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Conserved domains on  [gi|571330764|ref|NP_001275729|]
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zinc finger protein 585A isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-85 8.77e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764    27 VSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 85
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-529 1.15e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 184 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 254
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 255 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 289
Cdd:COG5048  112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 290 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 369
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 370 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 436
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 437 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 505
Cdd:COG5048  351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 571330764 506 RSDLITHQRIHTGEKPYECNTCGK 529
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
476-768 2.13e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 476 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLN--IHQKIHTGERQ 549
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 550 YEC----------------HECGKAFN----QKSILIVHQKIHTGEKPYV------------CTECGRAFIRKSNFI--- 594
Cdd:COG5048   92 DLNskslplsnskasssslSSSSSNSNdnnlLSSHSLPPSSRDPQLPDLLsisnlrnnplpgNNSSSVNTPQSNSLHppl 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 595 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 658
Cdd:COG5048  172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 659 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 725
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 571330764 726 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 768
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-85 8.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764    27 VSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 85
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 2.08e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.30  E-value: 2.08e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 571330764   26 SVSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 3.66e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 3.66e-19
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 571330764  27 VSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLS 65
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-529 1.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 184 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 254
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 255 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 289
Cdd:COG5048  112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 290 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 369
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 370 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 436
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 437 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 505
Cdd:COG5048  351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 571330764 506 RSDLITHQRIHTGEKPYECNTCGK 529
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
476-768 2.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 476 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLN--IHQKIHTGERQ 549
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 550 YEC----------------HECGKAFN----QKSILIVHQKIHTGEKPYV------------CTECGRAFIRKSNFI--- 594
Cdd:COG5048   92 DLNskslplsnskasssslSSSSSNSNdnnlLSSHSLPPSSRDPQLPDLLsisnlrnnplpgNNSSSVNTPQSNSLHppl 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 595 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 658
Cdd:COG5048  172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 659 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 725
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 571330764 726 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 768
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
705-728 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....
gi 571330764  705 LQVHQRIHTGEKPYVCAECGKAFT 728
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  508 DLITHQRIHTGEKPYECNTCGKAFTQ 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-85 8.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764    27 VSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 85
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 2.08e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.30  E-value: 2.08e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 571330764   26 SVSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLSVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 3.66e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 3.66e-19
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 571330764  27 VSFRDVAIDFSREEWRHLDPSQRNLYRDVMLETYSHLLS 65
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-529 1.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 184 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 254
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 255 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 289
Cdd:COG5048  112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 290 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 369
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 370 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 436
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 437 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 505
Cdd:COG5048  351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 571330764 506 RSDLITHQRIHTGEKPYECNTCGK 529
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-768 4.35e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 4.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 336 SNNSNLVTHKKVQSREKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSD--CGKAFTQKSALTVHQRIHTGEKSYICM 413
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 414 KCG------LAFIQKAHLIAHQIIHTGEKPHKCGHcgKLFTSKSQLHVHKRIHTGEKPYMCNKCGKAfTNRSNLITHQKT 487
Cdd:COG5048   96 KSLplsnskASSSSLSSSSSNSNDNNLLSSHSLPP--SSRDPQLPDLLSISNLRNNPLPGNNSSSVN-TPQSNSLHPPLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 488 HTgeksyicSKCGKAFTQRSDLItHQRIHTGEKPYECNTCGKAFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILiv 567
Cdd:COG5048  173 AN-------SLSKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLS-- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 568 hqkihtgekpyvctecgrafIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTG-EKPYVCAECGKAFSGR 646
Cdd:COG5048  243 --------------------QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRS 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 647 SNLSKHQKT--HTGE--KPYICSE--CGKTFRQKSELITHHRIHTGEKPYEC--SDCGKSFTKKS-----QLQVHQRIHT 713
Cdd:COG5048  303 SPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLK 382

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 571330764 714 GEKPYVCA--ECGKAFTDRSNLNKHQTTHTGDKP--YKCGICGKGFVQKSVFSVHQSSH 768
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-682 9.36e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 9.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 268 RSYICIECGQAFIQKTHLIAHRRIHTGEKPYECS--NCGKSFISKSQLQVHQRVHTRVKPYIC--TEYGKVFSNNSNLVT 343
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 344 HKKVQSReKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSDCGKAF--TQKSALTVHQRIHTgeksyicMKCGLAFIQ 421
Cdd:COG5048  112 SSSSNSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 422 KAHLIAHQIIHTGEKPHKCGHCGKLFTSKSQLHVHKRIHTgEKPYMCNKCGKAFT------NRSNLITHQKTHTGEKSYI 495
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 496 CSKCGKAFTQRSDLITHQRIHTG-EKPYECNTCGKAFTQKSHLNIHQ--KIHTGE--RQYECHE--CGKAFNQKSILIVH 568
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 569 QKIHTGEKPYVC--TECGRAFIRKSN-----FITHQRIHTGEKPYECSD--CGKSFTSKSQLLVHQPVHTGEKPYVC--A 637
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 571330764 638 ECGKAFSGRSNLSKHQKTHTgEKPYICSECGKTFRQKSELITHHR 682
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-615 4.26e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 4.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 212 KLYECSQCGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQKSTLK---MHQKIHTGERSYICIECGQAFIQKTHLIAH 288
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsrHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 289 RRIHTGEKPYECSNCGKSFISKSQlqvhqrvhTRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICT--ECGKAFTYR 366
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDP--------QLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 367 SELIIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAF------IQKAHLIAHQIIHTGEKPHKC 440
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 441 GHCGKLFTSKSQLHVHKRIHTG-EKPYMCNKCGKAFTNRSNLITHQKT--HTGE--KSYIC--SKCGKAFTQRSDLITHQ 513
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 514 RIHTGEKPYECNTC------GKAFTQKSHLNIHQ-KIHTGERQYEC--HECGKAFNQKSILIVHQKIHTGEKPYVC--TE 582
Cdd:COG5048  344 LLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQyKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        410       420       430
                 ....*....|....*....|....*....|...
