NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|574957162|ref|NP_001276335|]
View 

major facilitator superfamily domain-containing protein 1 isoform 3 [Homo sapiens]

Protein Classification

major facilitator superfamily domain-containing protein 1( domain architecture ID 13023811)

major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4) in humans and is a putative solute carrier transporter affected by nutrient intake

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 14-330 7.16e-176

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 494.48  E-value: 7.16e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  14 WGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMN 93
Cdd:cd17340   66 LGTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNFN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  94 LMGWLYSKIEALlgSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIF 173
Cdd:cd17340  146 VMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKESNKTGEVIKLSDVKDFPLSFWLIC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 174 IICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAF 253
Cdd:cd17340  224 IICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAF 303

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162 254 TMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17340  304 TFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEVFFIAC 380
 
Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 14-330 7.16e-176

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 494.48  E-value: 7.16e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  14 WGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMN 93
Cdd:cd17340   66 LGTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNFN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  94 LMGWLYSKIEALlgSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIF 173
Cdd:cd17340  146 VMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKESNKTGEVIKLSDVKDFPLSFWLIC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 174 IICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAF 253
Cdd:cd17340  224 IICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAF 303

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162 254 TMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17340  304 TFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEVFFIAC 380
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-330 1.98e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 94.56  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  25 IGQVVFALGGIFNAF----WLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYs 100
Cdd:COG2223   75 IGLLLLGIGLLLLALavsyWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 101 kieallgsaghTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFslplWLIFIICVCYY 180
Cdd:COG2223  154 -----------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF----WLLSLLYFGTF 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 181 VAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPW- 259
Cdd:COG2223  219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL-LLLALALGSLWl 297

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 574957162 260 --IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----YLFLEVFFIAC 330
Cdd:COG2223  298 flVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsytaaFLVFAVLALVA 375
MFS_1 pfam07690
Major Facilitator Superfamily;
28-306 2.48e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.22  E-value: 2.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162   28 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEallg 107
Cdd:pfam07690  74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  108 saghttlgiTLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdVKDFSLPLWLIFIICVCYYVAVFPFI 187
Cdd:pfam07690 150 ---------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLALLLFGFAFFGL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  188 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVS----HMMLAFTMWNPWIAMC 263
Cdd:pfam07690 220 LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgllLLSLTLSSLWLLLALL 299

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 574957162  264 LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAI 306
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 46-319 3.74e-08

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 54.65  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162   46 RFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSkieallgsagHTTLGITLMIGGITC 125
Cdd:TIGR00893  89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI----------HFSWQWAFIIEGVLG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  126 ILSLICALAL--------AYLDQRAERILHK-----EQGKTGEVIKLTDVKD--FSLPLWLIFIICVCYYVAVFPFIGLG 190
Cdd:TIGR00893 159 IIWGVLWLKFipdppqkaKWLTEEEKYIVVGgllaeQQGKGPSTPKKYQIKEllKDRRVWGLALGQFLVNIGLGFFLTWF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  191 KVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVD---KTGKNIIWVLCAVAATLVSHMMLAF---TMWNPWIAMCL 264
Cdd:TIGR00893 239 PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFatnYVNIPYAALAL 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162  265 LGLSY--SLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:TIGR00893 319 VALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTG 375
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 224-327 1.16e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 41.06  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  224 GLLVDKTGKNIIWVLCAVAATLVSHMM-LAFTMWNPWIAMC---LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSI 299
Cdd:PRK08633   68 GFLADKFSKNRVIRIVKLFEVGLTLLIvLAYYLGWFWLAFAvtfLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAF 147

                          90       100
                  ....*....|....*....|....*...
gi 574957162  300 qnlglAIISIIAGMILDSrgyLFLEVFF 327
Cdd:PRK08633  148 -----TIVAILAGTALFS---FLFESVN 167
 
Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 14-330 7.16e-176

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 494.48  E-value: 7.16e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  14 WGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMN 93
Cdd:cd17340   66 LGTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNFN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  94 LMGWLYSKIEALlgSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIF 173
Cdd:cd17340  146 VMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKESNKTGEVIKLSDVKDFPLSFWLIC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 174 IICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAF 253
Cdd:cd17340  224 IICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAF 303

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162 254 TMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17340  304 TFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEVFFIAC 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 17-316 2.02e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 99.81  E-value: 2.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  17 IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMG 96
Cdd:cd06174   62 PVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  97 WLYSKIEALLGSAghttlgitLMIGGITCILSLIcALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIIC 176
Cdd:cd06174  142 ILASSLGFGWRAV--------FLIAAALALLAAI-LLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAI 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 177 VCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG--KNIIWVLCAVAATLVSHMMLAFT 254
Cdd:cd06174  213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIgrKPLLLIGLLLMALGLALLLLAPS 292

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574957162 255 MWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILD 316
Cdd:cd06174  293 LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-330 1.98e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 94.56  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  25 IGQVVFALGGIFNAF----WLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYs 100
Cdd:COG2223   75 IGLLLLGIGLLLLALavsyWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 101 kieallgsaghTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFslplWLIFIICVCYY 180
Cdd:COG2223  154 -----------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF----WLLSLLYFGTF 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 181 VAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPW- 259
Cdd:COG2223  219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL-LLLALALGSLWl 297

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 574957162 260 --IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----YLFLEVFFIAC 330
Cdd:COG2223  298 flVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsytaaFLVFAVLALVA 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
25-303 1.75e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.63  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  25 IGQVVFALGGIFNAF----WLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLys 100
Cdd:COG2814   80 LGLLLFALGSLLCALapslWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL-- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 101 kieallgsAGHTTLGITLMIGGITCILSLIcaLALAYLDQRAERILHKEQGKTGEVIKLTdvkdfslPLWLIFIICVCYY 180
Cdd:COG2814  158 --------ADLFGWRWVFLVNAVLALLALL--LLLRLLPESRPAARARLRGSLRELLRRP-------RLLLLLLLAFLLG 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 181 VAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLAFTMWNPW 259
Cdd:COG2814  221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGrRRLLLIGLLLLALGLLLLALAGSLWLLL 300

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 574957162 260 IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLG 303
Cdd:COG2814  301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-330 2.39e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.14  E-value: 2.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  28 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLyskieallg 107
Cdd:COG2271   87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL--------- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 108 sAGHTTLGITLMIGGITCILSLIcalalayldqraerilhkeqgktgevikltdvkdfsLPLWLIFIICVCYYVAVFPFI 187
Cdd:COG2271  158 -LAAFGWRAAFLILGLPGLLLAL------------------------------------LRFWLLALAYFLVYFALYGFL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 188 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPW---IAMCL 264
Cdd:COG2271  201 TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAlaiALLFL 280

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 574957162 265 LGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:COG2271  281 AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
82-320 9.46e-15

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 74.94  E-value: 9.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  82 SMARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGITCILSLICALALAyldqrAERILHKEQGKTGevikLTD 161
Cdd:COG2211  150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGT-----KERPVPEEEKVSL----KES 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 162 VKDF--SLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLC 239
Cdd:COG2211  221 LKALlkNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 240 AVAATLVSHMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQL-------GTAYGFMQSIQNLGLAIISI 309
Cdd:COG2211  301 LLLAALGLLLLFFLGPGNLWlllVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGA 380

                        250
                 ....*....|.
gi 574957162 310 IAGMILDSRGY 320
Cdd:COG2211  381 LAGLLLALFGY 391
MFS_1 pfam07690
Major Facilitator Superfamily;
28-306 2.48e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.22  E-value: 2.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162   28 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEallg 107
Cdd:pfam07690  74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  108 saghttlgiTLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdVKDFSLPLWLIFIICVCYYVAVFPFI 187
Cdd:pfam07690 150 ---------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLALLLFGFAFFGL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  188 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVS----HMMLAFTMWNPWIAMC 263
Cdd:pfam07690 220 LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgllLLSLTLSSLWLLLALL 299

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 574957162  264 LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAI 306
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 28-330 1.59e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.07  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  28 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIeallg 107
Cdd:cd17325   73 VSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 108 saGHTTLGItlmiggITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFI 187
Cdd:cd17325  148 --GYRAPFL------VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALE 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 188 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMM-LAFTMWNPWIAMCLLG 266
Cdd:cd17325  220 PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLpLATSFWLLLLLLALLG 299

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 574957162 267 LSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY----LFLEVFFIAC 330
Cdd:cd17325  300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFatpfLAAAALLLLA 367
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 19-330 2.82e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 61.05  E-value: 2.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  19 FSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWL 98
Cdd:cd17319   71 LAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  99 yskiealLGSAGHTTLGITlmIGGITCILSLICalaLAYLDQraerilhkeqgktgevikltdvkdfslpLWLIFIICVC 178
Cdd:cd17319  151 -------LLLFGWRWAFII--EGLLGLLLAVLW---WFYLRQ----------------------------VWGLALGYFG 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 179 YYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG----KNIIWVLCAVAATLvshMMLAFT 254
Cdd:cd17319  191 INYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVG---LLLAYL 267

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 574957162 255 MWNPWIAMCLLGLSYSLLACA---LWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17319  268 TTSPVVAVILLSLAGFGIGAAspvFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAA 346
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 169-330 2.82e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.00  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 169 LWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH 248
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 249 MMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEV 325
Cdd:cd17316  259 PLFYLLSGSPTlllLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338


                 ....*
gi 574957162 326 FFIAC 330
Cdd:cd17316  339 LILAL 343
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 144-326 4.87e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 57.17  E-value: 4.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 144 RILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVF 223
Cdd:cd17370  177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFL--ILRAQELGLSAALIPLLYALFNLVYALAAYPA 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 224 GLLVDKTGKN---IIWVLCAVAATLVshMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQ 300
Cdd:cd17370  255 GRLSDRIGRKkllILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV 332

                        170       180
                 ....*....|....*....|....*.
gi 574957162 301 NLGLAIISIIAGMILDSRGYLFLEVF 326
Cdd:cd17370  333 GIGWLLASLIAGYLWDLISPSAAFLF 358
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 46-319 3.74e-08

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 54.65  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162   46 RFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSkieallgsagHTTLGITLMIGGITC 125
Cdd:TIGR00893  89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI----------HFSWQWAFIIEGVLG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  126 ILSLICALAL--------AYLDQRAERILHK-----EQGKTGEVIKLTDVKD--FSLPLWLIFIICVCYYVAVFPFIGLG 190
Cdd:TIGR00893 159 IIWGVLWLKFipdppqkaKWLTEEEKYIVVGgllaeQQGKGPSTPKKYQIKEllKDRRVWGLALGQFLVNIGLGFFLTWF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  191 KVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVD---KTGKNIIWVLCAVAATLVSHMMLAF---TMWNPWIAMCL 264
Cdd:TIGR00893 239 PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFatnYVNIPYAALAL 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162  265 LGLSY--SLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:TIGR00893 319 VALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTG 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 126-329 2.37e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.17  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 126 ILSLICALALAYLdqrAERILHKEQGKTGEVIKLTDVKdFSLPLWLIFIICVCYY---VAVFPFIGLgkvFFTEKFGFSS 202
Cdd:cd17324  161 VLALLAALLLWRL---LPSLPPKKPGSLGLLSSLLLLL-RNPRLRLAYLITFLLFggfFALYTYLAP---FLTDVPGFSS 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 203 QAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVA 281
Cdd:cd17324  234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGrRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 574957162 282 FVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIA 329
Cdd:cd17324  314 RLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 107-320 1.27e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 49.91  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 107 GSAGHTTLGITLMIGGITCILSLICALalayldQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIIC-VCYYVAVFP 185
Cdd:cd17332  166 GNASRGYFLTALIIGIIGIILLLICFF------GTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAyLLYFLAFNI 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 186 FIGLGKVFFTEKFGFSSQAASAINSVVyVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPW---IAM 262
Cdd:cd17332  240 VNTVLVYYFKYVLGGRAELVLLLLLIL-SGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVlilVLA 318

