NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|555290162|ref|NP_001273137|]
View 

dynein regulatory complex subunit 4 isoform c [Homo sapiens]

Protein Classification

GAS domain-containing protein( domain architecture ID 12155935)

GAS (growth-arrest specific micro-tubule binding) domain-containing protein similar to Homo sapiens dynein regulatory complex subunit 4, also known as GAS-8/GAS-11, which is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes

Gene Ontology:  GO:0031514|GO:0048870

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
29-228 3.61e-84

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


:

Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 250.98  E-value: 3.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   29 TLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 108
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  109 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEK 188
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEKKLQALGETLEK 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 555290162  189 KEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 228
Cdd:pfam13851 161 KEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
 
Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
29-228 3.61e-84

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 250.98  E-value: 3.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   29 TLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 108
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  109 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEK 188
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEKKLQALGETLEK 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 555290162  189 KEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 228
Cdd:pfam13851 161 KEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
7-248 1.28e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162     7 ELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAlINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 86
Cdd:TIGR02168  228 ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLE-VSELEEEIEELQKELYALANEISRLEQQKQI 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    87 LADPLQKAREEMSEMQKQLANYERDKQILlctKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQ 166
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDEL---AEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   167 ktgFKNLVLERKLQALSAAvekKEVQFNEVLAASnLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTY 246
Cdd:TIGR02168  384 ---LRSKVAQLELQIASLN---NEIERLEARLER-LEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEEL 456

                   ..
gi 555290162   247 EA 248
Cdd:TIGR02168  457 ER 458
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
54-234 2.16e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  54 ALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILlctKARLKVREKELKDLQ 133
Cdd:COG1196  246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARL---EERRRELEERLEELE 322
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162 134 WEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRK 213
Cdd:COG1196  323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL 402
                        170       180
                 ....*....|....*....|.
gi 555290162 214 LEDVLESKNSTIKDLQYELAQ 234
Cdd:COG1196  403 EELEEAEEALLERLERLEEEL 423
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
2-206 2.26e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.16  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   2 KMLRDELDLRRKTELHEVEERKNGQIHTLMQRHE-----EAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 76
Cdd:PTZ00436  43 KLIKDGLIIRKPVKVHSRSRWRHMKEAKSMGRHEgagrrEGTREARMPSKELWMRRLRILRRLLRKYREEKKIDRHIYRE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  77 M-----AEVSGQNKRLADPLQKAREEMSEmQKQLANyerdkqillctkarlKVREKELKDLQWEHEVLEQRFTKVQQERD 151
Cdd:PTZ00436 123 LyvkakGNVFRNKRNLMEHIHKVKNEKKK-ERQLAE---------------QLAAKRLKDEQHRHKARKQELRKREKDRE 186
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 555290162 152 ELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAA 206
Cdd:PTZ00436 187 RARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAA 241
 
Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
29-228 3.61e-84

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 250.98  E-value: 3.61e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   29 TLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 108
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  109 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEK 188
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEKKLQALGETLEK 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 555290162  189 KEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 228
Cdd:pfam13851 161 KEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
7-248 1.28e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162     7 ELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAlINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 86
Cdd:TIGR02168  228 ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLE-VSELEEEIEELQKELYALANEISRLEQQKQI 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    87 LADPLQKAREEMSEMQKQLANYERDKQILlctKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQ 166
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDEL---AEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   167 ktgFKNLVLERKLQALSAAvekKEVQFNEVLAASnLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTY 246
Cdd:TIGR02168  384 ---LRSKVAQLELQIASLN---NEIERLEARLER-LEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEEL 456

