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Conserved domains on  [gi|574270145|ref|NP_001276036|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 147-458 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467701  Cd Length: 309  Bit Score: 561.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLlASLPAG 226
Cdd:cd23973    1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 227 SLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKD 306
Cdd:cd23973   80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VRYLHFLEGTRDYEWLEALLMNQTVMSKNLFwfRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYR 386
Cdd:cd23973  160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 387 PTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQR 458
Cdd:cd23973  238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 147-458 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 561.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLlASLPAG 226
Cdd:cd23973    1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 227 SLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKD 306
Cdd:cd23973   80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VRYLHFLEGTRDYEWLEALLMNQTVMSKNLFwfRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYR 386
Cdd:cd23973  160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 387 PTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQR 458
Cdd:cd23973  238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 172-452 3.90e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 277.18  E-value: 3.90e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  172 FLDSRHFNQSEWDRLEHFAPPFgfmelnySLVQKVVTRFPPVPqqqlllaslPAGSLRCITCAVVGNGGILNNSHMGQEI 251
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWWLPF-------TVTEELLELLPKVS---------PFDNKRCRRCAVVGNGGILRGSGCGKEI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  252 DSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLliLGNRGFKNvPLGKDVRYLHFLEGTRDYEWLEALLMNQTV 331
Cdd:pfam00777  65 DSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSK--YGNLGFSH-PRDPFVEFVLVPFKGRDLLWLPAFLTKGNV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  332 M---SKNLFWFRHRPQeafreaLHMDRYLLLHPDFLRYMKNRFLRSKTLDGahwriYRPTTGALLLLTALQLCDQVSAYG 408
Cdd:pfam00777 142 SrslRVLYTLKEVKIP------VDPDKVLFLHPDFLRYVANFWLRSHGLKG-----RRPSTGLLMLSLALHLCDEVSLYG 210

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 574270145  409 FIT-EGHERFSDHYYDT-SWKRLIFYINHDFKLEREVWKRLHDEGI 452
Cdd:pfam00777 211 FGPfLDSRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 147-458 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 561.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLlASLPAG 226
Cdd:cd23973    1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 227 SLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKD 306
Cdd:cd23973   80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VRYLHFLEGTRDYEWLEALLMNQTVMSKNLFwfRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYR 386
Cdd:cd23973  160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 387 PTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQR 458
Cdd:cd23973  238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 147-457 3.95e-136

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 393.55  E-value: 3.95e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLlaSLPAG 226
Cdd:cd23964    1 CPSSLRKKLQKSPWFRERFIPDIKVLLDSEDFNPEEYNRLSHYKLPFGWGGLNREVVERLLRNLNLTSSRYMF--VLRGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 227 SLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLilgnrgfKNVPLGKD 306
Cdd:cd23964   79 RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLL-------KHVPQDKD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VRYLHFLEGTRDYEWLEALLMNQTVMSKNLfwFRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTldgahwrIYR 386
Cdd:cd23964  152 TKYLFIPFKIRDYDYLDAVLSGKPVPDGCD--KGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSST-------SYR 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 387 PTTGALLLLTALQLCDQVSAYGFITegHERFSDHYYDTSWKRLI-FYINHDFKLEREVWKRLHDEGIIRLYQ 457
Cdd:cd23964  223 PTTGALMLLTALHTCDQVSVYGFGY--DPRFSLHYYDKTFVKFTvFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 147-458 2.68e-91

