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Conserved domains on  [gi|568214361|ref|NP_001274739|]
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cytoplasmic FMR1-interacting protein 1 isoform a [Homo sapiens]

Protein Classification

FragX_IP domain-containing protein( domain architecture ID 10532330)

FragX_IP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 389-1222 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


:

Pssm-ID: 461799  Cd Length: 842  Bit Score: 1441.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   389 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 468
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   469 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 548
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   549 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 626
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   627 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 706
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   707 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 785
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   786 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 863
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   864 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 943
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   944 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 1023
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1024 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 1096
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1097 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1176
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 568214361  1177 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1222
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 389-1222 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1441.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   389 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 468
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   469 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 548
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   549 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 626
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   627 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 706
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   707 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 785
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   786 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 863
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   864 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 943
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   944 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 1023
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1024 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 1096
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1097 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1176
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 568214361  1177 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1222
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 5-1240 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 600.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361    5 VTLEDAlsnVDLLEELPLPDQQPCIEPPPSSLL---YQPNFNTNFEDRNAFVTGIAryiEQATVHSSMNEMLEEGQEYAV 81
Cdd:PLN03099    3 VPVEEA---VAALSTFSLEDEQPDVQGLAVTLSagrAATESPIDYSDVAAYQLSLS---EDTKAINQLNTLIQEGKEMVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   82 MLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITL 161
Cdd:PLN03099   77 ILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEIGRLREIQRWQSSAASKLAADMQRFSRPERRINGPTVTHMWSM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  162 GKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQES-QNLSMFLANHNKITQSLQQQLEVISGYEELLA 239
Cdd:PLN03099  157 LKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMREElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  240 DIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLdaKKRINLSKIDKYFKQlqvvplfgdmqielaryi 319
Cdd:PLN03099  237 VLIVFCLESLESDFVLLYSERHILLRVLPVLVVLATSSEKEGESL--FKRIKINRLINIFQR------------------ 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  320 ktsahyeenksrwtctssgsspQYNICEQMIQIREDH----MRFISELARYSNSEVVTGSGRQEAQKTDAEyrkLFDLAL 395
Cdd:PLN03099  297 ----------------------EYLIVNHMGAIRAEHddfcIRFASAMNQLQLLKSADGVDTAWSREIKEN---MYDVVV 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  396 QGLQLLSQWSAHVMEVYSWKLVHPT-DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNH 474
Cdd:PLN03099  352 EGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVRCNYTAEERKALVELIGYIKGVGSMLERCDTLVAD 431

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  475 AIRHTVYAALQDFSQVTLREPLRQAIKKKKNvIQSVLQAIRKTVCDWETGHEPFNDPALRG-EKDPKSGFDIKVprRAVG 553
Cdd:PLN03099  432 ALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAADWMANTRPEEKMPSRQrENDESRPNFFYP--RPVA 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  554 PSSTQLYMVRTMLESLIADKSGSKKTL---RSSLEGPT--ILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFL 628
Cdd:PLN03099  509 PTAAQLHCLQFLIHELVSGGSPKKPGGffgNNGSEIPVndLKQLETFFNKLAFFPHILDYRATIGHLTDLGFLWFREFYL 588

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  629 ELTmgRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLAD 708
Cdd:PLN03099  589 ETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDSAQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSE 666

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  709 QIFAYYKVMAGSLLLDKRLRSECKNqGATIHLPPSnRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFE 788
Cdd:PLN03099  667 SIFTYYKSRAASKLLDPSFLAAVDN-GEKFSVQPK-RYDALFKMRRVKILGRTIDLASLIAQRMNKIFRENLDFLFERFE 744

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  789 SEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNRFVR 866
Cdd:PLN03099  745 SQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISlvSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVR 824

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  867 TVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGtIL 946
Cdd:PLN03099  825 SSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLPHMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LE 903

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  947 QYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYaELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAA 1026
Cdd:PLN03099  904 PMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSEVLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVA 982

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1027 PFQNILPRvhvKEGE--RLDAKMKRLES--KYAPLHLVPLIERLGTPQQIAIAREG---DLLTKERLCCG------LSMF 1093
Cdd:PLN03099  983 PWLGLVPG---KEGQlqQADDNESPLVSlfKEATSAVVSSPGCLNPSAFVSMSKQAevaDLLYKSNLNTGsvleytLAFT 1059

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1094 EVILTRIRSFLDDPiwrgplPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRR 1173
Cdd:PLN03099 1060 SAVLDRHRSKWSAP------PKTGFIDITTSKDFYRIYSGLQYVYLEEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLR 1133

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1174 FAVLDFCYHLLKVQK-------HDGKDEIIKN----VPLKKMVERIRKFQILNDEIITIL-------DKYLKSGDGEGTP 1235
Cdd:PLN03099 1134 FELLDFIYHVLSVSEvesasasHTHRNERLKSpsyhQGWEGFLENARKARRLNNHVFSLLrarcpleDKLASMIKQSGAP 1213


