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Conserved domains on  [gi|574584363|ref|NP_001276096|]
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zinc finger protein 227 isoform b [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584363 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584363 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 8.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 574584363  343 NLRVHQRVHRGEKPYKCEECGKGFTQ 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584363 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-655 2.64e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 224 EKCFSQSSHLRTHQRIHPGEKLNRCHESGD---CFNKSSFHSYQSNHTGEKSYRC-DSCGKGFSSSTGLIIHYRTHTGEK 299
Cdd:COG5048   40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSND 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 300 PYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECgkgFGWSVNLRVHQRVHrgeKPYKCEECGKGFTQAAHFHIHQRVH 379
Cdd:COG5048  120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 380 TGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVH 459
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 460 QNVHTGekrfkcetcgkgfSQSSKLQThqrvhtgeKPYRCDVCGKDFSYSSNLKLHQ--VIHTGE--KPYKCEE--CGKG 533
Cdd:COG5048  274 SPNESD-------------SSSEKGFS--------LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 534 FSWRSNLHAHQRVHSGEKPYKC--EQCDKSFSQAIDFRVHQRV--HTGEKPYKCGV-----CGKGFSQSSGLQSHQRVHT 604
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHL 412

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 574584363 605 GEKP--YKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKgFGRSLNLRHH 655
Cdd:COG5048  413 SFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 549-632 2.52e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 549 GEKPYKCE--QCDKSFSQAIDFRVHqRVHtgekpykcGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIY 626
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 574584363 627 HqRGHT 632
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
469-747 2.67e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 469 FKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL--HQVIHTGEKPYKCEECGKG--FSWRSNLHAHQ 544
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 545 RVHS--GEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQ-------------------SHQRVH 603
Cdd:COG5048  114 SSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 604 TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECG------KAFSLP 677
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574584363 678 SNLRVHLGVHTREKL-FKCEECGKGFSQSARLEAHQR--VHTGE--KPYKCDI--CDKDFRHRSRLTYHQKVHTGKK 747
Cdd:COG5048  274 SPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 8.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 574584363  343 NLRVHQRVHRGEKPYKCEECGKGFTQ 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
596-620 9.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.06e-04
                          10        20
                  ....*....|....*....|....*
gi 574584363  596 LQSHQRVHTGEKPYKCDVCGKGFRY 620
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-508 9.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.15e-04
                          10        20
                  ....*....|....*....|....*
gi 574584363  484 LQTHQRVHTGEKPYRCDVCGKDFSY 508
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 437-515 1.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 437 GEKPYKCK--ECGKGFSQASNLQVHQnvhtgekrfKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL 514
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 574584363 515 H 515
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 566-660 1.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 566 IDFRVHQRVHTGEKPYKCGV--CGKGFSQSSGLQSHqRVHTGEKPYKCDVCGKgfryssqfIYHQRGHTGEKPYKCEECG 643
Cdd:COG5189  335 IDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCD 405

                         90
                 ....*....|....*..
gi 574584363 644 KGFGRSLNLRHHqRVHT 660
Cdd:COG5189  406 KRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 521-604 1.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 521 GEKPYKCE--ECGKGFSWRSNLHAHqRVHSGEKPYKCEQCDKSfsqaidfrVHQRVHTGEKPYKCGVCGKGFSQSSGLQS 598
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 574584363 599 HqRVHT 604
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
707-732 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 574584363  707 RLEAHQRVHTGEKPYKCDICDKDFRH 732
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 3.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.28e-03
                          10        20
                  ....*....|....*....|....*
gi 574584363  511 NLKLHQVIHTGEKPYKCEECGKGFS 535
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-741 3.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 661 GEKPHICE--ECGKAFSLPSNLRVHLgvhtreklfKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTY 738
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 574584363 739 HQK 741
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-564 5.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.05e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  543 HQRVHSGEKPYKCEQCDKSFSQ 564
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-452 6.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  431 HFRVHTGEKPYKCKECGKGFSQ 452
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-396 6.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.40e-03
                          10        20
                  ....*....|....*....|..
gi 574584363  375 HQRVHTGEKPYKCDVCGKGFSH 396
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 353-404 6.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 574584363 353 GEKPYKCE--ECGKGFTQA-------AHFHIHQRVH------------TGEKPYKCDVCGKGFSHNSPLICHR 404
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQnglkyhmLHGHQNQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 605-685 7.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584363 605 GEKPYKCDVCGKGFRYSSQF--IYHQR-GHTGEKPYKCEECGKgfgrslnlrhHQRVHTGEKPHICEECGKAFSLPSNLR 681
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNglKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 574584363 682 VHLG 685
Cdd:COG5189  416 YHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 9.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.14e-03
                          10        20
                  ....*....|....*....|...
gi 574584363  441 YKCKECGKGFSQASNLQVHQNVH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
567-592 9.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 574584363  567 DFRVHQRVHTGEKPYKCGVCGKGFSQ 592
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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