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 279.79  E-value: 2.68e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAG 226
Cdd:cd23972    1 CPHSLHLRIQRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLFFPRDTPG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 227 slRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKD 306
Cdd:cd23972   81 --KCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VRYLHFLEGTRDYEWLEALLMNQTV---MSKNlfwfrHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWR 383
Cdd:cd23972  159 LQYIFIPSDIRDYVMLRSAILGVPVpegLDKG-----DRPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGH 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 574270145 384 IYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQR 458
Cdd:cd23972  234 LYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLYQR 308
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 172-452 3.90e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 277.18  E-value: 3.90e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  172 FLDSRHFNQSEWDRLEHFAPPFgfmelnySLVQKVVTRFPPVPqqqlllaslPAGSLRCITCAVVGNGGILNNSHMGQEI 251
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWWLPF-------TVTEELLELLPKVS---------PFDNKRCRRCAVVGNGGILRGSGCGKEI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  252 DSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLliLGNRGFKNvPLGKDVRYLHFLEGTRDYEWLEALLMNQTV 331
Cdd:pfam00777  65 DSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSK--YGNLGFSH-PRDPFVEFVLVPFKGRDLLWLPAFLTKGNV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145  332 M---SKNLFWFRHRPQeafreaLHMDRYLLLHPDFLRYMKNRFLRSKTLDGahwriYRPTTGALLLLTALQLCDQVSAYG 408
Cdd:pfam00777 142 SrslRVLYTLKEVKIP------VDPDKVLFLHPDFLRYVANFWLRSHGLKG-----RRPSTGLLMLSLALHLCDEVSLYG 210

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 574270145  409 FIT-EGHERFSDHYYDT-SWKRLIFYINHDFKLEREVWKRLHDEGI 452
Cdd:pfam00777 211 FGPfLDSRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 147-457 1.17e-89

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 275.48  E-value: 1.17e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKIKASKSLWlQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLL-LASLPA 225
Cdd:cd23974    1 CPNGIRKRLANTEF-SGKFLENIPVLQWAKHATLSEYQRLKRYAGAHGWQEVDWDVLKDALNLLNSSANGQMFdWWDRPN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 226 GSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGK 305
Cdd:cd23974   80 GRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 306 DVRYLHFLEGTRDYEWLEALLMNqTVMSKNLFWFRhRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIY 385
Cdd:cd23974  160 ETRYIFLPDHDRDYLLVKAALTH-TPIDRGRDKSK-RPSKYFGKDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQRDIY 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 386 RPTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQ 457
Cdd:cd23974  238 RPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIKLYM 309
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 233-447 2.70e-32

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 121.70  E-value: 2.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 233 CAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYgFTAFSLTQSLLILGNRGFKNVPLGKDVRYLHF 312
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFR-VLNSKWAGFYLRGPRCGCHPLPLEEEVVLILS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 313 LEGTRDYEWLEAllmnqtvmsknlfwfRHRPqeafrealHMDRYLLLH---PDFLRYMKNRFLRSKTLDGAHWRiyRPTT 389
Cdd:cd19952   80 RAAAADFKRLKR---------------RKKR--------HDNAVLLLTdpaPDLLSYVRKRLEKLGLKSFFGGN--APSS 134

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 390 GALLLLTALQLCDQVSAYGFI--TEGHERFSDHYYDTSwKRLIFYINHDFKLEREVWKRL 447
Cdd:cd19952  135 GLLAVLLALQLCDSVDLYGFGvdSGHAPKVPYHYYDLV-EAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 147-457 7.53e-30

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 117.38  E-value: 7.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 147 CPDSVKiKASKSLWLQKLFLPNLTLFLDSRHFNQSE-----WDRLEhfappfGFMELNYS-LVQKVVTRFPPVPQQqlll 220
Cdd:cd23966    1 CRRCVQ-EGGDSDWFDERFNPSIEPLLTRKNKELPPdvlkwWLSLQ------SSKNSDLReVLEKLFQVVPGENPY---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 221 asLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTS---FYGFTAFSLTQSL-LILgnr 296
Cdd:cd23966   70 --RTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTThhfMYPESAVDLDPGVhLVL--- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 297 gfknVPLgkdvrylhfleGTRDYEWLEALLMNQTVMSKnlfWFRHRPQ-EAFRealhmDRYLLLHPDFLRYMKNRFLRSK 375
Cdd:cd23966  145 ----VPF-----------KVLDLQWLISALTTGEITRT---YTPVKRFiKADK-----DKVLVINPAFIKYVHDNWTEHH 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 376 tldgAHWriyrPTTGALLLLTALQLCDQVSAYGFITEGHERFsDHYYDTSWKRLIFYIN--HDFKLEREVWKRLHDEGII 453
Cdd:cd23966  202 ----GRY----PSTGFLALIFALHICDEVSVFGFGADSKGNW-HHYWEKNRSAGAFRKTgvHDADFESDIIKKLAKEGKI 272


