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Conserved domains on  [gi|568214318|ref|NP_001274737|]
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sodium-dependent lysophosphatidylcholine symporter 1 isoform 3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-340 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17451:

Pssm-ID: 475125  Cd Length: 419  Bit Score: 538.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17451  112 LQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMA---------------------------- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  81 etqkAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17451  164 ----AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17451  240 LFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVA 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17451  320 AAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSA 399

                        330       340
                 ....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17451  400 APVVLILLGLLLFKLYPIDE 419
 
Name Accession Description Interval E-value
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
 1-340 0e+00

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 538.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17451  112 LQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMA---------------------------- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  81 etqkAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17451  164 ----AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17451  240 LFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVA 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17451  320 AAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSA 399

                        330       340
                 ....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17451  400 APVVLILLGLLLFKLYPIDE 419
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 2-340 3.93e-66

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 215.64  E-value: 3.93e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318    2 VTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGqadtpcfqdlnsstvasqsanhthGTTSHRE 81
Cdd:pfam13347 111 YTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL------------------------ILGGTGL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   82 TQKAYLLAAGVIVCIYIICAVILILGVRE---QREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:pfam13347 167 ERKGYRIFALIGAVLMLLGVIITAAGTKErvsMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGL 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  159 FVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALM-ESNLIITYAVAVAAGI 237
Cdd:pfam13347 247 LLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLgPNNTLLFLVLYIIIGF 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  238 SVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEpiFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNML 317
Cdd:pfam13347 327 GYGSSFFLPWSMLADVVDYGELRTGKRREGT--FFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLL 404

                         330       340
                  ....*....|....*....|...
gi 568214318  318 VTMAPIVLILLGLLLFKMYPIDE 340
Cdd:pfam13347 405 YAVLPAVLFLVALLLLYFYPLDR 427
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-356 3.36e-46

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 163.53  E-value: 3.36e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTpcfqdlnsstvasqsanhthgttshrET 82
Cdd:COG2211  125 TLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG--------------------------DA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  83 QKAYLLAAGVIVCIYIICAVILILGVREQREPyeaqQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:COG2211  179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPVP----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGIS-SAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:COG2211  255 FKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTrGCSQPERVKFTLNMLVTM 320
Cdd:COG2211  335 AILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFL 411

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 568214318 321 APIVLILLGLLLFKMYPIDEERRRQNKKALQALRDE 356
Cdd:COG2211  412 LPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
PRK09669 PRK09669
putative symporter YagG; Provisional
 1-342 4.36e-07

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 51.65  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIV---GQADTpcfqdlnsstvasqsanhthgtt 77
Cdd:PRK09669 122 VYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPLVdilGKGDE----------------------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  78 shretQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSepiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEG 157
Cdd:PRK09669 179 -----QKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRGG 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 158 NFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAG 236
Cdd:PRK09669 251 ATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFN 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 237 ISVAAAFLLPWSMLPDVIDdfHLKQPHFHGTEPIFFSFYVFFTKFasGVSLGISTL--SLDFAGYQTRGCSQPERVKFTL 314
Cdd:PRK09669 331 FIQNLTTPLQWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTI 406

                        330       340
                 ....*....|....*....|....*...
gi 568214318 315 NMLVTMAPIVLILLGLLLFKMYPIDEER 342
Cdd:PRK09669 407 NLLFTVIPGVLFAGMAIILNFYKLNDAR 434
 
Name Accession Description Interval E-value
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
 1-340 0e+00

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 538.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17451  112 LQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMA---------------------------- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  81 etqkAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17451  164 ----AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17451  240 LFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVA 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17451  320 AAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSA 399

                        330       340
                 ....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17451  400 APVVLILLGLLLFKLYPIDE 419
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 1-340 0e+00

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 537.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASqsanhTHGTTSHR 80
Cdd:cd17392  112 FMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIVGVAHRPRRQDCTATPGTS-----DHPVTVLP 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  81 ETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17392  187 NTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLSYLAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFV 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17392  267 LFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFIGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLA 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17392  347 ALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGLSLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAP 426

                        330       340
                 ....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17392  427 VPICLILAGLVLFYVYPINE 446
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 1-340 4.06e-131

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 381.86  E-value: 4.06e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17452  112 LATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIVASA---------------------------- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  81 etqkaYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17452  164 -----YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFV 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAvYVGISSAVPFLILVALMeSNLIITYAVAVAAGISVA 240
Cdd:cd17452  239 LFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAA-ACGISWMIPFAIMLVTI-PNLIVAYVVAFVSGLSIA 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17452  317 ASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGACKQPESVVLTLKLLIGA 396

                        330       340
                 ....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17452  397 APTCMILIGLCILMFYPITE 416
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 3-340 4.78e-67

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 217.86  E-value: 4.78e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCfqdlnsstvasqsanhthgttshreT 82
Cdd:cd17332  114 TLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGN-------------------------A 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  83 QKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:cd17332  169 SRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL-PLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAGISVAA 241
Cdd:cd17332  248 FKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAVLAGIGYGG 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 242 AFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMA 321
Cdd:cd17332  328 ANLLPWAMLADVIDYGELK--TGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVL 405

                        330
                 ....*....|....*....
gi 568214318 322 PIVLILLGLLLFKMYPIDE 340
Cdd:cd17332  406 PAVLLLLALILMSFYPLDK 424
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 2-340 3.93e-66

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 215.64  E-value: 3.93e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318    2 VTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGqadtpcfqdlnsstvasqsanhthGTTSHRE 81
Cdd:pfam13347 111 YTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL------------------------ILGGTGL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   82 TQKAYLLAAGVIVCIYIICAVILILGVRE---QREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:pfam13347 167 ERKGYRIFALIGAVLMLLGVIITAAGTKErvsMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGL 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  159 FVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALM-ESNLIITYAVAVAAGI 237
Cdd:pfam13347 247 LLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLgPNNTLLFLVLYIIIGF 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  238 SVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEpiFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNML 317
Cdd:pfam13347 327 GYGSSFFLPWSMLADVVDYGELRTGKRREGT--FFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLL 404

                         330       340
                  ....*....|....*....|...
gi 568214318  318 VTMAPIVLILLGLLLFKMYPIDE 340
Cdd:pfam13347 405 YAVLPAVLFLVALLLLYFYPLDR 427
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-356 3.36e-46

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 163.53  E-value: 3.36e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTpcfqdlnsstvasqsanhthgttshrET 82
Cdd:COG2211  125 TLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG--------------------------DA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  83 QKAYLLAAGVIVCIYIICAVILILGVREQREPyeaqQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:COG2211  179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPVP----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGIS-SAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:COG2211  255 FKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTrGCSQPERVKFTLNMLVTM 320
Cdd:COG2211  335 AILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFL 411

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 568214318 321 APIVLILLGLLLFKMYPIDEERRRQNKKALQALRDE 356
Cdd:COG2211  412 LPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
PRK09669 PRK09669
putative symporter YagG; Provisional
 1-342 4.36e-07

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 51.65  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318   1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIV---GQADTpcfqdlnsstvasqsanhthgtt 77
Cdd:PRK09669 122 VYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPLVdilGKGDE----------------------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  78 shretQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSepiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEG 157
Cdd:PRK09669 179 -----QKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRGG 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 158 NFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAG 236
Cdd:PRK09669 251 ATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFN 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 237 ISVAAAFLLPWSMLPDVIDdfHLKQPHFHGTEPIFFSFYVFFTKFasGVSLGISTL--SLDFAGYQTRGCSQPERVKFTL 314
Cdd:PRK09669 331 FIQNLTTPLQWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTI 406

                        330       340
                 ....*....|....*....|....*...
gi 568214318 315 NMLVTMAPIVLILLGLLLFKMYPIDEER 342
Cdd:PRK09669 407 NLLFTVIPGVLFAGMAIILNFYKLNDAR 434
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 86-243 5.02e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  86 YLLAAGVIVCIYIICAVILILG-------VREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:cd17325  142 LLADALGYRAPFLVCAALALLAlvlalllLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 159 FVLFCTYTLGFrNEFQN--LLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMeSNLIITYAVAVAAG 236
Cdd:cd17325  222 LPLYAAELGGL-SPAQIglLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA-TSFWLLLLLLALLG 299


                 ....*..
gi 568214318 237 ISVAAAF 243
Cdd:cd17325  300 LGLGLVF 306
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
89-253 2.98e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  89 AAGVIVCIYIICAVILILGVREqrEPYEAQQSEPIAyFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLG 168
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRD--PPAGAAAAAKAS-LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 169 FRNEFQNLLLAIM-LSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPW 247
Cdd:COG2223  238 LSAATAGLLAALFaLLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317


                 ....*.
gi 568214318 248 SMLPDV 253
Cdd:COG2223  318 ALVPDI 323
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
92-253 2.17e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  92 VIVCIYIICAVILILGVREQREPYEAQQSepiayfRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGF-R 170
Cdd:COG2814  169 VNAVLALLALLLLLRLLPESRPAARARLR------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLsA 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 171 NEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMeSNLIITYAVAVAAGISVAAAFLLPWSML 250
Cdd:COG2814  243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-GSLWLLLLALFLLGFGFGLLFPLLQALV 321


                 ...
gi 568214318 251 PDV 253
Cdd:COG2814  322 AEL 324
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 87-243 2.28e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.93  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  87 LLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHgpyIKLITGFLFTSLAFMLVEGNFV-LFCTY 165
Cdd:cd17478  148 GLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA---LLLLLIIVFLRSWVLSSLTTFLpFYLVQ 224

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568214318 166 TLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALmeSNLIITYAVAVAAGISVAAAF 243
Cdd:cd17478  225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASF 300
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 89-283 3.51e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.98  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  89 AAGVIVCI-YIICAVILILGVREQREPYEAQQSEPIAY-FRGLRLVMSHGPYIKLITGFLftsLAFML----VEGNFVLF 162
Cdd:COG2270  185 ISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRAgFRELRRTLRELRRYRDLLRFL---LAYFFyrdgVQTVIAFA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTY---TLGFrnEFQNLLLAIMLSATLTIP---IWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIItYAVAVAAG 236
Cdd:COG2270  262 GIYaagVLGF--STTELIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF-WILGLLIG 338

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568214318 237 ISVAAAFLLPWSMLPDVIddfhlkqPHFHGTEpiFFSFYVFFTKFAS 283
Cdd:COG2270  339 LVMGGIQALSRSLLARLI-------PPGREAE--FFGLYALSGKAAS 376
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 129-243 4.72e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.66  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 129 LRLVMSHGPYIKLITGflftslAFMLVEGNFVLFCTYTLGF--------RNEFQNLLLAIMLSATLTIPIWQWFLTRFGK 200
Cdd:cd17369  220 VEVLRRHWRALLLAIG------LRLAENVLFYLFTTFALSYatqtlgvdRSTVLLAVLIASVVAAITIPLFGWLSDRVGR 293

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568214318 201 KTAVYVG----ISSAVPFLILVALmESNLIITYAVAVAAGISVAAAF 243
Cdd:cd17369  294 RPVYLAGallaALFAFPFFWLLDT-GSTWLIVLAAVVVLGVLHGMMY 339
PRK10429 PRK10429
melibiose:sodium transporter MelB;
92-372 4.83e-03

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 38.92  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  92 VIVCIYIICAVILILGVREQREPYEAQQSEPIAY-FRG-LRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGF 169
Cdd:PRK10429 185 VLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLtLKDiVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 170 RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTaVYVGISSaVPFLILVALMesnLIITYAVAVAAGISVAAAFL----- 244
Cdd:PRK10429 265 ADLFPYYLSYAGAANLVTLILFPRLVKSLSRRI-LWAGASI-FPVLSCGVLL---LMGLAAPHNALLIVIAGILLnigta 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 245 LPWS----MLPDVID--DFHLKQPhfhgTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYqTRGCSQPERVKFTLNMLV 318
Cdd:PRK10429 340 LFWVlqviMVADTVDygEYKLGIR----CESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGY-VPNVEQSAQTLLGMQFIM 414

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568214318 319 TMAPIVLILLGLLL-FKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELAS 372
Cdd:PRK10429 415 IGLPTLFFMITLVLyFRYYRLNGDFLRRIQIHLLDKYRKVPPEPVHAEIPVGAVS 469
PRK09952 PRK09952
shikimate transporter; Provisional
 78-234 8.30e-03

shikimate transporter; Provisional


Pssm-ID: 182163 [Multi-domain]  Cd Length: 438  Bit Score: 38.17  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318  78 SHRETQKAYLLAAGVIVCIYIICAVILILGVR---EQREPYEAQQSEPIAYFRGLRLV---MSHGPYIKLITGFLFTSLA 151
Cdd:PRK09952 185 SMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRngmEESAEFEQQQHEQAAAKKRIPVIealLRHPGAFLKIIALRLCELL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 152 FMLVEGNFVL-FCTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKK----TAVYVGISSAVPFLILVALMESNL 225
Cdd:PRK09952 265 TMYIVTAFALnYSTQNLGLpRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRrvyiTGALIGTLSAFPFFMALEAQSIFW 344


                 ....*....
gi 568214318 226 IITYAVAVA 234
Cdd:PRK09952 345 IVFFSIMLA 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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