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Conserved domains on  [gi|574284911|ref|NP_001276062|]
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BTB/POZ domain-containing protein 7 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 46-143 3.39e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


:

Pssm-ID: 350564  Cd Length: 98  Bit Score: 201.00  E-value: 3.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  46 ISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLM 125
Cdd:cd18489    1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                         90
                 ....*....|....*...
gi 574284911 126 KRIADREPNLLSGTAHSV 143
Cdd:cd18489   81 KRMEEREPNLLSHTAHSV 98
 
Name Accession Description Interval E-value
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 46-143 3.39e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 201.00  E-value: 3.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  46 ISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLM 125
Cdd:cd18489    1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                         90
                 ....*....|....*...
gi 574284911 126 KRIADREPNLLSGTAHSV 143
Cdd:cd18489   81 KRMEEREPNLLSHTAHSV 98
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 59-137 6.37e-12

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 62.36  E-value: 6.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911    59 SHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKRIaDREPNLLS 137
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 62-127 7.63e-09

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 53.70  E-value: 7.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574284911   62 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKR 127
Cdd:pfam07707  11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77
 
Name Accession Description Interval E-value
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 46-143 3.39e-61

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 201.00  E-value: 3.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  46 ISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLM 125
Cdd:cd18489    1 LSLDTLVGILRWSSQPHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEHQLI 80

                         90
                 ....*....|....*...
gi 574284911 126 KRIADREPNLLSGTAHSV 143
Cdd:cd18489   81 KRMEEREPNLLSHTAHSV 98
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 59-137 6.37e-12

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 62.36  E-value: 6.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911    59 SHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKRIaDREPNLLS 137
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 46-127 2.81e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 54.25  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  46 ISLDTLIAILKWSShPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQL 124
Cdd:cd18480    1 LDLSNCLQLLSFAE-SYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNvPDEEAVLKAVLRWTKHDL 79


                 ...
gi 574284911 125 MKR 127
Cdd:cd18480   80 EAR 82
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 62-127 7.63e-09

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 53.70  E-value: 7.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574284911   62 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKR 127
Cdd:pfam07707  11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 52-127 1.73e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 49.62  E-value: 1.73e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574284911  52 IAILKWSSHpYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLIKWGEHQLMKR 127
Cdd:cd18455    6 IGIRDFAER-FSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVgNEEYIFEAVLRWVRHDPEER 81
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 47-102 3.07e-06

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 44.96  E-value: 3.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 574284911  47 SLDTLIAILKWSSHpYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQS 102
Cdd:cd14733    1 DPENCLGILELADL-YNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 71-130 4.04e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 43.21  E-value: 4.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 574284911  71 ALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLIKWGEHQLMKRIAD 130
Cdd:cd18516   25 ARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVeKEEDVFEAVMKWVGKDQEERTKA 85
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 62-137 7.76e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 39.74  E-value: 7.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574284911  62 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLIKWGEHQLMKRIADRePNLLS 137
Cdd:cd18469   18 HGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVrDEQSRLEAVLRWVGHDPQARAAHL-PELLS 93
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 68-137 1.75e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 38.75  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  68 HRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEH----------QLMKRIadREPnLL 136
Cdd:cd18445   22 LKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTvPSEEKVFEAVMSWVNHdpenrkehlaELLEHV--RLP-LL 98


                 .
gi 574284911 137 S 137
Cdd:cd18445   99 S 99
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 62-119 2.10e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 37.29  E-value: 2.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 574284911  62 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKW 119
Cdd:cd18494   15 YGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREW 72
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 79-138 2.99e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 37.90  E-value: 2.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 574284911  79 FSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKRiADREPNLLSG 138
Cdd:cd18514   33 FETVRESEDFYSLSKDKLLDLISSDELEiEDEQVVFNAVLQWVKYDLEKR-KDYLPELLRN 92
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 70-122 3.03e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 37.78  E-value: 3.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 574284911  70 QALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQAS-EQDILKYLIKWGEH 122
Cdd:cd18485   24 RARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSrEESILDLVLRWVNH 77
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 69-137 3.34e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 37.79  E-value: 3.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574284911  69 RQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLIKWGEHQLMKRIADREpNLLS 137
Cdd:cd18462   23 KESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVwKEEVLIEAVVKWVAHDVEKRIECAY-DLLS 91
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 79-127 4.88e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 37.03  E-value: 4.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 574284911  79 FSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLMKR 127
Cdd:cd18476   33 FPDVAASEDLKELCASELLDYLGDDELCGEEEQVFETLMVWIRHDPKAR 81
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 76-122 9.65e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 36.44  E-value: 9.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 574284911  76 CEEF-----SQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEH 122
Cdd:cd14822   25 CCQFmdrnaQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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