                 ....
gi 574270145 454 RLYQ 457
Cdd:cd23966  273 RVYR 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 232-455 5.99e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 103.88  E-value: 5.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 232 TCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSfygFTAFSLTqsllILGNRgFKNvpLGKDVRYLH 311
Cdd:cd23963   65 TCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTN---LTTLNPS----ILKRR-YNS--LKKNRDRDK 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 312 FLEGTRDYewleallmNQTVMSKNLFWFRHRPQEAFREALHMDRY------LLLHPDFL----RYMKNRFLRSK------ 375
Cdd:cd23963  135 FLNRLKEY--------NGSILWYPKFSFKSSTNLLLKAARALKKNglnltvVYSNPEHFlavqKFWKRRGLEKRpstgly 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 376 ------TLdgahwriyrpttgalllltalqlCDQVSAYGF----ITEGHERFSDHYYDTSWKRLIFYiNHDFKLEREVWK 445
Cdd:cd23963  207 lvslalTF-----------------------CDEIHLYGFwpfpTDPNGRPVPYHYYDDLSPSTKNK-VHNMPEEFKLLR 262

                        250
                 ....*....|
gi 574270145 446 RLHDEGIIRL 455
Cdd:cd23963  263 ELHKKGVLKL 272
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 232-455 9.42e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 94.79  E-value: 9.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 232 TCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFygftaFSLTQSLLILGNRGFKNVPL-GKDVRYL 310
Cdd:cd23969   66 TCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-----TTMNPSVIPHAYGDLVNATDkEKFVERL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 311 HFLEGT------------RDY-EWLEALLMNQTVMSKNLFwfrhrPQeafrealhmdrylllhPDFLRYMKNRFLRSKTl 377
Cdd:cd23969  141 RQLGDSilwipafvskggEEHvQWTNEIILKHKLNVKTAY-----PP----------------LRLNHAIRGYWLTTKF- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 378 dgahwRIYRPTTGALLLLTALQLCDQVSAYGF--ITEGH--ERFSDHYYDTswKRLIFYIN-HDFKLEREVWKRLHDEGI 452
Cdd:cd23969  199 -----RIKRPSTGLLMYTLATRFCDEIHLYGFypFSEDGngRAVKYHYYDN--RKYLTTARpHKMPEEFRALRSLHQRGA 271


                 ...
gi 574270145 453 IRL 455
Cdd:cd23969  272 LRL 274
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 229-447 1.32e-21

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 92.35  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 229 RCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSF---YGFTAFsltqsllilgnrgFKNVPLGK 305
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFrmfYPESAF-------------RDPEEYDS 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 306 DVRYLHFLEGTRDYEWLEALLMNQTvMSKNLFWFR------HRPQEAFRealhmdrylLLHPDFLRymKNRFLRSKTLDG 379
Cdd:cd23967   68 DWLLVLVPFKSMDLLWLQAVIKGKK-PNGKGGFWKkiatsvPKPPKKIR---------ILNPYILQ--EAAFDLIGLPMN 135

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 574270145 380 AHWRIYRPTTGALLLLTALQLCDQVSAYGFiteGHErFSD-----HYYDTSWKRLI-FYINHDFKLEREVWKRL 447
Cdd:cd23967  136 GKQGKNVPTTGIIAIVMALHYCDEVDIAGF---GYD-PSDpnaplHYYDSLTMKAIkRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 229-447 3.46e-20

