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Conserved domains on  [gi|574272649|ref|NP_001276020|]
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zinc finger MYM-type protein 1 isoform b [Homo sapiens]

Protein Classification

DUF4371 and hAT family dimerization domain-containing protein( domain architecture ID 10250830)

DUF4371 and hAT family dimerization domain-containing protein contains an N-terminal DUF4371 domain and a C-terminal domain involved in dimerization of transposases of elements belonging to the Activator (hAT) superfamily; similar to Homo sapiens zinc finger MYM-type protein 1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
134-367 9.77e-29

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 115.02  E-value: 9.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  134 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 205
Cdd:pfam14291   2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  206 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 284
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  285 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 364
Cdd:pfam14291 156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ...
gi 574272649  365 KFN 367
Cdd:pfam14291 233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 669-758 6.70e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 67.67  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  669 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 748
Cdd:pfam05699   1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 574272649  749 PALMAVEQEL 758
Cdd:pfam05699  74 EALLCIEDWL 83
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
92-171 8.89e-05

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 41.71  E-value: 8.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649    92 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 166
Cdd:smart00597   1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                   ....*
gi 574272649   167 REYQF 171
Cdd:smart00597  80 EQRQS 84
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
134-367 9.77e-29

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 115.02  E-value: 9.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  134 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 205
Cdd:pfam14291   2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  206 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 284
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  285 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 364
Cdd:pfam14291 156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ...
gi 574272649  365 KFN 367
Cdd:pfam14291 233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 669-758 6.70e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 67.67  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  669 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 748
Cdd:pfam05699   1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 574272649  749 PALMAVEQEL 758
Cdd:pfam05699  74 EALLCIEDWL 83
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
92-171 8.89e-05

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 41.71  E-value: 8.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649    92 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 166
Cdd:smart00597   1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                   ....*
gi 574272649   167 REYQF 171
Cdd:smart00597  80 EQRQS 84
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
134-367 9.77e-29

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 115.02  E-value: 9.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  134 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 205
Cdd:pfam14291   2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  206 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 284
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  285 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 364
Cdd:pfam14291 156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ...
gi 574272649  365 KFN 367
Cdd:pfam14291 233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 669-758 6.70e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 67.67  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649  669 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 748
Cdd:pfam05699   1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 574272649  749 PALMAVEQEL 758
Cdd:pfam05699  74 EALLCIEDWL 83
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
92-171 8.89e-05

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 41.71  E-value: 8.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574272649    92 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 166
Cdd:smart00597   1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                   ....*
gi 574272649   167 REYQF 171
Cdd:smart00597  80 EQRQS 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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