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Conserved domains on  [gi|556695460|ref|NP_001273349|]
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ER membrane protein complex subunit 4 isoform b [Homo sapiens]

Protein Classification

ER membrane protein complex subunit 4( domain architecture ID 5075)

ER membrane protein complex subunit 4 (EMC4) is a component of the ER membrane protein complex (EMC) required for efficient folding of proteins in the endoplasmic reticulum (ER)

Gene Symbol:  EMC4
Gene Ontology:  GO:0072546|GO:0005789

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1077 super family cl05757
Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic ...
 56-118 1.07e-30

Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic proteins of unknown function.


The actual alignment was detected with superfamily member pfam06417:

Pssm-ID: 461902  Cd Length: 118  Bit Score: 106.89  E-value: 1.07e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556695460   56 SVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISA 118
Cdd:pfam06417   1 SSKEELEALKVKKAWEIALAPAKSLPMNLFMMYMSGNSLQIFSIMMVGMLLWNPIKAIFSINK 63
 
Name Accession Description Interval E-value
DUF1077 pfam06417
Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic ...
 56-118 1.07e-30

Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461902  Cd Length: 118  Bit Score: 106.89  E-value: 1.07e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556695460   56 SVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISA 118
Cdd:pfam06417   1 SSKEELEALKVKKAWEIALAPAKSLPMNLFMMYMSGNSLQIFSIMMVGMLLWNPIKAIFSINK 63
 
Name Accession Description Interval E-value
DUF1077 pfam06417
Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic ...
 56-118 1.07e-30

Protein of unknown function (DUF1077); This family consists of several hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461902  Cd Length: 118  Bit Score: 106.89  E-value: 1.07e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556695460   56 SVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISA 118
Cdd:pfam06417   1 SSKEELEALKVKKAWEIALAPAKSLPMNLFMMYMSGNSLQIFSIMMVGMLLWNPIKAIFSINK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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