                  ....*
gi 568214361 1236 VEHVR 1240
Cdd:PLN03099 1214 VHRVK 1218
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 389-1222 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1441.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   389 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 468
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   469 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 548
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   549 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 626
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   627 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 706
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   707 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 785
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   786 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 863
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   864 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 943
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   944 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 1023
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1024 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 1096
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  1097 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1176
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 568214361  1177 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1222
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 5-1240 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 600.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361    5 VTLEDAlsnVDLLEELPLPDQQPCIEPPPSSLL---YQPNFNTNFEDRNAFVTGIAryiEQATVHSSMNEMLEEGQEYAV 81
Cdd:PLN03099    3 VPVEEA---VAALSTFSLEDEQPDVQGLAVTLSagrAATESPIDYSDVAAYQLSLS---EDTKAINQLNTLIQEGKEMVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361   82 MLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITL 161
Cdd:PLN03099   77 ILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEIGRLREIQRWQSSAASKLAADMQRFSRPERRINGPTVTHMWSM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  162 GKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQES-QNLSMFLANHNKITQSLQQQLEVISGYEELLA 239
Cdd:PLN03099  157 LKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMREElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  240 DIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLdaKKRINLSKIDKYFKQlqvvplfgdmqielaryi 319
Cdd:PLN03099  237 VLIVFCLESLESDFVLLYSERHILLRVLPVLVVLATSSEKEGESL--FKRIKINRLINIFQR------------------ 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  320 ktsahyeenksrwtctssgsspQYNICEQMIQIREDH----MRFISELARYSNSEVVTGSGRQEAQKTDAEyrkLFDLAL 395
Cdd:PLN03099  297 ----------------------EYLIVNHMGAIRAEHddfcIRFASAMNQLQLLKSADGVDTAWSREIKEN---MYDVVV 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  396 QGLQLLSQWSAHVMEVYSWKLVHPT-DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNH 474
Cdd:PLN03099  352 EGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVRCNYTAEERKALVELIGYIKGVGSMLERCDTLVAD 431

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  475 AIRHTVYAALQDFSQVTLREPLRQAIKKKKNvIQSVLQAIRKTVCDWETGHEPFNDPALRG-EKDPKSGFDIKVprRAVG 553
Cdd:PLN03099  432 ALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAADWMANTRPEEKMPSRQrENDESRPNFFYP--RPVA 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  554 PSSTQLYMVRTMLESLIADKSGSKKTL---RSSLEGPT--ILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFL 628
Cdd:PLN03099  509 PTAAQLHCLQFLIHELVSGGSPKKPGGffgNNGSEIPVndLKQLETFFNKLAFFPHILDYRATIGHLTDLGFLWFREFYL 588

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  629 ELTmgRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLAD 708
Cdd:PLN03099  589 ETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDSAQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSE 666

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  709 QIFAYYKVMAGSLLLDKRLRSECKNqGATIHLPPSnRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFE 788
Cdd:PLN03099  667 SIFTYYKSRAASKLLDPSFLAAVDN-GEKFSVQPK-RYDALFKMRRVKILGRTIDLASLIAQRMNKIFRENLDFLFERFE 744

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  789 SEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNRFVR 866
Cdd:PLN03099  745 SQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISlvSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVR 824

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  867 TVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGtIL 946
Cdd:PLN03099  825 SSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLPHMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LE 903

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361  947 QYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYaELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAA 1026
Cdd:PLN03099  904 PMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSEVLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVA 982

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1027 PFQNILPRvhvKEGE--RLDAKMKRLES--KYAPLHLVPLIERLGTPQQIAIAREG---DLLTKERLCCG------LSMF 1093
Cdd:PLN03099  983 PWLGLVPG---KEGQlqQADDNESPLVSlfKEATSAVVSSPGCLNPSAFVSMSKQAevaDLLYKSNLNTGsvleytLAFT 1059

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1094 EVILTRIRSFLDDPiwrgplPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRR 1173
Cdd:PLN03099 1060 SAVLDRHRSKWSAP------PKTGFIDITTSKDFYRIYSGLQYVYLEEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLR 1133

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214361 1174 FAVLDFCYHLLKVQK-------HDGKDEIIKN----VPLKKMVERIRKFQILNDEIITIL-------DKYLKSGDGEGTP 1235
Cdd:PLN03099 1134 FELLDFIYHVLSVSEvesasasHTHRNERLKSpsyhQGWEGFLENARKARRLNNHVFSLLrarcpleDKLASMIKQSGAP 1213


                  ....*
gi 568214361 1236 VEHVR 1240
Cdd:PLN03099 1214 VHRVK 1218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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