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 88.57  E-value: 3.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 229 RCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTS---FYGFTAFSltqsllilgNRGFKNVPlgk 305
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTirlFYPESAQF---------DPGIENDP--- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 306 DVRYLHFLEGTRDYEWLEALLMNQTVMSKnLFWfRHRPQEAFREAlhmDRYLLLHPDFLRYMKNRFLrskTLDGAHWRIY 385
Cdd:cd23982   69 DTLLVLVPFKPLDFYWLYEILSNEKRVRK-GFW-KQPPRIWDANP---KQIRILNPYYTYVAATKLL---QVPGQRKKKQ 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 574270145 386 RPTTGALLLLTALQLCDQVS--AYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRL 447
Cdd:cd23982  141 KPTTGLLAITLALHLCDEVHiaGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 232-455 2.01e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 82.44  E-value: 2.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 232 TCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAfsltqSLLilgNRGFKNvpLGKDVRYLH 311
Cdd:cd23970   70 TCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SIL---EKYYNN--LLTIQDRNN 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 312 FLEGTRDYE----WLEALLMNQTVMSKNL---FWFRHRPQEAFREALhmdrylllhP-DFLRYMkNRFLRSKTLDGahwr 383
Cdd:cd23970  140 FFLSLKKLDgailWIPAFFFHTSATVTRTlvdFFVEHRGQLKVQLAW---------PgNIMQHV-NRYWKTKHLSP---- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 384 iYRPTTGALLLLTALQLCDQVSAYGF----ITEGHERFSDHYYDTswKRLIFYIN----HDFKLEREVWKRLHDEGIIRL 455
Cdd:cd23970  206 -KRLSTGILMYTLASAICEEIHLYGFwpfgFDPTGTPLPYHYYDK--KGTKFTTKwqesHQLPAEFVLLYKMHGAGVLKL 282
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 229-447 2.81e-16

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 77.27  E-value: 2.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 229 RCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTsfygftafsltqSLLILGNRGFKNVPLGKDVR 308
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKT------------TLRITYPEGAIQKPEQYEKD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 309 YLHFLEGTR--DYEWLEALLMNQTVMSKNLFWfRHRPQEAFREALHMDrylLLHPDFLRYMKNRFLRSKTLDGAHWRIYR 386
Cdd:cd23981   69 SLFVLAGFKwqDFKWLKYIVYKEKVSASDGFW-KSVATRVPREPHEIR---ILNPYFIQEAAFSFIGLPFNNGLMGRGNI 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 574270145 387 PTTGALLLLTALQLCDQVSAYGFiteGHERFSD----HYYDT--------SWkrlifyiNHDFKLEREVWKRL 447
Cdd:cd23981  145 PTLGSVAITMALHNCDEVAVAGF---GYDMNTPnaplHYYETikmsaikeSW-------THNIQREKEFLRKL 207
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 217-455 1.13e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 76.91  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 217 QLLLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKgYEQDVGTRTSFygftafsLTQSLLILGNR 296
Cdd:cd23971   51 SMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-------VTANPSILREK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 297 gFKNvpLGKdvRYLHFLEGTRDYE----WLEAllmnqtvmsknlFWFRHRPQEAFReALHM-------DRYLLLHPDFLR 365
Cdd:cd23971  123 -FHN--LKK--RRRPFVERMKVYGnallLLPA------------FSYTSNTEPSLR-ALYTledfgspQKVLFFNPEYLR 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 366 YMkNRFLRSKTLdgahwRIYRPTTGALLLLTALQLCDQVSAYGF----ITEGHERFSDHYYDTSWKRLIFyinHDFKLER 441
Cdd:cd23971  185 NL-SRYWKSKGL-----KARRLSTGLMLVSAALELCENVHLYGFwpfsTDLDGNPISHHYYDNVLPKKGV---HAMPEEF 255

                        250
                 ....*....|....
gi 574270145 442 EVWKRLHDEGIIRL 455
Cdd:cd23971  256 LRYLKLHSQGVLRL 269
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 232-454 4.53e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.00  E-value: 4.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 232 TCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTS-------------FYGFTAFSLTQSLLILGNRGF 298
Cdd:cd23968   47 TCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrlinsqilskpeFNFLTDPLYRNVTLLVWDPSS 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 299 KNVPLGKDVRylhflegTRDYEWLEALlmnqtvmsknLFWFRHRPQEAFrealhmdrYlLLHPDFLRYMKNrFLRSktld 378
Cdd:cd23968  127 YNVNLEKWYK-------KPDFDFFPNY----------IKYRRRHPEEPF--------Y-LIDPRFLWRLWD-ILQE---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 379 GAHWRIYR--PTTGALLLLTALQLCDQVSAYGFITEghERFSD--HYYDT---------SWkrlifyinHDFKLEREVWK 445
Cdd:cd23968  176 YTPEKIKPnpPSSGFIGIVLMLHLCDWVDVYEYVPS--VRQTDrcHYYDVekdlactlgAW--------HPLAAEKLLVR 245

                        250
                 ....*....|..
gi 574270145 446 RLH---DEGIIR 454
Cdd:cd23968  246 HLNvgsDDDIFR 257
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 230-422 4.65e-15

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 73.63  E-value: 4.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLtqsllilgnrgFKNvPLGKD--- 306
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI-----------FSD-PSHYDpnt 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 -VRYLHFleGTRDYEWLEALLMNQTVmSKNLFWfrHRPQEAFREALHMDRylLLHPDFLRYMKNRFLR-SKTLDGAHWRI 384
Cdd:cd23984   70 tVVLIPF--KPHDLRWLLDLLMGKKV-SAKGFW--KKPALNLIYKPNQIR--ILNPFILRIAAYELLHfPKRFPKEKKPK 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 574270145 385 YrPTTGALLLLTALQLCDQVSAYGFitegHERFSD-----HYY 422
Cdd:cd23984  143 H-PTTGIIAITLALHICNEVHIAGF----KYDFSNlnstlHYY 180
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 233-455 5.34e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 75.18  E-value: 5.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 233 CAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKG-YEQDVGTRTSFygftaFSLTQSLLIL--GNRGFKNVPlgkdvry 309
Cdd:cd23991   67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-----VTANPSIISIkyAKLNERRKP------- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 310 lhFLEGTRDYEwlEALLM-------NQTVMSknlfwFR-HRPQEAFREALhmdRYLLLHPdflRYMKN--RFLRSKTLdg 379
Cdd:cd23991  135 --FLETVSVYG--DAFLLlpafsyrSNTALS-----FKvYYTLEDFKAKQ---KVIFFHP---IYLKHlaQFWRSKGV-- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 380 ahwRIYRPTTGALLLLTALQLCDQVSAYGF-----ITEGhERFSDHYYDTSWKRLIFyinHDFKLEREVWKRLHDEGIIR 454
Cdd:cd23991  198 ---QVYRLSTGLMITSAALELCEEVKLYGFwpfskNTEG-KPISHHYYDNQLPKPGF---HSMPKEFYQLLQLHSKGILK 270


                 .
gi 574270145 455 L 455
Cdd:cd23991  271 L 271
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 217-455 1.17e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 74.21  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 217 QLLLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFygftaFSLTQSLLilgNR 296
Cdd:cd23987   51 ELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-----VTMNPSVV---QR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 297 GFKNVplgkdvrylhflegtRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFREALH-MDRYLLLHPDFLR--YMKNRFLR 373
Cdd:cd23987  123 AFEDL---------------VNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEwVNDLILKHHINVRtaYPSLRLLH 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 374 SKTldgAHW-----RIYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSD----HYYDT-SWKRLIFYINHDFKLEREV 443
Cdd:cd23987  188 AVR---GYWltnkvHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNpvkyHYYDSlKYGYTSQASPHTMPLEFKA 264

                        250
                 ....*....|..
gi 574270145 444 WKRLHDEGIIRL 455
Cdd:cd23987  265 LKNLHQQGALKL 276
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 230-447 2.41e-14

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 71.69  E-value: 2.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSF---YGFTAFSLTQ-----SLLILgnRGFKNV 301
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIrmtYPEGAPKSEQeydptSLFVA--VLFKSV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 302 plgkdvrylhflegtrDYEWLEALLMNQTVMSKNLFWFRHRPQEAFreALHMDRYLLLHPDFLRYMKNRFLR----SKTL 377
Cdd:cd23983   80 ----------------DFAWLKAMVKKEPLSFWSRLFFWKEVADSI--PLKPSQFRILNPLIIKETALDILQypepQSRL 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574270145 378 DGahWRIYRPTTGALLLLTALQLCDQVSAYGFITE-GHERFSDHYYDT-SWKRLIFYINHDFKLEREVWKRL 447
Cdd:cd23983  142 WG--WDKNVPTLGVTAVVLATHLCDEVSLAGFGYDlSQPHAPLHYYDSvCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 226-409 2.91e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 72.99  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 226 GSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYgftaFSLTQSllilgnrgFKNvpLGK 305
Cdd:cd23980   77 RLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHH----FVYPES--------FRE--LAQ 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 306 DVRYLHFLEGTRDYEWLEALLMNQTVMsknlfwFRHRPQEAfREALHMDRYLLLHPDFLRYMKNRFLRSktldgaHWRIy 385
Cdd:cd23980  143 NVSMILVPFKTLDLEWVISATTTGTIS------HTYVPVPR-KIKVKKEKILIYHPAFIKYVFDRWLQG------HGRY- 208

                        170       180
                 ....*....|....*....|....
gi 574270145 386 rPTTGALLLLTALQLCDQVSAYGF 409
Cdd:cd23980  209 -PSTGILSVIFSLHVCDEVDLYGF 231
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 224-455 2.70e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 69.98  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 224 PAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFygftaFSLTQSLLILGNRGFKN-VP 302
Cdd:cd23988   58 PMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDF-----ITMNPSVVQRAFGGFRNeSD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 303 LGKDVRYLHFLE-------------GTRDYEWLEALLMnqtvmsKNlfwfrhrpQEAFREALHMDRylLLHPdflryMKN 369
Cdd:cd23988  133 REKFVHRLSMLNdsvlwipafmvkgGEKHVEWVNALIL------KN--------KLKVRTAYPSLR--LIHA-----VRG 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 370 RFLRSKTldgahwRIYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSD----HYYDTSWKRliFYIN---HDFKLERE 442
Cdd:cd23988  192 YWLTNKV------NIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNpvkyHYYDDLKYR--YFSNagpHRMPLEFK 263

                        250
                 ....*....|...
gi 574270145 443 VWKRLHDEGIIRL 455
Cdd:cd23988  264 TLNVLHNRGALKL 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 228-457 1.49e-12