gi 571330764 583 CGRAFIRKSNFITHQRIHTGEKPYECSDCGKSF 615
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
476-768 2.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 476 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLN--IHQKIHTGERQ 549
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 550 YEC----------------HECGKAFN----QKSILIVHQKIHTGEKPYV------------CTECGRAFIRKSNFI--- 594
Cdd:COG5048   92 DLNskslplsnskasssslSSSSSNSNdnnlLSSHSLPPSSRDPQLPDLLsisnlrnnplpgNNSSSVNTPQSNSLHppl 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 595 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 658
Cdd:COG5048  172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 659 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 725
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 571330764 726 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 768
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-347 8.30e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 184 KPFKCNECGKSFFQVSSLFRHQR--IHTGEKLYECSQ----CGKGFSYNSDLSIHEKIHTGERHHEC--TDCGKAFTQKS 255
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 256 TLK-----MHQKIHTGERSYICI--ECGQAFIQKTHLIAHRRIHTGEKPYECSN--CGKSFISKSQLQVHQRVHTRVKPY 326
Cdd:COG5048  368 NNEppqslQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|.
gi 571330764 327 ICTEYGKvFSNNSNLVTHKKV 347
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 462-542 7.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 462 GEKPYMCN--KCGKAFTNRSNLITHQKThtgeksyicSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLNI 539
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 571330764 540 HQK 542
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
705-728 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....
gi 571330764  705 LQVHQRIHTGEKPYVCAECGKAFT 728
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  508 DLITHQRIHTGEKPYECNTCGKAFTQ 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
592-617 2.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  592 NFITHQRIHTGEKPYECSDCGKSFTS 617
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  368 ELIIHQRIHTGEKPYECSDCGKAFTQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 690-712 3.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.59e-03
                          10        20
                  ....*....|....*....|...
gi 571330764  690 YECSDCGKSFTKKSQLQVHQRIH 712
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-561 3.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  536 HLNIHQKIHTGERQYECHECGKAFNQ 561
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 686-753 4.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571330764 686 GEKPYECS--DCGKSFTKKSQLQVHqRIHtgekpyvcAECGKAFTDRSNLNKHQTTHTGDKPYKCGICGK 753
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 4.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  284 HLIAHRRIHTGEKPYECSNCGKSFIS 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
676-701 5.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  676 ELITHHRIHTGEKPYECSDCGKSFTK 701
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 6.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.10e-03
                          10        20
                  ....*....|....*....|...
gi 571330764  466 YMCNKCGKAFTNRSNLITHQKTH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 382-404 7.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|...
gi 571330764  382 YECSDCGKAFTQKSALTVHQRIH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
732-757 8.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  732 NLNKHQTTHTGDKPYKCGICGKGFVQ 757
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 522-544 8.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.86e-03
                          10        20
                  ....*....|....*....|...
gi 571330764  522 YECNTCGKAFTQKSHLNIHQKIH 544
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
648-673 9.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  648 NLSKHQKTHTGEKPYICSECGKTFRQ 673
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-477 9.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.09e-03
                          10        20
                  ....*....|....*....|..
gi 571330764  456 HKRIHTGEKPYMCNKCGKAFTN 477
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 9.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 571330764  200 SLFRHQRIHTGEKLYECSQCGKGFSY 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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