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 574957162 263 CLLGLSYSLLACALWPMVAFVVPEHQL-------GTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:cd17332  319 VLAGIGYGGANLLPWAMLADVIDYGELktgkrreGIFYSVMTFFRKLGLALAGALVGLILSLAGY 383
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
170-320 1.28e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 170 WLIFIICVCYYVAVFPF---IGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLV 246
Cdd:COG2271    9 WRILALLFLAYFLNYLDrsnLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574957162 247 ShmMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:COG2271   89 T--LLFGFATSFWqllLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
MFS_1 pfam07690
Major Facilitator Superfamily;
172-320 1.47e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  172 IFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMML 251
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  252 AFTMWNPWIAM-CLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:pfam07690  81 FASSLWLLLVLrVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW 150
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 25-318 2.86e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.71  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  25 IGQVVFALG----GIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLys 100
Cdd:cd17321   66 IGLALFGLAsllcALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL-- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 101 kieallgsAGHTTLGITLMIGGITCILSLICAlalayldqraerilhkeqgktgevikltdvKDFSLPLWLIFIICVCYY 180
Cdd:cd17321  144 --------LELFGWRWIFLINVPIGLVALLLA------------------------------RTFSGAVLAAFLLGAALG 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 181 VAVFPFIglgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNII----WVLCAVAATLVSHMMLAFTMW 256
Cdd:cd17321  186 GLLFLLP----LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVlvagLLLTAVGLLLLALLGADSSVW 261

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574957162 257 NPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSR 318
Cdd:cd17321  262 LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 198-330 3.84e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 3.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 198 FGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH-MMLAFTMWNPWIAMCLLGLSYSLLACAL 276
Cdd:cd06174   26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALlFAFAPSFWLLLLGRFLLGLGSGLIDPAV 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 574957162 277 WPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd06174  106 LALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 219-320 4.85e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 219 MSPVFGLLVDKTGKNIIWVLCAVAATLVshMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGF 295
Cdd:cd17489  243 SRPFSGKLSDRKGPKTVIIPGLLLLALG--LLLLSFAGSPWmllLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320

                         90       100
                 ....*....|....*....|....*
gi 574957162 296 MQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:cd17489  321 FFIFFDLGIGLGGLLLGLVAELFGY 345
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
14-330 4.87e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  14 WGTIIFSCFVCIGQVVFALGGifnAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMArIGSTVNMN 93
Cdd:COG0738   74 RGLLLGLLLMALGLLLFALAP---SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  94 LMGWLyskieaLLGSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdvkdfslPLWLIF 173
Cdd:COG0738  150 LGGLL------ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNP-------RLLLGG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 174 IICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLA 252
Cdd:COG0738  217 LAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLA 296

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 574957162 253 FTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:COG0738  297 PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
199-319 4.97e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.95  E-value: 4.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 199 GFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFT-MWNPWIAMCLLGLSYSllacALW 277
Cdd:COG2807  246 GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQG----GLF 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 574957162 278 PMVAFVVPEH-----QLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:COG2807  322 PLALTLIGLRartpaEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
192-319 6.44e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 6.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 192 VFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT----GKNIIWVL-CAVAATLVSHMMLAFTMWNPW------- 259
Cdd:COG2211   35 YFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRRPWILiGAIPLALSFVLLFTAPDLSPTgkliyal 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 574957162 260 IAMCLLGLSYSLLACALWPMVAFVVPE-HQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:COG2211  115 VTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
193-320 1.27e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 193 FFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShmMLAFTMWNPW---IAMCLLGLSY 269
Cdd:COG2814   35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS--LLCALAPSLWlllAARFLQGLGA 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 574957162 270 SLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:COG2814  113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 156-317 2.09e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 156 VIKLTDVKDFSLPLWLI-----FIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT 230
Cdd:cd17504  165 LVPLIDLRLLRRRNVLLanitaLLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARV 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 231 GKNIIwVLCAVAATLVSHMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAII 307
Cdd:cd17504  245 GPRRV-LLIGLVISAVGLLLLALLHSSLWalvVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323