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 67.97  E-value: 1.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 228 LRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYgftaFSLTQSLlilgnrgfKNVPlgKDV 307
Cdd:cd23979   78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH----FMYPESA--------KNLP--ANV 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 308 RYLHFLEGTRDYEWLEALLmnqtvmSKNLFWFRHRPQEAFREaLHMDRYLLLHPDFLRYMKNRFLRSktldgaHWRIyrP 387
Cdd:cd23979  144 SFVLVPFKTLDLLWITSAL------STGQIRFTYAPVKQFLR-VDKDKVQIYNPAFFKYIHDRWTEH------HGRY--P 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 574270145 388 TTGALLLLTALQLCDQVSAYGFITEG----HERFSDHYYDTSWKRLIFyinHDFKLEREVWKRLHDEGIIRLYQ 457
Cdd:cd23979  209 STGMLVLFFALHVCDEVNVYGFGADSrgnwHHYWENNRYAGEFRKTGV---HDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 228-455 1.66e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 67.55  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 228 LRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLS-GALIKGYEQDVGTRTSFygftafsLTQSLLILGNRgFKNVPLGKD 306
Cdd:cd23989   61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNlPPLSREYTDDVGTKTQL-------VTANPSIIDKR-FQNLLWSRK 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 307 VrylhFLEGT----RDYEWLEALLMNqtVMSKNLFWFRHrpqeAFREALHMDRYLLLHPDFLR----YMKNRFLRSKTLD 378
Cdd:cd23989  133 S----FVESMkvygRSYIYMPAFSMK--TGTDPSLRVYY----TLADVGANQTVLFANPNFLRnvgkFWKSKGVHAKRLS 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 379 GAHWRIyrpttgalllLTALQLCDQVSAYG---FITEGHERF-SDHYYDTSWKRLIFY-INHDFKlerEVWkRLHDEGII 453
Cdd:cd23989  203 TGLFLV----------SAALGLCEEVTIYGfwpFSVDLDERTiSHHYYDNVLPDSGFHaMPEEFL---QLW-HLHKSGVL 268


                 ..
gi 574270145 454 RL 455
Cdd:cd23989  269 RM 270
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 225-422 2.66e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 67.04  E-value: 2.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 225 AGSLRciTCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFygftafSLTQSLLI-LGNRGFKNVPL 303
Cdd:cd23985   42 VGPLG--RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTI------RLINSQLVtTEKHKFLKDSL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 304 gkdvrylhFLEGTrdyewleaLLM-NQTVMSKNLF-WFRhRPQEAFREALHmdRYLLLHPDFLRYMKNRFLRSKTLD--- 378
Cdd:cd23985  114 --------YNEGI--------LIVwDPAPYHSDIPeWYK-NPDYNFFENYK--TYRRLNPNQPFYILHPQMQWELWDiiq 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 574270145 379 -GAHWRIYR--PTTGALLLLTALQLCDQVSAYGFITEghERFSD--HYY 422
Cdd:cd23985  175 eNSPEEIQPnpPSSGMLGIILMMTLCDQVDVYEFLPS--KRKTDvcHYY 221
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 210-307 9.44e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 65.24  E-value: 9.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574270145 210 FPPVPQQQLLLASLPagslrciTCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQS 289
Cdd:cd23986   36 VPKIPLSKLHLRGFR-------SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNP 108

                         90
                 ....*....|....*...
gi 574270145 290 llilgNRGFKNVPLGKDV 307
Cdd:cd23986  109 -----NHHFIDSSLYKDV 121
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 230-301 1.64e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 63.80  E-value: 1.64e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTS--FYGFTAFS--LTQSLLILGNRGFKNV 301
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTirVVSHSSLPrlLRNAILLLAGTRAPTV 76
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 230-298 1.14e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 55.64  E-value: 1.14e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSfygFTAFSLTQSLLILGNRGF 298
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSS---LRVVSHTSVPLLLRNQGY 66
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 233-276 2.37e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 55.23  E-value: 2.37e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 574270145 233 CAVVGNGGILNNSHMGQEIDSHDYVFRLS-GALIKGYEQDVGTRT 276
Cdd:cd23990   67 CAVVGNGGILKNSKCGREIDSADFVFRCNlPPISEKYVRDVGVKT 111
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 230-277 2.58e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 48.39  E-value: 2.58e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTS 277
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTT 48
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 228-278 7.40e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 47.17  E-value: 7.40e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 574270145 228 LRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSF 278
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSL 63
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 230-278 3.38e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 45.23  E-value: 3.38e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 574270145 230 CITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSF 278
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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