                   ..
gi 555290162   247 EA 248
Cdd:TIGR02168  457 ER 458
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
54-234 2.16e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  54 ALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILlctKARLKVREKELKDLQ 133
Cdd:COG1196  246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARL---EERRRELEERLEELE 322
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162 134 WEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRK 213
Cdd:COG1196  323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL 402
                        170       180
                 ....*....|....*....|.
gi 555290162 214 LEDVLESKNSTIKDLQYELAQ 234
Cdd:COG1196  403 EELEEAEEALLERLERLEEEL 423
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
4-252 4.75e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   4 LRDELDLRRKT-------ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALiNSLKEQMEDMRKKEDHLERE 76
Cdd:COG1196  218 LKEELKELEAEllllklrELEAELEELEAELEELEAELEELEAELAELEAELEELRLEL-EELELELEEAQAEEYELLAE 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  77 MAEVSGQNKRLADPLQKAREEMSEMQKQLAN----YERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 152
Cdd:COG1196  297 LARLEQDIARLEERRRELEERLEELEEELAEleeeLEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162 153 L---YRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAAsNLDPAALTLVSRKLEDVLESKNSTIKDLQ 229
Cdd:COG1196  377 AeeeLEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL-EEALAELEEEEEEEEEALEEAAEEEAELE 455
                        250       260
                 ....*....|....*....|...
gi 555290162 230 YELAQVCKAHNDLLRTYEAKLLA 252
Cdd:COG1196  456 EEEEALLELLAELLEEAALLEAA 478
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1-205 7.11e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 7.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   1 MKMLRDELDLRRKT--ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNlALINSLKEQMEDMRKKEDHLEREMA 78
Cdd:COG4942   29 LEQLQQEIAELEKElaALKKEEKALLKQLAALERRIAALARRIRALEQELAALE-AELAELEKEIAELRAELEAQKEELA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  79 EV------SGQNKRLA------DPLQKAREEM------SEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLE 140
Cdd:COG4942  108 ELlralyrLGRQPPLAlllspeDFLDAVRRLQylkylaPARREQAEELRADLAELAALRAELEAERAELEALLAELEEER 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555290162 141 QRFTKVQQERDELYRKFTAAIQEVQQKTGfKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPA 205
Cdd:COG4942  188 AALEALKAERQKLLARLEKELAELAAELA-ELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
2-206 2.26e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.16  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   2 KMLRDELDLRRKTELHEVEERKNGQIHTLMQRHE-----EAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 76
Cdd:PTZ00436  43 KLIKDGLIIRKPVKVHSRSRWRHMKEAKSMGRHEgagrrEGTREARMPSKELWMRRLRILRRLLRKYREEKKIDRHIYRE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  77 M-----AEVSGQNKRLADPLQKAREEMSEmQKQLANyerdkqillctkarlKVREKELKDLQWEHEVLEQRFTKVQQERD 151
Cdd:PTZ00436 123 LyvkakGNVFRNKRNLMEHIHKVKNEKKK-ERQLAE---------------QLAAKRLKDEQHRHKARKQELRKREKDRE 186
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 555290162 152 ELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAA 206
Cdd:PTZ00436 187 RARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAA 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
59-187 2.53e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.28  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    59 LKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILlctKARLKVREKELKDLQWEHEV 138
Cdd:TIGR02169  383 TRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINEL---EEEKEDKALEIKKQEWKLEQ 459
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 555290162   139 LEQRFTKVQQErdelYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVE 187
Cdd:TIGR02169  460 LAADLSKYEQE----LYDLKEEYDRVEKELSKLQRELAEAEAQARASEE 504
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
4-153 3.02e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    4 LRDELDlRRKTELHEVEERKNgqihTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQ 83
Cdd:COG4913   293 LEAELE-ELRAELARLEAELE----RLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEAL 367
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 555290162   84 NKRLADPLQKAREEMSEMQKQLANyerdkqillcTKARLKVREKELKDLQWEHEV----LEQRFTKVQQERDEL 153
Cdd:COG4913   368 LAALGLPLPASAEEFAALRAEAAA----------LLEALEEELEALEEALAEAEAalrdLRRELRELEAEIASL 431
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
47-249 3.38e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.74  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   47 DITLNNLALINSLKEQMEDMRKKEDHLEREmaevsgqnKRLADPLQKAREEMSEMQ--KQLANYERDKQILLCTKARLKV 124
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREQIELLEPI--------RELAERYAAARERLAELEylRAALRLWFAQRRLELLEAELEE 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  125 REKELKDLQWEHEVLEQRFTKVQQERDELYRkftaAIQEV--QQKTGFKNLV--LERKLQALSAAVEKKEVQFNEVLAAS 200
Cdd:COG4913   300 LRAELARLEAELERLEARLDALREELDELEA----QIRGNggDRLEQLEREIerLERELEERERRRARLEALLAALGLPL 375
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 555290162  201 NLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAK 249
Cdd:COG4913   376 PASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELREL 424
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
6-249 3.96e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.90  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162     6 DELDLRRKTELHEVEERKNgQIHTLMQRHEEAFTDIKNYYNDITLNNlALINSLKEQMEDMRKKEDHLEREMAEVSGQNK 85
Cdd:TIGR02169  684 EGLKRELSSLQSELRRIEN-RLDELSQELSDASRKIGEIEKEIEQLE-QEEEKLKERLEELEEDLSSLEQEIENVKSELK 761
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    86 RLADPLQKAREEMSEMQKQLANYERD----------------KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQE 149
Cdd:TIGR02169  762 ELEARIEELEEDLHKLEEALNDLEARlshsripeiqaelsklEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQ 841
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   150 RDELyrkfTAAIQEVQQKTGfknlVLERKLQALSAAVEKKEVQFNEvlaasnldpaaltlvsrkLEDVLESKNSTIKDLQ 229
Cdd:TIGR02169  842 RIDL----KEQIKSIEKEIE----NLNGKKEELEEELEELEAALRD------------------LESRLGDLKKERDELE 895
                          250       260
                   ....*....|....*....|
gi 555290162   230 YELAQVCKAHNDLLRTYEAK 249
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKK 915
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
58-252 4.18e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 4.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162    58 SLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKvreKELKDLQWEHE 137
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLK---ERLEELEEDLS 747
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162   138 VLEQRFTKVQQERDELyrkfTAAIQEVQQKTGFKNLVLE-----------RKLQALSAAVEKKEVQFNEVLAASNLDPAA 206
Cdd:TIGR02169  748 SLEQEIENVKSELKEL----EARIEELEEDLHKLEEALNdlearlshsriPEIQAELSKLEEEVSRIEARLREIEQKLNR 823
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 555290162   207 LTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHnDLLRTYEAKLLA 252
Cdd:TIGR02169  824 LTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEI-ENLNGKKEELEE 868
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
56-167 6.28e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 37.21  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555290162  56 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAR--EEMSEMQKQLANYERDKQIL----LCTKARLKVREKEL 129
Cdd:COG1579   47 LEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRnnKEYEALQKEIESLKRRISDLedeiLELMERIEELEEEL 126
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555290162 130 KDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK 167
Cdd:COG1579  127 AELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH