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Conserved domains on  [gi|558472844|ref|NP_001273761|]
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RCC1 and BTB domain-containing protein 2 isoform 4 [Homo sapiens]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13034835)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Arabidopsis thaliana At4g08455, which may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-216 4.05e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 257.56  E-value: 4.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 100 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 179
Cdd:cd18354    1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 558472844 180 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 216
Cdd:cd18354   81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 213-277 1.84e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


:

Pssm-ID: 350604  Cd Length: 65  Bit Score: 131.96  E-value: 1.84e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558472844 213 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 277
Cdd:cd18529    1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
 
Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-216 4.05e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 257.56  E-value: 4.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 100 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 179
Cdd:cd18354    1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 558472844 180 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 216
Cdd:cd18354   81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 213-277 1.84e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


Pssm-ID: 350604  Cd Length: 65  Bit Score: 131.96  E-value: 1.84e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558472844 213 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 277
Cdd:cd18529    1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 121-213 5.92e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 76.96  E-value: 5.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844   121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 558472844   197 RENRLKKLCQQTIKQGI 213
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 110-211 2.19e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 73.06  E-value: 2.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844  110 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDD----IVEMSEFSYPVYRAFLEYLYTDSIsLSPEE 185
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 558472844  186 AVGLLDLATFYRENRLKKLCQQTIKQ 211
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
PHA03098 PHA03098
kelch-like protein; Provisional
 124-263 6.69e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 6.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 124 FLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDDIveMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRL 201
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNfkENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558472844 202 KKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVtqtsgfaEMDHDLLK 263
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 218-267 5.53e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 35.78  E-value: 5.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 558472844   218 AIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 267
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLS 50
 
Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-216 4.05e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 257.56  E-value: 4.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 100 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 179
Cdd:cd18354    1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 558472844 180 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 216
Cdd:cd18354   81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-212 1.70e-59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 184.77  E-value: 1.70e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 101 DDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYT 176
Cdd:cd18353    2 DDFLTVAESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQshwnEDMKEVIEIDQFSYPVYRAFLEYLYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 558472844 177 DSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQG 212
Cdd:cd18353   82 DSVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRG 117
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 108-211 5.47e-56

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 175.52  E-value: 5.47e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 108 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSP 183
Cdd:cd18298    1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHwnedDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                         90       100
                 ....*....|....*....|....*...
gi 558472844 184 EEAVGLLDLATFYRENRLKKLCQQTIKQ 211
Cdd:cd18298   81 EDAIGLLDLANSYCEERLKKLCEDIIKQ 108
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 213-277 1.84e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


Pssm-ID: 350604  Cd Length: 65  Bit Score: 131.96  E-value: 1.84e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558472844 213 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 277
Cdd:cd18529    1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
BACK_RCBTB1 cd18528
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 ...
 212-277 3.48e-30

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1, also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), or CLL deletion region gene 7 protein, or regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5, is a novel chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. Moreover, RCBTB1 acts as a putative substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy.


Pssm-ID: 350603  Cd Length: 66  Bit Score: 108.06  E-value: 3.48e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558472844 212 GICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 277
Cdd:cd18528    1 GITVENAFSLLSAAVRYDAEDLEEFCFKFCVNHLTEVTQTAAFWQMDGNLLKEFIAKASKCGAFKN 66
BACK_RCBTB1_2 cd18498
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, ...
 213-276 7.55e-30

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.


Pssm-ID: 350573  Cd Length: 64  Bit Score: 106.98  E-value: 7.55e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558472844 213 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFK 276
Cdd:cd18498    1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDFIVKAAEAGAFK 64
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-217 4.35e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 85.79  E-value: 4.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYT---DSISLSPEEA 186
Cdd:cd18297    7 VNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSsgstEAQTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDA 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 558472844 187 VGLLDLATFYRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-209 1.65e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 84.22  E-value: 1.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 107 AESLKREFDNPDTADLKFLV--DGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEF---SYP--VYRAFLEYLYTDSI 179
Cdd:cd18294    2 AADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLvlsDIEpeVFRAVLEFIYTNCV 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 558472844 180 SLSPEEAVGLLDLATFYRENRLKKLCQQTI 209
Cdd:cd18294   82 TLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 121-213 5.92e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 76.96  E-value: 5.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844   121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 558472844   197 RENRLKKLCQQTIKQGI 213
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 114-209 1.75e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 76.12  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEH----FRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPE-EAVG 188
Cdd:cd18300    4 LNKGLFSDVTFIVEDGTIPAHKALLVARCDVmaamFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDgDCVG 83

                         90       100
                 ....*....|....*....|.
gi 558472844 189 LLDLATFYRENRLKKLCQQTI 209
Cdd:cd18300   84 LIVLANRLCLPRLVALCEQYI 104
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 110-211 2.19e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 73.06  E-value: 2.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844  110 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDD----IVEMSEFSYPVYRAFLEYLYTDSIsLSPEE 185
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 558472844  186 AVGLLDLATFYRENRLKKLCQQTIKQ 211
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 115-217 1.52e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 70.97  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 115 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLL 190
Cdd:cd18352    9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDggyrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                         90       100
                 ....*....|....*....|....*..
gi 558472844 191 DLATFYRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18352   89 RAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 120-196 1.66e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 69.89  E-value: 1.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 120 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 195
Cdd:cd18186    2 CDVTLVVGGREFPAHRAVLAARSPYFRamfsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81


                 .
gi 558472844 196 Y 196
Cdd:cd18186   82 L 82
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 103-207 1.07e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 65.77  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 103 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVEMSE--FSYPVYRAFLEYLY 175
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndwwSESKQSEIELVEdpECAAVFEKFLRYLY 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 558472844 176 TDSISLSPEEAVGLLDLATFYRENRLKKLCQQ 207
Cdd:cd18292   81 TGQISVNLETALPLLMLADKYNVTDLKQLCVD 112
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-219 2.83e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 65.38  E-value: 2.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED---NEDDIVEMSEFSYPVYRAFLEYLY---TDSISLSPEEAV 187
Cdd:cd18351   19 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNkpsAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIM 98

                         90       100       110
                 ....*....|....*....|....*....|..
gi 558472844 188 GLLDLATFYRENRLKKLCQQTIKQGICEENAI 219
Cdd:cd18351   99 ELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 115-214 3.78e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 64.62  E-value: 3.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 115 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN---------EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEE 185
Cdd:cd18296   13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHfaeseenngSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                         90       100
                 ....*....|....*....|....*....
gi 558472844 186 AVGLLDLATFYRENRLKKLCQQTIKQGIC 214
Cdd:cd18296   93 AYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-219 7.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 64.10  E-value: 7.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 115 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDNEDDIVEMSEFSYPVYRAFLEYLY---TDSISLSPEE 185
Cdd:cd18350   20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFkslltnKSEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIAD 99

                         90       100       110
                 ....*....|....*....|....*....|....
gi 558472844 186 AVGLLDLATFYRENRLKKLCQQTIKQGICEENAI 219
Cdd:cd18350  100 VLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-235 5.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 61.48  E-value: 5.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 102 DHLT-VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIvEMSEFSYPVYRAFLEYLY 175
Cdd:cd18287    4 DHVHfLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmrESQQSEI-ELKDTNAEAFKALLKYIY 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 176 TdsislspeeavGLLDLATFYrenrlkklcqqtikqgicEENAIALLSAAVKYDAQDLEE 235
Cdd:cd18287   83 T-----------GRLTLTDLK------------------EDVLLDVLGLAHQYGFEELEA 113
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-206 5.91e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.80  E-value: 5.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 115 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI----------- 179
Cdd:cd18280   10 ESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSmlfgPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsds 89

                         90       100
                 ....*....|....*....|....*...
gi 558472844 180 -SLSPEEAVGLLDLATFYRENRLKKLCQ 206
Cdd:cd18280   90 sSLDTTMAQHLLAAADRYALERLRLLCE 117
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 117-217 1.72e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 54.70  E-value: 1.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 117 PDTADLKFLVDGKYIYAHKVLLKIRCEH----FRSSLEdnEDDIVEMS--EFSyPVYRAF---LEYLYTDSISLSPEEAV 187
Cdd:cd18309   18 GDFCDITLLLDGHPIPAHKAILAARCSYfeamFRSFMP--EDNTVNISigEMV-PSRQAFdslLRYIYYGDVTMPPEDSL 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 558472844 188 GLLDLATFY--RENRLKKLCQQTIKQGICEEN 217
Cdd:cd18309   95 YLFSAPYFYgfTNNRLQAYCKQNLEMNVSFEN 126
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 114-205 3.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 53.12  E-value: 3.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVeMSEFSYPVYRAFLEYLYTDSISLSPEEAVG 188
Cdd:cd18314    1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVT-LEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                         90
                 ....*....|....*..
gi 558472844 189 LLDLATFYRENRLKKLC 205
Cdd:cd18314   80 LLMLASKYQVPDLEKLC 96
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-222 4.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 53.48  E-value: 4.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEhFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLsPEEAVGLLDLA 193
Cdd:cd18303   13 FDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSDISYEVVLALLRWLYTDELDL-TLDDEFLLELM 90

                         90       100
                 ....*....|....*....|....*....
gi 558472844 194 TFYRENRLKKLcqqtikQGICEENAIALL 222
Cdd:cd18303   91 KAAKRFQLTDL------VERCERALMSSV 113
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 214-267 7.02e-09

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 51.12  E-value: 7.02e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 558472844 214 CEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 267
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLS 54
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 110-209 7.79e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 52.54  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 110 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS-ISLSPE 184
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEvmaaMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDScCPASIL 80

                         90       100
                 ....*....|....*....|....*
gi 558472844 185 EAVGLLDLATFYRENRLKKLCQQTI 209
Cdd:cd18360   81 QAMALLICAEMYQVSRLQHICELYI 105
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 107-214 5.54e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 50.34  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 107 AESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIvEMSEFSYPVYRAFLEYLYTDSISL 181
Cdd:cd18286    5 GKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLsgswaESNSSEI-TLTGVSHAAVSFVLLFIYGGVLDL 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 558472844 182 SPEEAVG-LLDLATFYRENRLKKLCQQTIKQGIC 214
Cdd:cd18286   84 PDDVNLGeLLSLADMYGLDGLKDVVAYTLRRDYC 117
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 123-196 3.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 46.89  E-value: 3.23e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558472844 123 KFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRalfrGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 109-191 8.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 47.30  E-value: 8.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 109 SLKREFDNPDT--ADLKFLVD-GKYIYAHKVLLKIRCEHFRSSLEDNE------------DDIVEMSEFSYPVYRAFLEY 173
Cdd:cd18310    6 DLENLLDSPDLfySDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKaegantkpklelRELIPGGIVGYDAFMLVLSY 85

                         90
                 ....*....|....*...
gi 558472844 174 LYTDSISLSPEEAVGLLD 191
Cdd:cd18310   86 LYSGRLRLVPKEGSACVD 103
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-213 2.54e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 45.43  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 126 VDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVEMsEFSYPVYRAFLEYLYTDSISLSPE----EAV-GLLDLATF 195
Cdd:cd18302   13 EDGKEFPCHKCVLVARLEYFHSMLssswiEASSCSALTM-PIPSDILEIILDYLYTDEASAVKEsqnvEFLcNVLVIADQ 91

                         90
                 ....*....|....*...
gi 558472844 196 YRENRLKKLCQQTIKQGI 213
Cdd:cd18302   92 LLITRLKEICEVALVELL 109
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-217 2.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.77  E-value: 2.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 106 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 181
Cdd:cd18343    8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSpvfnAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 558472844 182 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18343   88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-195 2.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 45.18  E-value: 2.82e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN-EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 195
Cdd:cd18226   24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKNpNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKF 99
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 103-218 3.55e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 45.22  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 103 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS 178
Cdd:cd18345    2 ECRLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPvfnaMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 558472844 179 ISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 218
Cdd:cd18345   82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-217 9.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 43.96  E-value: 9.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 105 TVAESLKREFDNPDTADLKFLVdGK-----YIYAHKVLLKIRC----EHFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLY 175
Cdd:cd18281    8 TVKERFAFLFNNETLSDVHFIV-GKgdneqRIPAHKFVLSIGSavfdAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 558472844 176 TDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18281   86 SDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-206 1.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 43.38  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDnEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENR 200
Cdd:cd18206   24 DCTFVVDGVDFKAHKAVLAACSEYFRMLFVD-QKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQD 102


                 ....*.
gi 558472844 201 LKKLCQ 206
Cdd:cd18206  103 IVTACH 108
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-217 2.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 42.86  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIrCEH-----FRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 195
Cdd:cd18237   23 DVILIVEGREIKAHRVVLAA-ASHffhlmFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQ 101

                         90       100
                 ....*....|....*....|..
gi 558472844 196 YRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18237  102 YQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-222 2.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 42.47  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLednEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENR 200
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARL---SRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPC 82

                         90       100
                 ....*....|....*....|..
gi 558472844 201 LKKLCQQTIKQGICEENAIALL 222
Cdd:cd18275   83 AAQCAVDAVRAQLCLGNCYEVL 104
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 108-207 2.63e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 42.62  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 108 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--NEDDIVEMSE--FSYPVYRAFLEYLYTDSISLSP 183
Cdd:cd18295    8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwKDKREINLKHplVNPDAFRALLQYLYTGRLEIHV 87

                         90       100
                 ....*....|....*....|....
gi 558472844 184 EEAVGLLDLAtfyRENRLKKLCQQ 207
Cdd:cd18295   88 DDVEDCKRLA---KQCRLEELIEE 108
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-205 3.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 42.33  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 115 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDD----IVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVG 188
Cdd:cd18245   10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDgstyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQD 89

                         90
                 ....*....|....*..
gi 558472844 189 LLDLATFYRENRLKKLC 205
Cdd:cd18245   90 IVQAADLLLMTDLKDLC 106
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-217 5.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.75  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 106 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 181
Cdd:cd18279    5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAmfehEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 558472844 182 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 217
Cdd:cd18279   85 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-207 5.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 41.61  E-value: 5.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLVDGKY----IYAHKVLLKIRCE----HFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLYTDSISLSPEE 185
Cdd:cd18282    2 FNNELMADVHFIVGPPGgtqrIPAHKYVLATGSSvfyaMFYGGLAENKNEI-EIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                         90       100
                 ....*....|....*....|..
gi 558472844 186 AVGLLDLATFYRENRLKKLCQQ 207
Cdd:cd18282   81 VLATLYAAKKYLVPHLARACVQ 102
PHA03098 PHA03098
kelch-like protein; Provisional
 124-263 6.69e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 6.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 124 FLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDDIveMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRL 201
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNfkENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558472844 202 KKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVtqtsgfaEMDHDLLK 263
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-205 8.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 41.30  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:cd18265   25 DVVLLVDGKDFPCHRATLSANSAYFRAmfggHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLL 104


                 ....*....
gi 558472844 197 RENRLKKLC 205
Cdd:cd18265  105 QVSKLREAC 113
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 120-193 9.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 40.23  E-value: 9.96e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 558472844 120 ADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN---EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLA 193
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKETppdEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-211 1.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 41.10  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 133 AHKVLLKIRCEHFRSSLEDNEDDI-----VEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQ 207
Cdd:cd18207   41 AHRAVLAACSEYFESVFSAQEGDGgtpreLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQE 120


                 ....
gi 558472844 208 TIKQ 211
Cdd:cd18207  121 VIKQ 124
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 104-207 1.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 40.54  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 104 LTVAESLKREFDNPDTADLKFLV-------DGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYT 176
Cdd:cd18304    2 MELSEDLGLLYDSQQGCDFNISVltaggeeEELTFCAHRVILMLSPEANFLHKTGSSNITLDVDEECLPHVPDFLRYFYT 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 558472844 177 DSISLSPEEAVGLLDLATFYRENRLKKLCQQ 207
Cdd:cd18304   82 RQIDITLTSVKCFHKLASIYGVRKLREYCGQ 112
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-218 1.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 40.47  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 106 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 181
Cdd:cd18342    9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSpvfsAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 558472844 182 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 218
Cdd:cd18342   89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 217-264 1.74e-04

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 38.65  E-value: 1.74e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 558472844 217 NAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKN 264
Cdd:cd18500    5 NVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKE 52
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-218 1.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 40.71  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 101 DDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYT 176
Cdd:cd18344    5 DPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAmfehEMEERLKNPIEIHDLDPQVFKEMMGFIYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 558472844 177 DSISL--SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 218
Cdd:cd18344   85 GKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-213 2.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 40.03  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYP-VYRAFLEYLYTDSISLSPEEAVGLLDLATFYREN 199
Cdd:cd18222   27 DIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPtVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQ 106

                         90
                 ....*....|....
gi 558472844 200 RLKKLCQQtIKQGI 213
Cdd:cd18222  107 HIIDKCTQ-ILEGI 119
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-217 2.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 39.80  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAASCDYFRgmfaGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQL 104

                         90       100
                 ....*....|....*....|.
gi 558472844 197 RENRLKKLCQQTIKQGICEEN 217
Cdd:cd18251  105 QIPEVIGFCCDFLMSWVDNEN 125
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 213-257 2.64e-04

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 38.69  E-value: 2.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 558472844 213 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEM 257
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAEL 45
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-213 2.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 39.84  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----------EDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGL 189
Cdd:cd18228   21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlvSPAGKCVLDLHHVTVTGFAPLLEYAYTSTLSINTENIIDV 100

                         90       100
                 ....*....|....*....|....
gi 558472844 190 LDLATFYRENRLKKLCQQTIKQGI 213
Cdd:cd18228  101 LAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-206 3.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 39.37  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 107 AESLKREFDNPDTADLKFLVD-GKYIYAHKVLLKIRCEHF-----RSSLEDNEDDI-----VEMSEFSYPVYRAFLEYLY 175
Cdd:cd18288    6 AADFSAMVNNPHLSDVQFQTDsGEVLYAHSFVLYARCPLLiqmvhSEGFSVEEEGGvttrrVLLGDVSGEAARCFLQYLY 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 558472844 176 TDSISLSPEEAVGLLDLATFYRENRLKKLCQ 206
Cdd:cd18288   86 TADTGLPPGLSPHVSELADRFGVSELVHLCE 116
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 114-176 4.85e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 38.73  E-value: 4.85e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558472844 114 FDNPDTADLKFLVDGKY-IYAHKVLLKIRCEHFRSSLedNEDDIVEMSE-FSYPVYRAFLEYLYT 176
Cdd:cd18299    7 LHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMMTVVTLDSdITPEAFRRVLEFLYT 69
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-205 6.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 39.05  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:cd18271   26 DFNIIVKDETIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFL 105


                 ....*....
gi 558472844 197 RENRLKKLC 205
Cdd:cd18271  106 QVSLLSKAC 114
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-187 6.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 38.44  E-value: 6.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558472844 111 KREFDNpdTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED-NEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAV 187
Cdd:cd18221   12 QRELDQ--FTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDfTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEA 87
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 104-222 7.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 38.83  E-value: 7.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 104 LTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 179
Cdd:cd18270   11 VSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRamfmSGLSESKQTHVHLRNVDAATLQIIITYAYTGNL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 558472844 180 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALL 222
Cdd:cd18270   91 AINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 121-219 8.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 38.42  E-value: 8.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHF-----RSSLEDNEDDIVE--MSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLA 193
Cdd:cd18258   19 DLKIIVEGKEFEVHQNVLASCSLYFkdlikRSSRDSGGGEKLEltMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAA 98

                         90       100
                 ....*....|....*....|....*.
gi 558472844 194 TFYRENRLKKLCQQTIKQGICEENAI 219
Cdd:cd18258   99 NKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 120-207 1.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 37.95  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 120 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 195
Cdd:cd18272   33 ADVTISVEGKEFQLHRLVLSAQSCFFRsmftSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADM 112

                         90
                 ....*....|..
gi 558472844 196 YRENRLKKLCQQ 207
Cdd:cd18272  113 YQLTALFEECSR 124
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-205 1.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 37.27  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 114 FDNPDTADLKFLV----DGKYIYAHKVLL----KIRCEHFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLYTDSISLSPEE 185
Cdd:cd18349    3 FNNELMADVHFIVgppgASQRVPAHKYVLavgsSVFYAMFYGDLAEVKSEI-HIPDVEPAAFLILLKYMYSDEIDLEADT 81

                         90       100
                 ....*....|....*....|
gi 558472844 186 AVGLLDLATFYRENRLKKLC 205
Cdd:cd18349   82 VLATLYAAKKYIVPALAKAC 101
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 103-189 1.97e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 37.64  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 103 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS 178
Cdd:cd18358    4 HVRKANRIKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEwmaaMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                         90
                 ....*....|....*
gi 558472844 179 IS----LSPEEAVGL 189
Cdd:cd18358   84 LSptadLDPLELIAL 98
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-222 2.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 37.31  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 105 TVAESLKREFDNPDTADLKFLVD----GKYIYAHKVLLKIRCEHFRS----SLEDNEDDIvEMSEFSYPVYRAFLEYLYT 176
Cdd:cd18348    7 TIRERNAVMFNNDLMADIHFVVGppggTQRLPGHKYVLAVGSSVFHAmfygELAEDKDEI-RIPDVEPAAFLAMLKYIYC 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 558472844 177 DSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALL 222
Cdd:cd18348   86 DEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 120-201 3.41e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 36.91  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 120 ADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPE-EAVGLLDLAt 194
Cdd:cd18359   21 SDVTFMLDDGTISAHKPLLISSCDwmaaMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPDlDDMKLIILA- 99


                 ....*..
gi 558472844 195 fyreNRL 201
Cdd:cd18359  100 ----NRL 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 218-267 5.53e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 35.78  E-value: 5.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 558472844   218 AIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 267
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLS 50
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 121-213 9.38e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 35.17  E-value: 9.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472844 121 DLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 196
Cdd:cd18263   15 DVQLEADGSIFRVHRVILAAGSDYFRamftSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                         90
                 ....*....|....*..
gi 558472844 197 RENRLKKLCQQTIKQGI 213
Cdd:cd18263   95 QISGALALCLDFLQREI 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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