                        170
                 ....*....|
gi 574957162 308 SIIAGMILDS 317
Cdd:cd17504  324 PAIAGAILTT 333
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 169-320 3.09e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 169 LWLIFIICVCYYVAVFPFIGLgkvfFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH 248
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 574957162 249 MMLAFTmwNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:cd17325   77 LFAFAT--SYWqllLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGY 149
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 29-319 3.41e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 45.31  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  29 VFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLyskieallgs 108
Cdd:cd17475   74 AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL---------- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 109 AGHTTLGITLMIGGITCILSLICALALaYLDQRAERilhKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIG 188
Cdd:cd17475  144 ALHYGWRAAFVVAGLVSILAAVLFWLF-YREPPAAS---AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLT 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 189 LGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDK--TGKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLG 266
Cdd:cd17475  220 FLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 574957162 267 LSYSLLACALW-----PMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:cd17475  300 LILLGLFAIGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATH 357
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 23-330 3.47e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 45.26  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  23 VCIGQVVFALGGI----FNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWL 98
Cdd:cd17473   68 LIAGLLLYGIGGVaglfLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  99 yskieALLGSagHTTLGITLmiggitciLSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVC 178
Cdd:cd17473  148 -----AEIGW--RAPFLVYL--------LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 179 YYVAV--FPFiglgkvFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLvSHMMLAFTMW 256
Cdd:cd17473  213 FYVIPiqLPF------LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL-GFLLLALASG 285

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 574957162 257 NPWIAMCLL--GLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGlAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17473  286 LWVVLLGAIlaGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG-QFLSPLVLGPLVNLTGGLSGAFLILG 360
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 169-323 8.45e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.14  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 169 LWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIwVLCAVAATLVSH 248
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPV-MLAGLLLRALGF 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 574957162 249 MMLAFtMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAG-MILDSRGYLFL 323
Cdd:cd17329   80 ALLGF-AHSPWlfaIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGlLLLYSFRLLFL 157
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 16-330 1.32e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 43.39  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  16 TIIFSCFVCIGQVVFALGGifNAFWLMEFGRFVFGIGGESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLM 95
Cdd:cd17341   67 FIASLLLLLIPLLALALAV--SSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  96 GWLYSKIEALLGSAGHTtlgitlMIGGITCILSLICALALAYLDQRAerilhkEQGKTGEVIKLTDVKDfSLPLWLIFII 175
Cdd:cd17341  144 PLIAGAIVFDGGFVGWR------NAFFVPGILLAIAAVLVLLFGDDL------PTGKASALEFLKVQLA-VLKNYRTWIL 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 176 CVCYYVAVFPFIGLGKVF---FTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKN----IIWVLCAVAATLVSh 248
Cdd:cd17341  211 SLLYGVTFGSFVGFSNVLptyFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRrrlwWLFIVMTIGAALLS- 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 249 MMLAFTMWNPWIA---MCLLGLSYSLLACALWPMVAFVVPEhQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----Y 320
Cdd:cd17341  290 LSLPTSGTNLVLFlalFVALGLGAGAGNGSVFRMVPFIFRR-ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGsgvgaF 368

                        330
                 ....*....|
gi 574957162 321 LFLEVFFIAC 330
Cdd:cd17341  369 SLFGVLAVAC 378
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 17-310 2.17e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.01  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  17 IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNmNLMG 96
Cdd:cd17327   72 KWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  97 WLYSKIEALLGSAGHTTLgiTLMIGGITCILSLICALAL------AYLDQRAERILHKE------QGKTGEVIKLTDVKD 164
Cdd:cd17327  151 YGVFKILGVGGLAGWRWL--FIIEGLITIIIGLVIFFWLpdnpskAWFLTEEEKELAVErlranqTGKGDQKFKWKQIKE 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 165 F--SLPLWLIFIICVCYYVAVFpFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVA 242
Cdd:cd17327  229 AfkDPRTWLLFLFFFCSQITNN-GISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACV 307

