cdd:PTZ00421 167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                 .
gi 548923952 217 K 217
Cdd:PTZ00421 246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-131 1.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 548923952    95 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 131
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-131 2.05e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 548923952   95 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 131
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 324-471 4.64e-63

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 201.94  E-value: 4.64e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  324 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 403
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923952  404 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 471
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
31-288 3.98e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 3.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  31 PPYNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHT 108
Cdd:COG2319   88 PDGRLLASASAdgTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 109 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLSVE- 185
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLATGKLLRTLTg 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 186 HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVV 264
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260
                 ....*....|....*....|....*
gi 548923952 265 HSFD-YAASILSLALAHEDETIVVG 288
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
37-288 5.41e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 5.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  37 VTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTAD 114
Cdd:COG2319  136 ASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 115 KYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQPVE 191
Cdd:COG2319  216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS-VA--FSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVN 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 192 SVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF-DY 269
Cdd:COG2319  293 SVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtGH 371

                        250
                 ....*....|....*....
gi 548923952 270 AASILSLALAHEDETIVVG 288
Cdd:COG2319  372 TGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
35-260 4.71e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.95  E-value: 4.71e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  35 YAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFT 112
Cdd:COG2319  176 LLASGSDdgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 113 ADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQP 189
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGA 332

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 548923952 190 VESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTS 260
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDdGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
48-296 1.60e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.60e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  48 RYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTV 127
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 128 KLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVS 204
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTS-VA--FSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 205 AGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD-YAASILSLALAHED 282
Cdd:COG2319  222 GSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDG 300

                        250
                 ....*....|....
gi 548923952 283 ETIVVGMTNGILSV 296
Cdd:COG2319  301 KLLASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-296 1.56e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.66  E-value: 1.56e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  53 PIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 132
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 133 PNSKEILTFKEHSDYVRCgCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYV 210
Cdd:cd00200   81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 211 KVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGM 289
Cdd:cd00200  160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                 ....*..
gi 548923952 290 TNGILSV 296
Cdd:cd00200  239 EDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-287 1.94e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.58  E-value: 1.94e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  31 PPYNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHT 108
Cdd:cd00200   19 PDGKLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 109 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFDARTSESVLSVE-HG 187
Cdd:cd00200   99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTgHT 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 188 QPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHS 266
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256

                        250       260
                 ....*....|....*....|..
gi 548923952 267 FD-YAASILSLALaHEDETIVV 287
Cdd:cd00200  257 LSgHTNSVTSLAW-SPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-257 1.01e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 1.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  50 SQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKL 129
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 130 WDIPNSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFDARTSESVLS-VEHGQPVESVLLFPSGGLLVSAGG- 207
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEd 240

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 548923952 208 RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 257
Cdd:cd00200  241 GTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
67-296 3.26e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 3.26e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  67 ATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSD 146
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 147 YVRCGCASklnPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLL 222
Cdd:COG2319  122 AVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWD-LATGKLL 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548923952 223 VSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 296
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-174 1.63e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  32 PYNYAVTASSR---IHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHT 108
Cdd:cd00200  145 PDGTFVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548923952 109 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLfITGSYDHTVKMFD 174
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 72-217 4.82e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 4.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  72 DGRLLVAGSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEILTFKE 143
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 144 HSDYVrCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDML 216
Cdd:PTZ00421 167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                 .
gi 548923952 217 K 217
Cdd:PTZ00421 246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-131 1.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 548923952    95 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 131
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 219-257 1.85e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.85e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 548923952   219 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 257
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-131 2.05e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 548923952   95 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 131
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
219-257 4.58e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 548923952  219 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 66-299 1.43e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  66 CA-TFRQDGRLLVAGSEDGGVQLFDIS-----GRA---PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSK 136
Cdd:PLN00181 487 CAiGFDRDGEFFATAGVNKKIKIFECEsiikdGRDihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQ 566

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 137 EILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVlLFPSG---GLLVSAGGRYVKVW 213
Cdd:PLN00181 567 LVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCV-QFPSEsgrSLAFGSADHKVYYY 645

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 214 DMLKGGQLLVSLKNHHKTVTCLCLSSSGQrLLSGSLDRKVKVY------STTSYKVVHSFDYAASILS-LALAHEDETIV 286
Cdd:PLN00181 646 DLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdlsmsiSGINETPLHSFMGHTNVKNfVGLSVSDGYIA 724

                        250
                 ....*....|...
gi 548923952 287 VGMTNGILSVKHR 299
Cdd:PLN00181 725 TGSETNEVFVYHK 737
WD40 COG2319
WD40 repeat [General function prediction only];
175-288 2.65e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 175 ARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVK 254
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 548923952 255 VYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 288
Cdd:COG2319  104 LWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASG 138
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-174 1.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 548923952   134 NSKEILTFKEHSDYVRCGCASKlNPDLFITGSYDHTVKMFD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-174 1.81e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 548923952  135 SKEILTFKEHSDYVRCgCASKLNPDLFITGSYDHTVKMFD 174
Cdd:pfam00400   1 GKLLKTLEGHTGSVTS-LAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-89 4.76e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.76e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 548923952    50 SQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFD 89
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
160-287 1.06e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952 160 LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLL--VSAGGRYVKVWDmLKGGQLLVSLKNhHKTVTCLCL 237
Cdd:COG3391   82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyvADSGNGRVSVID-TATGKVVATIPV-GAGPHGIAV 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 548923952 238 SSSGQRLLSGSLDRK-----VKVYSTTSYKVVHSFDYAASILSLALAHEDETIVV 287
Cdd:COG3391  160 DPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYV 214
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 75-301 1.30e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952   75 LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI----PNSKEILTFKE------- 143
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSRNTQTefprkdh 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  144 ------------HSDYVRCGCASkLNPDLFITGSYDHTVKMFDARTSESVLSVEHgqpvesvllfPSG----GLLVSAGG 207
Cdd:pfam20426 176 viaetpfhilcgHDDIITCLYVS-VELDIVISGSKDGTCIFHTLREGRYVRSIRH----------PSGcplsKLVASRHG 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  208 RYVKVWDM--------LKGGQLLVSLKNHHktVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAA-SILSLAL 278
Cdd:pfam20426 245 RIVLYADDdlslhlysINGKHIASSESNGR--LNCIELSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGkIITSLTV 322

                         250       260
                  ....*....|....*....|....*....
gi 548923952  279 AHEdETIVVGMTNGILSV------KHRKS 301
Cdd:pfam20426 323 TPE-ECFLAGTKDGSLLVysienpQLRKA 350
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
15-210 1.86e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  15 LGEKITQDTLYWNNYKPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLL-VAGSEDGGVQLFDISGR 93
Cdd:COG3391   21 LAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  94 APLRQFEGHTKAvHTVDFTADKYHV-VSGADDYTVKLWDIPNSKEILTFKEHSDYVrcGCAskLNPD---LFITGSYDHT 169
Cdd:COG3391  101 KVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPH--GIA--VDPDgkrLYVANSGSNT 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 548923952 170 ----VKMFDARTSESVLSVEHG-QPVesvllfpsgGLLVSAGGRYV 210
Cdd:COG3391  176 vsviVSVIDTATGKVVATIPVGgGPV---------GVAVSPDGRRL 212
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
36-177 2.29e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 2.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923952  36 AVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHtKAVHTVDFTAD- 114
Cdd:COG3391   85 ANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDg 163

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 548923952 115 KYHVVSGADDYT----VKLWDIPNSKEILTFKEHSDyvrcGCASKLNPD---LFITGSY-------DHTVKMFDART 177
Cdd:COG3391  164 KRLYVANSGSNTvsviVSVIDTATGKVVATIPVGGG----PVGVAVSPDgrrLYVANRGsntsnggSNTVSVIDLAT 236
WD40 pfam00400
WD domain, G-beta repeat;
52-89 4.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 548923952   52 EPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFD 89
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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