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Conserved domains on  [gi|574584850|ref|NP_001276104|]
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vacuolar protein sorting-associated protein 52 homolog isoform 3 [Homo sapiens]

Protein Classification

VPS52 family protein( domain architecture ID 10514074)

VPS52 family protein such as yeast vacuolar protein sorting-associated protein 52(Vps52, also called Sac2), which is part of a multi subunit complex required for protein sorting at yeast late golgi.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps52 pfam04129
Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex ...
 1-476 0e+00

Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


:

Pssm-ID: 282044  Cd Length: 508  Bit Score: 725.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850    1 MEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAK 80
Cdd:pfam04129  33 MEDMLTEFQSDLSNISSDIDFLQEKSNEMQLRLENRQAVESKLSPFVDDLIVPPELIDDIIEGPVNEPFFATQLEILNKK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850   81 AAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIR 160
Cdd:pfam04129 113 LSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPMTNYQIIQNALLKYKFIFPFLLDNNRSLALELR 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  161 DEYVETLSKIYLSYYRSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKP-SLRSRNTIFTLGTRGSVISPtELEAPIL 239
Cdd:pfam04129 193 QAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETTAKGLFFSKPvSLKKRNTIFTIGKRGNILTM-QLDAPIL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  240 VPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLDSYLADCYDAIAVF 319
Cdd:pfam04129 272 VPHIAENNTTKYYIEALFRSLHLALLDNATSEYLFLKEFFAVSGDQAEDIFEQIFGKTLSEATKYLEQLISDCYDAIGVL 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  320 LCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSIN 399
Cdd:pfam04129 352 LSIRIINRLQLIAERRGVPALDSYLNSVLIQLWPRFQLVFDMHCESLRKANITTLVEPDTRPHYLTRRYAEFLSSFVTLS 431

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574584850  400 QTIPNERTMQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFI 476
Cdd:pfam04129 432 VTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLLGVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Name Accession Description Interval E-value
Vps52 pfam04129
Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex ...
 1-476 0e+00

Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 282044  Cd Length: 508  Bit Score: 725.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850    1 MEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAK 80
Cdd:pfam04129  33 MEDMLTEFQSDLSNISSDIDFLQEKSNEMQLRLENRQAVESKLSPFVDDLIVPPELIDDIIEGPVNEPFFATQLEILNKK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850   81 AAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIR 160
Cdd:pfam04129 113 LSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPMTNYQIIQNALLKYKFIFPFLLDNNRSLALELR 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  161 DEYVETLSKIYLSYYRSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKP-SLRSRNTIFTLGTRGSVISPtELEAPIL 239
Cdd:pfam04129 193 QAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETTAKGLFFSKPvSLKKRNTIFTIGKRGNILTM-QLDAPIL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  240 VPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLDSYLADCYDAIAVF 319
Cdd:pfam04129 272 VPHIAENNTTKYYIEALFRSLHLALLDNATSEYLFLKEFFAVSGDQAEDIFEQIFGKTLSEATKYLEQLISDCYDAIGVL 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  320 LCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSIN 399
Cdd:pfam04129 352 LSIRIINRLQLIAERRGVPALDSYLNSVLIQLWPRFQLVFDMHCESLRKANITTLVEPDTRPHYLTRRYAEFLSSFVTLS 431

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574584850  400 QTIPNERTMQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFI 476
Cdd:pfam04129 432 VTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLLGVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Name Accession Description Interval E-value
Vps52 pfam04129
Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex ...
 1-476 0e+00

Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 282044  Cd Length: 508  Bit Score: 725.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850    1 MEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAK 80
Cdd:pfam04129  33 MEDMLTEFQSDLSNISSDIDFLQEKSNEMQLRLENRQAVESKLSPFVDDLIVPPELIDDIIEGPVNEPFFATQLEILNKK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850   81 AAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIR 160
Cdd:pfam04129 113 LSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPMTNYQIIQNALLKYKFIFPFLLDNNRSLALELR 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  161 DEYVETLSKIYLSYYRSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKP-SLRSRNTIFTLGTRGSVISPtELEAPIL 239
Cdd:pfam04129 193 QAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETTAKGLFFSKPvSLKKRNTIFTIGKRGNILTM-QLDAPIL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  240 VPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLDSYLADCYDAIAVF 319
Cdd:pfam04129 272 VPHIAENNTTKYYIEALFRSLHLALLDNATSEYLFLKEFFAVSGDQAEDIFEQIFGKTLSEATKYLEQLISDCYDAIGVL 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584850  320 LCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSIN 399
Cdd:pfam04129 352 LSIRIINRLQLIAERRGVPALDSYLNSVLIQLWPRFQLVFDMHCESLRKANITTLVEPDTRPHYLTRRYAEFLSSFVTLS 431

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574584850  400 QTIPNERTMQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFI 476
Cdd:pfam04129 432 VTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLLGVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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