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Conserved domains on  [gi|548960447|ref|NP_001271427|]
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large neutral amino acids transporter small subunit 4 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
87-239 3.87e-05

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960447 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738  119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-239 3.87e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960447 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738  119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 4.48e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.88  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548960447 167 TLPNMFGDLRSTFIAlMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174  112 LFPERERGRALGLLQ-AFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 1.74e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447   87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548960447  167 TLPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-239 3.87e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960447 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738  119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 4.48e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.88  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548960447 167 TLPNMFGDLRSTFIAlMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174  112 LFPERERGRALGLLQ-AFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-227 8.58e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 8.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnaLSVLIFIALALnGFGGMCMTFTSLTLP 169
Cdd:COG2223   44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS----YWLLLLLGLLL-GIGGGGSFAVGIALV 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 548960447 170 NMF--GDLRSTF--IALMIGSYASSAVTFPGIKLIYDAGVSfiVVLVVWAGCSGLVFLNCFF 227
Cdd:COG2223  119 SKWfpPDRRGLAlgLAAGGGNLGAAVAAFLAPLLIAAFGWR--NAFLILGILLLVVAVLAWL 178
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 1.74e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447   87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548960447  167 TLPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 90-195 3.86e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.03  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  90 LAFTVGsFLLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgASKPNALSVLIFIaLALNGFGGMCMTFTSLTL 168
Cdd:cd17355   42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLAL-ATSLWQLYLLWGL-LGGGGAGTLAAVAFATVA 118

                         90       100
                 ....*....|....*....|....*..
gi 548960447 169 PNMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:cd17355  119 AWWFERRRGLALGILTAGGGLGSLVFL 145
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 98-167 1.03e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 1.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548960447  98 LLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgaSKPNALSVLIFIALALNGFgGMCMTFTSLT 167
Cdd:cd17503  225 LASAILSPLvGRLLDKFGPRLLLLAGLLLLALGTLLLAF--LTPDTSLWLIILPLFIRGL-GMGLVFMPLN 292
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 90-160 1.30e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.44  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548960447  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGaskpnalsvlIFIALALNGFGGMC 160
Cdd:cd17353   42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFA----------ISLPLLFLGYGVLG 102
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-231 2.56e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.24  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  85 DEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnalSVLIFIALALNGFG-GMCMTF 163
Cdd:COG2271   44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS-----FWQLLLLRFLLGLGeAGFFPA 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548960447 164 TSLTLPNMF-GDLRSTFIAL-MIGSYASSAVTFPGIKLIYDA--------GVSFIVVLVVWAGCSGLVFLNCFFNWPL 231
Cdd:COG2271  119 ALKLIAEWFpPKERGRALGIfNAGGPLGGALAPPLLGWLLAAfgwraaflILGLPGLLLALLRFWLLALAYFLVYFAL 196
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 92-194 3.20e-03

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 39.93  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  92 FTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKP-NALSV-LIFIALALNGFGGMCMTFTSLTLP 169
Cdd:cd17354   43 LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTGLiSDLSFwLMCLCFFLIGNSTSSLYTAALVTC 122

                         90       100
                 ....*....|....*....|....*.
gi 548960447 170 N-MFGDLRSTFIALMIGSYASSAVTF 194
Cdd:cd17354  123 AkNFPESRGLAIGIPKGCYGLSGAIG 148
MFS_1 pfam07690
Major Facilitator Superfamily;
90-195 3.41e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447   90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                          90       100
                  ....*....|....*....|....*.
gi 548960447  170 NMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-185 5.00e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLsaitlplGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIAlalngfgGMCMTFTSL 166
Cdd:cd17365  214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA-------GACVNGAQV 279

                         90       100
                 ....*....|....*....|....
gi 548960447 167 TLPNMFGDL-----RSTFIALMIG 185
Cdd:cd17365  280 GLYALAARFyptevRATGVGWALG 303
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-187 6.11e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 6.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|....*...
gi 548960447 170 nmfGDLRSTFIALMIGSY 187
Cdd:COG2814  327 ---PEARGRASGLYNSAF 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
87-230 7.74e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 7.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960447  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnaLSVLIFIALALNGFGGMCMTFTSL 166
Cdd:COG2814   46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALA 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960447 167 TLPNMF-GDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWP 230
Cdd:COG2814  122 LIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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