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 574957162 243 ATLVSHMMLAFTMWNPWI--AMCLLGL-SYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISII 310
Cdd:cd17327  308 LALVGSIILLAAPNPPGAyfAAYILGGgSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQI 378
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 22-330 2.25e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  22 FVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWlysk 101
Cdd:cd17477   67 GAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL---- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 102 iealLGSAGHTTLgitlmigGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLtdvkdfslpLWLIFIICVCYYV 181
Cdd:cd17477  143 ----VGTAGALPF-------LIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRI---------APLALLGAFVAGF 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 182 AVFPFIGLGKVFFTEKfGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPWIA 261
Cdd:cd17477  203 LEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAA-LLLPLVPGLPLAL 280

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 574957162 262 MCLL----GLSYSLLACALwPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 330
Cdd:cd17477  281 LVLLflwgGAAGPLYTLAL-ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAV 352
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 117-319 3.59e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.15  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 117 TLMIGGITCILSLICALALAYLDQRAerilhkeqgktgevikltdvkdFSLPLWLIFIICVCYYVavfPFIGLgkVFFTE 196
Cdd:cd17352  159 ALLILGGLCLNLCVCGLLLRLLKDPT----------------------FVLLALGVSFAMLGFFV---PFVYL--PSYAK 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 197 KFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVlCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACAL 276
Cdd:cd17352  212 SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYL-YIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSY 290

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 574957162 277 WPMVAFVVPEH----QLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 319
Cdd:cd17352  291 SSLTPVILADLvgleKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 193-328 5.43e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 193 FFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNiiWVLcaVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLL 272
Cdd:cd17478   21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR--YLL--PLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 273 ACALW----PMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFI 328
Cdd:cd17478   97 GSAAFhpegARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI 156
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
170-320 9.51e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.02  E-value: 9.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 170 WLIFIICVCYYVAVFPFIglgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSH 248
Cdd:COG2223   11 TLAFFLAFGVWYLWSVLA----PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLGIGLLL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 574957162 249 MMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 320
Cdd:COG2223   87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 224-327 1.16e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 41.06  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  224 GLLVDKTGKNIIWVLCAVAATLVSHMM-LAFTMWNPWIAMC---LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSI 299
Cdd:PRK08633   68 GFLADKFSKNRVIRIVKLFEVGLTLLIvLAYYLGWFWLAFAvtfLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAF 147

                          90       100
                  ....*....|....*....|....*...
gi 574957162  300 qnlglAIISIIAGMILDSrgyLFLEVFF 327
Cdd:PRK08633  148 -----TIVAILAGTALFS---FLFESVN 167
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 130-274 3.99e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.82  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 130 ICALALAYLDQRAERILHKEQGKTGEVIK---LTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAAS 206
Cdd:cd17367  183 VLAVVVLWLRRGLEETESFEAIAESNEASagtLRELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDAT 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 207 AINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAF--TMWNPWIAMCLLGLSYSLLAC 274
Cdd:cd17367  263 WITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAldHTDSPYTAFALVLVGLVFLSG 332
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 17-329 5.74e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 38.36  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  17 IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMG 96
Cdd:cd17485   70 LPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162  97 WLYSKIeallgsaghttlGITLMIGGITCILSLICALALAYLDQRAERilHKEQGKTGEVIKLTDVKDFSLP--LWLIFI 174
Cdd:cd17485  150 WLYDLI------------GWQSLLLSLAALYLLLLLPVLFLRELELPQ--QPPASERGAALKASLRAFLRRPgtRWLLLF 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 175 IcVCYYVAVFPFIGLGKVFFTEKfGFSSQAASAINSVV-YVISAPMSPVFGLLVDKTGKN---IIWVLCAVAA----TLV 246
Cdd:cd17485  216 L-LLYKLGEQGALAMLPPFLVDR-GFSLSQIGLLSGVGgSLVSIAGSLLGGYLLKRRGRRrllLLGGLLRLLLlglyTLL 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574957162 247 SHMMLAFTMWNPWIAMCLLGLSYSLLACALWP-MVAFVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEV 325
Cdd:cd17485  294 ALGGSGLNWVLLLASLALLHLVGGMITTALFTlMMDCSQQAQA-GTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFL 372


                 ....
gi 574957162 326 FFIA 329
Cdd:cd17485  373 LFAI 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH